Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [85]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15440-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15440-1-AP, RRID:AB_2137152
- Product name
- LONP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LONP1 antibody (Cat. #15440-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5-POLG Axis.
WITHDRAWN: LonP1 Drives Proneural Mesenchymal Transition in IDH1-R132H Diffuse Glioma.
WITHDRAWN: Dual targeting of mitochondrial Lon peptidase 1 and chymotrypsin-like protease by small molecule BT317, as potential therapeutics in malignant astrocytomas.
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP.
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma.
Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion.
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary.
Xinyang tablet alleviated cardiac dysfunction in a cardiac pressure overload model by regulating the receptor-interacting serum/three-protein kinase 3/FUN14 domain containing 1-mediated mitochondrial unfolded protein response and mitophagy.
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis.
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.
Decreased LONP1 expression contributes to DNA damage and meiotic defects in oocytes.
A cytosolic surveillance mechanism activates the mitochondrial UPR.
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC-OXPHOS axis.
The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy.
The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.
Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives.
Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.
The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals.
Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.
Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis.
Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.
The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response.
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
UPR(mt) activation protects against MPP(+)-induced toxicity in a cell culture model of Parkinson's disease.
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Self-assembly of multi-component mitochondrial nucleoids via phase separation.
Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na(+)/Ca(2+) Exchanger, NCLX, and Apoptosis.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia.
LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.
LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix.
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1(G93A) Mice.
Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma.
Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
A High-Density Human Mitochondrial Proximity Interaction Network.
ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Toxicity of Necrostatin-1 in Parkinson's Disease Models.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.
Glucose-regulated protein 75 in foodborne disease models induces renal tubular necrosis.
TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics.
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.
Fidelity of translation initiation is required for coordinated respiratory complex assembly.
Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.
CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma.
miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.
Circadian Oscillation of Sulfiredoxin in the Mitochondria.
RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.
Central role of Nix in the autophagic response to ochratoxin A.
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis.
Chen X, Meng F, Chen C, Li S, Chou Z, Xu B, Mo JQ, Guo Y, Guan MX
The Journal of biological chemistry 2024 May;300(5):107235
The Journal of biological chemistry 2024 May;300(5):107235
AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5-POLG Axis.
Chen Y, Ma G, Gai Y, Yang Q, Liu X, de Avila JM, Mao S, Zhu MJ, Du M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(20):e2307480
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(20):e2307480
WITHDRAWN: LonP1 Drives Proneural Mesenchymal Transition in IDH1-R132H Diffuse Glioma.
Douglas C, Lomeli N, Vu T, Pham J, Bota DA
bioRxiv : the preprint server for biology 2024 May 23;
bioRxiv : the preprint server for biology 2024 May 23;
WITHDRAWN: Dual targeting of mitochondrial Lon peptidase 1 and chymotrypsin-like protease by small molecule BT317, as potential therapeutics in malignant astrocytomas.
Douglas C, Jain S, Lomeli N, Di K, Nandwana NK, Mohammed AS, Vu T, Pham J, Lepe J, Kenney MC, Das B, Bota DA
bioRxiv : the preprint server for biology 2024 May 23;
bioRxiv : the preprint server for biology 2024 May 23;
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway.
Bi PY, Killackey SA, Schweizer L, Arnoult D, Philpott DJ, Girardin SE
Communications biology 2024 Mar 30;7(1):391
Communications biology 2024 Mar 30;7(1):391
NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP.
Lv L, Mo J, Qing Y, Wang S, Chen L, Mei A, Xu R, Huang H, Tan J, Li Y, Liu J
Cell reports 2024 Mar 26;43(3):113860
Cell reports 2024 Mar 26;43(3):113860
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.
Xu WN, Zheng HL, Yang RZ, Sun YF, Peng BR, Liu C, Song J, Jiang SD, Zhu LX
Cell biology and toxicology 2024 Mar 13;40(1):16
Cell biology and toxicology 2024 Mar 13;40(1):16
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma.
Zhang S, Guo H, Wang H, Liu X, Wang M, Liu X, Fan Y, Tan K
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):768-784
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):768-784
Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion.
Liu K, Zhou Y, Song X, Zeng J, Wang Z, Wang Z, Zhang H, Xu J, Li W, Gong Z, Wang M, Liu B, Xiao N, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155570
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155570
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Shi L, Tan Y, Zheng W, Cao G, Zhou H, Li P, Cui J, Song Y, Feng L, Li H, Shan W, Zhang B, Yi W
Cell death discovery 2024 Jan 26;10(1):53
Cell death discovery 2024 Jan 26;10(1):53
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary.
