NB100-123
antibody from Novus Biologicals
Targeting: HIF1A
bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
Antibody data
- Antibody Data
- Antigen structure
- References [142]
- Comments [0]
- Validations
- Western blot [4]
- Immunoprecipitation [1]
- Immunohistochemistry [5]
Submit
Validation data
Reference
Comment
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- Product number
- NB100-123 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-123, RRID:AB_10001569
- Product name
- Mouse Monoclonal HIF-1 alpha Antibody
- Antibody type
- Monoclonal
- Description
- Protein A purified.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Chicken/Avian, Porcine, Rabbit, Sheep, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Sodium-glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice.
Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.
Serial Texture Analyses on ADC Maps for Evaluation of Antiangiogenic Therapy in Rat Breast Cancer.
Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage.
Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series.
Effects of 17β-estradiol and 2-methoxyestradiol on the oxidative stress-hypoxia inducible factor-1 pathway in hypoxic pulmonary hypertensive rats.
Astrocytic expression of the CXCL12 receptor, CXCR7/ACKR3 is a hallmark of the diseased, but not developing CNS.
Increased risk of brain cancer incidence in stroke patients: a clinical case series, population-based and longitudinal follow-up study.
Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.
Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Correlation of volumetric perfusion CT parameters with hypoxia inducible factor-1 alpha expression in a rabbit VX2 tumor model.
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
The HIF/PHF8/AR axis promotes prostate cancer progression.
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: molecular analysis of aggressive invasion and metastasis.
Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype.
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction.
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.
The importance of physiological oxygen concentrations in the sandwich cultures of rat hepatocytes on gas-permeable membranes.
Ischemia induces different levels of hypoxia inducible factor-1α protein expression in interneurons and pyramidal neurons.
Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.
The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.
B cells promote tumor progression via STAT3 regulated-angiogenesis.
The mechanisms of chansu in inducing efficient apoptosis in colon cancer cells.
Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas.
Biological correlation of ¹⁸F-FDG uptake on PET in pulmonary neuroendocrine tumors.
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia.
The role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.
Upregulation of VEGF expression is associated with accumulation of HIF-1α in the skin of naïve scleroderma patients.
MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma.
Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties.
Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy.
Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.
Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors.
18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1α, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours.
Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure.
Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways.
The role of hypoxic-inducible factor (HIF1α) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients.
18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study.
Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma.
Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling.
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma.
Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer.
Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease.
Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy.
Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.
Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.
Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma.
Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.
Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.
Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas.
Molecular and functional aspects of menstruation in the macaque.
Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids.
Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation.
MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer.
The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy.
Unfavourable consequences of chronic cardiac HIF-1α stabilization.
LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer.
Immunoexpression status and prognostic value of mTOR and hypoxia-induced pathway members in primary and metastatic clear cell renal cell carcinomas.
Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors.
Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.
Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis.
Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors.
Hypoxia-inducible factor and mammalian target of rapamycin pathway markers in urothelial carcinoma of the bladder: possible therapeutic implications.
Hypoxia inducible factor-1α directly induces the expression of receptor activator of nuclear factor-κB ligand in periodontal ligament fibroblasts.
Hypoxia-inducible factor 1α regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues.
Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma.
Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}.
Biologic correlates of ¹⁸F-FDG uptake on PET in pulmonary pleomorphic carcinoma.
L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma.
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.
Methionine sulfoxide reductase A: Structure, function and role in ocular pathology.
Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation.
A robust automated measure of average antibody staining in immunohistochemistry images.
Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors.
Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane.
Low vasa vasorum densities correlate with inflammation and subintimal thickening: potential role in location--determination of atherogenesis.
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway.
ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells.
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression.
Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma.
Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme.
Comparison of hypoxia-inducible factor-1alpha expression before and after transcatheter arterial embolization in rabbit VX2 liver tumors.
Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.
Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney.
Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.
Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.
Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: relationship with pathological factors and prognostic impact on survival.
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter.
Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma.
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
The proliferative response of hela cells to 2-deoxy-D-glucose under hypoxic or anoxic conditions: an analogue for studying some properties of in vivo solid cancers.
Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors.
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.
Tissue expression and plasma levels of adrenomedullin in renal cancer patients.
Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer.
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia.
Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress.
Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma.
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Determination of the role of hypoxia-inducible factor 1 in wound healing.
Methods to detect hypoxia-induced ischemic tolerance in the brain.
Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head.
Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers.
Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules.
Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor.
Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy.
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.
Effect of hypoxia on human seminoma cells.
Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells.
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells.
HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha.
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Cai T, Ke Q, Fang Y, Wen P, Chen H, Yuan Q, Luo J, Zhang Y, Sun Q, Lv Y, Zen K, Jiang L, Zhou Y, Yang J
Cell death & disease 2020 May 22;11(5):390
Cell death & disease 2020 May 22;11(5):390
Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.
Kalainayakan SP, Ghosh P, Dey S, Fitzgerald KE, Sohoni S, Konduri PC, Garrossian M, Liu L, Zhang L
Scientific reports 2019 Feb 5;9(1):1405
Scientific reports 2019 Feb 5;9(1):1405
Serial Texture Analyses on ADC Maps for Evaluation of Antiangiogenic Therapy in Rat Breast Cancer.
Lee SM, Lee KW, Kim MA, Song YS, Goo JM, Park CM
Anticancer research 2019 Apr;39(4):1875-1882
Anticancer research 2019 Apr;39(4):1875-1882
Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage.
