Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 301310 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#301310, RRID:AB_314162
- Product name
- APC anti-human CD11b
- Antibody type
- Monoclonal
- Antigen
- CD11b
- Description
- CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and Factor X.
- Reactivity
- Human, Porcine, Simian
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Neutrophils express distinct RNA receptors in a non-canonical way.
Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Berger M, Hsieh CY, Bakele M, Marcos V, Rieber N, Kormann M, Mays L, Hofer L, Neth O, Vitkov L, Krautgartner WD, von Schweinitz D, Kappler R, Hector A, Weber A, Hartl D
The Journal of biological chemistry 2012 Jun 1;287(23):19409-17
The Journal of biological chemistry 2012 Jun 1;287(23):19409-17
Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis.
Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE
Infection and immunity 2010 Nov;78(11):4936-43
Infection and immunity 2010 Nov;78(11):4936-43
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood granulocytes stained with ICRF44 APC
- Conjugate
- Red dye