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- Antigen structure
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- Product number
- 15649-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15649-1-AP, RRID:AB_2122307
- Product name
- IKBKB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IKBKB antibody (Cat. #15649-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo.
ROS-Scavenging Bamboo-Derived Carbon Dot-Methotrexate Nanocomposite Ameliorates Rheumatoid Arthritis through Dual Therapeutic Mechanisms.
Piezo2 Mediates a Vicious Cycle of "Mechanical Homeostasis Imbalance-Inflammation" in Sensory Nerves and the Cartilage Endplate.
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis.
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
14-3-3 Proteins Negatively Regulate Microglial Activation via Inhibition of the NF-κB Pathway.
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Kaempferol Alleviates Dry Eye Disease Via Modulation of the IDH3B/CCAR2/IKBKB Axis.
LPAR1 Promotes Activation of Pathways Alveolar Hypercoagulation and Fibrinolytic Inhibition in ARDS via NF-κB Signaling Pathway.
Strand-specific functions of miR-301a-3p and -5p drive opposing roles in pancreatic cancer via ferroptosis and pyroptosis.
Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model.
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Targeted suppression of CCR7/NF-κB signaling by apoptotic body-inspired colchicine nanovesicles halts atherosclerotic progression.
Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF-κB Signaling Pathway in LPS-Induced ARDS.
Polystyrene microplastics trigger colonic inflammation in rats via the TLR4/NF-κB/COX-2 pathway and modulation of intestinal microbiota.
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis.
Inhibitory Effect and Mechanism of the Down-Regulation of TRIM32 in Colorectal Cancer.
Structural characterization of an apple polysaccharide and its anti-inflammatory effect through suppressing TLR4/NF-κB signaling.
Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.
Targeted lipidomic reveals dietary LA/n-3 PUFAs regulate inflammation and redox status via oxylipins in bivalves.
Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice.
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation.
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα.
ZIP8 Regulates Inflammation and Macrophage Polarisation in Intervertebral Disc Degeneration via the Wnt/β-Catenin Pathway.
Propofol inhibits glioma growth by blocking the formation of the NF-κB/LGI4 feedback loop to activate TP53 self-transcription.
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways.
The β2-adrenergic receptor modulates activity of porcine alveolar macrophages in response to Actinobacillus pleuropneumoniae infection.
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Multidimensional role of adapalene in regulating cell death in multiple myeloma.
Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway.
Efficacy and mechanism of action of ginsenoside Rg3 on radiation proctitis in rats.
Ginsenoside compound K alleviates D-galactose-induced mild cognitive impairment by modulating gut microbiota-mediated short-chain fatty acid metabolism.
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Rhein inhibits M1 polarization of BV2 microglia through MAPK/IκB signalling pathway and reduces neurotoxicity caused by neuroinflammation.
Role of NF-κB signaling pathway in H(2)O(2)-induced oxidative stress of hiPSCs.
EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β.
Sirtuin 5-Mediated Desuccinylation of ALDH2 Alleviates Mitochondrial Oxidative Stress Following Acetaminophen-Induced Acute Liver Injury.
Aucklandiae radix targeted PKM2 to alleviate ulcerative colitis: Insights from the photocrosslinking target fishing technique.
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.
WNT2B activates macrophages via NF-κB signaling pathway in inflammatory bowel disease.
Eucalyptol, limonene and pinene enteric capsules attenuate airway inflammation and obstruction in lipopolysaccharide-induced chronic bronchitis rat model via TLR4 signaling inhibition.
Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway.
Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury via HDAC9-mediated NF-κB pathway.
Weissella paramesenteroides NRIC1542 inhibits dextran sodium sulfate-induced colitis in mice through regulating gut microbiota and SIRT1/NF-κB signaling pathway.
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation.
6-Gingerol ameliorates alveolar hypercoagulation and fibrinolytic inhibition in LPS-provoked ARDS via RUNX1/NF-κB signaling pathway.
GDF-15 alleviates diabetic nephropathy via inhibiting NEDD4L-mediated IKK/NF-κB signalling pathways.
KDF1 promotes ameloblast differentiation by inhibiting the IKK/IκB/NF-κB axis.
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway.
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways.
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88.
The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.
Role of NLRP3 inflammasome activation in HCC cell progression.
Xuelian injection ameliorates complete Freund's adjuvant-induced acute arthritis in rats via inhibiting TLR4 signaling.
Arenobufagin increases the sensitivity of gastric cancer to cisplatin via alkaliptosis.
Rabdosichuanin C inhibits productions of pro-inflammatory mediators regulated by NF-κB signaling in LPS-stimulated RAW264.7 cells.
Network Analysis and Experimental Verification of the Mechanisms of Hydroxysafflor Yellow A in Ischemic Stroke Following Atherosclerosis.
Schwann Cell-Derived Exosomes and Methylprednisolone Composite Patch for Spinal Cord Injury Repair.
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Chinese herbal formula, modified Xianfang Huoming Yin, alleviates the inflammatory proliferation of rat synoviocytes induced by IL-1β through regulating the migration and differentiation of T lymphocytes.
miR-9 targeting RUNX1 improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-κB inactivation in ARDS.
