Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [44]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15649-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15649-1-AP, RRID:AB_2122307
- Product name
- IKBKB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IKBKB antibody (Cat. #15649-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Renoprotective activity of Ribes diacanthum pall (RDP) against inflammation in cisplatin-stimulated mice model and human renal tubular epithelial cells.
RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway.
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.
HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM2.5.
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Evaluation of cancer-derived myocardial impairments using a mouse model.
Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Therapeutic potential of proteasome inhibitors for dihydropyridine-induced gingival overgrowth.
Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.
Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Omentin-1 protects against bleomycin-induced acute lung injury.
Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
scAAV9-VEGF-165 inhibits neuroinflammatory responses and invasion of macrophages into the peripheral nervous system of ALS transgenic mice.
Crucial microRNAs and genes in metformin's anti-pancreatic cancer effect explored by microRNA-mRNA integrated analysis.
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ.
Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
Renoprotective activity of Ribes diacanthum pall (RDP) against inflammation in cisplatin-stimulated mice model and human renal tubular epithelial cells.
Wu Y, Zhao L, Gu L, Tilyek A, Yu B, Chai C
Journal of ethnopharmacology 2022 Jan 30;283:114696
Journal of ethnopharmacology 2022 Jan 30;283:114696
RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway.
Han H, Lin T, Fang Z, Zhou G
BioMed research international 2021;2021:6697476
BioMed research international 2021;2021:6697476
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312
Frontiers in pharmacology 2021;12:730312
Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.
Yang S, Deng Q, Sun L, Zhu Y, Dong K, Wu S, Huang R, Li Y
Frontiers in cellular and infection microbiology 2021;11:641412
Frontiers in cellular and infection microbiology 2021;11:641412
HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells.
Chen DD, Peng X, Wang Y, Jiang M, Xue M, Shang G, Liu X, Jia X, Liu B, Lu Y, Mu H, Zhang F, Hu Y
Aging 2021 Sep 8;13(17):21547-21570
Aging 2021 Sep 8;13(17):21547-21570
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.
Zhou W, Zhong Z, Lin D, Liu Z, Zhang Q, Xia H, Peng S, Liu A, Lu Z, Wang Y, Ye S, Ye Q
Cell death & disease 2021 Feb 24;12(2):211
Cell death & disease 2021 Feb 24;12(2):211
Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM2.5.
Zhang X, Qi W, Shi Y, Li X, Yin J, Huo C, Zhang R, Zhao W, Ye J, Zhou L, Ye L
Toxicology 2021 Dec;464:152993
Toxicology 2021 Dec;464:152993
Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.
Tian S, Liao L, Zhou Q, Huang X, Zheng P, Guo Y, Deng T, Tian X
Oncology letters 2021 Apr;21(4):286
Oncology letters 2021 Apr;21(4):286
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Fu N, Li D, Li W, Zhao W, Zhang S, Liu L, Zhao S, Du J, Kong L, Wang R, Zhang Y, Nan Y
Frontiers in molecular biosciences 2020;7:199
Frontiers in molecular biosciences 2020;7:199
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Evaluation of cancer-derived myocardial impairments using a mouse model.
Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Oncotarget 2020 Oct 13;11(41):3712-3722
Oncotarget 2020 Oct 13;11(41):3712-3722
Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice.
Liu N, Zhang GX, Niu YT, Wang Q, Zheng J, Yang JM, Sun T, Niu JG, Yu JQ
Food & function 2020 Oct 1;11(10):8537-8546
Food & function 2020 Oct 1;11(10):8537-8546
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.
Wang Q, Tang Q, Zhao L, Zhang Q, Wu Y, Hu H, Liu L, Liu X, Zhu Y, Guo A, Yang X
Cancer biology & medicine 2020 May 15;17(2):401-417
Cancer biology & medicine 2020 May 15;17(2):401-417
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.
Dong X, Zheng Z, Lin P, Fu X, Li F, Jiang J, Zhu P
Cellular & molecular immunology 2020 Mar;17(3):261-271
Cellular & molecular immunology 2020 Mar;17(3):261-271
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Dong X, Sun R, Wang J, Yu S, Cui J, Guo Z, Pan X, Sun J, Yang J, Pan LL
Biochemical pharmacology 2020 Dec;182:114289
Biochemical pharmacology 2020 Dec;182:114289
Therapeutic potential of proteasome inhibitors for dihydropyridine-induced gingival overgrowth.
