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- Product number
- 20960-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20960-1-AP, RRID:AB_10732601
- Product name
- HIF1a antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HIF1a antibody (Cat. #20960-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation.
Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy.
TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair.
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy.
Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions.
LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis.
Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β.
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
P4HA1 as an unfavorable prognostic marker promotes cell migration and invasion of glioblastoma via inducing EMT process under hypoxia microenvironment.
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis.
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.
Hypoxic colorectal cancer-secreted exosomes deliver miR-210-3p to normoxic tumor cells to elicit a protumoral effect.
Mitochondrial calcium uniporter promotes cell proliferation and migration in esophageal cancer.
LncRNA ZNFTR functions as an inhibitor in pancreatic cancer by modulating ATF3/ZNF24/VEGFA pathway.
Assessing the protective effects of cryptotanshinone on CoCl(2)‑induced hypoxia in RPE cells.
Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets.
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis.
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Ultrathin 2D Titanium Carbide MXene (Ti3 C2 Tx ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages.
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone.
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.
The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
The Expression and Role of Hypoxia-induced Factor-1α in Human Tenon's Capsule Fibroblasts under Hypoxia.
SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
The essential role of PRAK in tumor metastasis and its therapeutic potential.
p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells.
A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism.
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Thioredoxin-interacting protein is a favored target of miR-125b, promoting metastasis and progression of pancreatic cancer via the HIF1α pathway.
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.
Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells.
Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis.
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species.
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1α in clear cell renal cell carcinoma.
BML-111, the lipoxin A4 agonist, modulates VEGF or CoCl2-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models.
microRNA-322/424 promotes liver fibrosis by regulating angiogenesis through targeting CUL2/HIF-1α pathway.
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.
A single-cell transcriptomic landscape of the lungs of patients with COVID-19.
miR-126 regulates angiogenesis in myocardial ischemia by targeting HIF-1α.
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Lysosome Fe2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.
Leptin attenuates hypoxia-induced apoptosis in human periodontal ligament cells via the reactive oxygen species-hypoxia-inducible factor-1α pathway.
USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma.
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.
Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway.
The Regulatory Mechanism and Biological Significance of Mitochondrial Calcium Uniporter in the Migration, Invasion, Angiogenesis and Growth of Gastric Cancer.
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma.
Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma.
Human Umbilical Cord Mesenchymal Stem Cell Differentiation Into Odontoblast-Like Cells and Endothelial Cells: A Potential Cell Source for Dental Pulp Tissue Engineering.
Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System.
Characterization of Group I Metabotropic Glutamate Receptors in Rat and Human Adrenal Glands.
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a.
Therapeutic effects of Choreito, a traditional Japanese (Kampo) medicine, on detrusor overactivity induced by acetic acid in rats.
Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF-1α under a hypoxic microenvironment.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner.
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway.
USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer.
Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
LncRNA HOTAIR knockdown inhibits glycolysis by regulating miR-130a-3p/HIF1A in hepatocellular carcinoma under hypoxia.
Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway.
P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.
Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation.
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.
Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α.
Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Severe OSA associated with higher risk of mortality in stage III and IV lung cancer.
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells.
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a.
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.
Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.
Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia.
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction.
LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α.
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Aspirin, a Potential GLUT1 Inhibitor in a Vascular Endothelial Cell Line.
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway.
Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization.
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals.
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia.
DZNep inhibits Hif-1α and Wnt signalling molecules to attenuate the proliferation and invasion of BGC-823 gastric cancer cells.
RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway(✰).
Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma.
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.
Inhibiting Hypoxia and Chemotherapy-Induced Cancer Cell Metastasis under a Valid Therapeutic Effect by an Assistance of Biomimetic Oxygen Delivery.
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.
Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment.
Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.
Transplantation of Amniotic Fluid-Derived Stem Cells Preconditioned with Glial Cell Line-Derived Neurotrophic Factor Gene Alleviates Renal Fibrosis.
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury.
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.
Nicotine-induced hypoxia in rat urothelium deteriorates bladder storage functions.
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α.
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway.
FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization.
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α.
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Recombinant human maspin inhibits high glucose-induced oxidative stress and angiogenesis of human retinal microvascular endothelial cells via PI3K/AKT pathway.
SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment.
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation.
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma.
Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy.
Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders.
Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance.
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis.
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
V-ATPase-dependent repression of androgen receptor in prostate cancer cells.
Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum.
Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models.
Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling.
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis.
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.
Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells.
Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma.
Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
BNIP3 promotes the motility and migration of keratinocyte under hypoxia.
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration.
Discordant mRNA and protein expression of CXCR4 under in vitro CoCl2-induced hypoxic conditions.
Regulation of angiogenic behaviors by oxytocin receptor through Gli1-indcued transcription of HIF-1α in human umbilical vein endothelial cells.
Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis.
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.
Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α.
Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138.
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice.
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.
Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.
Preparation of artificial red cell and its application on alleviation of tumor hypoxia.
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression.
Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function.
Hydrogen Sulfide and Carbon Monoxide Protect Gastric Mucosa Compromised by Mild Stress Against Alendronate Injury.
Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression.
Association between the expression of HIF-1α and VEGF and prognostic implications in primary liver cancer.
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model.
Paper-based microreactor array for rapid screening of cell signaling cascades.
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer.
The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer.
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma.
DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.
Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells.
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.
Interferon-γ-induced intestinal epithelial barrier dysfunction by NF-κB/HIF-1α pathway.
Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: angiogenic markers of neoadjuvant chemoradiation.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer.
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.
Valsartan inhibited HIF-1α pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats.
He Y, Wang W, Lin S, Yang Y, Song L, Jing Y, Chen L, He Z, Li W, Xiong A, Yeung KWK, Zhao Q, Jiang Y, Li Z, Pei G, Zhang ZY
Bioactive materials 2022 Mar;9:491-507
Bioactive materials 2022 Mar;9:491-507
Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy.
Feng L, Chen M, Li R, Zhou L, Wang C, Ye P, Hu X, Yang J, Sun Y, Zhu Z, Fang K, Chai K, Shi S, Dong C
Acta biomaterialia 2022 Jan 15;138:463-477
Acta biomaterialia 2022 Jan 15;138:463-477
TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair.
Tang S, Fan C, Iroegbu CD, Zhou W, Zhang Z, Wu M, Chen W, Wu X, Peng J, Li Z, Yang J
Frontiers in cell and developmental biology 2021;9:670913
Frontiers in cell and developmental biology 2021;9:670913
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Su X, Yang Y, Guo C, Zhang R, Sun S, Wang Y, Qiao Q, Fu Y, Pang Q
Oxidative medicine and cellular longevity 2021;2021:5549047
Oxidative medicine and cellular longevity 2021;2021:5549047
Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy.
Guo Z, Sun X, Yang J, Xie J, Zhong F, Li X, Zhang Y, Han F, Yang X, Yang S, Zhou W, Chang B
Journal of diabetes research 2021;2021:3181347
Journal of diabetes research 2021;2021:3181347
Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions.
Yu W, Ke X, Li M, Ye P, Peng J, Li H
Open medicine (Warsaw, Poland) 2021;16(1):1428-1437
Open medicine (Warsaw, Poland) 2021;16(1):1428-1437
LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis.
Cen X, Huang Y, Lu Z, Shao W, Zhuo C, Bao C, Feng S, Wei C, Tang X, Cen L, Guo W, Tian X, Tang Q, Huang X
Cancer management and research 2021;13:5957-5968
Cancer management and research 2021;13:5957-5968
Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β.