Zhan XZ, Luo P, Zhang C, Zhang LJ, Shen X, Jiang DL, Liu WJ
Animal reproduction science 2024 Aug;267:107540
Animal reproduction science 2024 Aug;267:107540
Xinyang tablet alleviated cardiac dysfunction in a cardiac pressure overload model by regulating the receptor-interacting serum/three-protein kinase 3/FUN14 domain containing 1-mediated mitochondrial unfolded protein response and mitophagy.
Dong X, Zhuang HW, Wen RJ, Huang YS, Liang BX, Li H, Xian SX, Li C, Wang LJ, Wang JY
Journal of ethnopharmacology 2024 Aug 10;330:118152
Journal of ethnopharmacology 2024 Aug 10;330:118152
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Yamashita A, Ignatenko O, Nguyen M, Lambert R, Watt K, Daneault C, Robillard-Frayne I, Topisirovic I, Rosiers CD, McBride HM
Biology direct 2023 Sep 22;18(1):60
Biology direct 2023 Sep 22;18(1):60
Mitochondrial oxidative stress regulates LonP1-TDP-43 pathway and rises mitochondrial damage in carbon tetrachloride-induced liver fibrosis.
Shan S, Liu Z, Wang S, Liu Z, Chao S, Zhang C, Li M, Song F
Ecotoxicology and environmental safety 2023 Oct 1;264:115409
Ecotoxicology and environmental safety 2023 Oct 1;264:115409
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
Wu J, Subbaiah KCV, Hedaya O, Chen S, Munger J, Tang WHW, Yan C, Yao P
bioRxiv : the preprint server for biology 2023 May 22;
bioRxiv : the preprint server for biology 2023 May 22;
SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.
Yang J, Chen X
Immunity, inflammation and disease 2023 Mar;11(3):e809
Immunity, inflammation and disease 2023 Mar;11(3):e809
Decreased LONP1 expression contributes to DNA damage and meiotic defects in oocytes.
Liu C, Xu M, Guan Y, Li L, Liu W, Guo B, Sheng X, Zhang Y, Zhou J, Zhen X, Yan G, Sun H, Ding L
Molecular reproduction and development 2023 Jun;90(6):358-368
Molecular reproduction and development 2023 Jun;90(6):358-368
A cytosolic surveillance mechanism activates the mitochondrial UPR.
Sutandy FXR, Gößner I, Tascher G, Münch C
Nature 2023 Jun;618(7966):849-854
Nature 2023 Jun;618(7966):849-854
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
Deng H, Chen W, Zhang B, Zhang Y, Han L, Zhang Q, Yao S, Wang H, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H
The EMBO journal 2023 Jul 3;42(13):e113033
The EMBO journal 2023 Jul 3;42(13):e113033
A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC-OXPHOS axis.
Jiang R, Chen Z, Ni M, Li X, Ying H, Fen J, Wan D, Peng C, Zhou W, Gu L
Journal of translational medicine 2023 Jul 26;21(1):504
Journal of translational medicine 2023 Jul 26;21(1):504
The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Luo G, Aldridge K, Chen T, Aslot V, Kim BG, Han EH, Singh N, Li S, Xiao TS, Sporn MB, Letterio JJ
Molecular oncology 2023 Dec;17(12):2526-2545
Molecular oncology 2023 Dec;17(12):2526-2545
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy.
Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Münch C
Nature communications 2022 Sep 2;13(1):5164
Nature communications 2022 Sep 2;13(1):5164
The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Yakhine-Diop SMS, Rodríguez-Arribas M, Canales-Cortés S, Martínez-Chacón G, Uribe-Carretero E, Blanco-Benítez M, Duque-González G, Paredes-Barquero M, Alegre-Cortés E, Climent V, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, Fuentes JM, González-Polo RA
Cell biology and toxicology 2022 Oct;38(5):889-911
Cell biology and toxicology 2022 Oct;38(5):889-911
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Zheng J, Cao Y, Yang J, Jiang H
EMBO reports 2022 Oct 6;23(10):e54859
EMBO reports 2022 Oct 6;23(10):e54859
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X
Acta neuropathologica 2022 Nov;144(5):911-938
Acta neuropathologica 2022 Nov;144(5):911-938
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG
Nature communications 2022 Nov 28;13(1):7338
Nature communications 2022 Nov 28;13(1):7338
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Lan B, Zhao H, He Y, Zhao Z, Wang N, Gao Y
Experimental cell research 2022 Nov 15;420(2):113358
Experimental cell research 2022 Nov 15;420(2):113358
Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.
