NB100-449
antibody from Novus Biologicals
Targeting: HIF1A
bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
Antibody data
- Antibody Data
- Antigen structure
- References [227]
- Comments [0]
- Validations
- Western blot [13]
- Immunoprecipitation [2]
- Immunohistochemistry [3]
- Flow cytometry [1]
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Validation data
Reference
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- Product number
- NB100-449 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-449, RRID:AB_10001045
- Product name
- Rabbit Polyclonal HIF-1 alpha Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian, Goat, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Intra-Pancreatic Insulin Nourishes Cancer Cells: Do Insulin-Receptor Antagonists such as PGG and EGCG Play a Role?
Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogs.
HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis.
Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice.
Hypoxia drives the assembly of the multienzyme purinosome complex.
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation.
Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively.
Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages.
HIF-1-VEGF-Notch mediates angiogenesis in temporomandibular joint osteoarthritis.
Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling.
A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease.
Dietary Supplementation of 25-Hydroxycholecalciferol Improves Livability in Broiler Breeder Hens-Amelioration of Cardiac Pathogenesis and Hepatopathology.
Effects of VEGF inhibitors on human retinal pigment epithelium under high glucose and hypoxia.
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.
NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells.
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.
HIF-1α protects against oxidative stress by directly targeting mitochondria.
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia.
Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism.
Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling.
Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia.
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans.
PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin.
Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism.
Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors.
HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice.
HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.
Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging.
Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis.
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia.
Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.
Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models.
WITHDRAWN:Mitochondrial targeting of HIF-1α inhibits hypoxia-induced apoptosis independently of its transcriptional activity.
Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production.
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.
Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.
Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.
Imaging Monitoring of Kupffer Cell Function and Hepatic Oxygen Saturation in Preneoplastic Changes During Cholangiocarcinogenesis.
HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis.
Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells.
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis.
Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions.
Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice.
GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation.
BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.
PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.
Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice.
Direct visualization of the phenotype of hypoxic tumor cells at single cell resolution in vivo using a new hypoxia probe.
NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress.
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.
Immunohistochemical evidence of tissue hypoxia and astrogliosis in the rostral ventrolateral medulla of spontaneously hypertensive rats.
Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency.
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin.
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels.
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation.
Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.
Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor.
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.
Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation.
Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines.
CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma.
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin.
Hypoxia-Inducible Factor 1 Is an Inductor of Transcription Factor Activating Protein 2 Epsilon Expression during Chondrogenic Differentiation.
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma.
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.
Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease.
Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype.
Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1.
Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice.
Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture.
Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.
Preclinical and Clinical Evidence of Mycobacterium tuberculosis Persistence in the Hypoxic Niche of Bone Marrow Mesenchymal Stem Cells after Therapy.
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Exercise induces stromal cell-derived factor-1α-mediated release of endothelial progenitor cells with increased vasculogenic function.
siRNA delivery into cultured primary human myoblasts--optimization of electroporation parameters and theoretical analysis.
Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes.
Strong hypoxia reduces leptin synthesis in purified primary human trophoblasts.
A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance.
Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.
CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells.
Hyperoxygenation attenuated a murine model of atopic dermatitis through raising skin level of ROS.
Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke.
Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Moderate, chronic ethanol feeding exacerbates carbon-tetrachloride-induced hepatic fibrosis via hepatocyte-specific hypoxia inducible factor 1α
Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1α-mediated transcriptional regulation.
Regulation of hypoxia-inducible factor-1α and related genes in equine digital lamellae and in cultured keratinocytes.
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.
Gene-environment interaction demonstrates the vulnerability of the embryonic heart.
Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats.
Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice.
Therapeutic targets in subependymoma.
Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor.
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.
FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.
Role of hypoxia-inducible factor-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma.
Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage.
Activin A regulation under global hypoxia in developing mouse brain.
Effects of ginkgo biloba extract on cultured human retinal pigment epithelial cells under chemical hypoxia.
HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells.
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.
Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.
Proangiogenic and prosurvival functions of glucose in human mesenchymal stem cells upon transplantation.
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.
Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells.
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.
Notch3 is activated by chronic hypoxia and contributes to the progression of human prostate cancer.
The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.
Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition.
Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs.
Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α.
Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.
Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.
Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.
Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.
Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes.
Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice.
Estrogen receptor expression affected by hypoxia inducible factor-1α in stromal cells from patients with endometriosis.
Inflammation modulates expression of laminin in the central nervous system following ischemic injury.
Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation.
Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors.
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.
Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.
Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.
Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia.
Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate.
Impaired hypoxic response in senescent mouse brain.
Scaffold porosity and oxygenation of printed hydrogel constructs affect functionality of embedded osteogenic progenitors.
Impaired response of mature adipocytes of diabetic mice to hypoxia.
Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.
PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.
Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells.
Hypoxia activates constitutive luciferase reporter constructs.
Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis.
Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli.
Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.
HIF-2 directly activates CD82 gene expression in endothelial cells.
Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress.
Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity.
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
Regulation of VEGF-A in uveal melanoma.
Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells.
Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms.
Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration.
The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization.
Rapid microsatellite isolation from a butterfly by de novo transcriptome sequencing: performance and a comparison with AFLP-derived distances.
Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites.
FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells.
HIF-1alpha response to hypoxia is functionally separated from the glucocorticoid stress response in the in vitro regenerating human skeletal muscle.
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.
Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.
Constitutive HIF-1 activity in malignant melanoma.
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice.
U19/Eaf2 binds to and stabilizes von hippel-lindau protein.
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses.
Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9.
Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes.
Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.
Teratogen responsive signaling pathways in organogenesis stage mouse limbs.
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance.
HIF-1: an age-dependent regulator of lens cell proliferation.
Hyperbaric oxygen reduces tissue hypoxia and hypoxia-inducible factor-1 alpha expression in focal cerebral ischemia.
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.
2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis.
The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes.
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling.
Oxygen tension regulates survival and fate of mouse central nervous system precursors at multiple levels.
S-nitrosothiols signal hypoxia-mimetic vascular pathology.
Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.
Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood.
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.
Perinecrotic hypoxia contributes to ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases.
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells.
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis.
Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model.
HIF1alpha delays premature senescence through the activation of MIF.
Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia.
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.
Gastric cancer--therapeutic implications of new concepts of gastric tumor biology.
Hu L, Chen X, Qiu S, Yang J, Liu H, Zhang J, Zhang D, Wang F
The American journal of Chinese medicine 2020;48(4):1005-1019
The American journal of Chinese medicine 2020;48(4):1005-1019
Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogs.
Yamazaki H, Tanaka T, Mie K, Nishida H, Miura N, Akiyoshi H
Journal of veterinary internal medicine 2020 May;34(3):1272-1281
Journal of veterinary internal medicine 2020 May;34(3):1272-1281
HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis.
Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S
PLoS biology 2020 May;18(5):e3000660
PLoS biology 2020 May;18(5):e3000660
Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice.
Sugahara M, Tanaka S, Tanaka T, Saito H, Ishimoto Y, Wakashima T, Ueda M, Fukui K, Shimizu A, Inagi R, Yamauchi T, Kadowaki T, Nangaku M
Journal of the American Society of Nephrology : JASN 2020 Mar;31(3):560-577
Journal of the American Society of Nephrology : JASN 2020 Mar;31(3):560-577
Hypoxia drives the assembly of the multienzyme purinosome complex.
Doigneaux C, Pedley AM, Mistry IN, Papayova M, Benkovic SJ, Tavassoli A
The Journal of biological chemistry 2020 Jul 10;295(28):9551-9566
The Journal of biological chemistry 2020 Jul 10;295(28):9551-9566
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation.
Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D, Zanoni I
Nature immunology 2020 Jan;21(1):42-53
Nature immunology 2020 Jan;21(1):42-53
Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively.
Sola-Penna M, Paixão LP, Branco JR, Ochioni AC, Albanese JM, Mundim DM, Baptista-de-Souza D, Figueiredo CP, Coelho WS, Marcondes MC, Zancan P
British journal of cancer 2020 Jan;122(2):194-208
British journal of cancer 2020 Jan;122(2):194-208
Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
Das Gupta K, Shakespear MR, Curson JEB, Murthy AMV, Iyer A, Hodson MP, Ramnath D, Tillu VA, von Pein JB, Reid RC, Tunny K, Hohenhaus DM, Moradi SV, Kelly GM, Kobayashi T, Gunter JH, Stevenson AJ, Xu W, Luo L, Jones A, Johnston WA, Blumenthal A, Alexandrov K, Collins BM, Stow JL, Fairlie DP, Sweet MJ
Cell reports 2020 Feb 25;30(8):2712-2728.e8
Cell reports 2020 Feb 25;30(8):2712-2728.e8
Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages.