Huang YN, Xu YY, Ma Q, Li MQ, Guo JX, Wang X, Jin X, Shang J, Jiao LX
Journal of Cancer 2021;12(11):3367-3377
Journal of Cancer 2021;12(11):3367-3377
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Chen L, Yi C, Li W, Tseng Y, Zhang J, Liu J
Journal of Cancer 2021;12(1):89-98
Journal of Cancer 2021;12(1):89-98
Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
Yu P, Li Y, Zhong G, Li W, Chen B, Zhang J
Frontiers in physiology 2021;12:737474
Frontiers in physiology 2021;12:737474
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
Qian L, Ren S, Xu Z, Zheng Y, Wu L, Yang Y, Wang Y, Li J, Yan S, Fang Z
Frontiers in pharmacology 2021;12:667433
Frontiers in pharmacology 2021;12:667433
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Du JK, Yu Q, Liu YJ, Du SF, Huang LY, Xu DH, Ni X, Zhu XY
Theranostics 2021;11(9):4207-4231
Theranostics 2021;11(9):4207-4231
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
P4HA1 as an unfavorable prognostic marker promotes cell migration and invasion of glioblastoma via inducing EMT process under hypoxia microenvironment.
Zhu X, Liu S, Yang X, Wang W, Shao W, Ji T
American journal of cancer research 2021;11(2):590-617
American journal of cancer research 2021;11(2):590-617
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Yan X, Qu X, Liu B, Zhao Y, Xu L, Yu S, Wang J, Wang L, Su J
Frontiers in oncology 2021;11:742460
Frontiers in oncology 2021;11:742460
Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis.
Geng B, Zhu Y, Yuan Y, Bai J, Dou Z, Sui A, Luo W
Frontiers in oncology 2021;11:714646
Frontiers in oncology 2021;11:714646
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma.
Yao S, Ertay A, Zhou Y, Yao L, Hill C, Chen J, Guan Y, Sun H, Ewing RM, Liu Y, Lv X, Wang Y
Frontiers in oncology 2021;11:654812
Frontiers in oncology 2021;11:654812
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.
Nisar MA, Zheng Q, Saleem MZ, Ahmmed B, Ramzan MN, Ud Din SR, Tahir N, Liu S, Yan Q
Frontiers in oncology 2021;11:618839
Frontiers in oncology 2021;11:618839
Hypoxic colorectal cancer-secreted exosomes deliver miR-210-3p to normoxic tumor cells to elicit a protumoral effect.
Ge L, Zhou F, Nie J, Wang X, Zhao Q
Experimental biology and medicine (Maywood, N.J.) 2021 Sep;246(17):1895-1906
Experimental biology and medicine (Maywood, N.J.) 2021 Sep;246(17):1895-1906
Mitochondrial calcium uniporter promotes cell proliferation and migration in esophageal cancer.
Miao Y, Wang X, Lai Y, Lin W, Huang Y, Yin H, Hou R, Zhang F
Oncology letters 2021 Sep;22(3):686
Oncology letters 2021 Sep;22(3):686
LncRNA ZNFTR functions as an inhibitor in pancreatic cancer by modulating ATF3/ZNF24/VEGFA pathway.
Li W, Han S, Hu P, Chen D, Zeng Z, Hu Y, Xu F, Tang J, Wang F, Zhao Y, Huang M, Zhao G
Cell death & disease 2021 Sep 3;12(9):830
Cell death & disease 2021 Sep 3;12(9):830
Assessing the protective effects of cryptotanshinone on CoCl(2)‑induced hypoxia in RPE cells.
Gu Y, Liu W, Liu G, Li X, Lu P
Molecular medicine reports 2021 Oct;24(4)
Molecular medicine reports 2021 Oct;24(4)
Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
Xia S, Wang Z, Chen L, Zhou Y, Li Y, Wang S, Chen A, Xu X, Shao J, Zhang Z, Tan S, Zhang F, Zheng S
Biochemical pharmacology 2021 Oct;192:114730
Biochemical pharmacology 2021 Oct;192:114730
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets.
Duo Y, Luo G, Li Z, Chen Z, Li X, Jiang Z, Yu B, Huang H, Sun Z, Yu XF
Small (Weinheim an der Bergstrasse, Germany) 2021 Oct;17(40):e2103239
Small (Weinheim an der Bergstrasse, Germany) 2021 Oct;17(40):e2103239
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Li Q, Zhang Y, Yang Y, Huang S, Zou X, Wei C, Liang T, Zhong X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.
Yang Y, Wang J, Zhang Y, Hu X, Li L, Chen P
Aging 2021 Oct 25;13(20):23769-23779
Aging 2021 Oct 25;13(20):23769-23779
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
Xu K, Lu C, Ren X, Wang J, Xu P, Zhang Y
Environmental toxicology 2021 Nov;36(11):2123-2137
Environmental toxicology 2021 Nov;36(11):2123-2137
PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis.
Cheng WX, Liu YZ, Meng XB, Zheng ZT, Li LL, Ke LQ, Li L, Huang CS, Zhu GY, Pan HD, Qin L, Wang XL, Zhang P
Journal of orthopaedic translation 2021 Nov;31:41-51
Journal of orthopaedic translation 2021 Nov;31:41-51
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Wang F, Zhang J, Zhou G
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Ultrathin 2D Titanium Carbide MXene (Ti3 C2 Tx ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.
Cui D, Kong N, Ding L, Guo Y, Yang W, Yan F
Advanced healthcare materials 2021 Nov;10(22):e2101215
Advanced healthcare materials 2021 Nov;10(22):e2101215
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Su X, Yang Y, Yang Q, Pang B, Sun S, Wang Y, Qiao Q, Guo C, Liu H, Pang Q
BMC cancer 2021 Nov 5;21(1):1181
BMC cancer 2021 Nov 5;21(1):1181
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Yan PJ, Ren ZX, Shi ZF, Wan CL, Han CJ, Zhu LS, Li NN, Waddington JL, Zhen XC
Acta pharmacologica Sinica 2021 Nov 22;
Acta pharmacologica Sinica 2021 Nov 22;
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages.
Lee S, Pham DV, Park PH
Archives of pharmacal research 2021 Nov 19;
Archives of pharmacal research 2021 Nov 19;
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Tang L, Wang F, Xiao L, Shen M, Xia S, Zhang Z, Zhang F, Zheng S, Tan S
Journal of ethnopharmacology 2021 Nov 15;280:114411
Journal of ethnopharmacology 2021 Nov 15;280:114411
Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone.
Lin Q, Fang X, Liang G, Luo Q, Cen Y, Shi Y, Jia S, Li J, Yang W, Sanders AJ, Gong C, Jiang W
Cancers 2021 Nov 15;13(22)
Cancers 2021 Nov 15;13(22)
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.
Guo C, Li N, Dong C, Wang L, Li Z, Liu Q, Ma Q, Greenaway FT, Tian Y, Hao L, Liu S, Sun MZ
Journal of advanced research 2021 May;30:85-102
Journal of advanced research 2021 May;30:85-102
The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway.
Guan D, Li C, Li Y, Li Y, Wang G, Gao F, Li C
Journal of inorganic biochemistry 2021 May;218:111413
Journal of inorganic biochemistry 2021 May;218:111413
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Cheng L, Peng R, Guo P, Zhang H, Liu D, Liao X, Liu Y, Mo X, Liao Y
Experimental cell research 2021 May 1;402(1):112547
Experimental cell research 2021 May 1;402(1):112547
The Expression and Role of Hypoxia-induced Factor-1α in Human Tenon's Capsule Fibroblasts under Hypoxia.
Qin X, Wu K, Zuo C, Lin M
Current eye research 2021 Mar;46(3):417-425
Current eye research 2021 Mar;46(3):417-425
SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
Xiaoshi J, Maoquan L, Jiwei W, Jinqiu N, Ke Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21283
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21283
YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
Zeng Z, Lei S, He Z, Chen T, Jiang J
Journal of cellular physiology 2021 Mar;236(3):2087-2098
Journal of cellular physiology 2021 Mar;236(3):2087-2098
The essential role of PRAK in tumor metastasis and its therapeutic potential.
Wang Y, Wang W, Wu H, Zhou Y, Qin X, Wang Y, Wu J, Sun XY, Yang Y, Xu H, Qian X, Pang X, Li Y, Zhang Z, Han J, Zhang Y
Nature communications 2021 Mar 19;12(1):1736
Nature communications 2021 Mar 19;12(1):1736
p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
Li C, Huang Y, Fan Q, Quan H, Dong Y, Nie M, Wang J, Xie F, Ji J, Zhou L, Zheng Z, Wang L
Cell death & disease 2021 Mar 17;12(4):286
Cell death & disease 2021 Mar 17;12(4):286
Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells.