Sun X, Dong M, Gao Y, Wang Y, Du L, Liu Y, Wang Q, Ji K, He N, Wang J, Zhang M, Gu Y, Song H, Zhai H, Feng L, Xu C, Liu Q
Biochemical pharmacology 2022 May;199:114981
Biochemical pharmacology 2022 May;199:114981
Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives.
Lee J, Pandey AK, Venkatesh S, Thilagavathi J, Honda T, Singh K, Suzuki CK
The Journal of biological chemistry 2022 Mar;298(3):101719
The Journal of biological chemistry 2022 Mar;298(3):101719
Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.
Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z
Science advances 2022 Jul 29;8(30):eabo0340
Science advances 2022 Jul 29;8(30):eabo0340
The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals.
Sheng X, Liu C, Yan G, Li G, Liu J, Yang Y, Li S, Li Z, Zhou J, Zhen X, Zhang Y, Diao Z, Hu Y, Fu C, Yao B, Li C, Cao Y, Lu B, Yang Z, Qin Y, Sun H, Ding L
EBioMedicine 2022 Jan;75:103790
EBioMedicine 2022 Jan;75:103790
Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.
Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, Chen X, Zhang J, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu MS, Fei W, Lu B, Gan Z
Nature communications 2022 Feb 16;13(1):894
Nature communications 2022 Feb 16;13(1):894
Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis.
Li X, Zhao T, Gu J, Wang Z, Lin J, Wang R, Duan T, Li Z, Dong R, Wang W, Hong KF, Liu Z, Huang W, Gui D, Zhou H, Xu Y
Chinese medicine 2022 Feb 12;17(1):22
Chinese medicine 2022 Feb 12;17(1):22
Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.
Hermeling JC, Herholz M, Baumann L, Cores EC, Zečić A, Hoppe T, Riemer J, Trifunovic A
Redox biology 2022 Dec;58:102533
Redox biology 2022 Dec;58:102533
The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response.
Chamseddine D, Mahmud SA, Westfall AK, Castoe TA, Berg RE, Pellegrino MW
Cell reports 2022 Dec 13;41(11):111789
Cell reports 2022 Dec 13;41(11):111789
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis.
Sidarala V, Zhu J, Levi-D'Ancona E, Pearson GL, Reck EC, Walker EM, Kaufman BA, Soleimanpour SA
Nature communications 2022 Apr 29;13(1):2340
Nature communications 2022 Apr 29;13(1):2340
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
UPR(mt) activation protects against MPP(+)-induced toxicity in a cell culture model of Parkinson's disease.
Hu D, Liu Z, Qi X
Biochemical and biophysical research communications 2021 Sep 10;569:17-22
Biochemical and biophysical research communications 2021 Sep 10;569:17-22
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Pérez MJ, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, Al-Shaana R, Kaeser SA, Fraschka SA, Jucker M, Zeviani M, Viscomi C, Deleidi M
Molecular psychiatry 2021 Oct;26(10):5733-5750
Molecular psychiatry 2021 Oct;26(10):5733-5750
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion.
Silva-Pinheiro P, Pardo-Hernández C, Reyes A, Tilokani L, Mishra A, Cerutti R, Li S, Rozsivalova DH, Valenzuela S, Dogan SA, Peter B, Fernández-Silva P, Trifunovic A, Prudent J, Minczuk M, Bindoff L, Macao B, Zeviani M, Falkenberg M, Viscomi C
Nucleic acids research 2021 May 21;49(9):5230-5248
Nucleic acids research 2021 May 21;49(9):5230-5248
Self-assembly of multi-component mitochondrial nucleoids via phase separation.
Feric M, Demarest TG, Tian J, Croteau DL, Bohr VA, Misteli T
The EMBO journal 2021 Mar 15;40(6):e107165
The EMBO journal 2021 Mar 15;40(6):e107165
Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na(+)/Ca(2+) Exchanger, NCLX, and Apoptosis.
Britti E, Delaspre F, Tamarit J, Ros J
Neurochemical research 2021 Jan;46(1):108-119
Neurochemical research 2021 Jan;46(1):108-119
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia.
Britti E, Delaspre F, Sanz-Alcázar A, Medina-Carbonero M, Llovera M, Purroy R, Mincheva-Tasheva S, Tamarit J, Ros J
The Biochemical journal 2021 Jan 15;478(1):1-20
The Biochemical journal 2021 Jan 15;478(1):1-20
LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.