Timpano S, Guild BD, Specker EJ, Melanson G, Medeiros PJ, Sproul SLJ, Uniacke J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5716-5728
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5716-5728
Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series.
Megele R, Riemenschneider MJ, Dodoo-Schittko F, Feyrer M, Kleindienst A
Oncology letters 2018 Nov;16(5):5813-5822
Oncology letters 2018 Nov;16(5):5813-5822
Effects of 17β-estradiol and 2-methoxyestradiol on the oxidative stress-hypoxia inducible factor-1 pathway in hypoxic pulmonary hypertensive rats.
Wang L, Zheng Q, Yuan Y, Li Y, Gong X
Experimental and therapeutic medicine 2017 May;13(5):2537-2543
Experimental and therapeutic medicine 2017 May;13(5):2537-2543
Astrocytic expression of the CXCL12 receptor, CXCR7/ACKR3 is a hallmark of the diseased, but not developing CNS.
Puchert M, Pelkner F, Stein G, Angelov DN, Boltze J, Wagner DC, Odoardi F, Flügel A, Streit WJ, Engele J
Molecular and cellular neurosciences 2017 Dec;85:105-118
Molecular and cellular neurosciences 2017 Dec;85:105-118
Increased risk of brain cancer incidence in stroke patients: a clinical case series, population-based and longitudinal follow-up study.
Chen CW, Cheng TJ, Ho CH, Wang JJ, Weng SF, Hou YC, Cheng HC, Chio CC, Shan YS, Chang WT
Oncotarget 2017 Dec 12;8(65):108989-108999
Oncotarget 2017 Dec 12;8(65):108989-108999
Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.
Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
PloS one 2016;11(2):e0148666
PloS one 2016;11(2):e0148666
Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Timpano S, Uniacke J
The Journal of biological chemistry 2016 May 13;291(20):10772-82
The Journal of biological chemistry 2016 May 13;291(20):10772-82
Correlation of volumetric perfusion CT parameters with hypoxia inducible factor-1 alpha expression in a rabbit VX2 tumor model.
Kim JI, Lee HJ, Goo JM, Kim MA, Chung DH
Acta radiologica (Stockholm, Sweden : 1987) 2016 Jun;57(6):708-15
Acta radiologica (Stockholm, Sweden : 1987) 2016 Jun;57(6):708-15
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Jablonska B, Gierdalski M, Chew LJ, Hawley T, Catron M, Lichauco A, Cabrera-Luque J, Yuen T, Rowitch D, Gallo V
Nature communications 2016 Dec 19;7:13866
Nature communications 2016 Dec 19;7:13866
The HIF/PHF8/AR axis promotes prostate cancer progression.
Tong D, Liu Q, Liu G, Yuan W, Wang L, Guo Y, Lan W, Zhang D, Dong S, Wang Y, Xiao H, Mu J, Mao C, Wong J, Jiang J
Oncogenesis 2016 Dec 19;5(12):e283
Oncogenesis 2016 Dec 19;5(12):e283
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: molecular analysis of aggressive invasion and metastasis.
Ohmoto T, Yoshitani N, Nishitsuji K, Takayama T, Yanagisawa Y, Takeya M, Sakashita N
Pathology international 2015 May;65(5):264-70
Pathology international 2015 May;65(5):264-70
Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype.
Hénique C, Mansouri A, Vavrova E, Lenoir V, Ferry A, Esnous C, Ramond E, Girard J, Bouillaud F, Prip-Buus C, Cohen I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jun;29(6):2473-83
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jun;29(6):2473-83
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
Obama T, Takayanagi T, Kobayashi T, Bourne AM, Elliott KJ, Charbonneau M, Dubois CM, Eguchi S
American journal of hypertension 2015 Jan;28(1):10-4
American journal of hypertension 2015 Jan;28(1):10-4
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM
The Journal of clinical endocrinology and metabolism 2015 Jan;100(1):E30-40
The Journal of clinical endocrinology and metabolism 2015 Jan;100(1):E30-40
Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction.
Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA
American journal of physiology. Lung cellular and molecular physiology 2015 Jan 15;308(2):L158-67
American journal of physiology. Lung cellular and molecular physiology 2015 Jan 15;308(2):L158-67
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
Motzer RJ, Hutson TE, Hudes GR, Figlin RA, Martini JF, English PA, Huang X, Valota O, Williams JA
Cancer chemotherapy and pharmacology 2014 Oct;74(4):739-50
Cancer chemotherapy and pharmacology 2014 Oct;74(4):739-50
HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, Rissanen TT, André H, Pereira T, Poellinger L, Alitalo K, Ylä-Herttuala S
European journal of clinical investigation 2014 Oct;44(10):989-99
European journal of clinical investigation 2014 Oct;44(10):989-99
The importance of physiological oxygen concentrations in the sandwich cultures of rat hepatocytes on gas-permeable membranes.
Xiao W, Shinohara M, Komori K, Sakai Y, Matsui H, Osada T
Biotechnology progress 2014 Nov-Dec;30(6):1401-10
Biotechnology progress 2014 Nov-Dec;30(6):1401-10
Ischemia induces different levels of hypoxia inducible factor-1α protein expression in interneurons and pyramidal neurons.
Ramamoorthy P, Shi H
Acta neuropathologica communications 2014 May 5;2:51
Acta neuropathologica communications 2014 May 5;2:51
Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.
Sun W, Depping R, Jelkmann W
Cell death & disease 2014 Jan 23;5(1):e1020
Cell death & disease 2014 Jan 23;5(1):e1020
The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.