Niu G, Zhou M, Wang F, Yang J, Huang J, Zhu Z
Drug development research 2021 Jun;82(4):523-532
Drug development research 2021 Jun;82(4):523-532
A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism.
Liu R, Feng Y, Deng Y, Zou Z, Ye J, Cai Z, Zhu X, Liang Y, Lu J, Zhang H, Luo Y, Han Z, Zhuo Y, Xie Q, Hon CT, Liang Y, Wu CL, Zhong W
Journal of experimental & clinical cancer research : CR 2021 Jun 7;40(1):188
Journal of experimental & clinical cancer research : CR 2021 Jun 7;40(1):188
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Yang X, Bao M, Fang Y, Yu X, Ji J, Ding X
Journal of translational medicine 2021 Jun 30;19(1):283
Journal of translational medicine 2021 Jun 30;19(1):283
Thioredoxin-interacting protein is a favored target of miR-125b, promoting metastasis and progression of pancreatic cancer via the HIF1α pathway.
Wang P, Zheng D, Qi H, Gao Q
Journal of biochemical and molecular toxicology 2021 Jul;35(7):e22782
Journal of biochemical and molecular toxicology 2021 Jul;35(7):e22782
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Pei L, Le Y, Chen H, Feng J, Liu Z, Zhu J, Wang C, Chen L, Dou X, Lu D
Fitoterapia 2021 Jul;152:104922
Fitoterapia 2021 Jul;152:104922
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.
Daly LA, Brownridge PJ, Batie M, Rocha S, Sée V, Eyers CE
Science signaling 2021 Jul 20;14(692)
Science signaling 2021 Jul 20;14(692)
Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.
Li M, Liu H, Li J, Guo S, Lv Y
Respiratory research 2021 Jul 1;22(1):190
Respiratory research 2021 Jul 1;22(1):190
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Shi Y, Jiang J, Cui Y, Chen Y, Dong T, An H, Liu P
DNA and cell biology 2021 Jan;40(1):93-100
DNA and cell biology 2021 Jan;40(1):93-100
Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143
RNA biology 2021 Jan;18(1):131-143
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Wang XH, Jiang ZH, Yang HM, Zhang Y, Xu LH
Clinical and translational medicine 2021 Jan;11(1):e279
Clinical and translational medicine 2021 Jan;11(1):e279
Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells.
Meng P, Zhang YF, Zhang W, Chen X, Xu T, Hu S, Liang X, Feng M, Yang X, Ho M
Scientific reports 2021 Jan 8;11(1):40
Scientific reports 2021 Jan 8;11(1):40
Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis.
Li S, Wang Y, Wang Z, Chen L, Zuo B, Liu C, Sun D
Stem cell research & therapy 2021 Jan 7;12(1):27
Stem cell research & therapy 2021 Jan 7;12(1):27
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species.
Yang Z, Huang Y, Zhu L, Yang K, Liang K, Tan J, Yu B
Cell death & disease 2021 Jan 12;12(1):77
Cell death & disease 2021 Jan 12;12(1):77
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Ma Y, Wu T, Zhou H, He G, Li Y, Wang B, Guo Q, Chen B, Li W
Translational neuroscience 2021 Jan 1;12(1):309-319
Translational neuroscience 2021 Jan 1;12(1):309-319
Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1α in clear cell renal cell carcinoma.
Zhao P, Deng Y, Wu Y, Guo Q, Zhou L, Yang X, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21160
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21160
BML-111, the lipoxin A4 agonist, modulates VEGF or CoCl2-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Lin L, Wang Q, Xu F, Luo X, Xu J, Yan L, Li Q, Hao H
Immunology letters 2021 Feb;230:27-35
Immunology letters 2021 Feb;230:27-35
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
Sun LT, Zhang LY, Shan FY, Shen MH, Ruan SM
Chinese journal of natural medicines 2021 Feb;19(2):143-152
Chinese journal of natural medicines 2021 Feb;19(2):143-152
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.
Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H
Genomics, proteomics & bioinformatics 2021 Feb 26;
Genomics, proteomics & bioinformatics 2021 Feb 26;
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models.
Locquet MA, Dechaume AL, Berchard P, Abbes L, Pissaloux D, Tirode F, Ramos I, Bedoucha J, Valantin J, Karanian M, Perret R, Gille O, Blay JY, Dutour A
Cells 2021 Feb 15;10(2)
Cells 2021 Feb 15;10(2)
microRNA-322/424 promotes liver fibrosis by regulating angiogenesis through targeting CUL2/HIF-1α pathway.
Wang Q, Zhang F, Lei Y, Liu P, Liu C, Tao Y
Life sciences 2021 Feb 1;266:118819
Life sciences 2021 Feb 1;266:118819
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.
Lin J, Wang Y, Lin Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11170-11184
Journal of cellular and molecular medicine 2021 Dec;25(24):11170-11184
A single-cell transcriptomic landscape of the lungs of patients with COVID-19.
Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J, Zhang W, Liu GH, Bian XW
Nature cell biology 2021 Dec;23(12):1314-1328
Nature cell biology 2021 Dec;23(12):1314-1328
miR-126 regulates angiogenesis in myocardial ischemia by targeting HIF-1α.
Gao S, Gao H, Dai L, Han Y, Lei Z, Wang X, Chang H, Liu S, Wang Z, Tong H, Wu H
Experimental cell research 2021 Dec 15;409(2):112925
Experimental cell research 2021 Dec 15;409(2):112925
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Luo Y, Chen H, Huang R, Wu Q, Li Y, He Y
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Lysosome Fe2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.
Wang K, Chen X, Zuyi W, Chen L, Fu W
Environmental toxicology 2021 Aug;36(8):1654-1663
Environmental toxicology 2021 Aug;36(8):1654-1663
Leptin attenuates hypoxia-induced apoptosis in human periodontal ligament cells via the reactive oxygen species-hypoxia-inducible factor-1α pathway.
Gao J, Zhu J, Zhao Y, Gan X, Yu H
Experimental physiology 2021 Aug;106(8):1752-1761
Experimental physiology 2021 Aug;106(8):1752-1761
USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma.
Lv C, Wang S, Lin L, Wang C, Zeng K, Meng Y, Sun G, Wei S, Liu Y, Zhao Y
Cell death & disease 2021 Aug 21;12(9):803
Cell death & disease 2021 Aug 21;12(9):803
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Huo N, Cong R, Sun ZJ, Li WC, Zhu X, Xue CY, Chen Z, Ma LY, Chu Z, Han YC, Kang XF, Jia SH, Du N, Kang L, Xu XJ
Cell death & disease 2021 Aug 17;12(9):799
Cell death & disease 2021 Aug 17;12(9):799
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Miwa T, Kanda M, Shimizu D, Umeda S, Sawaki K, Tanaka H, Tanaka C, Hattori N, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y
British journal of cancer 2021 Apr;124(8):1449-1460
British journal of cancer 2021 Apr;124(8):1449-1460
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
Yang Y, Xiang K, Sun D, Zheng M, Song Z, Li M, Wang X, Li H, Chen L
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.
Zhou W, Zhang B, Fan K, Yin X, Liu J, Gou S
Cardiovascular drugs and therapy 2021 Apr 12;
Cardiovascular drugs and therapy 2021 Apr 12;
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Xu WN, Yang RZ, Zheng HL, Jiang LS, Jiang SD
Frontiers in cell and developmental biology 2020;8:515051
Frontiers in cell and developmental biology 2020;8:515051
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Tang BI, Tang MM, Xu QM, Guo JL, Xuan L, Zhou J, Wang XJ, Zhang H, Kang PF
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.
Cong L, Bai Z, Du Y, Cheng Y
BioMed research international 2020;2020:9210891
BioMed research international 2020;2020:9210891
Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition.
