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HAP1
Huntingtin associated protein 1HAP2, hHLP1, HIP5, HLP
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  NB110-74569 |
10 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA1-46412 |
4 references | Monoclonal |
WB
IP
IHC
FC
OA
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| antibodies-online | ABIN259097 |
7 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| Proteintech Group | 25133-1-AP |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| OriGene | TA306425 |
1 references | Polyclonal |
WB
ICC
IHC
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