Igari K, Kelly MJ, Yamanouchi D
Journal of vascular research 2019;56(2):55-64
Journal of vascular research 2019;56(2):55-64
HIF-1-VEGF-Notch mediates angiogenesis in temporomandibular joint osteoarthritis.
Chen Y, Zhao B, Zhu Y, Zhao H, Ma C
American journal of translational research 2019;11(5):2969-2982
American journal of translational research 2019;11(5):2969-2982
Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling.
Elder MJ, Webster SJ, Fitzmaurice TJ, Shaunak ASD, Steinmetz M, Chee R, Mallat Z, Cohen ES, Williams DL, Gaston JSH, Goodall JC
Frontiers in immunology 2019;10:921
Frontiers in immunology 2019;10:921
A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease.
Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I
Cell metabolism 2019 Sep 3;30(3):493-507.e6
Cell metabolism 2019 Sep 3;30(3):493-507.e6
Dietary Supplementation of 25-Hydroxycholecalciferol Improves Livability in Broiler Breeder Hens-Amelioration of Cardiac Pathogenesis and Hepatopathology.
Lin HY, Chou PC, Chen YH, Lai LS, Chung TK, Walzem RL, Huang SY, Chen SE
Animals : an open access journal from MDPI 2019 Oct 8;9(10)
Animals : an open access journal from MDPI 2019 Oct 8;9(10)
Effects of VEGF inhibitors on human retinal pigment epithelium under high glucose and hypoxia.
Bahrami B, Shen W, Zhu L, Zhang T, Chang A, Gillies MC
Clinical & experimental ophthalmology 2019 Nov;47(8):1074-1081
Clinical & experimental ophthalmology 2019 Nov;47(8):1074-1081
The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.
Nasyrov E, Nolan KA, Wenger RH, Marti HH, Kunze R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12812-12824
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12812-12824
NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells.
Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, Chen M
Cell reports 2019 Nov 12;29(7):1862-1877.e7
Cell reports 2019 Nov 12;29(7):1862-1877.e7
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin CH, Miyazono K
Science signaling 2019 Nov 12;12(607)
Science signaling 2019 Nov 12;12(607)
Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.
Chowdhury D, Alrefai H, Landero Figueroa JA, Candor K, Porollo A, Fecher R, Divanovic S, Deepe GS Jr, Subramanian Vignesh K
Cell reports 2019 Jun 25;27(13):3873-3886.e7
Cell reports 2019 Jun 25;27(13):3873-3886.e7
HIF-1α protects against oxidative stress by directly targeting mitochondria.
Li HS, Zhou YN, Li L, Li SF, Long D, Chen XL, Zhang JB, Feng L, Li YP
Redox biology 2019 Jul;25:101109
Redox biology 2019 Jul;25:101109
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.
Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, Hale A, Starr A, Nandi M, Stylianou E, McShane H, Davis S, Fischer R, Kessler BM, McCullagh J, Channon KM, Crabtree MJ
Cell reports 2019 Jul 2;28(1):218-230.e7
Cell reports 2019 Jul 2;28(1):218-230.e7
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
Valencia-Cervantes J, Huerta-Yepez S, Aquino-Jarquín G, Rodríguez-Enríquez S, Martínez-Fong D, Arias-Montaño JA, Dávila-Borja VM
Oncology reports 2019 Jan;41(1):178-190
Oncology reports 2019 Jan;41(1):178-190
Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression.
Krueger K, Catanese L, Sciesielski LK, Kirschner KM, Scholz H
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):71-83
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):71-83
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N
eLife 2019 Dec 3;8
eLife 2019 Dec 3;8
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia.
Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyre DR, Warman ML, Nishimura G, Sharp PA, Kobayashi T
Nature medicine 2019 Apr;25(4):583-590
Nature medicine 2019 Apr;25(4):583-590
Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism.
Duan LJ, Fong GH
Development (Cambridge, England) 2019 Apr 17;146(8)
Development (Cambridge, England) 2019 Apr 17;146(8)
Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism.
Fauzia E, Barbhuyan TK, Shrivastava AK, Kumar M, Garg P, Khan MA, Robertson AAB, Raza SS
Frontiers in pharmacology 2018;9:1034
Frontiers in pharmacology 2018;9:1034
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
Ferecatu I, Canal F, Fabbri L, Mazure NM, Bouton C, Golinelli-Cohen MP
PloS one 2018;13(3):e0194782
PloS one 2018;13(3):e0194782
Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling.
Li B, Zhu Y, Sun Q, Yu C, Chen L, Tian Y, Yan J
International journal of molecular medicine 2018 Sep;42(3):1391-1400
International journal of molecular medicine 2018 Sep;42(3):1391-1400
Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia.
Hamann I, Krys D, Glubrecht D, Bouvet V, Marshall A, Vos L, Mackey JR, Wuest M, Wuest F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Sep;32(9):5104-5118
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Sep;32(9):5104-5118
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans.
Koenis DS, Medzikovic L, Vos M, Beldman TJ, van Loenen PB, van Tiel CM, Hamers AAJ, Otermin Rubio I, de Waard V, de Vries CJM
The Journal of biological chemistry 2018 Sep 28;293(39):15070-15083
The Journal of biological chemistry 2018 Sep 28;293(39):15070-15083
PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin.
Mouly L, Mamouni K, Gence R, Cristini A, Cherier J, Castinel A, Legrand M, Favre G, Sordet O, Monferran S
Cell death & disease 2018 Sep 12;9(9):931
Cell death & disease 2018 Sep 12;9(9):931
Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage.
Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD
Cell death & disease 2018 Nov 12;9(11):1125
Cell death & disease 2018 Nov 12;9(11):1125
Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism.
Fukushima A, Zhang L, Huqi A, Lam VH, Rawat S, Altamimi T, Wagg CS, Dhaliwal KK, Hornberger LK, Kantor PF, Rebeyka IM, Lopaschuk GD
JCI insight 2018 May 17;3(10)
JCI insight 2018 May 17;3(10)
Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors.
Mekki MS, Mougel A, Vinchent A, Paquet C, Copin MC, Leroy C, Kherrouche Z, Bonte JP, Melnyk O, Vicogne J, Tulasne D
Oncotarget 2018 Jun 5;9(43):27039-27058
Oncotarget 2018 Jun 5;9(43):27039-27058
HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice.
Kim YE, Lee M, Gu H, Kim J, Jeong S, Yeo S, Lee YJ, Im SH, Sung YC, Kim HJ, Weissman IL, Ahn GO
Disease models & mechanisms 2018 Jul 30;11(7)
Disease models & mechanisms 2018 Jul 30;11(7)
HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.
MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR
Matrix biology : journal of the International Society for Matrix Biology 2018 Jan;65:45-58
Matrix biology : journal of the International Society for Matrix Biology 2018 Jan;65:45-58
Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging.
Lee S, Kim JH, Lee JH, Lee JH, Han JK
European radiology 2018 Jan;28(1):372-381
European radiology 2018 Jan;28(1):372-381
Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis.
Goodwin J, Choi H, Hsieh MH, Neugent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW
American journal of respiratory cell and molecular biology 2018 Feb;58(2):216-231
American journal of respiratory cell and molecular biology 2018 Feb;58(2):216-231
Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia.
Almiron Bonnin DA, Havrda MC, Lee MC, Liu H, Zhang Z, Nguyen LN, Harrington LX, Hassanpour S, Cheng C, Israel MA
Oncogene 2018 Feb 22;37(8):1107-1118
Oncogene 2018 Feb 22;37(8):1107-1118
Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Evers-van Gogh IJ, Van den Bossche J, Speijer D, Kim Y, Wessels L, Zelcer N, Zwart W, Kalkhoven E, de Vries CJ
Cell reports 2018 Aug 21;24(8):2127-2140.e7
Cell reports 2018 Aug 21;24(8):2127-2140.e7
Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models.