Cai Q, Wang X, Wang S, Jin L, Ding J, Zhou D, Ma F
International journal of nanomedicine 2020;15:253-262
International journal of nanomedicine 2020;15:253-262
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway.
Luo J, Luo X, Liu X, Fang Z, Xu J, Li L
OncoTargets and therapy 2020;13:1321-1330
OncoTargets and therapy 2020;13:1321-1330
The Regulatory Mechanism and Biological Significance of Mitochondrial Calcium Uniporter in the Migration, Invasion, Angiogenesis and Growth of Gastric Cancer.
Wang X, Song X, Cheng G, Zhang J, Dong L, Bai J, Luo D, Xiong Y, Li S, Liu F, Sun Y, Wang X, Li Y, Huang Y
OncoTargets and therapy 2020;13:11781-11794
OncoTargets and therapy 2020;13:11781-11794
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma.
Huang G, Chen J, Liu J, Zhang X, Duan H, Fang Q
OncoTargets and therapy 2020;13:10817-10828
OncoTargets and therapy 2020;13:10817-10828
Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma.
Qin S, Yi M, Jiao D, Li A, Wu K
Journal of Cancer 2020;11(1):153-167
Journal of Cancer 2020;11(1):153-167
Human Umbilical Cord Mesenchymal Stem Cell Differentiation Into Odontoblast-Like Cells and Endothelial Cells: A Potential Cell Source for Dental Pulp Tissue Engineering.
Zhang S, Zhang W, Li Y, Ren L, Deng H, Yin X, Gao X, Pan S, Niu Y
Frontiers in physiology 2020;11:593
Frontiers in physiology 2020;11:593
Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System.
Wang X, Zhu H, Lei L, Zhang Y, Tang C, Wu JX, Zhou JR, Xiao XR
Frontiers in genetics 2020;11:581789
Frontiers in genetics 2020;11:581789
Characterization of Group I Metabotropic Glutamate Receptors in Rat and Human Adrenal Glands.
Fan YN, Li C, Huang L, Chen L, Tang Z, Han G, Liu Y
Frontiers in physiology 2020;11:401
Frontiers in physiology 2020;11:401
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Zhang Q, Wang L, Jiang J, Lin S, Luo A, Zhao P, Tan W, Zhang M
Frontiers in immunology 2020;11:2040
Frontiers in immunology 2020;11:2040
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, Huang G
Theranostics 2020;10(11):4762-4778
Theranostics 2020;10(11):4762-4778
Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.
Zhong L, Wang R, Wang Y, Peng S, Ma Y, Ding S, Yang H, Chen S, Luo X, Wang W
Neoplasia (New York, N.Y.) 2020 Sep;22(9):365-375
Neoplasia (New York, N.Y.) 2020 Sep;22(9):365-375
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a.
Brennan L, Disatham J, Kantorow M
Experimental eye research 2020 Sep;198:108129
Experimental eye research 2020 Sep;198:108129
Therapeutic effects of Choreito, a traditional Japanese (Kampo) medicine, on detrusor overactivity induced by acetic acid in rats.
Ueno M, Minagawa T, Saito T, Imamura T, Nagai T, Ogawa T, Ishizuka O
Lower urinary tract symptoms 2020 Sep;12(3):198-205
Lower urinary tract symptoms 2020 Sep;12(3):198-205
Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF-1α under a hypoxic microenvironment.
Huang X, Zhou W, Zhang Y
Environmental toxicology 2020 Sep 3;
Environmental toxicology 2020 Sep 3;
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner.
Yan Y, Wu X, Wang P, Zhang S, Sun L, Zhao Y, Zeng G, Liu B, Xu G, Liu H, Wang L, Wang X, Jiang C
Redox biology 2020 Oct;37:101742
Redox biology 2020 Oct;37:101742
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway.
Wang X, Che X, Yu Y, Cheng Y, Bai M, Yang Z, Guo Q, Xie X, Li D, Guo M, Hou K, Guo W, Qu X, Cao L
Journal of experimental & clinical cancer research : CR 2020 Oct 20;39(1):221
Journal of experimental & clinical cancer research : CR 2020 Oct 20;39(1):221
USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer.
Wang S, Zhong X, Wang C, Luo H, Lin L, Sun H, Sun G, Zeng K, Zou R, Liu W, Sun N, Song H, Liu W, Zhang Q, Liao Z, Teng X, Zhou T, Sun X, Zhao Y
Cell death and differentiation 2020 Nov;27(11):3131-3145
Cell death and differentiation 2020 Nov;27(11):3131-3145
Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis.
Zhang GL, Qian C, Zhang SZ, Tuo YH, Zeng BY, Ji YX, Wang YZ
World journal of stem cells 2020 Nov 26;12(11):1396-1409
World journal of stem cells 2020 Nov 26;12(11):1396-1409
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
LncRNA HOTAIR knockdown inhibits glycolysis by regulating miR-130a-3p/HIF1A in hepatocellular carcinoma under hypoxia.
Hu M, Fu Q, Jing C, Zhang X, Qin T, Pan Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109703
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109703
Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway.
Pang X, Zhang Y, Shi X, Peng Z, Xing Y, Jiarui H
Medical science monitor : international medical journal of experimental and clinical research 2020 May 30;26:e921894
Medical science monitor : international medical journal of experimental and clinical research 2020 May 30;26:e921894
P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.
Jiang S, Gao Y, Yu QH, Li M, Cheng X, Hu SB, Song ZF, Zheng QC
Biochemical and biophysical research communications 2020 May 21;526(1):98-104
Biochemical and biophysical research communications 2020 May 21;526(1):98-104
Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation.
Kong P, Yu KN, Yang M, Almahi WA, Nie L, Chen G, Han W
International journal of molecular sciences 2020 May 11;21(9)
International journal of molecular sciences 2020 May 11;21(9)
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Liu R, Deng X, Peng Y, Feng W, Xiong R, Zou Y, Lei X, Zheng X, Xie Z, Tang G
Bioorganic chemistry 2020 Mar;96:103652
Bioorganic chemistry 2020 Mar;96:103652
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Cell biochemistry and function 2020 Mar;38(2):130-140
Cell biochemistry and function 2020 Mar;38(2):130-140
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.
Liu M, Wang Y, Yang C, Ruan Y, Bai C, Chu Q, Cui Y, Chen C, Ying G, Li B
The Journal of experimental medicine 2020 Mar 2;217(3)
The Journal of experimental medicine 2020 Mar 2;217(3)
Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α.
Huang Y, Tan F, Zhuo Y, Liu J, He J, Duan D, Lu M, Hu Z
Aging 2020 Jun 7;12(11):10931-10950
Aging 2020 Jun 7;12(11):10931-10950
Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma.
Teraoku H, Morine Y, Uyama N, Ikemoto T, Iwahashi S, Saito Y, Takasu C, Imura S, Harada M, Shimada M
World journal of surgery 2020 Jul;44(7):2350-2358
World journal of surgery 2020 Jul;44(7):2350-2358
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Wang F, Zhang J, Zhou G
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Severe OSA associated with higher risk of mortality in stage III and IV lung cancer.
Huang HY, Lin SW, Chuang LP, Wang CL, Sun MH, Li HY, Chang CJ, Chang SC, Yang CT, Chen NH
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2020 Jul 15;16(7):1091-1098
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2020 Jul 15;16(7):1091-1098
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
Wang X, Lin L, Chai X, Wu Y, Li Y, Liu X
International journal of molecular medicine 2020 Jan;45(1):175-185
International journal of molecular medicine 2020 Jan;45(1):175-185
SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells.
Yuan L, Wu XJ, Li WC, Zhuo C, Xu Z, Tan C, Ma R, Wang J, Pu J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820983029
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820983029
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, Yu Q, Kong R, Li S, Zhang J, Ji J, Wu J, Mo W, Xu X, Guo C
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
Sun C, Li X, Guo E, Li N, Zhou B, Lu H, Huang J, Xia M, Shan W, Wang B, Li K, Weng D, Xu X, Gao Q, Wang S, Hu J, Lu Y, Mills GB, Chen G
Oncogene 2020 Feb;39(8):1681-1695
Oncogene 2020 Feb;39(8):1681-1695
CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.
