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- Antibody Data
- Antigen structure
- References [38]
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- Product number
- ABIN343466 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN343466, RRID:AB_10786637
- Product name
- anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to a sequence mapping at the C-terminal of human HIF-1alpha, identical to the related rat and mouse sequence.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µg
- Storage
- At -20°C for one year. After reconstitution, at 4°C for at least one month. It can also be aliquotted and stored frozen at -20°C for longer time. Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.
Submitted references Huanglian-Jie-Du-Tang extract protects against chronic brain injury after focal cerebral ischemia via hypoxia-inducible-factor-1α-regulated vascular endothelial growth factor signaling in mice.
Downregulating hypoxia-inducible factor-2α improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma.
Effect of Yifei Huoxue Granule on the proliferation of rat pulmonary artery smooth muscle cells upon exposure to chronic hypoxic conditions in vitro.
Improved radiosensitizing effect of the combination of etanidazole and paclitaxel for hepatocellular carcinoma in vivo.
Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin.
The role of psychologic stress-induced hypoxia-inducible factor-1α in rat experimental periodontitis.
Protective effects of deferoxamine mesylate preconditioning on pancreatic tissue in orthotopic liver autotransplantation in rats.
Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma.
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells.
Transplantation of neural stem cells expressing hypoxia-inducible factor-1alpha (HIF-1alpha) improves behavioral recovery in a rat stroke model.
AQP-4 in peritumoral edematous tissue is correlated with the degree of glioma and with expression of VEGF and HIF-alpha.
Effect of hypoxia-inducible factor-1alpha silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide.
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
Antisense hypoxia-inducible factor 1alpha gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma.
Expression and role of factor inhibiting hypoxia-inducible factor-1 in pulmonary arteries of rat with hypoxia-induced hypertension.
Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues.
Inducible nitric oxide synthase mediates hypoxia-induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor expression in oxygen-induced retinopathy.
KCl depolarization increases HIF-1 transcriptional activity via the calcium-independent pathway in SGC7901 gastric cancer cells.
Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice.
Up-regulation of vascular endothelial growth factor in synovial fibroblasts from human temporomandibular joint by hypoxia.
Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas.
Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha.
Diversities in hepatic HIF-1, IGF-I/IGFBP-1, LDH/ICD, and their mRNA expressions induced by CoCl(2) in Qinghai-Tibetan plateau mammals and sea level mice.
The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model.
Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect.
Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia.
Role of peritubular capillary loss and hypoxia in progressive tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy.
Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension.
Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
Expression of hypoxia inducible factor-1alpha and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma.
Inhibition of expression of hypoxia-inducible factor-1alpha mRNA by nitric oxide in hypoxic pulmonary hypertension rats.
Hypoxia-inducible factor-1 alpha regulates the role of vascular endothelial growth factor on pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.
Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension.
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha.
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
Ye Y, Huang C, Jiang L, Shen X, Zhu S, Rao Y, Wang J, Zhang Q
Biological & pharmaceutical bulletin 2012;35(3):355-61
Biological & pharmaceutical bulletin 2012;35(3):355-61
Downregulating hypoxia-inducible factor-2α improves the efficacy of doxorubicin in the treatment of hepatocellular carcinoma.
He C, Sun XP, Qiao H, Jiang X, Wang D, Jin X, Dong X, Wang J, Jiang H, Sun X
Cancer science 2012 Mar;103(3):528-34
Cancer science 2012 Mar;103(3):528-34
Effect of Yifei Huoxue Granule on the proliferation of rat pulmonary artery smooth muscle cells upon exposure to chronic hypoxic conditions in vitro.
Zhang LY, Ou M, Huang YZ, Qiao YY, Zhang DJ
Chinese journal of integrative medicine 2012 Jul;18(7):507-13
Chinese journal of integrative medicine 2012 Jul;18(7):507-13
Improved radiosensitizing effect of the combination of etanidazole and paclitaxel for hepatocellular carcinoma in vivo.
Yang Y, Jin C, Li H, He Y, Liu Z, Bai L, Dou K
Experimental and therapeutic medicine 2012 Feb;3(2):299-303
Experimental and therapeutic medicine 2012 Feb;3(2):299-303
Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin.