Niland S, Komljenovic D, Macas J, Bracht T, Bäuerle T, Liebner S, Eble JA
Oncotarget 2018 Apr 27;9(32):22406-22422
Oncotarget 2018 Apr 27;9(32):22406-22422
WITHDRAWN:Mitochondrial targeting of HIF-1α inhibits hypoxia-induced apoptosis independently of its transcriptional activity.
Li HS, Zhou YN, Li L, Li SF, Long D, Chen XL, Zhang JB, Li YP, Feng L
Free radical biology & medicine 2018 Apr 26;
Free radical biology & medicine 2018 Apr 26;
Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
Cho JH, Kim GY, Mansfield BC, Chou JY
Biochemical and biophysical research communications 2018 Apr 15;498(4):925-931
Biochemical and biophysical research communications 2018 Apr 15;498(4):925-931
β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production.
Elder MJ, Webster SJ, Chee R, Williams DL, Hill Gaston JS, Goodall JC
Frontiers in immunology 2017;8:791
Frontiers in immunology 2017;8:791
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.
Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KHG, O'Neill LA
Frontiers in immunology 2017;8:1300
Frontiers in immunology 2017;8:1300
Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.
Tavernier SJ, Vanlangenakker N, Vetters J, Carmeliet P, Janssens S, Lambrecht BN
Journal of leukocyte biology 2017 Oct;102(4):1115-1126
Journal of leukocyte biology 2017 Oct;102(4):1115-1126
Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.
Domingo-Gonzalez R, Das S, Griffiths KL, Ahmed M, Bambouskova M, Gopal R, Gondi S, Muñoz-Torrico M, Salazar-Lezama MA, Cruz-Lagunas A, Jiménez-Álvarez L, Ramirez-Martinez G, Espinosa-Soto R, Sultana T, Lyons-Weiler J, Reinhart TA, Arcos J, de la Luz Garcia-Hernandez M, Mastrangelo MA, Al-Hammadi N, Townsend R, Balada-Llasat JM, Torrelles JB, Kaplan G, Horne W, Kolls JK, Artyomov MN, Rangel-Moreno J, Zúñiga J, Khader SA
JCI insight 2017 Oct 5;2(19)
JCI insight 2017 Oct 5;2(19)
Imaging Monitoring of Kupffer Cell Function and Hepatic Oxygen Saturation in Preneoplastic Changes During Cholangiocarcinogenesis.
Lee S, Kim JH, Lee JH, Zen Y, Han JK
Scientific reports 2017 Oct 27;7(1):14203
Scientific reports 2017 Oct 27;7(1):14203
HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis.
Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G
Haematologica 2017 Nov;102(11):1956-1968
Haematologica 2017 Nov;102(11):1956-1968
Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells.
Geoghegan F, Buckland RJ, Rogers ET, Khalifa K, O'Connor EB, Rooney MF, Behnam-Motlagh P, Nilsson TK, Grankvist K, Porter RK
Oncotarget 2017 Nov 7;8(55):94711-94725
Oncotarget 2017 Nov 7;8(55):94711-94725
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cancer cell 2017 Nov 13;32(5):669-683.e5
Cancer cell 2017 Nov 13;32(5):669-683.e5
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.
Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW
Nature communications 2017 May 26;8:15503
Nature communications 2017 May 26;8:15503
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis.
Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl PO, Belting M, Von Euler L, Rundqvist H, Johnson RS, Branco C
Biology open 2017 May 15;6(5):688-697
Biology open 2017 May 15;6(5):688-697
Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions.
Shen W, Yau B, Lee SR, Zhu L, Yam M, Gillies MC
International journal of molecular sciences 2017 Mar 1;18(3)
International journal of molecular sciences 2017 Mar 1;18(3)
Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice.
Kowalski GM, Kraakman MJ, Mason SA, Murphy AJ, Bruce CR
The Journal of endocrinology 2017 Jun;233(3):269-279
The Journal of endocrinology 2017 Jun;233(3):269-279
GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation.
Carlessi R, Chen Y, Rowlands J, Cruzat VF, Keane KN, Egan L, Mamotte C, Stokes R, Gunton JE, Bittencourt PIH, Newsholme P
Scientific reports 2017 Jun 1;7(1):2661
Scientific reports 2017 Jun 1;7(1):2661
BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
Papathanassiu AE, Ko JH, Imprialou M, Bagnati M, Srivastava PK, Vu HA, Cucchi D, McAdoo SP, Ananieva EA, Mauro C, Behmoaras J
Nature communications 2017 Jul 12;8:16040
Nature communications 2017 Jul 12;8:16040
Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.
Zhang JT, Wang Y, Chen JJ, Zhang XH, Dong JD, Tsang LL, Huang XR, Cai Z, Lan HY, Jiang XH, Chan HC
Scientific reports 2017 Jul 12;7(1):5233
Scientific reports 2017 Jul 12;7(1):5233
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.
Gardner PJ, Liyanage SE, Cristante E, Sampson RD, Dick AD, Ali RR, Bainbridge JW
Scientific reports 2017 Jan 23;7:40830
Scientific reports 2017 Jan 23;7:40830
PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.
Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ
Journal of cellular biochemistry 2017 Dec;118(12):4383-4393
Journal of cellular biochemistry 2017 Dec;118(12):4383-4393
Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice.
Bok S, Kim YE, Woo Y, Kim S, Kang SJ, Lee Y, Park SK, Weissman IL, Ahn GO
Oncotarget 2017 Dec 19;8(67):111508-111521
Oncotarget 2017 Dec 19;8(67):111508-111521
Direct visualization of the phenotype of hypoxic tumor cells at single cell resolution in vivo using a new hypoxia probe.
Wang Y, Wang H, Li J, Entenberg D, Xue A, Wang W, Condeelis J
Intravital 2016;5(2)
Intravital 2016;5(2)
NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress.
Alonso J, Galán M, Martí-Pàmies I, Romero JM, Camacho M, Rodríguez C, Martínez-González J
Scientific reports 2016 Sep 22;6:34056
Scientific reports 2016 Sep 22;6:34056
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, Däbritz JHM, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA
Cell 2016 Oct 6;167(2):457-470.e13
Cell 2016 Oct 6;167(2):457-470.e13
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 29;113(48):E7778-E7787
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 29;113(48):E7778-E7787
Immunohistochemical evidence of tissue hypoxia and astrogliosis in the rostral ventrolateral medulla of spontaneously hypertensive rats.
Turlejski T, Humoud I, Desai R, Smith KJ, Marina N
Brain research 2016 Nov 1;1650:178-183
Brain research 2016 Nov 1;1650:178-183
Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency.
Nüsken E, Wohlfarth M, Lippach G, Rauh M, Schneider H, Dötsch J, Nüsken KD
Endocrinology 2016 May;157(5):1813-25
Endocrinology 2016 May;157(5):1813-25
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin.
Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH
The Journal of clinical investigation 2016 May 2;126(5):1926-38
The Journal of clinical investigation 2016 May 2;126(5):1926-38
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Nature communications 2016 May 18;7:11635
Nature communications 2016 May 18;7:11635
Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels.
Chapple SJ, Keeley TP, Mastronicola D, Arno M, Vizcay-Barrena G, Fleck R, Siow RCM, Mann GE
Free radical biology & medicine 2016 Mar;92:152-162
Free radical biology & medicine 2016 Mar;92:152-162
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation.
Shukla PK, Chaudhry KK, Mir H, Gangwar R, Yadav N, Manda B, Meena AS, Rao R
BMC cancer 2016 Mar 7;16:189
BMC cancer 2016 Mar 7;16:189
Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.
Kurihara T, Westenskow PD, Gantner ML, Usui Y, Schultz A, Bravo S, Aguilar E, Wittgrove C, Friedlander MSh, Paris LP, Chew E, Siuzdak G, Friedlander M
eLife 2016 Mar 15;5
eLife 2016 Mar 15;5
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.
Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T
Nature communications 2016 Jun 22;7:12047
Nature communications 2016 Jun 22;7:12047
Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor.
Tu DG, Chang WW, Lin ST, Kuo CY, Tsao YT, Lee CH
Oncotarget 2016 Jun 21;7(25):37513-37523
Oncotarget 2016 Jun 21;7(25):37513-37523
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN
Cell metabolism 2016 Jul 12;24(1):158-66
Cell metabolism 2016 Jul 12;24(1):158-66
Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.
Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS
The Journal of clinical investigation 2016 Jul 1;126(7):2509-18
The Journal of clinical investigation 2016 Jul 1;126(7):2509-18
Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation.