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression.
A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis.
A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice.
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction.
Galectin-3 Inhibition Ameliorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice.
MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway.
Qizhi Kebitong Formula Ameliorates Streptozocin-Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF-κB Pathway.
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Equus β-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage.
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion.
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Renoprotective activity of Ribes diacanthum pall (RDP) against inflammation in cisplatin-stimulated mice model and human renal tubular epithelial cells.
tRNA-derived fragment TRF365 regulates the metabolism of anterior cruciate ligament cells by targeting IKBKB.
Qiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology.
Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.
Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells.
Curcumin activates the Nrf2 Pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings.
RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway.
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.
HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway.
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM(2.5).
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Evaluation of cancer-derived myocardial impairments using a mouse model.
Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Therapeutic potential of proteasome inhibitors for dihydropyridine-induced gingival overgrowth.
Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.
Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Omentin-1 protects against bleomycin-induced acute lung injury.
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
scAAV9-VEGF-165 inhibits neuroinflammatory responses and invasion of macrophages into the peripheral nervous system of ALS transgenic mice.
Crucial microRNAs and genes in metformin's anti-pancreatic cancer effect explored by microRNA-mRNA integrated analysis.
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Dopamine D(2) receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ.
Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.
Hao R, Sun Y, Wang C, Wang Y, Li L, Sun H, Chen L
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Li Q, Chen L, Sun Y, Wang C, Sun Y, Lu K, Li L, Sun H, Liu M
Journal of nanobiotechnology 2026 Jan 29;24(1)
Journal of nanobiotechnology 2026 Jan 29;24(1)
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Chen C, Ma L, Dawuti A, Feng X, Chen S, An X, Bai Y, Zhang T, Aydin M, Kashmiri K, Ma Z, Zhang W, Yaermaimaiti S, Abulizi A
NPJ science of food 2026 Jan 23;10(1):73
NPJ science of food 2026 Jan 23;10(1):73
FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo.
Fu Q, Ou Y, Wu Q, Gong J, Li F, Wang T, Lin Z, Huang K, Xie J
International journal of molecular medicine 2026 Feb;57(2)
International journal of molecular medicine 2026 Feb;57(2)
ROS-Scavenging Bamboo-Derived Carbon Dot-Methotrexate Nanocomposite Ameliorates Rheumatoid Arthritis through Dual Therapeutic Mechanisms.
Hu XR, Wang F, Zhao BF, Xu F, Wang Y
ACS omega 2026 Feb 3;11(4):5853-5864
ACS omega 2026 Feb 3;11(4):5853-5864
Piezo2 Mediates a Vicious Cycle of "Mechanical Homeostasis Imbalance-Inflammation" in Sensory Nerves and the Cartilage Endplate.
Xu H, Geng W, Du Z, Du Y, Wu D, Tong B, Liang H, Zhou X, Ou Z, Wei J, Wang K, Song Y, Hua W, Xu Y, Ke W, Wang B, Yang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e07299
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e07299
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Zhong C, Song N, Huang P, Han L, Zhang J, Lu Z, Wang L
Biomaterials research 2025;29:0249
Biomaterials research 2025;29:0249
SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis.
Yu Q, Yang D, Ran B, Pan J, Song Y, Cui M, He Q, Mei C, Wang H, Li H, Li G, Meng Y, Wang F, Guo W, Zhu C, Chen S
International journal of biological sciences 2025;21(10):4663-4682
International journal of biological sciences 2025;21(10):4663-4682
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Wei J, Xie J, He Z, Feng X
Frontiers in pharmacology 2025;16:1742401
Frontiers in pharmacology 2025;16:1742401
14-3-3 Proteins Negatively Regulate Microglial Activation via Inhibition of the NF-κB Pathway.
Stone WJ, Pair FS, Ekkatine R, Gannon M, Scholz K, Pattanayak R, Syed R, Yacoubian TA
Journal of neurochemistry 2025 Sep;169(9):e70228
Journal of neurochemistry 2025 Sep;169(9):e70228
DCAAA mitigates neuroinflammation and microglial pyroptosis in spinal cord injury by inhibiting PI3K/AKT/NF-κB and NLRP3/caspase-1/GSDMD signaling.
Gao J, Liu Y, Li R, Liu Y, Qi Z, Zhang Z
European journal of pharmacology 2025 Sep 5;1002:177816
European journal of pharmacology 2025 Sep 5;1002:177816
Kaempferol Alleviates Dry Eye Disease Via Modulation of the IDH3B/CCAR2/IKBKB Axis.
Zhang S, Sha Y, Xie Y, Hong J
Investigative ophthalmology & visual science 2025 Sep 2;66(12):50
Investigative ophthalmology & visual science 2025 Sep 2;66(12):50
LPAR1 Promotes Activation of Pathways Alveolar Hypercoagulation and Fibrinolytic Inhibition in ARDS via NF-κB Signaling Pathway.
Liu Y, Chen X, Liu M, Yuan J, Li Q, Li L, Dong Q, Tao J, Shen F, Xiao C
FASEB bioAdvances 2025 Oct;7(10):e70050
FASEB bioAdvances 2025 Oct;7(10):e70050
Strand-specific functions of miR-301a-3p and -5p drive opposing roles in pancreatic cancer via ferroptosis and pyroptosis.