Yin X, Xia J, Sun Y, Zhang Z
BMC pulmonary medicine 2020 Feb 13;20(1):40
BMC pulmonary medicine 2020 Feb 13;20(1):40
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Gao P, Wang LL, Liu J, Dong F, Song W, Liao L, Wang B, Zhang W, Zhou X, Xie Q, Sun R, Liu J
Life sciences 2020 Feb 1;242:117221
Life sciences 2020 Feb 1;242:117221
LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a.
Wang J, Yu Z, Wang J, Shen Y, Qiu J, Zhuang Z
Cancer medicine 2020 Dec;9(24):9499-9510
Cancer medicine 2020 Dec;9(24):9499-9510
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.
Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC, Hancks DC
PLoS biology 2020 Dec;18(12):e3001045
PLoS biology 2020 Dec;18(12):e3001045
Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.
Chen T, Wu G, Hu H, Wu C
Journal of gastrointestinal oncology 2020 Aug;11(4):695-707
Journal of gastrointestinal oncology 2020 Aug;11(4):695-707
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Liu JR, Cai GY, Ning YC, Wang JC, Lv Y, Guo YN, Fu B, Hong Q, Sun XF, Chen XM
Aging 2020 Aug 27;12(18):18052-18072
Aging 2020 Aug 27;12(18):18052-18072
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.
Han X, Ma W, Zhu Y, Sun X, Liu N
Molecular and cellular endocrinology 2020 Aug 20;514:110878
Molecular and cellular endocrinology 2020 Aug 20;514:110878
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D
Life sciences 2020 Aug 15;255:117719
Life sciences 2020 Aug 15;255:117719
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Ren C, Pan R, Hou L, Wu H, Sun J, Zhang W, Tian X, Chen H
Molecular medicine reports 2020 Apr;21(4):1739-1748
Molecular medicine reports 2020 Apr;21(4):1739-1748
Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.
Lin H, Zhou W, Huang Y, Ren M, Xu F, Wang H
Acta biochimica et biophysica Sinica 2020 Apr 20;52(4):421-429
Acta biochimica et biophysica Sinica 2020 Apr 20;52(4):421-429
Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia.
Li Y, Li J, Hou Y, Huang L, Bian Y, Song G, Qiao C
Life sciences 2020 Apr 15;247:117441
Life sciences 2020 Apr 15;247:117441
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.
Tian XP, Wang CY, Jin XH, Li M, Wang FW, Huang WJ, Yun JP, Xu RH, Cai QQ, Xie D
Theranostics 2019;9(7):1965-1979
Theranostics 2019;9(7):1965-1979
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Zhu Y, Yu F, Tan Y, Hong Y, Meng T, Liu Y, Dai S, Qiu G, Yuan H, Hu F
Theranostics 2019;9(23):6764-6779
Theranostics 2019;9(23):6764-6779
Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction.
Choong OK, Chen CY, Zhang J, Lin JH, Lin PJ, Ruan SC, Kamp TJ, Hsieh PCH
Theranostics 2019;9(22):6550-6567
Theranostics 2019;9(22):6550-6567
LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α.
Zeng Z, Xu FY, Zheng H, Cheng P, Chen QY, Ye Z, Zhong JX, Deng SJ, Liu ML, Huang K, Li Q, Li W, Hu YH, Wang F, Wang CY, Zhao G
Theranostics 2019;9(18):5298-5314
Theranostics 2019;9(18):5298-5314
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810
Theranostics 2019;9(16):4795-4810
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
Gao Y, Liu B, Feng L, Sun B, He S, Yang Y, Wu G, E G, Liu C, Gao Y, Zhang E, Zhu B
Frontiers in oncology 2019;9:33
Frontiers in oncology 2019;9:33
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Zhang X, Ma N, Yao W, Li S, Ren Z
Cancer cell international 2019;19:356
Cancer cell international 2019;19:356
Aspirin, a Potential GLUT1 Inhibitor in a Vascular Endothelial Cell Line.
Hu Y, Lou X, Wang R, Sun C, Liu X, Liu S, Wang Z, Ni C
Open medicine (Warsaw, Poland) 2019;14:552-560
Open medicine (Warsaw, Poland) 2019;14:552-560
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
Dong C, Liu X, Wang H, Li J, Dai L, Li J, Xu Z
OncoTargets and therapy 2019;12:1947-1956
OncoTargets and therapy 2019;12:1947-1956
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pan C, Liu Q, Wu X
Cancer management and research 2019;11:10145-10156
Cancer management and research 2019;11:10145-10156
HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway.
Xu WN, Zheng HL, Yang RZ, Jiang LS, Jiang SD
Frontiers in endocrinology 2019;10:922
Frontiers in endocrinology 2019;10:922
Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization.
Lu H, Cheng S, Wu C, Zheng S, Hong W, Liu L, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 Sep;62:152976
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 Sep;62:152976
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Chen L, Tian Q, Wang W
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Chu X, Xiang M, Feng L, Liu H, Zhou C
Journal of thoracic disease 2019 Sep;11(9):3941-3950
Journal of thoracic disease 2019 Sep;11(9):3941-3950
Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
Li Y, Xu Q, Yang W, Wu T, Lu X
Gene 2019 Sep 5;712:143956
Gene 2019 Sep 5;712:143956
Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals.
Dai W, Wang Y, Yang T, Wang J, Wu W, Gu J
Cell communication and signaling : CCS 2019 Sep 2;17(1):113
Cell communication and signaling : CCS 2019 Sep 2;17(1):113
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Kang L, Shen L, Lu L, Wang D, Zhao Y, Chen C, Du L, Gong J, Zhang Y, Mi X, Xiang R, Zhang M, Tan X
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2267-2275
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2267-2275
Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia.
Tamada S, Mitsui T, Ohira A, Tani K, Maki J, Eguchi T, Eto E, Hayata K, Masuyama H
Acta medica Okayama 2019 Oct;73(5):433-440
Acta medica Okayama 2019 Oct;73(5):433-440
DZNep inhibits Hif-1α and Wnt signalling molecules to attenuate the proliferation and invasion of BGC-823 gastric cancer cells.
Huang R, Jin X, Gao Y, Yuan H, Wang F, Cao X
Oncology letters 2019 Oct;18(4):4308-4316
Oncology letters 2019 Oct;18(4):4308-4316
RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.
Bera R, Chiu MC, Huang YJ, Lin TH, Kuo MC, Shih LY
Journal of hematology & oncology 2019 Oct 22;12(1):104
Journal of hematology & oncology 2019 Oct 22;12(1):104
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway(✰).
Lian G, Li X, Zhang L, Zhang Y, Sun L, Zhang X, Liu H, Pang Y, Kong W, Zhang T, Wang X, Jiang C
EBioMedicine 2019 Nov;49:291-304
EBioMedicine 2019 Nov;49:291-304
Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma.
Ohta S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito YU, Yamada S, Wada Y, Yamashita S, Bando Y, Shimada M
Anticancer research 2019 Nov;39(11):6025-6033
Anticancer research 2019 Nov;39(11):6025-6033
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.
Li J, Yuan YQ, Zhang L, Zhang H, Zhang SW, Zhang Y, Xuan XX, Wang MJ, Zhang JY
Experimental and therapeutic medicine 2019 Nov;18(5):3948-3958
Experimental and therapeutic medicine 2019 Nov;18(5):3948-3958
Inhibiting Hypoxia and Chemotherapy-Induced Cancer Cell Metastasis under a Valid Therapeutic Effect by an Assistance of Biomimetic Oxygen Delivery.