Qiu J, Wang G, Hu J, Peng Q, Zheng Y
Molecular and cellular biochemistry 2011 Nov;357(1-2):125-33
Molecular and cellular biochemistry 2011 Nov;357(1-2):125-33
The role of psychologic stress-induced hypoxia-inducible factor-1α in rat experimental periodontitis.
Huang S, Lu F, Zhang Z, Yang X, Chen Y
Journal of periodontology 2011 Jun;82(6):934-41
Journal of periodontology 2011 Jun;82(6):934-41
Protective effects of deferoxamine mesylate preconditioning on pancreatic tissue in orthotopic liver autotransplantation in rats.
Li Y, Zhang PJ, Jin C, Zhou B, Liu XY, Tao LD, Feng M
Transplantation proceedings 2011 Jun;43(5):1450-5
Transplantation proceedings 2011 Jun;43(5):1450-5
Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma.
Liang X, Zheng M, Jiang J, Zhu G, Yang J, Tang Y
Oral oncology 2011 Feb;47(2):92-7
Oral oncology 2011 Feb;47(2):92-7
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells.
Ding Z, Yang L, Xie X, Xie F, Pan F, Li J, He J, Liang H
Journal of cancer research and clinical oncology 2010 Nov;136(11):1697-707
Journal of cancer research and clinical oncology 2010 Nov;136(11):1697-707
Transplantation of neural stem cells expressing hypoxia-inducible factor-1alpha (HIF-1alpha) improves behavioral recovery in a rat stroke model.
Wu W, Chen X, Hu C, Li J, Yu Z, Cai W
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2010 Jan;17(1):92-5
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2010 Jan;17(1):92-5
AQP-4 in peritumoral edematous tissue is correlated with the degree of glioma and with expression of VEGF and HIF-alpha.
Mou K, Chen M, Mao Q, Wang P, Ni R, Xia X, Liu Y
Journal of neuro-oncology 2010 Dec;100(3):375-83
Journal of neuro-oncology 2010 Dec;100(3):375-83
Effect of hypoxia-inducible factor-1alpha silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide.
Chen L, Feng P, Li S, Long D, Cheng J, Lu Y, Zhou D
Neurochemical research 2009 May;34(5):984-90
Neurochemical research 2009 May;34(5):984-90
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
Ndubuizu OI, Chavez JC, LaManna JC
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Jul;297(1):R158-65
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Jul;297(1):R158-65
Antisense hypoxia-inducible factor 1alpha gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma.
Liu F, Wang P, Jiang X, Tan G, Qiao H, Jiang H, Krissansen GW, Sun X
Cancer science 2008 Oct;99(10):2055-61
Cancer science 2008 Oct;99(10):2055-61
Expression and role of factor inhibiting hypoxia-inducible factor-1 in pulmonary arteries of rat with hypoxia-induced hypertension.
Fu D, Dai A, Hu R, Chen Y, Zhu L
Acta biochimica et biophysica Sinica 2008 Oct;40(10):883-92
Acta biochimica et biophysica Sinica 2008 Oct;40(10):883-92
Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
Wu W, Pan C, Yu H, Gong H, Wang Y
Journal of gastroenterology and hepatology 2008 Mar;23(3):491-7
Journal of gastroenterology and hepatology 2008 Mar;23(3):491-7
Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues.
Yin T, Yu S, Xiao L, Zhang J, Liu C, Lu Y, Liu C
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008 Jun;28(3):346-8
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008 Jun;28(3):346-8
Inducible nitric oxide synthase mediates hypoxia-induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor expression in oxygen-induced retinopathy.
He T, Ai M, Zhao XH, Xing YQ
Pathobiology : journal of immunopathology, molecular and cellular biology 2007;74(6):336-43
Pathobiology : journal of immunopathology, molecular and cellular biology 2007;74(6):336-43
KCl depolarization increases HIF-1 transcriptional activity via the calcium-independent pathway in SGC7901 gastric cancer cells.
Lan M, Shi Y, Sun L, Liu L, Guo X, Lu Y, Wang J, Liang J, Fan D
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2007;28(3):173-80
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2007;28(3):173-80
Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice.
Liu F, Tan G, Li J, Dong X, Krissansen GW, Sun X
Cancer science 2007 Sep;98(9):1381-7
Cancer science 2007 Sep;98(9):1381-7
Up-regulation of vascular endothelial growth factor in synovial fibroblasts from human temporomandibular joint by hypoxia.