Chen Y, Dai S, Cai W, Zhao J, Zhang F, Cheng CS, Chen L
Cell biology and toxicology 2025 Oct 28;41(1):145
Cell biology and toxicology 2025 Oct 28;41(1):145
Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model.
Lei C, Zhang B, Yamaguchi J, Tamura R, Zhong W, Cao X, Liu Y, Seki M, Suzuki Y, Suzuki K, Tanida I, Uchiyama Y, Hisatsune T
Journal of neuroinflammation 2025 Oct 21;22(1):237
Journal of neuroinflammation 2025 Oct 21;22(1):237
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Wei K, He L, Li X, Wu M, Wang H, Hu L, Xu H, Zhang Y, Zhou L, Xu X, Guo L
International journal of biological macromolecules 2025 Nov;329(Pt 2):147834
International journal of biological macromolecules 2025 Nov;329(Pt 2):147834
Targeted suppression of CCR7/NF-κB signaling by apoptotic body-inspired colchicine nanovesicles halts atherosclerotic progression.
Chen Q, Peng YS, Zhong Q, Zhang YB, Hu LB, Zhang GY, Xu YX, Dong PN, Shen S, Wang JH, Wang ZG, Zhang HT, Zeng R, Wang H
Journal of nanobiotechnology 2025 Nov 25;23(1):798
Journal of nanobiotechnology 2025 Nov 25;23(1):798
Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF-κB Signaling Pathway in LPS-Induced ARDS.
Chen X, Liu Y, Mu S, Chen T, Yuan J, Xiao C, Dong Q, Li Q, Wang Y, Chen Q, Li S, Li W, Shen F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 15;39(21):e71147
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 15;39(21):e71147
Polystyrene microplastics trigger colonic inflammation in rats via the TLR4/NF-κB/COX-2 pathway and modulation of intestinal microbiota.
Feng X, Zhang M, Zhao T, Cui J, Ye H, Zhou C, Ye L, Zhou L
Toxicology 2025 May;513:154090
Toxicology 2025 May;513:154090
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Meng Y, Jia Y, He Z, Li J, Yuan L
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis.
Yan LS, Kang JY, Gu CY, Qiu XY, Li JJ, Cheng BC, Wang YW, Luo G, Zhang Y
Journal of ethnopharmacology 2025 May 28;348:119801
Journal of ethnopharmacology 2025 May 28;348:119801
Inhibitory Effect and Mechanism of the Down-Regulation of TRIM32 in Colorectal Cancer.
Ning J, Cai X, Su Y, Fan X, Shen M
International journal of molecular sciences 2025 May 23;26(11)
International journal of molecular sciences 2025 May 23;26(11)
Structural characterization of an apple polysaccharide and its anti-inflammatory effect through suppressing TLR4/NF-κB signaling.
Ma S, Zhang R, Li L, Wang J, Zheng M, Guo X, Miao S, Quan W, Liu W, Shi X
International journal of biological macromolecules 2025 Mar;296:139760
International journal of biological macromolecules 2025 Mar;296:139760
Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.
Gao Q, Zhang M, Chen R, Teng P, Dai X, Wu B, Hong L, Ma L, Liu L, Wu S, Li M
Scientific reports 2025 Mar 24;15(1):10132
Scientific reports 2025 Mar 24;15(1):10132
Targeted lipidomic reveals dietary LA/n-3 PUFAs regulate inflammation and redox status via oxylipins in bivalves.
Zhu Y, Liao K, Liu Y, Huang H, Zhang Y, Ge H, Chen D, Ma B, Xu J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159631
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159631
Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice.
Wang K, Shi G, Li Y, Liu Q, Zhang Q, Wu C, Jiao Y, Ma Y, Qi A, Huang M
Environmental toxicology and pharmacology 2025 Jun;116:104706
Environmental toxicology and pharmacology 2025 Jun;116:104706
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models.
Chen H, Li G, Deng L, Li S, Huang S, Lee SM, Nie X, Bian JS
Biological research 2025 Jul 10;58(1):48
Biological research 2025 Jul 10;58(1):48
PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation.
Zhang L, Gao Y, Zhou H, Liang X, Jiang X, Gong W, Sun Y, Zhang D, Wang X, Nauwynck H, Bai J, Jiang P
PLoS pathogens 2025 Jan;21(1):e1012915
PLoS pathogens 2025 Jan;21(1):e1012915
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα.
Gao H, Sun M, Gao H, Sun Y, Chen W, Dong N
International immunopharmacology 2025 Jan 3;145:113781
International immunopharmacology 2025 Jan 3;145:113781
ZIP8 Regulates Inflammation and Macrophage Polarisation in Intervertebral Disc Degeneration via the Wnt/β-Catenin Pathway.
Xu J, Gu H, Zhou K, Wu L, Zhang Y, Bian C, Huang Z, Chen G, Cheng X, Yin X
Journal of cellular and molecular medicine 2025 Feb;29(4):e70431
Journal of cellular and molecular medicine 2025 Feb;29(4):e70431
Propofol inhibits glioma growth by blocking the formation of the NF-κB/LGI4 feedback loop to activate TP53 self-transcription.
