BS3514
antibody from Bioworld Technology, Inc
Targeting: HIF1A
bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS3514 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS3514, RRID:AB_1663164
- Product name
- HIF 1Ï« (K377) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 345-398 of Human HIF-1Ï«.
- Description
- Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1Ï«, Arnt 1 (also designated HIF-1ÉÇ), EPAS-1 (also designated HIF-2Ï«) and HIF-3Ï«, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1Ï« is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of HIF-1¦Á (K377) pAb at 1:500 dilutionLane1:HepG2 whole cell lysateLane2:Mouse kidney tissue lysateLane3:Rat kidney tissue lysate