Sceneay J, Liu MC, Chen A, Wong CS, Bowtell DD, Möller A
PloS one 2013;8(6):e66388
PloS one 2013;8(6):e66388
B cells promote tumor progression via STAT3 regulated-angiogenesis.
Yang C, Lee H, Pal S, Jove V, Deng J, Zhang W, Hoon DS, Wakabayashi M, Forman S, Yu H
PloS one 2013;8(5):e64159
PloS one 2013;8(5):e64159
The mechanisms of chansu in inducing efficient apoptosis in colon cancer cells.
Li C, Hashimi SM, Cao S, Mellick AS, Duan W, Good D, Wei MQ
Evidence-based complementary and alternative medicine : eCAM 2013;2013:849054
Evidence-based complementary and alternative medicine : eCAM 2013;2013:849054
Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas.
Chaux A, Albadine R, Schultz L, Hicks J, Carducci MA, Argani P, Allaf M, Netto GJ
Human pathology 2013 Oct;44(10):2323-30
Human pathology 2013 Oct;44(10):2323-30
Biological correlation of ¹⁸F-FDG uptake on PET in pulmonary neuroendocrine tumors.
Kaira K, Murakami H, Endo M, Ohde Y, Naito T, Kondo H, Nakajima T, Yamamoto N, Takahashi T
Anticancer research 2013 Oct;33(10):4219-28
Anticancer research 2013 Oct;33(10):4219-28
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia.
Tanaka T, Yamaguchi J, Higashijima Y, Nangaku M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Oct;27(10):4059-75
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Oct;27(10):4059-75
The role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.
Jeong CW, Yoon CY, Jeong SJ, Hong SK, Byun SS, Kwak C, Lee SE
Urologic oncology 2013 Nov;31(8):1448-56
Urologic oncology 2013 Nov;31(8):1448-56
Upregulation of VEGF expression is associated with accumulation of HIF-1α in the skin of naïve scleroderma patients.
Ioannou M, Pyrpasopoulou A, Simos G, Paraskeva E, Nikolaidou C, Venizelos I, Koukoulis G, Aslanidis S, Douma S
Modern rheumatology 2013 Nov;23(6):1245-8
Modern rheumatology 2013 Nov;23(6):1245-8
MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma.
Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, Teishima J, Matsubara A, Oue N, Kitadai Y, Yasui W
International journal of urology : official journal of the Japanese Urological Association 2013 May;20(5):468-77
International journal of urology : official journal of the Japanese Urological Association 2013 May;20(5):468-77
Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties.
Reddy VD, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu N
Molecular and cellular biochemistry 2013 Mar;375(1-2):39-47
Molecular and cellular biochemistry 2013 Mar;375(1-2):39-47
Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy.
Gu HF, Zheng X, Abu Seman N, Gu T, Botusan IR, Sunkari VG, Lokman EF, Brismar K, Catrina SB
Diabetes care 2013 Feb;36(2):415-21
Diabetes care 2013 Feb;36(2):415-21
Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.
Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC
Annals of the American Thoracic Society 2013 Feb;10(1):1-9
Annals of the American Thoracic Society 2013 Feb;10(1):1-9
Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors.
Aziz SA, Sznol JA, Adeniran A, Parisi F, Kluger Y, Camp RL, Kluger HM
BMC clinical pathology 2013 Feb 1;13:3
BMC clinical pathology 2013 Feb 1;13:3
18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1α, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours.
Toba H, Kondo K, Sadohara Y, Otsuka H, Morimoto M, Kajiura K, Nakagawa Y, Yoshida M, Kawakami Y, Takizawa H, Kenzaki K, Sakiyama S, Bando Y, Tangoku A
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2013 Aug;44(2):e105-12
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2013 Aug;44(2):e105-12
Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure.
Li J, Levick SP, DiPette DJ, Janicki JS, Supowit SC
Regulatory peptides 2013 Aug 10;185:20-8
Regulatory peptides 2013 Aug 10;185:20-8
Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.
Kar AN, MacGibeny MA, Gervasi NM, Gioio AE, Kaplan BB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 24;33(17):7165-74
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 24;33(17):7165-74
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways.
Clarke DN, Al Ahmad A, Lee B, Parham C, Auckland L, Fertala A, Kahle M, Shaw CS, Roberts J, Bix GJ
PloS one 2012;7(9):e45257
PloS one 2012;7(9):e45257
The role of hypoxic-inducible factor (HIF1α) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients.
Mhawech-Fauceglia P, Wang D, Samrao D, Menesses T, Godoy H, Ough F, Lele S, Liu S, Pejovic T
BMJ open 2012;2(4)
BMJ open 2012;2(4)
18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study.
Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Hayashi I, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N
European journal of radiology 2012 Sep;81(9):2423-9
European journal of radiology 2012 Sep;81(9):2423-9
Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma.
Kaira K, Ohde Y, Nakagawa K, Okumura T, Murakami H, Takahashi T, Kondo H, Nakajima T, Endo M, Yamamoto N
Medical oncology (Northwood, London, England) 2012 Sep;29(3):1663-72
Medical oncology (Northwood, London, England) 2012 Sep;29(3):1663-72
Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling.
Chu W, Wan L, Zhao D, Qu X, Cai F, Huo R, Wang N, Zhu J, Zhang C, Zheng F, Cai R, Dong D, Lu Y, Yang B
Journal of cellular and molecular medicine 2012 Sep;16(9):2022-34
Journal of cellular and molecular medicine 2012 Sep;16(9):2022-34
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.
