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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [15]
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- Western blot [1]
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- Product number
- HPA002192 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA002192, RRID:AB_1079695
- Product name
- Anti-LONP1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human LONP1, Gene description: lon peptidase 1, mitochondrial, Alternative Gene Names: hLON, LonHS, PIM1, PRSS15, Validated applications: WB, IHC, ICC, Uniprot ID: P36776, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.3 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins
Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population
CLPX regulates mitochondrial fatty acid β-oxidation in liver cells
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease
The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population
Loss of the mitochondrial i ‐ AAA protease YME 1L leads to ocular dysfunction and spinal axonopathy
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation
Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness
StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors
Proteomics Analysis Reveals Novel Components in the Detergent-Insoluble Subproteome in Alzheimer’s Disease
Chen C, McDonald D, Blain A, Mossman E, Atkin K, Marusich M, Capaldi R, Bone L, Smith A, Filby A, Erskine D, Russell O, Hudson G, Vincent A, Reeve A
npj Parkinson's Disease 2023;9(1)
npj Parkinson's Disease 2023;9(1)
Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse population
Morel J, Sleiman M, Li T, von Alvensleben G, Bachmann A, Hofer D, Broeckx E, Ma J, Carreira V, Chen T, Azhar N, Gonzalez-Villalobos R, Breyer M, Reilly D, Mullican S, Auwerx J
JCI Insight 2023;8(3)
JCI Insight 2023;8(3)
CLPX regulates mitochondrial fatty acid β-oxidation in liver cells
Suzuki K, Kubota Y, Kaneko K, Kamata C, Furuyama K
Journal of Biological Chemistry 2023;299(10):105210
Journal of Biological Chemistry 2023;299(10):105210
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease
Bai M, Wu M, Jiang M, He J, Deng X, Xu S, Fan J, Miao M, Wang T, Li Y, Yu X, Wang L, Zhang Y, Huang S, Yang L, Jia Z, Zhang A
EMBO Molecular Medicine 2023;15(2)
EMBO Molecular Medicine 2023;15(2)
The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins
Rupprecht A, Theisen U, Wendt F, Frank M, Hinz B
Cancers 2022;14(13):3129
Cancers 2022;14(13):3129
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population
Williams E, Wu Y, Wolski W, Kim J, Lan J, Hasan M, Halter C, Jha P, Ryu D, Auwerx J, Aebersold R
Molecular & Cellular Proteomics 2018;17(9):1766-1777
Molecular & Cellular Proteomics 2018;17(9):1766-1777
Loss of the mitochondrial i ‐ AAA protease YME 1L leads to ocular dysfunction and spinal axonopathy
Sprenger H, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli E, Bergami M, Langer T
EMBO Molecular Medicine 2018;11(1)
EMBO Molecular Medicine 2018;11(1)
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Quirós P, Prado M, Zamboni N, D’Amico D, Williams R, Finley D, Gygi S, Auwerx J
Journal of Cell Biology 2017;216(7):2027-2045
Journal of Cell Biology 2017;216(7):2027-2045
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation
Münch C, Harper J
Nature 2016;534(7609):710-713
Nature 2016;534(7609):710-713
Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis
Kubota Y, Nomura K, Katoh Y, Yamashita R, Kaneko K, Furuyama K
Journal of Biological Chemistry 2016;291(39):20516-20529
Journal of Biological Chemistry 2016;291(39):20516-20529
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, Zuo X, Liu Y, Luo K, Song W, Wang K, Pang M
Neoplasia 2016;18(4):242-252
Neoplasia 2016;18(4):242-252
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness
Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby B
Journal of Cell Biology 2015;211(2):373-389
Journal of Cell Biology 2015;211(2):373-389
StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation
Bahat A, Perlberg S, Melamed-Book N, Lauria I, Langer T, Orly J
Molecular Endocrinology 2014;28(2):208-224
Molecular Endocrinology 2014;28(2):208-224
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors
Gispert S, Parganlija D, Klinkenberg M, Drose S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, Buchel F, Adler T, Hrabe de Angelis M, Busch D, Zell A, Reichert A, Brandt U, Osiewacz H, Jendrach M, Auburger G
Human Molecular Genetics 2013;22(24):4871-4887
Human Molecular Genetics 2013;22(24):4871-4887
Proteomics Analysis Reveals Novel Components in the Detergent-Insoluble Subproteome in Alzheimer’s Disease
Gozal Y, Duong D, Gearing M, Cheng D, Hanfelt J, Funderburk C, Peng J, Lah J, Levey A
Journal of Proteome Research 2009;8(11):5069-5079
Journal of Proteome Research 2009;8(11):5069-5079
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LONP1 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