Shum LC, White NS, Mills BN, Bentley KL, Eliseev RA
Stem cells and development 2016 Jan 15;25(2):114-22
Stem cells and development 2016 Jan 15;25(2):114-22
Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines.
Mai J, Wang F, Qiu Q, Tang B, Lin Y, Luo N, Yuan W, Wang X, Chen Q, Wang J, Chen Y
Heart and vessels 2016 Feb;31(2):230-40
Heart and vessels 2016 Feb;31(2):230-40
CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma.
Prakash H, Nadella V, Singh S, Schmitz-Winnenthal H
Scientific reports 2016 Aug 11;6:31490
Scientific reports 2016 Aug 11;6:31490
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin.
Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O'Connor PM, Haase VH
The Journal of clinical investigation 2016 Apr 1;126(4):1425-37
The Journal of clinical investigation 2016 Apr 1;126(4):1425-37
Hypoxia-Inducible Factor 1 Is an Inductor of Transcription Factor Activating Protein 2 Epsilon Expression during Chondrogenic Differentiation.
Niebler S, Angele P, Kujat R, Bosserhoff AK
BioMed research international 2015;2015:380590
BioMed research international 2015;2015:380590
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V
Current gene therapy 2015;15(3):313-25
Current gene therapy 2015;15(3):313-25
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V
Current gene therapy 2015;15(3):313-25
Current gene therapy 2015;15(3):313-25
Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma.
Kambayashi S, Igase M, Kobayashi K, Kimura A, Shimokawa Miyama T, Baba K, Noguchi S, Mizuno T, Okuda M
The Journal of veterinary medical science 2015 Nov;77(11):1405-12
The Journal of veterinary medical science 2015 Nov;77(11):1405-12
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.
Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, Sormunen R, Kietzmann T
Antioxidants & redox signaling 2015 Nov 10;23(14):1059-75
Antioxidants & redox signaling 2015 Nov 10;23(14):1059-75
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism.
Teranishi Y, Matsubara T, Krausz KW, Le TT, Gonzalez FJ, Yoshizato K, Ikeda K, Kawada N
Laboratory investigation; a journal of technical methods and pathology 2015 May;95(5):515-24
Laboratory investigation; a journal of technical methods and pathology 2015 May;95(5):515-24
Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease.
Le Moan N, Baeten KM, Rafalski VA, Ryu JK, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K
eNeuro 2015 Mar-Apr;2(2)
eNeuro 2015 Mar-Apr;2(2)
Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype.
Hénique C, Mansouri A, Vavrova E, Lenoir V, Ferry A, Esnous C, Ramond E, Girard J, Bouillaud F, Prip-Buus C, Cohen I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jun;29(6):2473-83
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jun;29(6):2473-83
Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1.
Forsberg EA, Botusan IR, Wang J, Peters V, Ansurudeen I, Brismar K, Catrina SB
The Journal of endocrinology 2015 Jun;225(3):159-67
The Journal of endocrinology 2015 Jun;225(3):159-67
Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice.
Appel S, Turnwald EM, Ankerne J, Wohlfarth M, Appel J, Rother E, Janoschek R, Alejandre Alcazar MA, Schnare M, Meißner U, Dötsch J
Reproductive sciences (Thousand Oaks, Calif.) 2015 Jun;22(6):735-42
Reproductive sciences (Thousand Oaks, Calif.) 2015 Jun;22(6):735-42
Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture.
Hribar KC, Finlay D, Ma X, Qu X, Ondeck MG, Chung PH, Zanella F, Engler AJ, Sheikh F, Vuori K, Chen SC
Lab on a chip 2015 Jun 7;15(11):2412-8
Lab on a chip 2015 Jun 7;15(11):2412-8
Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.
Tsuboi I, Yamashita T, Nagano M, Kimura K, To'a Salazar G, Ohneda O
Journal of cellular physiology 2015 Jul;230(7):1534-48
Journal of cellular physiology 2015 Jul;230(7):1534-48
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization.
Fan D, Coughlin LA, Neubauer MM, Kim J, Kim MS, Zhan X, Simms-Waldrip TR, Xie Y, Hooper LV, Koh AY
Nature medicine 2015 Jul;21(7):808-14
Nature medicine 2015 Jul;21(7):808-14
Preclinical and Clinical Evidence of Mycobacterium tuberculosis Persistence in the Hypoxic Niche of Bone Marrow Mesenchymal Stem Cells after Therapy.
Garhyan J, Bhuyan S, Pulu I, Kalita D, Das B, Bhatnagar R
The American journal of pathology 2015 Jul;185(7):1924-34
The American journal of pathology 2015 Jul;185(7):1924-34
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA
Cell metabolism 2015 Jan 6;21(1):65-80
Cell metabolism 2015 Jan 6;21(1):65-80
Exercise induces stromal cell-derived factor-1α-mediated release of endothelial progenitor cells with increased vasculogenic function.
Chang E, Paterno J, Duscher D, Maan ZN, Chen JS, Januszyk M, Rodrigues M, Rennert RC, Bishop S, Whitmore AJ, Whittam AJ, Longaker MT, Gurtner GC
Plastic and reconstructive surgery 2015 Feb;135(2):340e-50e
Plastic and reconstructive surgery 2015 Feb;135(2):340e-50e
siRNA delivery into cultured primary human myoblasts--optimization of electroporation parameters and theoretical analysis.
Lojk J, Mis K, Pirkmajer S, Pavlin M
Bioelectromagnetics 2015 Dec;36(8):551-63
Bioelectromagnetics 2015 Dec;36(8):551-63
Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes.
Miao H, Chen L, Hao L, Zhang X, Chen Y, Ruan Z, Liang H
Scientific reports 2015 Aug 14;5:13092
Scientific reports 2015 Aug 14;5:13092
Strong hypoxia reduces leptin synthesis in purified primary human trophoblasts.
Nüsken E, Herrmann Y, Wohlfarth M, Goecke TW, Appel S, Schneider H, Dötsch J, Nüsken KD
Placenta 2015 Apr;36(4):427-32
Placenta 2015 Apr;36(4):427-32
A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.
Qiao S, Dennis M, Song X, Vadysirisack DD, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S, Shirihai OS, Lee RT, Reed JC, Ellisen LW
Nature communications 2015 Apr 28;6:7014
Nature communications 2015 Apr 28;6:7014
A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance.
Robin E, Marcillac F, Raddatz E
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Apr 1;308(7):R614-26
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Apr 1;308(7):R614-26
Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.
Matak P, Heinis M, Mathieu JR, Corriden R, Cuvellier S, Delga S, Mounier R, Rouquette A, Raymond J, Lamarque D, Emile JF, Nizet V, Touati E, Peyssonnaux C
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3259-66
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3259-66
CNN3 regulates trophoblast invasion and is upregulated by hypoxia in BeWo cells.
Appel S, Ankerne J, Appel J, Oberthuer A, Mallmann P, Dötsch J
PloS one 2014;9(7):e103216
PloS one 2014;9(7):e103216
Hyperoxygenation attenuated a murine model of atopic dermatitis through raising skin level of ROS.
Kim HR, Kim JH, Choi EJ, Lee YK, Kie JH, Jang MH, Seoh JY
PloS one 2014;9(10):e109297
PloS one 2014;9(10):e109297
Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke.
Reischl S, Li L, Walkinshaw G, Flippin LA, Marti HH, Kunze R
PloS one 2014;9(1):e84767
PloS one 2014;9(1):e84767
Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.
Duan LJ, Takeda K, Fong GH
PloS one 2014;9(1):e84736
PloS one 2014;9(1):e84736
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.
Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ
Molecular metabolism 2014 Sep;3(6):642-51
Molecular metabolism 2014 Sep;3(6):642-51
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R
Nature 2014 Sep 25;513(7519):559-63
Nature 2014 Sep 25;513(7519):559-63
Moderate, chronic ethanol feeding exacerbates carbon-tetrachloride-induced hepatic fibrosis via hepatocyte-specific hypoxia inducible factor 1α
Roychowdhury S, Chiang DJ, McMullen MR, Nagy LE
Pharmacology research & perspectives 2014 Oct;2(5):e00061
Pharmacology research & perspectives 2014 Oct;2(5):e00061
Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1α-mediated transcriptional regulation.
