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- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Immunocytochemistry [1]
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- Product number
- 66043-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- LONP1 antibody
- Antibody type
- Monoclonal
- Description
- LONP1 antibody (Cat. #66043-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1C6C12
- Vial size
- 20ul, 150ul
Submitted references BAM8-22 targets spinal MrgC receptors to modulate UPR(mt) activity in the mechanism of bone cancer pain.
Paraquat induced neuro-immunotoxicity: Dysregulated microglial antigen processing and mitochondrial activated mechanisms.
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis Under Hypoxia.
Atrazine exposure induces TDP-43 protein translocation: A potential mechanism for prefrontal cortical neurodegeneration induced by environmental pollutants.
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.
LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis.
Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis.
PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle.
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication.
A mitochondrial iron-responsive pathway regulated by DELE1.
Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer's disease.
Stress-dependent macromolecular crowding in the mitochondrial matrix.
ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response.
Xie M, Li D, Zeng H, Huang Y, Xu R, Wang Z, Yu J, Sun Y
Frontiers in pharmacology 2025;16:1575733
Frontiers in pharmacology 2025;16:1575733
Paraquat induced neuro-immunotoxicity: Dysregulated microglial antigen processing and mitochondrial activated mechanisms.
Shi G, Wang K, Liu Q, Wu C, Zhang Q, Ma Y, Qi A, Huang M
Chemico-biological interactions 2025 Nov 1;421:111721
Chemico-biological interactions 2025 Nov 1;421:111721
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Li M, Zhang W, Zhang M, Li L, Yao Y, Qin Y, Wang D, Yan G, Qiao Y, Tang C
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis Under Hypoxia.
Yu HC, Cui R, Chen MY, Du XY, Bai QR, Zhang SL, Guo JJ, Tong FC, Wu J
Antioxidants & redox signaling 2025 Jan;42(1-3):36-52
Antioxidants & redox signaling 2025 Jan;42(1-3):36-52
Atrazine exposure induces TDP-43 protein translocation: A potential mechanism for prefrontal cortical neurodegeneration induced by environmental pollutants.
Ma Y, Wang K, Jiao Y, Li Y, Hu R, Li Y, Shi G, Huang M
Toxicology 2025 Aug;515:154128
Toxicology 2025 Aug;515:154128
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.
Peng X, Sun B, Tang C, Shi C, Xie X, Wang X, Jiang D, Li S, Jia Y, Wang Y, Tang H, Zhong S, Piao M, Cui X, Zhang S, Wang F, Wang Y, Na R, Huang R, Jiang Y, Zhang W, Xu J, Lin K, Guo J, Pan Z, Wang K, Zhao Q, Liu H, Yu B, Ji Y, Zhang J, Li S, Tian J
Developmental cell 2025 Apr 7;60(7):1070-1086.e8
Developmental cell 2025 Apr 7;60(7):1070-1086.e8
LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis.
Zhang C, Shen S, Xu L, Li M, Tian B, Yao L, Zhu X
Journal of cellular and molecular medicine 2024 Sep;28(17):e70090
Journal of cellular and molecular medicine 2024 Sep;28(17):e70090
Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis.
Zhu W, Tan C, Zhang J
Biomolecules & biomedicine 2024 Sep 6;24(5):1258-1272
Biomolecules & biomedicine 2024 Sep 6;24(5):1258-1272
PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle.
Mozaffaritabar S, Koltai E, Zhou L, Bori Z, Kolonics A, Kujach S, Gu Y, Koike A, Boros A, Radák Z
Journal of physiology and biochemistry 2024 May;80(2):329-335
Journal of physiology and biochemistry 2024 May;80(2):329-335
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Lin N, Sun L, Chai J, Qi H, Zhao Y, Ma J, Xia M, Hu X
Cancer cell international 2024 Jan 18;24(1):38
Cancer cell international 2024 Jan 18;24(1):38
Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication.
Wang X, Wang M, Cai M, Shao R, Xia G, Zhao W
Acta pharmaceutica Sinica. B 2023 Nov;13(11):4477-4501
Acta pharmaceutica Sinica. B 2023 Nov;13(11):4477-4501
A mitochondrial iron-responsive pathway regulated by DELE1.
Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer's disease.
Kolonics A, Bori Z, Torma F, Abraham D, Fehér J, Radak Z
BMC neuroscience 2023 Dec 18;24(1):68
BMC neuroscience 2023 Dec 18;24(1):68
Stress-dependent macromolecular crowding in the mitochondrial matrix.
Bulthuis EP, Dieteren CEJ, Bergmans J, Berkhout J, Wagenaars JA, van de Westerlo EMA, Podhumljak E, Hink MA, Hesp LFB, Rosa HS, Malik AN, Lindert MK, Willems PHGM, Gardeniers HJGE, den Otter WK, Adjobo-Hermans MJW, Koopman WJH
The EMBO journal 2023 Apr 3;42(7):e108533
The EMBO journal 2023 Apr 3;42(7):e108533
ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response.
Liu Y, Zhang L, Zhang S, Liu J, Li X, Yang K, Yang D, Liu Y, Sun L, Liu F, Xiao L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):57
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LONP1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human LONP1. This antibody recognizes human, mouse, rat antigen. The LONP1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