Zhao Y, Xiong X, Jia L, Sun Y
Cell death & disease 2012 Sep 6;3:e386
Cell death & disease 2012 Sep 6;3:e386
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2012 Sep 1;11(17):3280-9
Cell cycle (Georgetown, Tex.) 2012 Sep 1;11(17):3280-9
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma.
Mayer A, Schneider F, Vaupel P, Sommer C, Schmidberger H
International journal of oncology 2012 Oct;41(4):1260-70
International journal of oncology 2012 Oct;41(4):1260-70
Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer.
Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A
Oral oncology 2012 Nov;48(11):1120-7
Oral oncology 2012 Nov;48(11):1120-7
Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease.
Ding A, Kalaignanasundaram P, Ricardo SD, Abdelkader A, Witting PK, Broughton BR, Kim HB, Wyse BF, Phillips JK, Evans RG
Clinical and experimental pharmacology & physiology 2012 Nov;39(11):917-29
Clinical and experimental pharmacology & physiology 2012 Nov;39(11):917-29
Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy.
Galzio R, Cristiano L, Fidoamore A, Cifone MG, Benedetti E, Cinque B, Menghini P, Raysi Dehcordi S, Ippoliti R, Giordano A, Cimini A
Journal of cellular biochemistry 2012 Nov;113(11):3342-52
Journal of cellular biochemistry 2012 Nov;113(11):3342-52
Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.
Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M
Circulation 2012 Nov 27;126(22):2589-600
Circulation 2012 Nov 27;126(22):2589-600
Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.
Salem AF, Howell A, Sartini M, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2012 Nov 15;11(22):4167-73
Cell cycle (Georgetown, Tex.) 2012 Nov 15;11(22):4167-73
Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma.
Kaira K, Serizawa M, Koh Y, Takahashi T, Hanaoka H, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N
European journal of cancer (Oxford, England : 1990) 2012 May;48(8):1244-54
European journal of cancer (Oxford, England : 1990) 2012 May;48(8):1244-54
Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.
Peurala E, Koivunen P, Bloigu R, Haapasaari KM, Jukkola-Vuorinen A
Breast cancer research and treatment 2012 May;133(1):179-88
Breast cancer research and treatment 2012 May;133(1):179-88
Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.
Kaira K, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Endo M, Kondo H, Nakajima T, Yamamoto N
International journal of surgical pathology 2012 Jun;20(3):223-32
International journal of surgical pathology 2012 Jun;20(3):223-32
Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas.
Chaux A, Schultz L, Albadine R, Hicks J, Kim JJ, Allaf ME, Carducci MA, Rodriguez R, Hammers HJ, Argani P, Reuter VE, Netto GJ
Human pathology 2012 Dec;43(12):2129-37
Human pathology 2012 Dec;43(12):2129-37
Molecular and functional aspects of menstruation in the macaque.
Brenner RM, Slayden OD
Reviews in endocrine & metabolic disorders 2012 Dec;13(4):309-18
Reviews in endocrine & metabolic disorders 2012 Dec;13(4):309-18
Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids.
Jiang W, Zhu Z, McGinley JN, El Bayoumy K, Manni A, Thompson HJ
Cancer research 2012 Aug 1;72(15):3795-806
Cancer research 2012 Aug 1;72(15):3795-806
Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation.
Schneider C, Krischke G, Rascher W, Gassmann M, Trollmann R
Brain & development 2012 Apr;34(4):261-73
Brain & development 2012 Apr;34(4):261-73
MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer.
Kaira K, Okumura T, Nakagawa K, Ohde Y, Takahashi T, Murakami H, Naito T, Endo M, Kondo H, Nakajima T, Yamamoto N
Pathology oncology research : POR 2012 Apr;18(2):439-47
Pathology oncology research : POR 2012 Apr;18(2):439-47
The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy.
Weber DC, Tille JC, Combescure C, Egger JF, Laouiti M, Hammad K, Granger P, Rubbia-Brandt L, Miralbell R
Radiation oncology (London, England) 2012 Apr 30;7:66
Radiation oncology (London, England) 2012 Apr 30;7:66
Unfavourable consequences of chronic cardiac HIF-1α stabilization.
Hölscher M, Schäfer K, Krull S, Farhat K, Hesse A, Silter M, Lin Y, Pichler BJ, Thistlethwaite P, El-Armouche A, Maier LS, Katschinski DM, Zieseniss A
Cardiovascular research 2012 Apr 1;94(1):77-86
Cardiovascular research 2012 Apr 1;94(1):77-86
LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer.
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
American journal of translational research 2011;3(5):468-78
American journal of translational research 2011;3(5):468-78
Immunoexpression status and prognostic value of mTOR and hypoxia-induced pathway members in primary and metastatic clear cell renal cell carcinomas.
Schultz L, Chaux A, Albadine R, Hicks J, Kim JJ, De Marzo AM, Allaf ME, Carducci MA, Rodriguez R, Hammers HJ, Argani P, Reuter VE, Netto GJ
The American journal of surgical pathology 2011 Oct;35(10):1549-56
The American journal of surgical pathology 2011 Oct;35(10):1549-56
Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors.
Kaira K, Ohde Y, Endo M, Nakagawa K, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Kondo H, Nakajima T, Yamamoto N
Oncology reports 2011 Oct;26(4):931-7
Oncology reports 2011 Oct;26(4):931-7
Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.