Rosafio K, Pellerin L
Glia 2014 Mar;62(3):477-90
Glia 2014 Mar;62(3):477-90
Regulation of hypoxia-inducible factor-1α and related genes in equine digital lamellae and in cultured keratinocytes.
Pawlak EA, Geor RJ, Watts MR, Black SJ, Johnson PJ, Belknap JK
Equine veterinary journal 2014 Mar;46(2):203-9
Equine veterinary journal 2014 Mar;46(2):203-9
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.
Ciavardelli D, Rossi C, Barcaroli D, Volpe S, Consalvo A, Zucchelli M, De Cola A, Scavo E, Carollo R, D'Agostino D, Forlì F, D'Aguanno S, Todaro M, Stassi G, Di Ilio C, De Laurenzi V, Urbani A
Cell death & disease 2014 Jul 17;5:e1336
Cell death & disease 2014 Jul 17;5:e1336
Gene-environment interaction demonstrates the vulnerability of the embryonic heart.
O'Reilly VC, Lopes Floro K, Shi H, Chapman BE, Preis JI, James AC, Chapman G, Harvey RP, Johnson RS, Grieve SM, Sparrow DB, Dunwoodie SL
Developmental biology 2014 Jul 1;391(1):99-110
Developmental biology 2014 Jul 1;391(1):99-110
Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats.
Zhao H, Luo X, Zhou Z, Liu J, Tralau-Stewart C, George AJ, Ma D
Kidney international 2014 Jan;85(1):112-23
Kidney international 2014 Jan;85(1):112-23
Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice.
Clinkenbeard EL, Farrow EG, Summers LJ, Cass TA, Roberts JL, Bayt CA, Lahm T, Albrecht M, Allen MR, Peacock M, White KE
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Feb;29(2):361-9
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Feb;29(2):361-9
Therapeutic targets in subependymoma.
Kong LY, Wei J, Haider AS, Liebelt BD, Ling X, Conrad CA, Fuller GN, Levine NB, Priebe W, Sawaya R, Heimberger AB
Journal of neuroimmunology 2014 Dec 15;277(1-2):168-75
Journal of neuroimmunology 2014 Dec 15;277(1-2):168-75
Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor.
Shiau AL, Shen YT, Hsieh JL, Wu CL, Lee CH
Environmental toxicology 2014 Apr;29(4):363-70
Environmental toxicology 2014 Apr;29(4):363-70
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Duan LJ, Takeda K, Fong GH
The American journal of pathology 2014 Apr;184(4):1240-1250
The American journal of pathology 2014 Apr;184(4):1240-1250
Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.
Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ
Nature communications 2013;4:2909
Nature communications 2013;4:2909
FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.
Balamurugan K, Sharan S, Klarmann KD, Zhang Y, Coppola V, Summers GH, Roger T, Morrison DK, Keller JR, Sterneck E
Nature communications 2013;4:1662
Nature communications 2013;4:1662
Role of hypoxia-inducible factor-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma.
Zhu Y, Zhang L, Gidday JM
Molecular vision 2013;19:2360-72
Molecular vision 2013;19:2360-72
Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage.
Sugimoto M, Cutler A, Shen B, Moss SE, Iyengar SK, Klein R, Folkman J, Anand-Apte B
The American journal of pathology 2013 Sep;183(3):987-95
The American journal of pathology 2013 Sep;183(3):987-95
Activin A regulation under global hypoxia in developing mouse brain.
Brackmann FA, Link AS, Jung S, Richter M, Zoglauer D, Walkinshaw G, Alzheimer C, Trollmann R
Brain research 2013 Sep 19;1531:65-74
Brain research 2013 Sep 19;1531:65-74
Effects of ginkgo biloba extract on cultured human retinal pigment epithelial cells under chemical hypoxia.
Oh JH, Oh J, Togloom A, Kim SW, Huh K
Current eye research 2013 Oct;38(10):1072-82
Current eye research 2013 Oct;38(10):1072-82
HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells.
Weidemann A, Breyer J, Rehm M, Eckardt KU, Daniel C, Cicha I, Giehl K, Goppelt-Struebe M
Cell communication and signaling : CCS 2013 Oct 21;11:80
Cell communication and signaling : CCS 2013 Oct 21;11:80
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.
Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW
Nature immunology 2013 Nov;14(11):1173-82
Nature immunology 2013 Nov;14(11):1173-82
Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.
Sun K, Halberg N, Khan M, Magalang UJ, Scherer PE
Molecular and cellular biology 2013 Mar;33(5):904-17
Molecular and cellular biology 2013 Mar;33(5):904-17
Proangiogenic and prosurvival functions of glucose in human mesenchymal stem cells upon transplantation.
Deschepper M, Manassero M, Oudina K, Paquet J, Monfoulet LE, Bensidhoum M, Logeart-Avramoglou D, Petite H
Stem cells (Dayton, Ohio) 2013 Mar;31(3):526-35
Stem cells (Dayton, Ohio) 2013 Mar;31(3):526-35
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.
Miranda E, Nordgren IK, Male AL, Lawrence CE, Hoakwie F, Cuda F, Court W, Fox KR, Townsend PA, Packham GK, Eccles SA, Tavassoli A
Journal of the American Chemical Society 2013 Jul 17;135(28):10418-25
Journal of the American Chemical Society 2013 Jul 17;135(28):10418-25
Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells.
Xiao H, Li S, Zhang D, Liu T, Yu M, Wang F
Oncology reports 2013 Jan;29(1):329-34
Oncology reports 2013 Jan;29(1):329-34
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.
Longati P, Jia X, Eimer J, Wagman A, Witt MR, Rehnmark S, Verbeke C, Toftgård R, Löhr M, Heuchel RL
BMC cancer 2013 Feb 27;13:95
BMC cancer 2013 Feb 27;13:95
Notch3 is activated by chronic hypoxia and contributes to the progression of human prostate cancer.
Danza G, Di Serio C, Ambrosio MR, Sturli N, Lonetto G, Rosati F, Rocca BJ, Ventimiglia G, del Vecchio MT, Prudovsky I, Marchionni N, Tarantini F
International journal of cancer 2013 Dec 1;133(11):2577-86
International journal of cancer 2013 Dec 1;133(11):2577-86
The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.
Kocemba KA, van Andel H, de Haan-Kramer A, Mahtouk K, Versteeg R, Kersten MJ, Spaargaren M, Pals ST
Leukemia 2013 Aug;27(8):1729-37
Leukemia 2013 Aug;27(8):1729-37
Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition.
Piao Y, Liang J, Holmes L, Henry V, Sulman E, de Groot JF
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4392-403
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4392-403
Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.
Baek KJ, Cho JY, Rosenthal P, Alexander LEC, Nizet V, Broide DH
Clinical immunology (Orlando, Fla.) 2013 Apr;147(1):27-37
Clinical immunology (Orlando, Fla.) 2013 Apr;147(1):27-37
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA
Nature 2013 Apr 11;496(7444):238-42
Nature 2013 Apr 11;496(7444):238-42
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs.
Huang C, Hales BF
PloS one 2012;7(12):e51937
PloS one 2012;7(12):e51937
Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α.
Riddell JR, Maier P, Sass SN, Moser MT, Foster BA, Gollnick SO
PloS one 2012;7(11):e50394
PloS one 2012;7(11):e50394
Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.
Shin MK, Drager LF, Yao Q, Bevans-Fonti S, Yoo DY, Jun JC, Aja S, Bhanot S, Polotsky VY
PloS one 2012;7(10):e46562
PloS one 2012;7(10):e46562
Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.
Kunze R, Zhou W, Veltkamp R, Wielockx B, Breier G, Marti HH
Stroke 2012 Oct;43(10):2748-56
Stroke 2012 Oct;43(10):2748-56
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.
Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ
American journal of respiratory and critical care medicine 2012 Oct 15;186(8):740-51
American journal of respiratory and critical care medicine 2012 Oct 15;186(8):740-51
Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.
Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 1;18(19):5234-46
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 1;18(19):5234-46
Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.
Veith C, Marsh LM, Wygrecka M, Rutschmann K, Seeger W, Weissmann N, Kwapiszewska G
The American journal of pathology 2012 Nov;181(5):1621-33
The American journal of pathology 2012 Nov;181(5):1621-33
Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes.