Wang Z, Zhang LN, Wu T, Pan X, Li L
Translational oncology 2025 Dec;62:102578
Translational oncology 2025 Dec;62:102578
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Zhang X, Su Y, Yang W, Song Z, Sun Z, Wu X, Chen J, Gao B, Wang Z, Wang L, Jiang Q, Bu L, Li J, Lin Y, Xie W, Li J, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Resolvin D1 Modulates the Inflammatory Processes of Human Periodontal Ligament Cells via NF-κB and MAPK Signaling Pathways.
Yan J, Cai J, Pan X, Li S, Fenton CG, Fenton KA, Kantarci A, Xue Y, Xue Y, Xing Z
Biomedicines 2025 Dec 10;13(12)
Biomedicines 2025 Dec 10;13(12)
The β2-adrenergic receptor modulates activity of porcine alveolar macrophages in response to Actinobacillus pleuropneumoniae infection.
Xing W, Shi H, Wu W, Lu S, Fu H, Lu J, Li S, Xu B
Developmental and comparative immunology 2025 Aug;169:105420
Developmental and comparative immunology 2025 Aug;169:105420
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Qin X, Wang S, Huang J, Hu B, Yang X, Liang L, Zhou R, Huang W
Frontiers in neuroscience 2024;18:1396345
Frontiers in neuroscience 2024;18:1396345
Multidimensional role of adapalene in regulating cell death in multiple myeloma.
Cao X, Xiang J, Zhang Q, Liu J, Zhou D, Xu Y, Xu P, Chen B, Bai H
Frontiers in pharmacology 2024;15:1415224
Frontiers in pharmacology 2024;15:1415224
Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway.
Shen G, Zhang W, Tu Q, Wang J
Frontiers in pharmacology 2024;15:1389786
Frontiers in pharmacology 2024;15:1389786
Efficacy and mechanism of action of ginsenoside Rg3 on radiation proctitis in rats.
Li X, Lin L, Duan X, Dai J, Hu T, Cai H
Immunity, inflammation and disease 2024 Sep;12(9):e70015
Immunity, inflammation and disease 2024 Sep;12(9):e70015
Ginsenoside compound K alleviates D-galactose-induced mild cognitive impairment by modulating gut microbiota-mediated short-chain fatty acid metabolism.
Yan X, Bai X, Fu R, Duan Z, Zeng W, Zhu C
Food & function 2024 Sep 16;15(18):9037-9052
Food & function 2024 Sep 16;15(18):9037-9052
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Jiang X, Liu K, Luo P, Li Z, Xiao F, Jiang H, Wu S, Tang M, Yuan F, Li X, Shu Y, Peng B, Chen S, Ni S, Guo F
Nature communications 2024 Sep 11;15(1):7948
Nature communications 2024 Sep 11;15(1):7948
Rhein inhibits M1 polarization of BV2 microglia through MAPK/IκB signalling pathway and reduces neurotoxicity caused by neuroinflammation.
Qin X, Li B, Hu B, Huang J, Tian X, Zhang X, Wang Y, Huang W
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2024 Oct;84(6):533-545
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2024 Oct;84(6):533-545
Role of NF-κB signaling pathway in H(2)O(2)-induced oxidative stress of hiPSCs.
Qin J, Yang J, Li J, Zhao D, An J, Zhai Z, Wang H, Li J, Dou M, Du R
In vitro cellular & developmental biology. Animal 2024 Oct;60(9):1021-1033
In vitro cellular & developmental biology. Animal 2024 Oct;60(9):1021-1033
EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β.
Qian X, Cai J, Zhang Y, Shen S, Wang M, Liu S, Meng X, Zhang J, Ye Z, Qiu S, Zhong X, Gao P
The EMBO journal 2024 Oct;43(19):4248-4273
The EMBO journal 2024 Oct;43(19):4248-4273
Sirtuin 5-Mediated Desuccinylation of ALDH2 Alleviates Mitochondrial Oxidative Stress Following Acetaminophen-Induced Acute Liver Injury.
Yu Q, Zhang J, Li J, Song Y, Pan J, Mei C, Cui M, He Q, Wang H, Li H, Cheng B, Zhang Y, Guo W, Zhu C, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2402710
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2402710
Aucklandiae radix targeted PKM2 to alleviate ulcerative colitis: Insights from the photocrosslinking target fishing technique.
Feng YL, Xu XR, Zhu QM, Chang J, Zhang HL, Wang N, Sun JB, Liu J, Zhang J, Sun CP
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155973
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155973
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.
Xu L, Zhu A, Xu S, Zhao J, Song S, Zhu H, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70152
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70152
WNT2B activates macrophages via NF-κB signaling pathway in inflammatory bowel disease.
Lan L, Huang C, Liu D, Cheng Y, Tang R, Gu J, Geng L, Cheng Y, Gong S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23551
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23551
Eucalyptol, limonene and pinene enteric capsules attenuate airway inflammation and obstruction in lipopolysaccharide-induced chronic bronchitis rat model via TLR4 signaling inhibition.
