IKBKB

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

Description

inhibitor of nuclear factor kappa B kinase subunit beta

Protein family

Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas), RAS pathway related proteins

Chromosome

8:p11.21 (42271302 - 42332653)

Ensembl ID

ENSG00000104365  (ver. 98.38)

Orthologs

Mouse Ikbkb: ENSMUSG00000031537

UniProt

O14920

neXtProt

NX_O14920

Human splice variants
Mouse splice variants