Chiusa M, Hool SL, Truetsch P, Djafarzadeh S, Jakob SM, Seifriz F, Scherer SJ, Suter TM, Zuppinger C, Zbinden S
Journal of molecular and cellular cardiology 2012 May;52(5):1164-75
Journal of molecular and cellular cardiology 2012 May;52(5):1164-75
Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice.
Copple BL, Kaska S, Wentling C
The Journal of pharmacology and experimental therapeutics 2012 May;341(2):307-16
The Journal of pharmacology and experimental therapeutics 2012 May;341(2):307-16
Estrogen receptor expression affected by hypoxia inducible factor-1α in stromal cells from patients with endometriosis.
Wu MH, Lu CW, Chang FM, Tsai SJ
Taiwanese journal of obstetrics & gynecology 2012 Mar;51(1):50-4
Taiwanese journal of obstetrics & gynecology 2012 Mar;51(1):50-4
Inflammation modulates expression of laminin in the central nervous system following ischemic injury.
Ji K, Tsirka SE
Journal of neuroinflammation 2012 Jul 3;9:159
Journal of neuroinflammation 2012 Jul 3;9:159
Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation.
Barta P, Van Pelt C, Men T, Dickey BF, Lotan R, Moghaddam SJ
Molecular cancer 2012 Jan 12;11:4
Molecular cancer 2012 Jan 12;11:4
Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors.
Gayed BA, O'Malley KJ, Pilch J, Wang Z
Clinical and translational science 2012 Feb;5(1):39-42
Clinical and translational science 2012 Feb;5(1):39-42
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.
Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM
The Journal of cell biology 2012 Feb 6;196(3):315-26
The Journal of cell biology 2012 Feb 6;196(3):315-26
Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.
Neumeister VM, Anagnostou V, Siddiqui S, England AM, Zarrella ER, Vassilakopoulou M, Parisi F, Kluger Y, Hicks DG, Rimm DL
Journal of the National Cancer Institute 2012 Dec 5;104(23):1815-24
Journal of the National Cancer Institute 2012 Dec 5;104(23):1815-24
Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.
Pohjoismäki JL, Boettger T, Liu Z, Goffart S, Szibor M, Braun T
Nucleic acids research 2012 Aug;40(14):6595-607
Nucleic acids research 2012 Aug;40(14):6595-607
Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia.
Huang M, Wu JC
Methods in molecular biology (Clifton, N.J.) 2011;709:211-21
Methods in molecular biology (Clifton, N.J.) 2011;709:211-21
Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.
Ko SH, Nauta A, Morrison SD, Zhou H, Zimmermann A, Gurtner GC, Ding S, Longaker MT
PloS one 2011;6(11):e27844
PloS one 2011;6(11):e27844
Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C
Journal of leukocyte biology 2011 Sep;90(3):551-62
Journal of leukocyte biology 2011 Sep;90(3):551-62
EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate.
Pascal LE, Ai J, Rigatti LH, Lipton AK, Xiao W, Gnarra JR, Wang Z
Angiogenesis 2011 Sep;14(3):331-43
Angiogenesis 2011 Sep;14(3):331-43
Impaired hypoxic response in senescent mouse brain.
Rabie T, Kunze R, Marti HH
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2011 Oct;29(6):655-61
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2011 Oct;29(6):655-61
Scaffold porosity and oxygenation of printed hydrogel constructs affect functionality of embedded osteogenic progenitors.
Fedorovich NE, Kuipers E, Gawlitta D, Dhert WJ, Alblas J
Tissue engineering. Part A 2011 Oct;17(19-20):2473-86
Tissue engineering. Part A 2011 Oct;17(19-20):2473-86
Impaired response of mature adipocytes of diabetic mice to hypoxia.
Hong SJ, Jin DP, Buck DW 2nd, Galiano RD, Mustoe TA
Experimental cell research 2011 Oct 1;317(16):2299-307
Experimental cell research 2011 Oct 1;317(16):2299-307
Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J
Molecular and cellular biology 2011 May;31(9):1870-84
Molecular and cellular biology 2011 May;31(9):1870-84
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.
Li Q, Michaud M, Canosa S, Kuo A, Madri JA
Angiogenesis 2011 May;14(2):173-85
Angiogenesis 2011 May;14(2):173-85
PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.
Dunford EC, Herbst EA, Jeoung NH, Gittings W, Inglis JG, Vandenboom R, LeBlanc PJ, Harris RA, Peters SJ
American journal of physiology. Regulatory, integrative and comparative physiology 2011 Jun;300(6):R1487-93
American journal of physiology. Regulatory, integrative and comparative physiology 2011 Jun;300(6):R1487-93
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection.
Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR
The Journal of clinical investigation 2011 Jun;121(6):2336-49
The Journal of clinical investigation 2011 Jun;121(6):2336-49
Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells.
Guadall A, Orriols M, Alcudia JF, Cachofeiro V, Martinez-Gonzalez J, Rodriguez C
Frontiers in bioscience (Elite edition) 2011 Jun 1;3:955-67
Frontiers in bioscience (Elite edition) 2011 Jun 1;3:955-67
Hypoxia activates constitutive luciferase reporter constructs.
Doran DM, Kulkarni-Datar K, Cool DR, Brown TL
Biochimie 2011 Feb;93(2):361-8
Biochimie 2011 Feb;93(2):361-8
Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis.
Copple BL, Bai S, Burgoon LD, Moon JO
Liver international : official journal of the International Association for the Study of the Liver 2011 Feb;31(2):230-44
Liver international : official journal of the International Association for the Study of the Liver 2011 Feb;31(2):230-44
Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli.
Camacho M, Rodríguez C, Guadall A, Alcolea S, Orriols M, Escudero JR, Martínez-González J, Vila L
Journal of lipid research 2011 Apr;52(4):720-31
Journal of lipid research 2011 Apr;52(4):720-31
Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.
Duan LJ, Takeda K, Fong GH
The American journal of pathology 2011 Apr;178(4):1881-90
The American journal of pathology 2011 Apr;178(4):1881-90
HIF-2 directly activates CD82 gene expression in endothelial cells.
Nagao K, Oka K
Biochemical and biophysical research communications 2011 Apr 1;407(1):260-5
Biochemical and biophysical research communications 2011 Apr 1;407(1):260-5
Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress.
Welford SM, Dorie MJ, Li X, Haase VH, Giaccia AJ
Molecular and cellular biology 2010 Oct;30(19):4595-603
Molecular and cellular biology 2010 Oct;30(19):4595-603
Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity.
Tam KK, Russell DL, Peet DJ, Bracken CP, Rodgers RJ, Thompson JG, Kind KL
Molecular and cellular endocrinology 2010 Oct 7;327(1-2):47-55
Molecular and cellular endocrinology 2010 Oct 7;327(1-2):47-55
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Höning S, Eckardt KU, Warnecke C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4443-58
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4443-58
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC
Haematologica 2010 May;95(5):776-84
Haematologica 2010 May;95(5):776-84
Regulation of VEGF-A in uveal melanoma.
el Filali M, Missotten GS, Maat W, Ly LV, Luyten GP, van der Velden PA, Jager MJ
Investigative ophthalmology & visual science 2010 May;51(5):2329-37
Investigative ophthalmology & visual science 2010 May;51(5):2329-37
Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells.
Copple BL, Bai S, Moon JO
Hepatology research : the official journal of the Japan Society of Hepatology 2010 May;40(5):530-9
Hepatology research : the official journal of the Japan Society of Hepatology 2010 May;40(5):530-9
Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms.
Copple BL
Liver international : official journal of the International Association for the Study of the Liver 2010 May;30(5):669-82
Liver international : official journal of the International Association for the Study of the Liver 2010 May;30(5):669-82
Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration.
Clever JL, Sakai Y, Wang RA, Schneider DB
American journal of physiology. Cell physiology 2010 May;298(5):C1087-99
American journal of physiology. Cell physiology 2010 May;298(5):C1087-99
The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization.
Porcelli AM, Ghelli A, Ceccarelli C, Lang M, Cenacchi G, Capristo M, Pennisi LF, Morra I, Ciccarelli E, Melcarne A, Bartoletti-Stella A, Salfi N, Tallini G, Martinuzzi A, Carelli V, Attimonelli M, Rugolo M, Romeo G, Gasparre G
Human molecular genetics 2010 Mar 15;19(6):1019-32
Human molecular genetics 2010 Mar 15;19(6):1019-32
Rapid microsatellite isolation from a butterfly by de novo transcriptome sequencing: performance and a comparison with AFLP-derived distances.
