ARHGEF10

This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Description

Rho guanine nucleotide exchange factor 10

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

8:p23.3 (1823926 - 1958641)

Ensembl ID

ENSG00000104728  (ver. 99.38)

Orthologs

Mouse Arhgef10: ENSMUSG00000071176

UniProt

O15013

neXtProt

NX_O15013

Human splice variants
Mouse splice variants