Tandon R, SenGupta D, Ndhlovu LC, Vieira RG, Jones RB, York VA, Vieira VA, Sharp ER, Wiznia AA, Ostrowski MA, Rosenberg MG, Nixon DF
Journal of virology 2011 Nov;85(21):11526-31
Journal of virology 2011 Nov;85(21):11526-31
Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis.
Monzon FA, Alvarez K, Peterson L, Truong L, Amato RJ, Hernandez-McClain J, Tannir N, Parwani AV, Jonasch E
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Nov;24(11):1470-9
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Nov;24(11):1470-9
Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors.
Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011 May;52(5):705-11
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011 May;52(5):705-11
Hypoxia-inducible factor and mammalian target of rapamycin pathway markers in urothelial carcinoma of the bladder: possible therapeutic implications.
Tickoo SK, Milowsky MI, Dhar N, Dudas ME, Gallagher DJ, Al-Ahmadie H, Gopalan A, Fine SW, Ishill N, Bajorin DF, Reuter VE
BJU international 2011 Mar;107(5):844-849
BJU international 2011 Mar;107(5):844-849
Hypoxia inducible factor-1α directly induces the expression of receptor activator of nuclear factor-κB ligand in periodontal ligament fibroblasts.
Park HJ, Baek KH, Lee HL, Kwon A, Hwang HR, Qadir AS, Woo KM, Ryoo HM, Baek JH
Molecules and cells 2011 Jun;31(6):573-8
Molecules and cells 2011 Jun;31(6):573-8
Hypoxia-inducible factor 1α regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Huang LJ, Chuang IC, Dong HP, Yang RC
Shock (Augusta, Ga.) 2011 Jul;36(1):90-6
Shock (Augusta, Ga.) 2011 Jul;36(1):90-6
Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues.
Evenou F, Hamon M, Fujii T, Takeuchi S, Sakai Y
Biotechnology progress 2011 Jul;27(4):1146-53
Biotechnology progress 2011 Jul;27(4):1146-53
Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma.
Weroha SJ, Oberg AL, Ziegler KL, Dakhilm SR, Rowland KM, Hartmann LC, Moore DF Jr, Keeney GL, Peethambaram PP, Haluska P
Gynecologic oncology 2011 Jul;122(1):116-20
Gynecologic oncology 2011 Jul;122(1):116-20
Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}.
Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM
The Journal of biological chemistry 2011 Jan 14;286(2):961-75
The Journal of biological chemistry 2011 Jan 14;286(2):961-75
Biologic correlates of ¹⁸F-FDG uptake on PET in pulmonary pleomorphic carcinoma.
Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Hayashi I, Kondo H, Nakajima T, Yamamoto N
Lung cancer (Amsterdam, Netherlands) 2011 Feb;71(2):144-50
Lung cancer (Amsterdam, Netherlands) 2011 Feb;71(2):144-50
L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma.
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
Anticancer research 2011 Dec;31(12):4075-82
Anticancer research 2011 Dec;31(12):4075-82
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.
Namas RA, Metukuri MR, Dhupar R, Velosa C, Jefferson BS, Myer E, Constantine GM, Billiar TR, Vodovotz Y, Zamora R
Shock (Augusta, Ga.) 2011 Aug;36(2):196-202
Shock (Augusta, Ga.) 2011 Aug;36(2):196-202
Methionine sulfoxide reductase A: Structure, function and role in ocular pathology.
Sreekumar PG, Hinton DR, Kannan R
World journal of biological chemistry 2011 Aug 26;2(8):184-92
World journal of biological chemistry 2011 Aug 26;2(8):184-92
Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A
The Journal of biological chemistry 2011 Apr 1;286(13):11185-94
The Journal of biological chemistry 2011 Apr 1;286(13):11185-94
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.
Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, Tanowitz HB, Casimiro MC, Wang C, Pestell RG, Grieshaber P, Caro J, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2010 Sep 1;9(17):3534-51
Cell cycle (Georgetown, Tex.) 2010 Sep 1;9(17):3534-51
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.
Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F
Cell cycle (Georgetown, Tex.) 2010 Sep 1;9(17):3515-33
Cell cycle (Georgetown, Tex.) 2010 Sep 1;9(17):3515-33
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, Simos G, Koukoulis GK
Oncology reports 2010 Jul;24(1):161-9
Oncology reports 2010 Jul;24(1):161-9
Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.
Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, Simos G, Koukoulis GK
Oncology reports 2010 Jul;24(1):161-9
Oncology reports 2010 Jul;24(1):161-9
HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation.
Monsef N, Soller M, Panagopoulos I, Abrahamsson PA
BMC cancer 2010 Jul 21;10:385
BMC cancer 2010 Jul 21;10:385
A robust automated measure of average antibody staining in immunohistochemistry images.
Choudhury KR, Yagle KJ, Swanson PE, Krohn KA, Rajendran JG
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010 Feb;58(2):95-107
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010 Feb;58(2):95-107
Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors.
Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Hayashi I, Serizawa M, Koh Y, Hanaoka H, Tominaga H, Oriuchi N, Kondo H, Nakajima T, Yamamoto N
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Aug 10;28(23):3746-53
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Aug 10;28(23):3746-53
Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane.
Evenou F, Fujii T, Sakai Y
Tissue engineering. Part C, Methods 2010 Apr;16(2):311-8
Tissue engineering. Part C, Methods 2010 Apr;16(2):311-8
Low vasa vasorum densities correlate with inflammation and subintimal thickening: potential role in location--determination of atherogenesis.