Qiu XY, Yan LS, Kang JY, Yu Gu C, Chi-Yan Cheng B, Wang YW, Luo G, Zhang Y
International immunopharmacology 2024 Mar 10;129:111571
International immunopharmacology 2024 Mar 10;129:111571
Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway.
Chang J, Wang Z, Hao Y, Song Y, Xia C
Animals : an open access journal from MDPI 2024 Jun 4;14(11)
Animals : an open access journal from MDPI 2024 Jun 4;14(11)
Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury via HDAC9-mediated NF-κB pathway.
Wang M, Li Q, Ren B, Hao D, Guo H, Yang L, Wang Z, Dai L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155599
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155599
Weissella paramesenteroides NRIC1542 inhibits dextran sodium sulfate-induced colitis in mice through regulating gut microbiota and SIRT1/NF-κB signaling pathway.
Li S, Chen J, Zheng Y, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23791
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23791
The protective effects of aqueous extract of Schisandra sphenanthera against alcoholic liver disease partly through the PI3K-AKT-IKK signaling pathway.
Liu D, Yang K, Li T, Tang T, Wang Y, Wang W, Li J, Zhou P, Wang X, Zhao C, Guo D, Xie Y, Cheng J, Wang M, Sun J, Zhang X
Heliyon 2024 Jul 15;10(13):e34214
Heliyon 2024 Jul 15;10(13):e34214
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca(2+) antagonism and maintaining mitochondrial function.
Shen G, Zhou Z, Guo Y, Li L, Zeng J, Wang J, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117192
IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation.
Iguchi Y, Takahashi Y, Li J, Araki K, Amakusa Y, Kawakami Y, Kobayashi K, Yokoi S, Katsuno M
The Journal of cell biology 2024 Feb 5;223(2)
The Journal of cell biology 2024 Feb 5;223(2)
6-Gingerol ameliorates alveolar hypercoagulation and fibrinolytic inhibition in LPS-provoked ARDS via RUNX1/NF-κB signaling pathway.
Li Q, Xiao C, Gu J, Chen X, Yuan J, Li S, Li W, Gao D, Li L, Liu Y, Shen F
International immunopharmacology 2024 Feb 15;128:111459
International immunopharmacology 2024 Feb 15;128:111459
GDF-15 alleviates diabetic nephropathy via inhibiting NEDD4L-mediated IKK/NF-κB signalling pathways.
Zhang X, Wang S, Chong N, Chen D, Shu J, Sun J, Sun Z, Wang R, Wang Q, Xu Y
International immunopharmacology 2024 Feb 15;128:111427
International immunopharmacology 2024 Feb 15;128:111427
KDF1 promotes ameloblast differentiation by inhibiting the IKK/IκB/NF-κB axis.
Liu H, Yu M, Sun K, Zheng J, Wang J, Liu H, Feng H, Liu Y, Han D
Journal of cellular physiology 2024 Dec;239(12):e31437
Journal of cellular physiology 2024 Dec;239(12):e31437
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
Cai Q, Zhao C, Xu Y, Lin H, Jia B, Huang B, Lin S, Chen D, Jia P, Wang M, Lin W, Zhang L, Chu J, Peng J
Journal of ethnopharmacology 2024 Apr 24;324:117712
Journal of ethnopharmacology 2024 Apr 24;324:117712
6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway.
Yu Q, Li J, Cui M, Mei C, He Q, Du X
Scientific reports 2024 Apr 2;14(1):7747
Scientific reports 2024 Apr 2;14(1):7747
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Dong M, Yang Z, Gao Q, Deng Q, Li L, Chen H
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y
International journal of biological sciences 2023;19(4):1110-1122
International journal of biological sciences 2023;19(4):1110-1122
Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways.
Yan LS, Cui S, Cheng BC, Yin XB, Wang YW, Qiu XY, Nima CR, Zhang Y, Zhang SF
Drug design, development and therapy 2023;17:297-312
Drug design, development and therapy 2023;17:297-312
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88.
Luan C, Lu Z, Chen J, Chen M, Zhao R, Li X
Drug design, development and therapy 2023;17:2821-2839
Drug design, development and therapy 2023;17:2821-2839
The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.
Li N, Xu X, Liu D, Gao J, Gao Y, Wu X, Sheng H, Li Q, Mi J
Theranostics 2023;13(4):1355-1369
Theranostics 2023;13(4):1355-1369
Role of NLRP3 inflammasome activation in HCC cell progression.
Dai B, Cao H, Hu Y, Gong Z, Huang X, Chen Y, Liu F, Peng X, Zhang Y, Lei X
Heliyon 2023 Sep;9(9):e19542
Heliyon 2023 Sep;9(9):e19542
Xuelian injection ameliorates complete Freund's adjuvant-induced acute arthritis in rats via inhibiting TLR4 signaling.
Yan LS, Cheng BC, Wang YW, Zhang SF, Qiu XY, Kang JY, Zhang C, Jia ZH, Luo G, Zhang Y
Heliyon 2023 Nov;9(11):e21635
Heliyon 2023 Nov;9(11):e21635
Arenobufagin increases the sensitivity of gastric cancer to cisplatin via alkaliptosis.