Mikheyev AS, Vo T, Wee B, Singer MC, Parmesan C
PloS one 2010 Jun 18;5(6):e11212
PloS one 2010 Jun 18;5(6):e11212
Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites.
Serra-Pérez A, Planas AM, Núñez-O'Mara A, Berra E, García-Villoria J, Ribes A, Santalucía T
The Journal of biological chemistry 2010 Jun 11;285(24):18217-24
The Journal of biological chemistry 2010 Jun 11;285(24):18217-24
FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells.
Samarin J, Wessel J, Cicha I, Kroening S, Warnecke C, Goppelt-Struebe M
The Journal of biological chemistry 2010 Feb 12;285(7):4328-36
The Journal of biological chemistry 2010 Feb 12;285(7):4328-36
HIF-1alpha response to hypoxia is functionally separated from the glucocorticoid stress response in the in vitro regenerating human skeletal muscle.
Pirkmajer S, Filipovic D, Mars T, Mis K, Grubic Z
American journal of physiology. Regulatory, integrative and comparative physiology 2010 Dec;299(6):R1693-700
American journal of physiology. Regulatory, integrative and comparative physiology 2010 Dec;299(6):R1693-700
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.
Xu D, Yao Y, Lu L, Costa M, Dai W
The Journal of biological chemistry 2010 Dec 10;285(50):38944-50
The Journal of biological chemistry 2010 Dec 10;285(50):38944-50
Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.
Costa B, Dettori D, Lorenzato A, Bardella C, Coltella N, Martino C, Cammarata C, Carmeliet P, Olivero M, Di Renzo MF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Aug;24(8):2680-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Aug;24(8):2680-8
Constitutive HIF-1 activity in malignant melanoma.
Kuphal S, Winklmeier A, Warnecke C, Bosserhoff AK
European journal of cancer (Oxford, England : 1990) 2010 Apr;46(6):1159-69
European journal of cancer (Oxford, England : 1990) 2010 Apr;46(6):1159-69
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Lu ZH, Shvartsman MB, Lee AY, Shao JM, Murray MM, Kladney RD, Fan D, Krajewski S, Chiang GG, Mills GB, Arbeit JM
Cancer research 2010 Apr 15;70(8):3287-98
Cancer research 2010 Apr 15;70(8):3287-98
The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.
Tanaka T, Wiesener M, Bernhardt W, Eckardt KU, Warnecke C
The Biochemical journal 2009 Oct 23;424(1):143-51
The Biochemical journal 2009 Oct 23;424(1):143-51
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
Volke M, Gale DP, Maegdefrau U, Schley G, Klanke B, Bosserhoff AK, Maxwell PH, Eckardt KU, Warnecke C
PloS one 2009 Nov 18;4(11):e7875
PloS one 2009 Nov 18;4(11):e7875
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Lomb DJ, Desouza LA, Franklin JL, Freeman RS
Molecular pharmacology 2009 May;75(5):1198-209
Molecular pharmacology 2009 May;75(5):1198-209
Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice.
Moon JO, Welch TP, Gonzalez FJ, Copple BL
American journal of physiology. Gastrointestinal and liver physiology 2009 Mar;296(3):G582-92
American journal of physiology. Gastrointestinal and liver physiology 2009 Mar;296(3):G582-92
U19/Eaf2 binds to and stabilizes von hippel-lindau protein.
Xiao W, Ai J, Habermacher G, Volpert O, Yang X, Zhang AY, Hahn J, Cai X, Wang Z
Cancer research 2009 Mar 15;69(6):2599-606
Cancer research 2009 Mar 15;69(6):2599-606
Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.
Loinard C, Ginouvès A, Vilar J, Cochain C, Zouggari Y, Recalde A, Duriez M, Lévy BI, Pouysségur J, Berra E, Silvestre JS
Circulation 2009 Jul 7;120(1):50-9
Circulation 2009 Jul 7;120(1):50-9
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses.
Vasseur S, Afzal S, Tardivel-Lacombe J, Park DS, Iovanna JL, Mak TW
Proceedings of the National Academy of Sciences of the United States of America 2009 Jan 27;106(4):1111-6
Proceedings of the National Academy of Sciences of the United States of America 2009 Jan 27;106(4):1111-6
Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9.
Gao P, Zhu Y, Ling F, Shen F, Lee B, Gabriel RA, Hao Q, Yang GY, Su H, Young WL
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Aug;29(8):1482-90
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009 Aug;29(8):1482-90
Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes.
Copple BL, Bustamante JJ, Welch TP, Kim ND, Moon JO
Liver international : official journal of the International Association for the Study of the Liver 2009 Aug;29(7):1010-21
Liver international : official journal of the International Association for the Study of the Liver 2009 Aug;29(7):1010-21
Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.
Houten SM, Chegary M, Te Brinke H, Wijnen WJ, Glatz JF, Luiken JJ, Wijburg FA, Wanders RJ
Cellular and molecular life sciences : CMLS 2009 Apr;66(7):1283-94
Cellular and molecular life sciences : CMLS 2009 Apr;66(7):1283-94
Teratogen responsive signaling pathways in organogenesis stage mouse limbs.
Huang C, Hales BF
Reproductive toxicology (Elmsford, N.Y.) 2009 Apr;27(2):103-10
Reproductive toxicology (Elmsford, N.Y.) 2009 Apr;27(2):103-10
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance.
Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ
The Journal of biological chemistry 2008 Oct 17;283(42):28106-14
The Journal of biological chemistry 2008 Oct 17;283(42):28106-14
HIF-1: an age-dependent regulator of lens cell proliferation.
Shui YB, Arbeit JM, Johnson RS, Beebe DC
Investigative ophthalmology & visual science 2008 Nov;49(11):4961-70
Investigative ophthalmology & visual science 2008 Nov;49(11):4961-70
Hyperbaric oxygen reduces tissue hypoxia and hypoxia-inducible factor-1 alpha expression in focal cerebral ischemia.
Sun L, Marti HH, Veltkamp R
Stroke 2008 Mar;39(3):1000-6
Stroke 2008 Mar;39(3):1000-6
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH
Blood 2008 Mar 15;111(6):3229-35
Blood 2008 Mar 15;111(6):3229-35
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R
Nature 2008 Jun 19;453(7198):1117-21
Nature 2008 Jun 19;453(7198):1117-21
The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS
Experimental cell research 2008 Jun 10;314(10):2016-27
Experimental cell research 2008 Jun 10;314(10):2016-27
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.
Yang Y, Bai J, Shen R, Brown SA, Komissarova E, Huang Y, Jiang N, Alberts GF, Costa M, Lu L, Winkles JA, Dai W
Cancer research 2008 Jun 1;68(11):4077-85
Cancer research 2008 Jun 1;68(11):4077-85
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung UI, Kataoka K
Molecular therapy : the journal of the American Society of Gene Therapy 2008 Jul;16(7):1227-34
Molecular therapy : the journal of the American Society of Gene Therapy 2008 Jul;16(7):1227-34
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.
May D, Gilon D, Djonov V, Itin A, Lazarus A, Gordon O, Rosenberger C, Keshet E
Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 8;105(1):282-7
Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 8;105(1):282-7
2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis.
Becker CM, Rohwer N, Funakoshi T, Cramer T, Bernhardt W, Birsner A, Folkman J, D'Amato RJ
The American journal of pathology 2008 Feb;172(2):534-44
The American journal of pathology 2008 Feb;172(2):534-44
The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes.
Vangeison G, Carr D, Federoff HJ, Rempe DA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb 20;28(8):1988-93
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb 20;28(8):1988-93
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling.
Scortegagna M, Cataisson C, Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, Arbeit JM
Blood 2008 Apr 1;111(7):3343-54
Blood 2008 Apr 1;111(7):3343-54
Oxygen tension regulates survival and fate of mouse central nervous system precursors at multiple levels.
Chen HL, Pistollato F, Hoeppner DJ, Ni HT, McKay RD, Panchision DM
Stem cells (Dayton, Ohio) 2007 Sep;25(9):2291-301
Stem cells (Dayton, Ohio) 2007 Sep;25(9):2291-301
S-nitrosothiols signal hypoxia-mimetic vascular pathology.