Ke J, Liu Y, Long X, Li J, Fang W, Meng Q, Zhang Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2007 May;36(5):290-6
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2007 May;36(5):290-6
Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas.
Jiang H, Meng Q, Tan H, Pan S, Sun B, Xu R, Sun X
International journal of cancer. Journal international du cancer 2007 Jul 15;121(2):416-24
International journal of cancer. Journal international du cancer 2007 Jul 15;121(2):416-24
Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha.
Jiang Y, Dai A, Li Q, Hu R
Acta biochimica et biophysica Sinica 2007 Jan;39(1):73-80
Acta biochimica et biophysica Sinica 2007 Jan;39(1):73-80
Diversities in hepatic HIF-1, IGF-I/IGFBP-1, LDH/ICD, and their mRNA expressions induced by CoCl(2) in Qinghai-Tibetan plateau mammals and sea level mice.
Chen XQ, Wang SJ, Du JZ, Chen XC
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Jan;292(1):R516-26
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Jan;292(1):R516-26
The influence of different microenvironments on melanoma invasiveness and microcirculation patterns: an animal experiment study in the mouse model.
Sun B, Zhang S, Zhang D, Gu Y, Zhang W, Zhao X
Journal of cancer research and clinical oncology 2007 Dec;133(12):979-85
Journal of cancer research and clinical oncology 2007 Dec;133(12):979-85
Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect.
Jin GH, Ma DY, Wu N, Marikar FM, Jin SZ, Jiang WW, Liu Y, Hua ZC
International journal of cancer. Journal international du cancer 2007 Dec 1;121(11):2539-46
International journal of cancer. Journal international du cancer 2007 Dec 1;121(11):2539-46
Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia.
Zhang L, Li QQ
Acta pharmacologica Sinica 2007 Apr;28(4):549-58
Acta pharmacologica Sinica 2007 Apr;28(4):549-58
Role of peritubular capillary loss and hypoxia in progressive tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy.
Sun D, Feng J, Dai C, Sun L, Jin T, Ma J, Wang L
American journal of nephrology 2006;26(4):363-71
American journal of nephrology 2006;26(4):363-71
Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension.
Chen YR, Dai AG, Hu RC, Jiang YL
Acta biochimica et biophysica Sinica 2006 Jun;38(6):423-34
Acta biochimica et biophysica Sinica 2006 Jun;38(6):423-34
Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
Liu LZ, Fang J, Zhou Q, Hu X, Shi X, Jiang BH
Molecular pharmacology 2005 Sep;68(3):635-43
Molecular pharmacology 2005 Sep;68(3):635-43
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P, Huang LE
Molecular cell 2005 Mar 18;17(6):793-803
Molecular cell 2005 Mar 18;17(6):793-803
Expression of hypoxia inducible factor-1alpha and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma.
Yu L, Liu Y, Cui Y
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2004;24(6):636-8
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2004;24(6):636-8
Inhibition of expression of hypoxia-inducible factor-1alpha mRNA by nitric oxide in hypoxic pulmonary hypertension rats.
Ao Q, Huang L, Zhu P, Xiong M, Wang D
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2004;24(1):5-8
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2004;24(1):5-8
Hypoxia-inducible factor-1 alpha regulates the role of vascular endothelial growth factor on pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.
Li QF, Dai AG
Chinese medical journal 2004 Jul;117(7):1023-8
Chinese medical journal 2004 Jul;117(7):1023-8
Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension.
Li QF, Dai AG
Acta biochimica et biophysica Sinica 2004 Feb;36(2):133-40
Acta biochimica et biophysica Sinica 2004 Feb;36(2):133-40
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha.
Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, Arbeit JM
Genes & development 2001 Oct 1;15(19):2520-32
Genes & development 2001 Oct 1;15(19):2520-32
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr
Science (New York, N.Y.) 2001 Apr 20;292(5516):464-8
Science (New York, N.Y.) 2001 Apr 20;292(5516):464-8
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
Sutter CH, Laughner E, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2000 Apr 25;97(9):4748-53
Proceedings of the National Academy of Sciences of the United States of America 2000 Apr 25;97(9):4748-53
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