Gössl M, Versari D, Lerman LO, Chade AR, Beighley PE, Erbel R, Ritman EL
Atherosclerosis 2009 Oct;206(2):362-8
Atherosclerosis 2009 Oct;206(2):362-8
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK
The Journal of biological chemistry 2009 Oct 16;284(42):29065-76
The Journal of biological chemistry 2009 Oct 16;284(42):29065-76
Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway.
Rhoads RP, Johnson RM, Rathbone CR, Liu X, Temm-Grove C, Sheehan SM, Hoying JB, Allen RE
American journal of physiology. Cell physiology 2009 Jun;296(6):C1321-8
American journal of physiology. Cell physiology 2009 Jun;296(6):C1321-8
ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells.
Hatipoglu OF, Hirohata S, Cilek MZ, Ogawa H, Miyoshi T, Obika M, Demircan K, Shinohata R, Kusachi S, Ninomiya Y
The Journal of biological chemistry 2009 Jun 12;284(24):16325-33
The Journal of biological chemistry 2009 Jun 12;284(24):16325-33
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression.
Aubert S, Fauquette V, Hémon B, Lepoivre R, Briez N, Bernard D, Van Seuningen I, Leroy X, Perrais M
Cancer research 2009 Jul 15;69(14):5707-15
Cancer research 2009 Jul 15;69(14):5707-15
Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma.
Diensthuber M, Potinius M, Rodt T, Stan AC, Welkoborsky HJ, Samii M, Schreyögg J, Lenarz T, Stöver T
Journal of neuro-oncology 2008 Sep;89(2):131-9
Journal of neuro-oncology 2008 Sep;89(2):131-9
Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme.
Flynn JR, Wang L, Gillespie DL, Stoddard GJ, Reid JK, Owens J, Ellsworth GB, Salzman KL, Kinney AY, Jensen RL
Cancer 2008 Sep 1;113(5):1032-42
Cancer 2008 Sep 1;113(5):1032-42
Comparison of hypoxia-inducible factor-1alpha expression before and after transcatheter arterial embolization in rabbit VX2 liver tumors.
Virmani S, Rhee TK, Ryu RK, Sato KT, Lewandowski RJ, Mulcahy MF, Kulik LM, Szolc-Kowalska B, Woloschak GE, Yang GY, Salem R, Larson AC, Omary RA
Journal of vascular and interventional radiology : JVIR 2008 Oct;19(10):1483-9
Journal of vascular and interventional radiology : JVIR 2008 Oct;19(10):1483-9
Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response.
Stagg J, Sharkey J, Pommey S, Young R, Takeda K, Yagita H, Johnstone RW, Smyth MJ
Proceedings of the National Academy of Sciences of the United States of America 2008 Oct 21;105(42):16254-9
Proceedings of the National Academy of Sciences of the United States of America 2008 Oct 21;105(42):16254-9
Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney.
Rosenberger C, Rosen S, Shina A, Frei U, Eckardt KU, Flippin LA, Arend M, Klaus SJ, Heyman SN
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Nov;23(11):3472-8
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Nov;23(11):3472-8
Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells.
Radek KA, Kovacs EJ, Gallo RL, DiPietro LA
American journal of physiology. Heart and circulatory physiology 2008 Jul;295(1):H174-84
American journal of physiology. Heart and circulatory physiology 2008 Jul;295(1):H174-84
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.
Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, Iwase H
Breast cancer research and treatment 2008 Aug;110(3):465-75
Breast cancer research and treatment 2008 Aug;110(3):465-75
Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.
López-Avilés S, Lambea E, Moldón A, Grande M, Fajardo A, Rodríguez-Gabriel MA, Hidalgo E, Aligue R
Molecular biology of the cell 2008 Apr;19(4):1670-9
Molecular biology of the cell 2008 Apr;19(4):1670-9
Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: relationship with pathological factors and prognostic impact on survival.
Cabuk D, Basaran G, Celikel C, Dane F, Yumuk PF, Iyikesici MS, Ekenel M, Turhal NS
Oncology 2007;72(1-2):111-7
Oncology 2007;72(1-2):111-7
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF
Molecular and cellular biology 2007 Sep;27(17):6229-42
Molecular and cellular biology 2007 Sep;27(17):6229-42
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter.
Ramanathan M, Pinhal-Enfield G, Hao I, Leibovich SJ
Molecular biology of the cell 2007 Jan;18(1):14-23
Molecular biology of the cell 2007 Jan;18(1):14-23
Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma.
Klatte T, Seligson DB, Riggs SB, Leppert JT, Berkman MK, Kleid MD, Yu H, Kabbinavar FF, Pantuck AJ, Belldegrun AS
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Dec 15;13(24):7388-93
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Dec 15;13(24):7388-93
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
Monsef N, Helczynski L, Lundwall A, Påhlman S, Anders-Bjartell.
The Prostate 2007 Aug 1;67(11):1219-29
The Prostate 2007 Aug 1;67(11):1219-29
Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice.
Gagnon PM, Simmons DD, Bao J, Lei D, Ortmann AJ, Ohlemiller KK
Hearing research 2007 Apr;226(1-2):79-91
Hearing research 2007 Apr;226(1-2):79-91
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
The proliferative response of hela cells to 2-deoxy-D-glucose under hypoxic or anoxic conditions: an analogue for studying some properties of in vivo solid cancers.