Jiang MS, Yin XY, Qin B, Xuan SY, Yuan XL, Yin H, Zhu C, Li X, Yang J, Du YZ, Luo LH, You J
Molecular pharmaceutics 2019 Nov 4;16(11):4530-4541
Molecular pharmaceutics 2019 Nov 4;16(11):4530-4541
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Xu WN, Zheng HL, Yang RZ, Liu T, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
The Journal of physiology 2019 May;597(9):2391-2401
The Journal of physiology 2019 May;597(9):2391-2401
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.
Li S, Wang Y, Chen L, Wang Z, Liu G, Zuo B, Liu C, Sun D
Journal of molecular medicine (Berlin, Germany) 2019 Jun;97(6):777-791
Journal of molecular medicine (Berlin, Germany) 2019 Jun;97(6):777-791
Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.
Liu DW, Zhang YN, Hu HJ, Zhang PQ, Cui W
Molecular medicine reports 2019 Jun;19(6):5335-5344
Molecular medicine reports 2019 Jun;19(6):5335-5344
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X
Cancer letters 2019 Jun 28;452:226-236
Cancer letters 2019 Jun 28;452:226-236
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Liu Y, Li Y, Huang ZN, Wang ZY, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Connective tissue research 2019 Jul;60(4):376-388
Connective tissue research 2019 Jul;60(4):376-388
Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment.
Li Y, Luo J, Lin MT, Zhi P, Guo WW, Han M, You J, Gao JQ
Molecular pharmaceutics 2019 Jul 1;16(7):2966-2979
Molecular pharmaceutics 2019 Jul 1;16(7):2966-2979
Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.
Feng J, Zhang Y, She X, Sun Y, Fan L, Ren X, Fu H, Liu C, Li P, Zhao C, Liu Q, Liu Q, Li G, Wu M
Oncogene 2019 Jan;38(1):103-119
Oncogene 2019 Jan;38(1):103-119
Transplantation of Amniotic Fluid-Derived Stem Cells Preconditioned with Glial Cell Line-Derived Neurotrophic Factor Gene Alleviates Renal Fibrosis.
Li S, Zhao Y, Wang Z, Wang J, Liu C, Sun D
Cell transplantation 2019 Jan;28(1):65-78
Cell transplantation 2019 Jan;28(1):65-78
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Wang Y, Bai C, Ruan Y, Liu M, Chu Q, Qiu L, Yang C, Li B
Nature communications 2019 Jan 14;10(1):201
Nature communications 2019 Jan 14;10(1):201
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Chai XX, Le YF, Wang JC, Mei CX, Feng JF, Zhao H, Wang C, Lu DZ
Journal of food science 2019 Dec;84(12):3825-3832
Journal of food science 2019 Dec;84(12):3825-3832
HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury.
Zhang Y, Liu D, Hu H, Zhang P, Xie R, Cui W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109464
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109464
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.
Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z
Molecular cell 2019 Dec 19;76(6):885-895.e7
Molecular cell 2019 Dec 19;76(6):885-895.e7
Nicotine-induced hypoxia in rat urothelium deteriorates bladder storage functions.
Nagai T, Imamura T, Ogawa T, Minagawa T, Domen T, Suzuki T, Ueno M, Ishizuka O
Neurourology and urodynamics 2019 Aug;38(6):1560-1570
Neurourology and urodynamics 2019 Aug;38(6):1560-1570
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L
Toxicology letters 2019 Aug;310:31-38
Toxicology letters 2019 Aug;310:31-38
Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.
Yang H, Li Q, Wang C, Wang J, Lv J, Wang L, Zhang ZS, Yao Z, Wang Q
Frontiers in immunology 2018;9:1987
Frontiers in immunology 2018;9:1987
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165
Frontiers in pharmacology 2018;9:165
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α.
Zhang F, Lu S, He J, Jin H, Wang F, Wu L, Shao J, Chen A, Zheng S
Theranostics 2018;8(3):610-626
Theranostics 2018;8(3):610-626
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov LN, Zhang X, Ma H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway.
Zhu G, Zhou L, Liu H, Shan Y, Zhang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(4):1735-1746
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(4):1735-1746
FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization.
Tang D, Zhang J, Yan T, Wei J, Jiang X, Zhang D, Zhang Q, Jia J, Huang Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2460-2470
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2460-2470
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α.
Xu L, Sun WJ, Jia AJ, Qiu LL, Xiao B, Mu L, Li JM, Zhang XF, Wei Y, Peng C, Zhang DS, Xiang XD
Journal of inflammation (London, England) 2018;15:15
Journal of inflammation (London, England) 2018;15:15
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.
Li Q, Li Y, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X, Cai S
International journal of biological sciences 2018;14(7):726-735
International journal of biological sciences 2018;14(7):726-735
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Jiang T, Zhou ML, Fan J
OncoTargets and therapy 2018;11:7865-7872
OncoTargets and therapy 2018;11:7865-7872
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, Wang Z
Cancer medicine 2018 Sep;7(9):4610-4618
Cancer medicine 2018 Sep;7(9):4610-4618
Recombinant human maspin inhibits high glucose-induced oxidative stress and angiogenesis of human retinal microvascular endothelial cells via PI3K/AKT pathway.
Qiu F, Tong H, Wang Y, Tao J, Wang H, Chen L
Molecular and cellular biochemistry 2018 Sep;446(1-2):127-136
Molecular and cellular biochemistry 2018 Sep;446(1-2):127-136
SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.
Kanda M, Tanaka H, Shimizu D, Miwa T, Umeda S, Tanaka C, Kobayashi D, Hattori N, Suenaga M, Hayashi M, Iwata N, Yamada S, Fujiwara M, Kodera Y
Oncogene 2018 Sep;37(39):5355-5366
Oncogene 2018 Sep;37(39):5355-5366
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment.
Pan F, Li W, Yang W, Yang XY, Liu S, Li X, Zhao X, Ding H, Qin L, Pan Y
Oncology letters 2018 Sep;16(3):3083-3091
Oncology letters 2018 Sep;16(3):3083-3091
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, Qi R, Gao X, Zhao R
Toxicology and applied pharmacology 2018 Sep 15;355:189-197
Toxicology and applied pharmacology 2018 Sep 15;355:189-197
Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation.
Xu Y, Jin X, Huang Y, Wang J, Wang X, Wang H
Oncology letters 2018 Oct;16(4):5041-5049
Oncology letters 2018 Oct;16(4):5041-5049
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
Xu Y, Wang X, Huang Y, Ma Y, Jin X, Wang H, Wang J
International journal of molecular medicine 2018 Nov;42(5):2737-2749
International journal of molecular medicine 2018 Nov;42(5):2737-2749
CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma.
Liu Q, Fan D, Adah D, Wu Z, Liu R, Yan QT, Zhang Y, Du ZY, Wang D, Li Y, Bao SY, Liu LP
Oncology reports 2018 Nov;40(5):2547-2557
Oncology reports 2018 Nov;40(5):2547-2557
Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy.
Guo X, Qu J, Zhu C, Li W, Luo L, Yang J, Yin X, Li Q, Du Y, Chen D, Qiu Y, Lou Y, You J
Drug delivery 2018 Nov;25(1):585-599
Drug delivery 2018 Nov;25(1):585-599
Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders.
Imamura T, Shimamura M, Ogawa T, Minagawa T, Nagai T, Silwal Gautam S, Ishizuka O
Tissue engineering. Part A 2018 Nov;24(21-22):1574-1587
Tissue engineering. Part A 2018 Nov;24(21-22):1574-1587
Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance.
Yang J, Li W, Luo L, Jiang M, Zhu C, Qin B, Yin H, Yuan X, Yin X, Zhang J, Luo Z, Du Y, You J
Biomaterials 2018 Nov;182:145-156
Biomaterials 2018 Nov;182:145-156
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Zhang X, Liu Z, Xiao Q, Zeng C, Lai CH, Fan X, Ye Q, Wang Y, Xiong Y
Artificial organs 2018 Mar;42(3):280-289
Artificial organs 2018 Mar;42(3):280-289
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis.