Liu C, Li D, Wang J, Wang Z
Heliyon 2023 Nov;9(11):e21110
Heliyon 2023 Nov;9(11):e21110
Rabdosichuanin C inhibits productions of pro-inflammatory mediators regulated by NF-κB signaling in LPS-stimulated RAW264.7 cells.
Lingxia Z, Hong W, Man G, Xinzhou W, Lili W, Zhimin W, Liping D, Erping X
Journal of cellular biochemistry 2023 Nov;124(11):1667-1684
Journal of cellular biochemistry 2023 Nov;124(11):1667-1684
Network Analysis and Experimental Verification of the Mechanisms of Hydroxysafflor Yellow A in Ischemic Stroke Following Atherosclerosis.
Han X, Zhou H, Yin J, Zhu J, Yang J, Wan H
Molecules (Basel, Switzerland) 2023 Nov 28;28(23)
Molecules (Basel, Switzerland) 2023 Nov 28;28(23)
Schwann Cell-Derived Exosomes and Methylprednisolone Composite Patch for Spinal Cord Injury Repair.
Zhu B, Gu G, Ren J, Song X, Li J, Wang C, Zhang W, Huo Y, Wang H, Jin L, Feng S, Wei Z
ACS nano 2023 Nov 28;17(22):22928-22943
ACS nano 2023 Nov 28;17(22):22928-22943
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Zhang J, Sun Y, Sun C, Shang D
Bioorganic chemistry 2023 Mar;132:106376
Bioorganic chemistry 2023 Mar;132:106376
Chinese herbal formula, modified Xianfang Huoming Yin, alleviates the inflammatory proliferation of rat synoviocytes induced by IL-1β through regulating the migration and differentiation of T lymphocytes.
Li D, Liu W, Sun S, Zhang Y, Zhang P, Feng G, Wei J, Chai L
Journal of ethnopharmacology 2023 Jun 12;309:116297
Journal of ethnopharmacology 2023 Jun 12;309:116297
miR-9 targeting RUNX1 improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-κB inactivation in ARDS.
Xiao C, Li Q, Xiao J, Chen X, Yuan J, Li S, Li W, Gao D, Li L, Liu Y, Shen F
International immunopharmacology 2023 Jul;120:110318
International immunopharmacology 2023 Jul;120:110318
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression.
Han H, Lin T, Wang Z, Song J, Fang Z, Zhang J, You X, Du Y, Ye J, Zhou G
Pharmacological research 2023 Jan;187:106593
Pharmacological research 2023 Jan;187:106593
A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis.
Li Y, Jin T, Liu N, Wang J, Qin Z, Yin S, Zhang Y, Fu Z, Wu Y, Wang Y, Liu Y, Yang M, Pang A, Sun J, Wang Y, Yang X
Journal of neuroinflammation 2023 Feb 28;20(1):53
Journal of neuroinflammation 2023 Feb 28;20(1):53
A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice.
Li Z, Zheng G, Wang N, Liang H, Li C, Wang Y, Cui Y, Yang L
Journal of agricultural and food chemistry 2023 Feb 15;71(6):2883-2897
Journal of agricultural and food chemistry 2023 Feb 15;71(6):2883-2897
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Wang L, Yu X, Li H, He D, Zeng S, Xiang Z
Chinese medicine 2023 Dec 1;18(1):158
Chinese medicine 2023 Dec 1;18(1):158
SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction.
Nie Y, Mou L, Long Q, Deng D, Hu R, Cheng J, Wu J
Virus research 2023 Apr 15;328:199086
Virus research 2023 Apr 15;328:199086
Galectin-3 Inhibition Ameliorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice.
Zhu N, Zhu L, Huang B, Xiang W, Zhao X
Frontiers in cardiovascular medicine 2022;9:868372
Frontiers in cardiovascular medicine 2022;9:868372
MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway.
Shen X, Tao J, Wang Z, Li G, Zhang Z, Li J, Diliar A
International heart journal 2022;63(5):881-892
International heart journal 2022;63(5):881-892
Qizhi Kebitong Formula Ameliorates Streptozocin-Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF-κB Pathway.
Tian L, Ding L, Wang G, Guo Y, Zhao Y, Wei Y, Li X, Zhang W, Mi J, Li X, Wang Z, Wang X
BioMed research international 2022;2022:4469766
BioMed research international 2022;2022:4469766
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Xu BL, Wang YY, Jiang LL, Liu Z, Liu DR, Zhao H, Li SL, Wang XB
Frontiers in pharmacology 2022;13:1096137
Frontiers in pharmacology 2022;13:1096137
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
He D, Liu Y, Li J, Wang H, Ye B, He Y, Li Z, Gao X, Fu S, Liu D
Cells 2022 Sep 19;11(18)
Cells 2022 Sep 19;11(18)
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Equus β-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage.
Pei L, Liu K, Wei W, Su H, Li F, Feng Y, Wang D, Li X, Hou Y, Cao G
Animals : an open access journal from MDPI 2022 Oct 27;12(21)
Animals : an open access journal from MDPI 2022 Oct 27;12(21)
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Xie Z, Wang B, Zheng C, Qu Y, Xu J, Wang B, Gao Y, Shen P
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.