Anderson KM, Tsui P, Guinan P, Rubenstein M
Anticancer research 2006 Nov-Dec;26(6B):4155-62
Anticancer research 2006 Nov-Dec;26(6B):4155-62
Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
An HJ, Maeng O, Kang KH, Lee JO, Kim YS, Paik SG, Lee H
The Journal of biological chemistry 2006 Nov 10;281(45):33939-48
The Journal of biological chemistry 2006 Nov 10;281(45):33939-48
Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors.
Kim CM, Vocke C, Torres-Cabala C, Yang Y, Schmidt L, Walther M, Linehan WM
The Journal of urology 2006 May;175(5):1908-14
The Journal of urology 2006 May;175(5):1908-14
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.
Zheng X, Ruas JL, Cao R, Salomons FA, Cao Y, Poellinger L, Pereira T
Molecular and cellular biology 2006 Jun;26(12):4628-41
Molecular and cellular biology 2006 Jun;26(12):4628-41
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments.
Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M, Viollet B
Molecular and cellular biology 2006 Jul;26(14):5336-47
Molecular and cellular biology 2006 Jul;26(14):5336-47
Tissue expression and plasma levels of adrenomedullin in renal cancer patients.
Michelsen J, Thiesson H, Walter S, Ottosen PD, Skøtt O, Jensen BL
Clinical science (London, England : 1979) 2006 Jul;111(1):61-70
Clinical science (London, England : 1979) 2006 Jul;111(1):61-70
Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer.
Isaacs JT, Pili R, Qian DZ, Dalrymple SL, Garrison JB, Kyprianou N, Björk A, Olsson A, Leanderson T
The Prostate 2006 Dec 1;66(16):1768-78
The Prostate 2006 Dec 1;66(16):1768-78
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia.
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, Brown AS, Hicklin DJ, Foster FS, Kerbel RS
Cancer research 2006 Apr 1;66(7):3639-48
Cancer research 2006 Apr 1;66(7):3639-48
Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U
International journal of oncology 2005 Sep;27(3):807-14
International journal of oncology 2005 Sep;27(3):807-14
The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress.
Murphy BJ, Sato BG, Dalton TP, Laderoute KR
Biochemical and biophysical research communications 2005 Nov 25;337(3):860-7
Biochemical and biophysical research communications 2005 Nov 25;337(3):860-7
Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma.
Brown NS, Streeter EH, Jones A, Harris AL, Bicknell R
British journal of cancer 2005 May 9;92(9):1696-701
British journal of cancer 2005 May 9;92(9):1696-701
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.
Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A
The Journal of biological chemistry 2005 Dec 23;280(51):41928-39
The Journal of biological chemistry 2005 Dec 23;280(51):41928-39
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L
Cancer cell 2005 Aug;8(2):143-53
Cancer cell 2005 Aug;8(2):143-53
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.
Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC
Cancer research 2005 Apr 15;65(8):3257-63
Cancer research 2005 Apr 15;65(8):3257-63
Determination of the role of hypoxia-inducible factor 1 in wound healing.
Reichner JS, Albina JE
Methods in enzymology 2004;381:527-38
Methods in enzymology 2004;381:527-38
Methods to detect hypoxia-induced ischemic tolerance in the brain.
Bernaudin M, Sharp FR
Methods in enzymology 2004;381:399-416
Methods in enzymology 2004;381:399-416
Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head.
Tezel G, Wax MB
Archives of ophthalmology (Chicago, Ill. : 1960) 2004 Sep;122(9):1348-56
Archives of ophthalmology (Chicago, Ill. : 1960) 2004 Sep;122(9):1348-56
Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers.
Cangul H
BMC genetics 2004 Sep 2;5:27
BMC genetics 2004 Sep 2;5:27
Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules.
Caron A, Desrosiers RR, Béliveau R
Archives of biochemistry and biophysics 2004 Nov 1;431(1):31-46
Archives of biochemistry and biophysics 2004 Nov 1;431(1):31-46
Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor.
Nordal RA, Nagy A, Pintilie M, Wong CS
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 May 15;10(10):3342-53
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 May 15;10(10):3342-53
Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.
Luyendyk JP, Maddox JF, Green CD, Ganey PE, Roth RA
Hepatology (Baltimore, Md.) 2004 Dec;40(6):1342-51
Hepatology (Baltimore, Md.) 2004 Dec;40(6):1342-51
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C
The Journal of biological chemistry 2004 Apr 9;279(15):14871-8
The Journal of biological chemistry 2004 Apr 9;279(15):14871-8
Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy.
Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L, Lewis CE
The American journal of pathology 2003 Oct;163(4):1233-43
The American journal of pathology 2003 Oct;163(4):1233-43
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.
de Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB, Muller WJ, Rosen N, Benezra R
Proceedings of the National Academy of Sciences of the United States of America 2003 Oct 14;100(21):12337-42
Proceedings of the National Academy of Sciences of the United States of America 2003 Oct 14;100(21):12337-42
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.
Seagroves TN, Hadsell D, McManaman J, Palmer C, Liao D, McNulty W, Welm B, Wagner KU, Neville M, Johnson RS
Development (Cambridge, England) 2003 Apr;130(8):1713-24
Development (Cambridge, England) 2003 Apr;130(8):1713-24
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.
Seagroves TN, Hadsell D, McManaman J, Palmer C, Liao D, McNulty W, Welm B, Wagner KU, Neville M, Johnson RS
Development (Cambridge, England) 2003 Apr;130(8):1713-24
Development (Cambridge, England) 2003 Apr;130(8):1713-24
Effect of hypoxia on human seminoma cells.