Song X, Yang C, Zhang H, Wang J, Sun X, Hu L, Liu Z, Wang D
The Annals of otology, rhinology, and laryngology 2018 Jun;127(6):357-366
The Annals of otology, rhinology, and laryngology 2018 Jun;127(6):357-366
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
Li Q, Li Y, Liang L, Li J, Luo D, Liu Q, Cai S, Li X
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
V-ATPase-dependent repression of androgen receptor in prostate cancer cells.
Licon-Munoz Y, Fordyce CA, Hayek SR, Parra KJ
Oncotarget 2018 Jun 22;9(48):28921-28934
Oncotarget 2018 Jun 22;9(48):28921-28934
Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum.
Chai W, Chen L, Lian XY, Zhang Z
Planta medica 2018 Jul;84(11):786-794
Planta medica 2018 Jul;84(11):786-794
Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models.
Li Y, Wang M, Zhi P, You J, Gao JQ
Oncotarget 2018 Jan 5;9(2):2158-2174
Oncotarget 2018 Jan 5;9(2):2158-2174
Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling.
Zhang C, Bian M, Chen X, Jin H, Zhao S, Yang X, Shao J, Chen A, Guo Q, Zhang F, Zheng S
Journal of cellular biochemistry 2018 Feb;119(2):2258-2268
Journal of cellular biochemistry 2018 Feb;119(2):2258-2268
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, Shi S, Liang C, Liu J, Meng Q, Liang D, Ni Q, Xu J, Zhang B, Yu X
Cell death & disease 2018 Feb 23;9(3):321
Cell death & disease 2018 Feb 23;9(3):321
Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.
Cheng Z, Liu L, Wang Z, Cai Y, Xu Q, Chen P
International journal of molecular sciences 2018 Feb 15;19(2)
International journal of molecular sciences 2018 Feb 15;19(2)
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Wu H, He L, Shi J, Hou X, Zhang H, Zhang X, An Q, Fan F
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, Kong R, Gu J, Xu Z, Chen Z, Sun J
Cancer medicine 2018 Aug;7(8):3834-3847
Cancer medicine 2018 Aug;7(8):3834-3847
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis.
Ma S, Lu CC, Yang LY, Wang JJ, Wang BS, Cai HQ, Hao JJ, Xu X, Cai Y, Zhang Y, Wang MR
Journal of experimental & clinical cancer research : CR 2018 Aug 6;37(1):183
Journal of experimental & clinical cancer research : CR 2018 Aug 6;37(1):183
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
Geng W, Qin F, Ren J, Xiao S, Wang A
Experimental cell research 2018 Aug 15;369(2):243-250
Experimental cell research 2018 Aug 15;369(2):243-250
R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.
Liu S, Yin Y, Yu R, Li Y, Zhang W
Biochemical and biophysical research communications 2018 Apr 30;499(1):59-65
Biochemical and biophysical research communications 2018 Apr 30;499(1):59-65
Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy.
Xie Z, Guo W, Guo N, Huangfu M, Liu H, Lin M, Xu W, Chen J, Wang T, Wei Q, Han M, Gao J
Acta biomaterialia 2018 Apr 15;71:351-362
Acta biomaterialia 2018 Apr 15;71:351-362
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Li W, Wang R, Ma JY, Wang M, Cui J, Wu WB, Liu RM, Zhang CX, Li W, Wang SM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X
International journal of biological sciences 2017;13(3):327-338
International journal of biological sciences 2017;13(3):327-338
Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells.
Guo X, Xu S, Gao X, Wang J, Xue H, Chen Z, Zhang J, Guo X, Qian M, Qiu W, Li G
Oncotarget 2017 Oct 6;8(46):80358-80372
Oncotarget 2017 Oct 6;8(46):80358-80372
Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma.
Ni W, Yang Z, Qi W, Cui C, Cui Y, Xuan Y
Human pathology 2017 Nov;69:38-45
Human pathology 2017 Nov;69:38-45
Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.
Wang X, Liow SS, Wu Q, Li C, Owh C, Li Z, Loh XJ, Wu YL
Macromolecular bioscience 2017 Nov;17(11)
Macromolecular bioscience 2017 Nov;17(11)
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R
Experimental cell research 2017 Nov 15;360(2):243-256
Experimental cell research 2017 Nov 15;360(2):243-256
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
BNIP3 promotes the motility and migration of keratinocyte under hypoxia.
Zhang J, Zhang D, Yan T, Jiang X, Zhang C, Zhao L, Li L, Tang D, Zhang Q, Jia J, Zhang J, Huang Y
Experimental dermatology 2017 May;26(5):416-422
Experimental dermatology 2017 May;26(5):416-422
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Zhang F, Hao M, Jin H, Yao Z, Lian N, Wu L, Shao J, Chen A, Zheng S
British journal of pharmacology 2017 Mar;174(5):409-423
British journal of pharmacology 2017 Mar;174(5):409-423
Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration.
Tang D, Yan T, Zhang J, Jiang X, Zhang D, Huang Y
Scientific reports 2017 Mar 7;7:43926
Scientific reports 2017 Mar 7;7:43926
Discordant mRNA and protein expression of CXCR4 under in vitro CoCl2-induced hypoxic conditions.
Tang M, Yang Y, Yu J, Wu N, Chen P, Xu L, Wang Q, Xu Z, Ge J, Yu K, Zhuang J
Biochemical and biophysical research communications 2017 Mar 4;484(2):285-291
Biochemical and biophysical research communications 2017 Mar 4;484(2):285-291
Regulation of angiogenic behaviors by oxytocin receptor through Gli1-indcued transcription of HIF-1α in human umbilical vein endothelial cells.
Zhu J, Wang H, Zhang X, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jun;90:928-934
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jun;90:928-934
Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis.
Pan F, Yang W, Li W, Yang XY, Liu S, Li X, Zhao X, Ding H, Qin L, Pan Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317708547
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317708547
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.
Yong Y, Zhang C, Gu Z, Du J, Guo Z, Dong X, Xie J, Zhang G, Liu X, Zhao Y
ACS nano 2017 Jul 25;11(7):7164-7176
ACS nano 2017 Jul 25;11(7):7164-7176
Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α.
Geng J, Wang L, Qu M, Song Y, Lin X, Chen Y, Mamtilahun M, Chen S, Zhang Z, Wang Y, Yang GY
Stem cell research & therapy 2017 Jul 11;8(1):163
Stem cell research & therapy 2017 Jul 11;8(1):163
Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138.
Cai Q, Wang Z, Wang S, Weng M, Zhou D, Li C, Wang J, Chen E, Quan Z
Open biology 2017 Jan;7(1)
Open biology 2017 Jan;7(1)
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Zhao CB, Shi L, Pu HH, Zhang QY
Pathology oncology research : POR 2017 Jan;23(1):47-53
Pathology oncology research : POR 2017 Jan;23(1):47-53
Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice.
Guo J, Luo X, Liang J, Xiao M, Sun X
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2017 Jan Feb;33(1):50-56
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2017 Jan Feb;33(1):50-56
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S
Toxicological sciences : an official journal of the Society of Toxicology 2017 Feb;155(2):432-443
Toxicological sciences : an official journal of the Society of Toxicology 2017 Feb;155(2):432-443
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.
Su CH, Hung KY, Hung SC, Tarn WY
Molecular and cellular biology 2017 Feb 1;37(3)
Molecular and cellular biology 2017 Feb 1;37(3)
Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.
Faget J, Groeneveld S, Boivin G, Sankar M, Zangger N, Garcia M, Guex N, Zlobec I, Steiner L, Piersigilli A, Xenarios I, Meylan E
Cell reports 2017 Dec 12;21(11):3190-3204
Cell reports 2017 Dec 12;21(11):3190-3204
Preparation of artificial red cell and its application on alleviation of tumor hypoxia.
Qu J, Guo X, Li W, Hou W, Zhang H, Luo L, Zhu C, Yang J, Yin X, Tao Y, Du Y, Lou Y, Chen D, You J
Colloids and surfaces. B, Biointerfaces 2017 Dec 1;160:446-454
Colloids and surfaces. B, Biointerfaces 2017 Dec 1;160:446-454
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression.