Ren X, Xing Y, He L, Xiu Z, Yang L, Han A, Jia Q, Dong Y
Journal of ethnopharmacology 2022 May 10;289:115029
Journal of ethnopharmacology 2022 May 10;289:115029
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion.
Zhang Y, Zhao M, Gao H, Yu G, Zhao Y, Yao F, Yang W
Nature metabolism 2022 Mar;4(3):374-388
Nature metabolism 2022 Mar;4(3):374-388
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Cai J, Liang J, Zhang Y, Shen L, Lin H, Hu T, Zhan S, Xie M, Liang S, Xian M, Wang S
Pharmacological research 2022 Jun;180:106230
Pharmacological research 2022 Jun;180:106230
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Liu Y, Sun R, Lin X, Wu L, Chen H, Shen S, Li Y, Wei Y, Deng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
Renoprotective activity of Ribes diacanthum pall (RDP) against inflammation in cisplatin-stimulated mice model and human renal tubular epithelial cells.
Wu Y, Zhao L, Gu L, Tilyek A, Yu B, Chai C
Journal of ethnopharmacology 2022 Jan 30;283:114696
Journal of ethnopharmacology 2022 Jan 30;283:114696
tRNA-derived fragment TRF365 regulates the metabolism of anterior cruciate ligament cells by targeting IKBKB.
Long D, Xu Y, Mao G, Xin R, Deng Z, Liao H, Li Z, Yang Z, Yu B, Yang Z, He A, Zhang Z, Kang Y
Cell death discovery 2022 Jan 10;8(1):19
Cell death discovery 2022 Jan 10;8(1):19
Qiangli Wuhu mixture alleviates LPS-induced pneumonia by inhibiting the TLR4/NF-κB/NLRP3 pathway: a study based on network pharmacology.
Tian J, Wang XL, Wang LC, Chen F, Tian Y, Ma L, Pan CY, Wang YP
Pharmaceutical biology 2022 Dec;60(1):1331-1340
Pharmaceutical biology 2022 Dec;60(1):1331-1340
Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease.
Sun ZJ, Chang DY, Chen M, Zhao MH
JCI insight 2022 Dec 22;7(24)
JCI insight 2022 Dec 22;7(24)
Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells.
Cui J, Zong W, Zhao N, Yuan R
Food science & nutrition 2022 Aug;10(8):2718-2726
Food science & nutrition 2022 Aug;10(8):2718-2726
Curcumin activates the Nrf2 Pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings.
Wan F, Tang L, Rao G, Zhong G, Jiang X, Wu S, Huang R, Tang Z, Ruan Z, Chen Z, Hu L
Toxicon : official journal of the International Society on Toxinology 2022 Apr 15;209:18-27
Toxicon : official journal of the International Society on Toxinology 2022 Apr 15;209:18-27
RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway.
Han H, Lin T, Fang Z, Zhou G
BioMed research international 2021;2021:6697476
BioMed research international 2021;2021:6697476
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312
Frontiers in pharmacology 2021;12:730312
Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.
Yang S, Deng Q, Sun L, Zhu Y, Dong K, Wu S, Huang R, Li Y
Frontiers in cellular and infection microbiology 2021;11:641412
Frontiers in cellular and infection microbiology 2021;11:641412
HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells.
Chen DD, Peng X, Wang Y, Jiang M, Xue M, Shang G, Liu X, Jia X, Liu B, Lu Y, Mu H, Zhang F, Hu Y
Aging 2021 Sep 8;13(17):21547-21570
Aging 2021 Sep 8;13(17):21547-21570
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway.
Wang XL, Chen F, Shi H, Zhang M, Yan L, Pei XY, Peng XD
International immunopharmacology 2021 Nov;100:108139
International immunopharmacology 2021 Nov;100:108139
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.
Zhou W, Zhong Z, Lin D, Liu Z, Zhang Q, Xia H, Peng S, Liu A, Lu Z, Wang Y, Ye S, Ye Q
Cell death & disease 2021 Feb 24;12(2):211
Cell death & disease 2021 Feb 24;12(2):211
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM(2.5).
Zhang X, Qi W, Shi Y, Li X, Yin J, Huo C, Zhang R, Zhao W, Ye J, Zhou L, Ye L
Toxicology 2021 Dec;464:152993
Toxicology 2021 Dec;464:152993
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Tian S, Liao L, Zhou Q, Huang X, Zheng P, Guo Y, Deng T, Tian X
Oncology letters 2021 Apr;21(4):286
Oncology letters 2021 Apr;21(4):286
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Fu N, Li D, Li W, Zhao W, Zhang S, Liu L, Zhao S, Du J, Kong L, Wang R, Zhang Y, Nan Y
Frontiers in molecular biosciences 2020;7:199
Frontiers in molecular biosciences 2020;7:199
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Evaluation of cancer-derived myocardial impairments using a mouse model.
Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Oncotarget 2020 Oct 13;11(41):3712-3722
Oncotarget 2020 Oct 13;11(41):3712-3722
Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice.