Palmer LA, Doctor A, Chhabra P, Sheram ML, Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B
The Journal of clinical investigation 2007 Sep;117(9):2592-601
The Journal of clinical investigation 2007 Sep;117(9):2592-601
Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.
van de Sluis B, Muller P, Duran K, Chen A, Groot AJ, Klomp LW, Liu PP, Wijmenga C
Molecular and cellular biology 2007 Jun;27(11):4142-56
Molecular and cellular biology 2007 Jun;27(11):4142-56
Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood.
Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, Shibuya M, Yoshikawa H, Ohneda O
Blood 2007 Jul 1;110(1):151-60
Blood 2007 Jul 1;110(1):151-60
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
Glassford AJ, Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS
American journal of physiology. Endocrinology and metabolism 2007 Dec;293(6):E1590-6
American journal of physiology. Endocrinology and metabolism 2007 Dec;293(6):E1590-6
Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.
Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L
Nature medicine 2007 Dec;13(12):1483-9
Nature medicine 2007 Dec;13(12):1483-9
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.
Takeda K, Cowan A, Fong GH
Circulation 2007 Aug 14;116(7):774-81
Circulation 2007 Aug 14;116(7):774-81
Perinecrotic hypoxia contributes to ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases.
van der Bilt JD, Soeters ME, Duyverman AM, Nijkamp MW, Witteveen PO, van Diest PJ, Kranenburg O, Borel Rinkes IH
The American journal of pathology 2007 Apr;170(4):1379-88
The American journal of pathology 2007 Apr;170(4):1379-88
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
Kim WY, Safran M, Buckley MR, Ebert BL, Glickman J, Bosenberg M, Regan M, Kaelin WG Jr
The EMBO journal 2006 Oct 4;25(19):4650-62
The EMBO journal 2006 Oct 4;25(19):4650-62
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH
Molecular and cellular biology 2006 Nov;26(22):8336-46
Molecular and cellular biology 2006 Nov;26(22):8336-46
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC
Molecular and cellular biology 2006 May;26(9):3514-26
Molecular and cellular biology 2006 May;26(9):3514-26
Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells.
Litz J, Krystal GW
Molecular cancer therapeutics 2006 Jun;5(6):1415-22
Molecular cancer therapeutics 2006 Jun;5(6):1415-22
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis.
Martin-Oliva D, Aguilar-Quesada R, O'valle F, Muñoz-Gámez JA, Martínez-Romero R, García Del Moral R, Ruiz de Almodóvar JM, Villuendas R, Piris MA, Oliver FJ
Cancer research 2006 Jun 1;66(11):5744-56
Cancer research 2006 Jun 1;66(11):5744-56
Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model.
Bedogni B, Welford SM, Kwan AC, Ranger-Moore J, Saboda K, Powell MB
Molecular cancer therapeutics 2006 Dec;5(12):3071-7
Molecular cancer therapeutics 2006 Dec;5(12):3071-7
HIF1alpha delays premature senescence through the activation of MIF.
Welford SM, Bedogni B, Gradin K, Poellinger L, Broome Powell M, Giaccia AJ
Genes & development 2006 Dec 15;20(24):3366-71
Genes & development 2006 Dec 15;20(24):3366-71
Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia.
Zampino M, Yuzhakova M, Hansen J, McKinney RD, Goldspink PH, Geenen DL, Buttrick PM
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H957-64
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H957-64
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.
Hsu T, Adereth Y, Kose N, Dammai V
The Journal of biological chemistry 2006 Apr 28;281(17):12069-80
The Journal of biological chemistry 2006 Apr 28;281(17):12069-80
Gastric cancer--therapeutic implications of new concepts of gastric tumor biology.
Sugerbaker PH
Cancer treatment and research 1991;55:xix-xxv
Cancer treatment and research 1991;55:xix-xxv
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Supportive validation
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Homogenate from pig (lanes 1 and 2) or rabbit (lane 4) aorta or lysate from cultured rat aortic smooth muscle cells (lane 3). Antibody: Affinity purified rabbit anti-SERCA2 used at 1 ug/ml (lanes 2 and 4) or 0.4 ug/ml (lane 3) for WB and 2 ug/mg lysate for IP or control (ctrl) monoclonal anti-SERCA2 (lanes 1 and 4) used at 1 ug/ml for WB. Detection: Chemiluminescence.
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - HIF-1 alpha induction on Caki-1 cell lysate using CoCl2. Image from verified customer review.
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- Simple Western: HIF-1 alpha Antibody [NB100-449] - Simple Western lane view shows a specific band for HIF-1 alpha in 0.5 mg/ml of hypoxic HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Analysis of HIF-1 alpha in human myeloma cell lysate using anti-HIF-1 alpha. Cells were untreated or treated with IGF-1, IL-6 or CoCl2. Image from verified customer review.
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Detection of mouse HIF-1 alpha on hypoxia treated MEFs
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Detection of Human HIF-1 alpha by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells that were either treated with cobalt chloride (+; 200 uM) or mock treated (-). Antibodies: Affinity purified rabbit anti-HIF1 alpha antibody used for WB at 0.1 ug/mL(A) and 1 ug/mL (B) and used for IP at 3 ug/mg lysate. HIF-1 alpha was also immunoprecipitated by a previous lot of this antibody. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Detection of HIF-1 alpha in a hypoxic sample. Lane 1: CoCl2 treated Cos-7 nuclear extract (hypoxic). Lane 2: Untreated Cos-7 nuclear extract (normoxic).
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells that were treated with cobalt chloride (+; 200 uM) or mock treated (-). Antibodies: Affinity purified rabbit anti-HIF1 alpha antibody NB100-449 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with exposure times of 30 seconds.
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Analysis of total protein using anti-HIF-1 alpha, -CAIX, -ISCU antibodies and VDACs antibody (PMID: 29596470).
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Analysis of total protein using anti-HIF-1 alpha, -ISCU, -FXN antibodies. CoCl2 was used to treat or not HeLa cells for 2 days (PMID: 29596470).
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - BMDM were seeded at 0.5x10^6 overnight. Cells were treated with 10 ng/ml LPS for 24 hrs. Image from verified customer review.
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - Detection of human HIF1 alpha by western blot. Samples: Whole cell lysate (15 and 50 ug) from HEK293T cells that were either treated with 200 uM cobalt chloride (+) or mock treated (-). Antibodies: Affinity purified rabbit anti-HIF1 alpha antibody NB100-449 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with exposure times of 3 minutes.
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- Western Blot: HIF-1 alpha Antibody [NB100-449] - 3T3-L1 mouse embryonic fibroblast adipose-like cell line. Antibody at 1:2000. WB image submitted by a verified customer review.
Supportive validation
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- Immunoprecipitation: HIF-1 alpha Antibody [NB100-449] - HIF-1 alpha analysis in HEK293 cells. Image from verified customer review.
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- Immunoprecipitation: HIF-1 alpha Antibody [NB100-449] - Detection of human HIF1 alpha by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HEK293T cells that were treated with 200 uM cobalt chloride. Antibodies: Affinity purified rabbit anti-HIF1 alpha antibody NB100-449 used for WB at 1 ug/ml and for IP at 6 ug/mg lysate. Detection: Chemiluminescence with exposure times of 3 minutes.
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- Immunohistochemistry: HIF-1 alpha Antibody [NB100-449] - Mouse Brain, Neurons 40X
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- Immunohistochemistry: HIF-1 alpha Antibody [NB100-449] - Detection of human HIF1-alpha by immunohistochemistry. Sample: FFPE section of renal cell carcinoma. Antibody: Affinity purified rabbit anti-HIF1-alpha antibody (NB110-58773). Detection: DAB
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody [NB100-449] - Analysis of microvascular density and HIF-1alpha activity. Low, homogenous expression of HIF-1alpha was detected in the tumors of NNK treated mice (40X, scale bar = 25 um). Image collected and cropped by CiteAb from the following publication (http://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-11-4), licensed under a CC-BY licence.
Supportive validation
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- Flow Cytometry: HIF-1 alpha Antibody [NB100-449] - HeLa cells were treated for 15 hrs with 200 uM CoCl2, fixed in PFA, and permeabilized in 90% MeOH. 1 X 10^6 cells were stained with 0.125 ug anti-HIF-1 alpha and secondary FITC-conjugated goat anti-rabbit (in a 150 uL reaction). Black: treated, anti-KLH control IgG; Red: untreated, anti-HIF-1 alpha; Blue: treated, anti-HIF-1 alpha.