Guo YC, Zhang M, Wang FX, Pei GC, Sun F, Zhang Y, He X, Wang Y, Song J, Zhu FM, Pandupuspitasari NS, Liu J, Huang K, Yang P, Xiong F, Zhang S, Yu Q, Yao Y, Wang CY
The American journal of pathology 2017 Aug;187(8):1736-1749
The American journal of pathology 2017 Aug;187(8):1736-1749
Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion.
Tong Y, Yang H, Xu X, Ruan J, Liang M, Wu J, Luo B
Cancer science 2017 Apr;108(4):753-762
Cancer science 2017 Apr;108(4):753-762
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
Zhang Z, Li HM, Zhou C, Li Q, Ma L, Zhang Z, Sun Y, Wang L, Zhang X, Zhu B, Hong YS, Wu CZ, Liu H
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function.
Liang X, Yin G, Ma Y, Xu K, Liu J, Li J
The Journal of pharmacy and pharmacology 2016 Nov;68(11):1409-1416
The Journal of pharmacy and pharmacology 2016 Nov;68(11):1409-1416
Hydrogen Sulfide and Carbon Monoxide Protect Gastric Mucosa Compromised by Mild Stress Against Alendronate Injury.
Magierowski M, Magierowska K, Szmyd J, Surmiak M, Sliwowski Z, Kwiecien S, Brzozowski T
Digestive diseases and sciences 2016 Nov;61(11):3176-3189
Digestive diseases and sciences 2016 Nov;61(11):3176-3189
Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression.
Xu Y, Jin X, Huang Y, Dong J, Wang H, Wang X, Cao X
Oncology reports 2016 May;35(5):2624-34
Oncology reports 2016 May;35(5):2624-34
Association between the expression of HIF-1α and VEGF and prognostic implications in primary liver cancer.
Guo LY, Zhu P, Jin XP
Genetics and molecular research : GMR 2016 May 9;15(2)
Genetics and molecular research : GMR 2016 May 9;15(2)
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
Yang L, Xiao M, Li X, Tang Y, Wang YL
International journal of molecular medicine 2016 Mar;37(3):734-42
International journal of molecular medicine 2016 Mar;37(3):734-42
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
Li X, Chen Y, Wang L, Shang G, Zhang C, Zhao Z, Zhang H, Liu A
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016 Jul 4;49(7)
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016 Jul 4;49(7)
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
Li W, Zhao X, Du B, Li X, Liu S, Yang XY, Ding H, Yang W, Pan F, Wu X, Qin L, Pan Y
Scientific reports 2016 Jul 29;6:30619
Scientific reports 2016 Jul 29;6:30619
Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, Pajdo R, Kwiecien S, Brzozowski T
Pharmacological research 2016 Dec;114:235-250
Pharmacological research 2016 Dec;114:235-250
Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model.
Gao F, Wang Y, Li S, Wang Z, Liu C, Sun D
Life sciences 2016 Dec 15;167:78-84
Life sciences 2016 Dec 15;167:78-84
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer.
Ge X, Liu X, Lin F, Li P, Liu K, Geng R, Dai C, Lin Y, Tang W, Wu Z, Chang J, Lu J, Li J
Oncotarget 2016 Apr 26;7(17):24466-82
Oncotarget 2016 Apr 26;7(17):24466-82
The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.
Zhang Y, Liu J, Wang S, Luo X, Li Y, Lv Z, Zhu J, Lin J, Ding L, Ye Q
Oncotarget 2016 Apr 26;7(17):23740-56
Oncotarget 2016 Apr 26;7(17):23740-56
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Peng B, Liu F, Han R, Luo G, Cathopoulis T, Lu K, Li X, Yang L, Liu GY, Cai JC, Shi SL
The international journal of biochemistry & cell biology 2015 Sep;66:45-58
The international journal of biochemistry & cell biology 2015 Sep;66:45-58
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213
Oncotarget 2015 Sep 29;6(29):27199-213
MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer.
Chen D, Dang BL, Huang JZ, Chen M, Wu D, Xu ML, Li R, Yan GR
Oncotarget 2015 Oct 20;6(32):32701-12
Oncotarget 2015 Oct 20;6(32):32701-12
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Qu K, Yan Z, Wu Y, Chen Y, Qu P, Xu X, Yuan P, Huang X, Xing J, Zhang H, Liu C, Zhang J
Journal of gastroenterology and hepatology 2015 May;30(5):925-32
Journal of gastroenterology and hepatology 2015 May;30(5):925-32
Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma.
Hunt SJ, Gade T, Soulen MC, Pickup S, Sehgal CM
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2015 Feb;34(2):275-87
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2015 Feb;34(2):275-87
DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.
Hu T, He N, Yang Y, Yin C, Sang N, Yang Q
Journal of experimental & clinical cancer research : CR 2015 Feb 28;34(1):22
Journal of experimental & clinical cancer research : CR 2015 Feb 28;34(1):22
Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells.
Liu F, Wang B, Li L, Dong F, Chen X, Li Y, Dong X, Wada Y, Kapron CM, Liu J
International journal of environmental research and public health 2015 Aug 28;12(9):10508-21
International journal of environmental research and public health 2015 Aug 28;12(9):10508-21
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y, Bai X
Oncogene 2014 Sep 11;33(37):4548-57
Oncogene 2014 Sep 11;33(37):4548-57
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L, Zhang X, Ye L
Carcinogenesis 2014 May;35(5):1144-53
Carcinogenesis 2014 May;35(5):1144-53
Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.
Xu Y, Zhou M, Wang J, Zhao Y, Li S, Zhou B, Su Z, Xu C, Xia Y, Qian H, Tu X, Xiao W, Chen X, Chen Q, Wang QK
Biochimica et biophysica acta 2014 May;1842(5):712-25
Biochimica et biophysica acta 2014 May;1842(5):712-25
Interferon-γ-induced intestinal epithelial barrier dysfunction by NF-κB/HIF-1α pathway.
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Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Mar;34(3):195-203
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Mar;34(3):195-203
Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
Wang L, Jiang M, Duan D, Zhao Z, Ge L, Teng X, Liu B, Liu B, Chen P, Lu M
Transplantation 2014 Jun 27;97(12):1225-32
Transplantation 2014 Jun 27;97(12):1225-32
Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: angiogenic markers of neoadjuvant chemoradiation.
Kim HJ, Bae SB, Jeong D, Kim ES, Kim CN, Park DG, Ahn TS, Cho SW, Shin EJ, Lee MS, Baek MJ
Oncology reports 2014 Dec;32(6):2493-500
Oncology reports 2014 Dec;32(6):2493-500
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, Li Y, Chen L, Deng X
Toxicology letters 2013 Oct 24;222(2):91-101
Toxicology letters 2013 Oct 24;222(2):91-101
Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer.
Shan X, Wang D, Chen J, Xiao X, Jiang Y, Wang Y, Fan Y
Journal of computer assisted tomography 2013 Jan-Feb;37(1):22-8
Journal of computer assisted tomography 2013 Jan-Feb;37(1):22-8
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.
Lin J, Qin X, Zhu Z, Mu J, Zhu L, Wu K, Jiao H, Xu X, Ye Q
IUBMB life 2012 Nov;64(11):921-30
IUBMB life 2012 Nov;64(11):921-30
Valsartan inhibited HIF-1α pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats.
Tang L, Yi R, Yang B, Li H, Chen H, Liu Z
Diabetes research and clinical practice 2012 Jul;97(1):125-31
Diabetes research and clinical practice 2012 Jul;97(1):125-31
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Whole cell lysate from HeLa cells that were either treated with cobalt chloride (+; 150 uM) or mock treated (-) and were subjected to SDS PAGE followed by western blot with 20960-1-AP( HIF1a Antibody) at dilution of 1:300.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using HIF1A antibody 20960-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human thyroid cancer using 20960-1-AP(HIF1A antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human thyroid cancer using 20960-1-AP(HIF1A antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