Shin CS, Meng S, Garbis SD, Moradian A, Taylor RW, Sweredoski MJ, Lomenick B, Chan DC
Nature communications 2021 Jan 11;12(1):265
Nature communications 2021 Jan 11;12(1):265
LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.
Kim JE, Park H, Kim TH, Kang TC
International journal of molecular sciences 2021 Feb 25;22(5)
International journal of molecular sciences 2021 Feb 25;22(5)
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Chen H, Zhang DM, Zhang ZP, Li MZ, Wu HF
Genes & genomics 2021 Dec;43(12):1433-1444
Genes & genomics 2021 Dec;43(12):1433-1444
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.
König T, Nolte H, Aaltonen MJ, Tatsuta T, Krols M, Stroh T, Langer T, McBride HM
Nature cell biology 2021 Dec;23(12):1271-1286
Nature cell biology 2021 Dec;23(12):1271-1286
Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix.
Matsushima Y, Takahashi K, Yue S, Fujiyoshi Y, Yoshioka H, Aihara M, Setoyama D, Uchiumi T, Fukuchi S, Kang D
Communications biology 2021 Aug 16;4(1):974
Communications biology 2021 Aug 16;4(1):974
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283
The EMBO journal 2021 Apr 15;40(8):e106283
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1(G93A) Mice.
Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, Xu R
International journal of biological sciences 2020;16(2):284-297
International journal of biological sciences 2020;16(2):284-297
Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma.
Yao R, Xie Y, Sun X, Zhang M, Zhou J, Liu L, Gao J, Xu K
Drug design, development and therapy 2020;14:3983-3993
Drug design, development and therapy 2020;14:3983-3993
Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.
Sun D, Yao S, Wu F, Deng W, Ma Y, Jin L, Wang J, Wang X
Frontiers in genetics 2020;11:577795
Frontiers in genetics 2020;11:577795
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Yang YL, Wang PW, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 Sep 19;21(18)
International journal of molecular sciences 2020 Sep 19;21(18)
A High-Density Human Mitochondrial Proximity Interaction Network.
Antonicka H, Lin ZY, Janer A, Aaltonen MJ, Weraarpachai W, Gingras AC, Shoubridge EA
Cell metabolism 2020 Sep 1;32(3):479-497.e9
Cell metabolism 2020 Sep 1;32(3):479-497.e9
ATF4 Mediates Mitochondrial Unfolded Protein Response in Alveolar Epithelial Cells.
Jiang D, Cui H, Xie N, Banerjee S, Liu RM, Dai H, Thannickal VJ, Liu G
American journal of respiratory cell and molecular biology 2020 Oct;63(4):478-489
American journal of respiratory cell and molecular biology 2020 Oct;63(4):478-489
Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha.
Yang YL, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 May 21;21(10)
International journal of molecular sciences 2020 May 21;21(10)
Toxicity of Necrostatin-1 in Parkinson's Disease Models.
Alegre-Cortés E, Muriel-González A, Canales-Cortés S, Uribe-Carretero E, Martínez-Chacón G, Aiastui A, López de Munain A, Niso-Santano M, Gonzalez-Polo RA, Fuentes JM, Yakhine-Diop SMS
Antioxidants (Basel, Switzerland) 2020 Jun 15;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 15;9(6)
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.
Shen Y, Ding M, Xie Z, Liu X, Yang H, Jin S, Xu S, Zhu Z, Wang Y, Wang D, Xu L, Zhou X, Wang P, Bi J
Frontiers in cellular neuroscience 2019;13:568
Frontiers in cellular neuroscience 2019;13:568
Glucose-regulated protein 75 in foodborne disease models induces renal tubular necrosis.
Yang X, Li Y, Zheng L, He X, Luo Y, Huang K, Xu W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Nov;133:110720
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Nov;133:110720
TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics.
Kim JE, Park H, Choi SH, Kong MJ, Kang TC
Cells 2019 Nov 1;8(11)
Cells 2019 Nov 1;8(11)
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY
PLoS genetics 2019 May;15(5):e1007947
PLoS genetics 2019 May;15(5):e1007947
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X
Acta neuropathologica 2019 Jun;137(6):939-960
Acta neuropathologica 2019 Jun;137(6):939-960
Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.
Fu Z, Liu F, Liu C, Jin B, Jiang Y, Tang M, Qi X, Guo X
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1428-1435
Biochimica et biophysica acta. Molecular basis of disease 2019 Jun 1;1865(6):1428-1435
Fidelity of translation initiation is required for coordinated respiratory complex assembly.
Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A
Science advances 2019 Dec;5(12):eaay2118
Science advances 2019 Dec;5(12):eaay2118
Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation.
Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O
The EMBO journal 2019 Dec 16;38(24):e102155
The EMBO journal 2019 Dec 16;38(24):e102155
CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.
Kim JE, Park H, Choi SH, Kong MJ, Kang TC
Cells 2019 Aug 5;8(8)
Cells 2019 Aug 5;8(8)
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients.
Yakhine-Diop SMS, Niso-Santano M, Rodríguez-Arribas M, Gómez-Sánchez R, Martínez-Chacón G, Uribe-Carretero E, Navarro-García JA, Ruiz-Hurtado G, Aiastui A, Cooper JM, López de Munaín A, Bravo-San Pedro JM, González-Polo RA, Fuentes JM
Molecular neurobiology 2019 Apr;56(4):2466-2481
Molecular neurobiology 2019 Apr;56(4):2466-2481
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
Iida R, Ueki M, Yasuda T
Oxidative medicine and cellular longevity 2018;2018:6956414
Oxidative medicine and cellular longevity 2018;2018:6956414
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Wu F, Li S, Zhang N, Huang W, Li X, Wang M, Bai D, Han B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.
Yang X, Wang H, Huang C, He X, Xu W, Luo Y, Huang K
Scientific reports 2017 Nov 7;7(1):14669
Scientific reports 2017 Nov 7;7(1):14669
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Polo M, Alegre F, Moragrega AB, Gibellini L, Marti-Rodrigo A, Blas-Garcia A, Esplugues JV, Apostolova N
British journal of pharmacology 2017 Dec;174(23):4409-4429
British journal of pharmacology 2017 Dec;174(23):4409-4429
Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma.
Di K, Lomeli N, Wood SD, Vanderwal CD, Bota DA
Oncotarget 2016 Nov 22;7(47):77457-77467
Oncotarget 2016 Nov 22;7(47):77457-77467
miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
Rang Z, Yang G, Wang YW, Cui F
Biochemical and biophysical research communications 2016 May 27;474(2):315-320
Biochemical and biophysical research communications 2016 May 27;474(2):315-320
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.
Pryde KR, Taanman JW, Schapira AH
Cell reports 2016 Dec 6;17(10):2522-2531
Cell reports 2016 Dec 6;17(10):2522-2531
Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.
Ogunbileje JO, Porter C, Herndon DN, Chao T, Abdelrahman DR, Papadimitriou A, Chondronikola M, Zimmers TA, Reidy PT, Rasmussen BB, Sidossis LS
American journal of physiology. Endocrinology and metabolism 2016 Aug 1;311(2):E436-48
American journal of physiology. Endocrinology and metabolism 2016 Aug 1;311(2):E436-48
Circadian Oscillation of Sulfiredoxin in the Mitochondria.
Kil IS, Ryu KW, Lee SK, Kim JY, Chu SY, Kim JH, Park S, Rhee SG
Molecular cell 2015 Aug 20;59(4):651-63
Molecular cell 2015 Aug 20;59(4):651-63
RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.
Cnop M, Abdulkarim B, Bottu G, Cunha DA, Igoillo-Esteve M, Masini M, Turatsinze JV, Griebel T, Villate O, Santin I, Bugliani M, Ladriere L, Marselli L, McCarthy MI, Marchetti P, Sammeth M, Eizirik DL
Diabetes 2014 Jun;63(6):1978-93
Diabetes 2014 Jun;63(6):1978-93
Central role of Nix in the autophagic response to ochratoxin A.
Shen XL, Zhang B, Liang R, Cheng WH, Xu W, Luo Y, Zhao C, Huang K
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2014 Jul;69:202-9
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2014 Jul;69:202-9
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P, Eizirik DL
PloS one 2012;7(2):e31062
PloS one 2012;7(2):e31062
Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis.
Zheng J, Bizzozero OA
Journal of neurochemistry 2011 Apr;117(1):143-53
Journal of neurochemistry 2011 Apr;117(1):143-53
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15440-1-AP(LONP1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LONP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LONP1. This antibody recognizes human,mouse,rat antigen. The LONP1 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-LONP1 (IP:15440-1-AP, 3ug; Detection:15440-1-AP 1:1000) with mouse heart tissue lysate 9500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 15440-1-AP(LONP1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 15440-1-AP(LONP1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