Liu N, Zhang GX, Niu YT, Wang Q, Zheng J, Yang JM, Sun T, Niu JG, Yu JQ
Food & function 2020 Oct 1;11(10):8537-8546
Food & function 2020 Oct 1;11(10):8537-8546
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.
Wang Q, Tang Q, Zhao L, Zhang Q, Wu Y, Hu H, Liu L, Liu X, Zhu Y, Guo A, Yang X
Cancer biology & medicine 2020 May 15;17(2):401-417
Cancer biology & medicine 2020 May 15;17(2):401-417
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.
Dong X, Zheng Z, Lin P, Fu X, Li F, Jiang J, Zhu P
Cellular & molecular immunology 2020 Mar;17(3):261-271
Cellular & molecular immunology 2020 Mar;17(3):261-271
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Dong X, Sun R, Wang J, Yu S, Cui J, Guo Z, Pan X, Sun J, Yang J, Pan LL
Biochemical pharmacology 2020 Dec;182:114289
Biochemical pharmacology 2020 Dec;182:114289
Therapeutic potential of proteasome inhibitors for dihydropyridine-induced gingival overgrowth.
Lu SL, Chang JH, Huang CF, Chen LS
Oral diseases 2020 Apr;26(3):630-636
Oral diseases 2020 Apr;26(3):630-636
Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice.
Silva PR, Nieva GV, Igaz LM
Frontiers in genetics 2019;10:369
Frontiers in genetics 2019;10:369
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.
Sun S, Li F, Liu Y, Qu H, Wong SW, Zeng L, Yu M, Feng H, Liu H, Han D
Archives of oral biology 2019 May;101:100-107
Archives of oral biology 2019 May;101:100-107
Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species.
Reho JJ, Guo DF, Rahmouni K
Journal of the American Heart Association 2019 May 7;8(9):e010662
Journal of the American Heart Association 2019 May 7;8(9):e010662
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
Li YM, Zhang J, Su LJ, Kellum JA, Peng ZY
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells.
Shi H, Wang XL, Quan HF, Yan L, Pei XY, Wang R, Peng XD
Molecules (Basel, Switzerland) 2019 Jan 21;24(2)
Molecules (Basel, Switzerland) 2019 Jan 21;24(2)
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Wu M, Li P, An Y, Ren J, Yan D, Cui J, Li D, Li M, Wang M, Zhong G
Pharmacological research 2019 Dec;150:104489
Pharmacological research 2019 Dec;150:104489
Omentin-1 protects against bleomycin-induced acute lung injury.
Zhou Y, Hao C, Li C, Huang X, Li X, Tang Y, Huang Y, Tang S, Liu W, Feng D, Xu J, Yue S, Xie H, Luo Z
Molecular immunology 2018 Nov;103:96-105
Molecular immunology 2018 Nov;103:96-105
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
scAAV9-VEGF-165 inhibits neuroinflammatory responses and invasion of macrophages into the peripheral nervous system of ALS transgenic mice.
Wang Y, Liu Y, Zhai J, Duan W, Sun S, Cui H, Chen X, Ji J, Liu Y
Brain research bulletin 2018 Jun;140:233-242
Brain research bulletin 2018 Jun;140:233-242
Crucial microRNAs and genes in metformin's anti-pancreatic cancer effect explored by microRNA-mRNA integrated analysis.
Li Y, Li L, Zhang G, Wang Y, Chen H, Kong R, Pan S, Sun B
Investigational new drugs 2018 Feb;36(1):20-27
Investigational new drugs 2018 Feb;36(1):20-27
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Ning C, Gao X, Wang C, Huo X, Liu Z, Sun H, Yang X, Sun P, Ma X, Meng Q, Liu K
International immunopharmacology 2018 Aug;61:266-276
International immunopharmacology 2018 Aug;61:266-276
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
Liu H, Ma S, Xia H, Lou H, Zhu F, Sun L
Journal of ethnopharmacology 2018 Aug 10;222:201-207
Journal of ethnopharmacology 2018 Aug 10;222:201-207
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Zuo T, Zhu M, Xu W, Wang Z, Song H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
He L, Li H, Huang N, Zhou X, Tian J, Li T, Wu J, Tian Y, Yin Y, Yao K
Oncotarget 2017 Nov 28;8(61):102974-102988
Oncotarget 2017 Nov 28;8(61):102974-102988
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
Dopamine D(2) receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, Wu D, Ni J, Zhang R, Xue J, Wan R, Wang X, Hu G
British journal of pharmacology 2017 Dec;174(24):4751-4770
British journal of pharmacology 2017 Dec;174(24):4751-4770
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D
Scientific reports 2016 Jun 8;6:27597
Scientific reports 2016 Jun 8;6:27597
GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ.
Li Z, Wang Y, Newton IP, Zhang L, Ji P, Li Z
Cellular signalling 2015 Jun;27(6):1237-45
Cellular signalling 2015 Jun;27(6):1237-45
Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.
Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2202-12
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2202-12
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IKBKB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IKBKB. This antibody recognizes human, mouse, rat antigen. The IKBKB antibody has been validated for the following applications: ELISA, WB analysis.