Lu SL, Chang JH, Huang CF, Chen LS
Oral diseases 2020 Apr;26(3):630-636
Oral diseases 2020 Apr;26(3):630-636
Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice.
Silva PR, Nieva GV, Igaz LM
Frontiers in genetics 2019;10:369
Frontiers in genetics 2019;10:369
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.
Sun S, Li F, Liu Y, Qu H, Wong SW, Zeng L, Yu M, Feng H, Liu H, Han D
Archives of oral biology 2019 May;101:100-107
Archives of oral biology 2019 May;101:100-107
Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species.
Reho JJ, Guo DF, Rahmouni K
Journal of the American Heart Association 2019 May 7;8(9):e010662
Journal of the American Heart Association 2019 May 7;8(9):e010662
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
Li YM, Zhang J, Su LJ, Kellum JA, Peng ZY
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells.
Shi H, Wang XL, Quan HF, Yan L, Pei XY, Wang R, Peng XD
Molecules (Basel, Switzerland) 2019 Jan 21;24(2)
Molecules (Basel, Switzerland) 2019 Jan 21;24(2)
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota.
Wu M, Li P, An Y, Ren J, Yan D, Cui J, Li D, Li M, Wang M, Zhong G
Pharmacological research 2019 Dec;150:104489
Pharmacological research 2019 Dec;150:104489
Omentin-1 protects against bleomycin-induced acute lung injury.
Zhou Y, Hao C, Li C, Huang X, Li X, Tang Y, Huang Y, Tang S, Liu W, Feng D, Xu J, Yue S, Xie H, Luo Z
Molecular immunology 2018 Nov;103:96-105
Molecular immunology 2018 Nov;103:96-105
Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
scAAV9-VEGF-165 inhibits neuroinflammatory responses and invasion of macrophages into the peripheral nervous system of ALS transgenic mice.
Wang Y, Liu Y, Zhai J, Duan W, Sun S, Cui H, Chen X, Ji J, Liu Y
Brain research bulletin 2018 Jun;140:233-242
Brain research bulletin 2018 Jun;140:233-242
Crucial microRNAs and genes in metformin's anti-pancreatic cancer effect explored by microRNA-mRNA integrated analysis.
Li Y, Li L, Zhang G, Wang Y, Chen H, Kong R, Pan S, Sun B
Investigational new drugs 2018 Feb;36(1):20-27
Investigational new drugs 2018 Feb;36(1):20-27
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
Ning C, Gao X, Wang C, Huo X, Liu Z, Sun H, Yang X, Sun P, Ma X, Meng Q, Liu K
International immunopharmacology 2018 Aug;61:266-276
International immunopharmacology 2018 Aug;61:266-276
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
Liu H, Ma S, Xia H, Lou H, Zhu F, Sun L
Journal of ethnopharmacology 2018 Aug 10;222:201-207
Journal of ethnopharmacology 2018 Aug 10;222:201-207
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Zuo T, Zhu M, Xu W, Wang Z, Song H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
He L, Li H, Huang N, Zhou X, Tian J, Li T, Wu J, Tian Y, Yin Y, Yao K
Oncotarget 2017 Nov 28;8(61):102974-102988
Oncotarget 2017 Nov 28;8(61):102974-102988
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, Wu D, Ni J, Zhang R, Xue J, Wan R, Wang X, Hu G
British journal of pharmacology 2017 Dec;174(24):4751-4770
British journal of pharmacology 2017 Dec;174(24):4751-4770
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D
Scientific reports 2016 Jun 8;6:27597
Scientific reports 2016 Jun 8;6:27597
GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ.
Li Z, Wang Y, Newton IP, Zhang L, Ji P, Li Z
Cellular signalling 2015 Jun;27(6):1237-45
Cellular signalling 2015 Jun;27(6):1237-45
Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.
Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2202-12
Journal of immunology (Baltimore, Md. : 1950) 2011 Sep 1;187(5):2202-12
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IKBKB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IKBKB. This antibody recognizes human, mouse, rat antigen. The IKBKB antibody has been validated for the following applications: ELISA, WB analysis.