Fujii T, Otsuki T, Moriya T, Sakaguchi H, Kurebayashi J, Yata K, Uno M, Kobayashi T, Kimura T, Jo Y, Kinugawa K, Furukawa Y, Morioka M, Ueki A, Tanaka H
International journal of oncology 2002 May;20(5):955-62
International journal of oncology 2002 May;20(5):955-62
Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.
Tang T, Arbiser JL, Brandt SJ
The Journal of biological chemistry 2002 May 24;277(21):18365-72
The Journal of biological chemistry 2002 May 24;277(21):18365-72
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH
Cancer cell 2002 Jun;1(5):459-68
Cancer cell 2002 Jun;1(5):459-68
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH
Cancer cell 2002 Jun;1(5):459-68
Cancer cell 2002 Jun;1(5):459-68
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells.
Tacchini L, Dansi P, Matteucci E, Desiderio MA
Carcinogenesis 2001 Sep;22(9):1363-71
Carcinogenesis 2001 Sep;22(9):1363-71
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells.
Tacchini L, Dansi P, Matteucci E, Desiderio MA
Carcinogenesis 2001 Sep;22(9):1363-71
Carcinogenesis 2001 Sep;22(9):1363-71
HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha.
Albina JE, Mastrofrancesco B, Vessella JA, Louis CA, Henry WL Jr, Reichner JS
American journal of physiology. Cell physiology 2001 Dec;281(6):C1971-7
American journal of physiology. Cell physiology 2001 Dec;281(6):C1971-7
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.
Duyndam MC, Hulscher TM, Fontijn D, Pinedo HM, Boven E
The Journal of biological chemistry 2001 Dec 21;276(51):48066-76
The Journal of biological chemistry 2001 Dec 21;276(51):48066-76
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW
Cancer research 1999 Nov 15;59(22):5830-5
Cancer research 1999 Nov 15;59(22):5830-5
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Supportive validation
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Analysis using the HRP conjugate of NB100-123. On day 1, MEF cells (+/+,-/-), were grown on 15cm dish (2x10 to the 6th cells). On day 2, cells were exposed to hypoxia for 4hrs. Cells were washed with ice cold PBS twice and whole cell protein was extracted extracted with RIPA buffer fortified with protease. Upon quantification, 100ug of protein was fractionated on 7% polyacralymide gel. Gel was transferred overnight onto nitrocellulose membrane. The membrane was probed with HIF-1 alpha monoclonal antibody at a 1:500 dilution (NB100-123). The secondary antibody was conjugated with HRP and was used at a 1:2500 dilution. Photo courtesy of Dr. Gregg Semenza, Johns Hopkins University.
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Analysis using the HRP conjugate of NB100-123. Detection of HIF-1 alpha in cobalt chloride treated/untreated COS-7 nuclear extracts using NB100-123.
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Immunoprecipitation of HIF-1alpha using NB100-123. Heavy and light chains are also detected. Image using the HRP form of this antibody.
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- Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - MLN4924 induces accumulation of HIF1a in a time dependent manner. Cells were treated with 0.1uM MLN4924 for indicated time periods, followed by IB with indicated antibodies. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/cddis2012125) licensed under a CC-BY licence.
Supportive validation
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- Immunoprecipitation: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - MG132 attenuates the inhibitory effect of interleukin-1beta on HIF-1/AM axis. U87MG cells were incubated for 2 h in hypoxia (1% O2) with or without interleukin-1beta (10 ng/ml). The proteasome inhibitor MG132 was added 30 min in advance to prevent ubiquitinated HIF-1alpha from proteasomal degradation. HIF-1alpha was precipitated by anti-HIF-1alpha antibody. Ubiquitin was detected by immunoblotting. Non-specific mouse IgG was used as a negative control. The results are representative for three independent experiments Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/cddis2013562) licensed under a CC-BY licence.
Supportive validation
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Staining on pig tissue (brown) using NB100-123. Image from verified customer review.
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- Immunohistochemistry: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Analysis of HIF-1 alpha in human lung tissue. Image courtesy of product review by Aneta Gandjeva.
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- Immunohistochemistry: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Staining of biotin conjugated HIF-1 alpha (NB100-123B) in human kidney.
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- Immunohistochemistry: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Results of in situ hybridization and immunohistochemistry on thin adjacent section to detect expression of HIF-1a1.2 mRNA and HIF1a protein in malignant and benign prostate tissue. In situ hybridization (antisense probe, Fig. 3a) and immunostaining with HIF1a Ab2 (Fig. 3c) on thin adjacent sections of NE-differentiated prostate adenocarcinoma showed co-localization of HIF1a1.2 transcript and HIF-1a protein. Incubation with sense probe did not generate any detectable hybridization signals (Fig. 3b). Both In situ hybridization (Fig. 3d antisense) and HIF-1a Ab2 immunostaining (Fig. 3f) were negative in non-NE-differentiated prostate adenocarcinoma. In situ hybridization with sense probe performed on non-NE-differentiated prostate cancer (Fig. 3e). Image collected and cropped by CiteAb from the following publication (http://www.biomedcentral.com/1471-2407/10/385), licensed under a CC-BY licence.
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (H1alpha67) [NB100-123] - Immunohistochemical detection of HIF-1alpha protein in human tissues. The nature of the tissue is indicated on top of each figure. Original magnifications are as follows: A, x400; B, x400; C, x100; D, x100; E, x100; F, x100; G, x40; H, x40. Image collected and cropped by CiteAb from the following publication (http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156-5-27), licensed under a CC-BY licence.