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- Antibody Data
- Antigen structure
- References [95]
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- Product number
- 66730-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- HIF1a antibody
- Antibody type
- Monoclonal
- Description
- HIF1a antibody (Cat. #66730-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1H3C12
- Vial size
- 20ul, 150ul
Submitted references Tumor-microenvironment-modulating microspheres to augment tumor-infiltrating lymphocyte therapy against solid tumors.
YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m(6)A signaling.
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Unveiling the active component of HuoXueTongFu formula: Emodin attenuates postoperative intra-abdominal adhesion by inhibiting HIF-1α-mediated glycolytic reprogramming.
NAT10-mediated ac4C modifications regulate glioblastoma progression.
Chrysophanein of Rhubarb rescues ILC3-Derived IL-22 by blocking CCDC25/ILK/HIF-1α for mucosal healing in ulcerative colitis mice.
Yuanzi-Shichangpu herb pair ameliorates mitochondrial energetics and restores blood-brain barrier integrity in Alzheimer's disease through the HIF-1α/GSK3β-Nrf2/PGC-1α axis.
Roxadustat: A catalyst for diabetic wound healing through re-epithelialization and angiogenesis.
Gua Sha Alleviates Radiculitis-Induced Pain Via HIF-1α-Mediated Metabolic Reprogramming Pathway in Rats.
Cinobufagin Inhibits Invasion and Migration of Non-Small Cell Lung Cancer via Regulating Glucose Metabolism Reprogramming in Tumor-Associated Macrophages.
IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.
Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.
Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms.
Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma.
Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis.
Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation.
USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α.
Lysophosphatidic acid (LPA) receptor signaling modulates cellular functions of colon cancer cells under cobalt chloride-induced hypoxic conditions.
Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging.
Small-molecule RNA therapeutics to target prostate cancer.
Microneedle-mediated hypoxic extracellular vesicle-encapsulated selenium nanoparticles delivery to treat androgenetic alopecia.
TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke.
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
Chondrocyte-targeted α-Solanine through HIF-1α regulating glycolysis to reduce the ferroptosis of chondrocyte in osteoarthritis.
Retinal Pigment Epithelium and Monocytes' Mitochondrial Control of Ferroptosis and its Relevance to Age-Related Macular Degeneration.
(124)I-labelled BMSC-Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP-Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis.
Functionalized Biomimetic Nanoparticles Targeting the IL-10/IL-10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis.
Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1α/VEGFA axis.
MiR-128-3p promotes hyperproliferation of keratinocytes and psoriasis-like inflammation by targeting SIRT1/HIF-1α.
Chinese herbal Jianpi Jiedu formula suppressed colorectal cancer growth in vitro and in vivo via modulating hypoxia-inducible factor 1 alpha-mediated fibroblasts activation.
Transarterial Embolization Using an Inorganic Phosphate Binder Modulates Immunity- and Angiogenesis-Related Factors in a Rat Model of Liver Cancer.
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway.
mTOR/HIF-1α pathway-mediated glucose reprogramming and macrophage polarization by Sini decoction plus ginseng soup in ALF.
STC2 Serves as a Critical Hypoxic Effector in Keloid Pathogenesis by Orchestrating Fibroblasts Activation and ECM Remodelling.
Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway.
Ferulic Acid Methyl Ester Attenuates Cerebral Ischemia-Reperfusion Injury in Rats by Modulating PI3K/HIF-1α/VEGF Signaling Pathway.
HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis.
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma.
PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms.
Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells.
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.
Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy.
Saturated fatty acids stimulate cytokine production in tanycytes via the PP2Ac-dependent signaling pathway.
Hypoxia-inducible factor prolyl hydroxylase inhibitor alleviates heatstroke-induced acute kidney injury by activating BNIP3-mediated mitophagy.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Genipin ameliorates diabetic retinopathy via the HIF-1α and AGEs-RAGE pathways.
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.
Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology.
Asiaticoside Down-Regulates HIF-1α to Inhibit Proliferation, Migration, and Angiogenesis in Thyroid Cancer Cells.
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma.
Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia.
Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using (13)C metabolic flux analysis.
Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation.
miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells.
Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury.
Mussel-Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration.
GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer.
Overexpression of KLF4 Suppresses Pulmonary Fibrosis through the HIF-1α/Endoplasmic Reticulum Stress Signaling Pathway.
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway.
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.
Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes.
Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.
Bifidobacterium infantis-Mediated Herpes Simplex Virus-TK/Ganciclovir Treatment Inhibits Cancer Metastasis in Mouse Model.
Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis.
Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma.
Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer.
ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma.
Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.
The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification.
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased inflammatory cellular reaction.
Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression.
IGFL2-AS1-induced suppression of HIF-1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9.
Chitosan Oligosaccharides Alleviate H(2)O(2)-stimulated Granulosa Cell Damage via HIF-1α Signaling Pathway.
Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy.
Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.
Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.
TSH-TSHR axis promotes tumor immune evasion.
Accumulated ROS Activates HIF-1α-Induced Glycolysis and Exerts a Protective Effect on Sensory Hair Cells Against Noise-Induced Damage.
Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2.
FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway.
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
The CDK4/6 inhibitor PD0332991 stabilizes FBP1 by repressing MAGED1 expression in pancreatic ductal adenocarcinoma.
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo.
Stanniocalcin‑1 promotes cell proliferation, chemoresistance and metastasis in hypoxic gastric cancer cells via Bcl‑2.
Li M, Yan S, Yan X, Nie Z, Wang H, Li Q, Liu H, Yu W, Zhang S, Liu Y, Chen H, Wu WD, Chao Y, Liu Z
Cell reports. Medicine 2026 May 8;:102794
Cell reports. Medicine 2026 May 8;:102794
YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m(6)A signaling.
Bi F, Yu T, Liu H, Cao M, He Y, Li J, Wang H, Kong C, Xiao H, Tian H, Liu F, Wu Y, Zhou Y, Shan H
iScience 2026 Mar 20;29(3):114810
iScience 2026 Mar 20;29(3):114810
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.
Dai S, Wan X, Xia L, Xu L, Xie C, Wang G, Tang J
Cell death & disease 2026 Mar 15;17(1)
Cell death & disease 2026 Mar 15;17(1)
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554
Journal of ethnopharmacology 2026 Jun 28;365:121554
Unveiling the active component of HuoXueTongFu formula: Emodin attenuates postoperative intra-abdominal adhesion by inhibiting HIF-1α-mediated glycolytic reprogramming.
Chen Y, Miao J, Yang L, Fang Y, Lian Y, Li G, Kong Z, Zhang L, Zeng L, Bian Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157719
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157719
NAT10-mediated ac4C modifications regulate glioblastoma progression.
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Cell death & disease 2026 Jan 8;17(1):181
Chrysophanein of Rhubarb rescues ILC3-Derived IL-22 by blocking CCDC25/ILK/HIF-1α for mucosal healing in ulcerative colitis mice.
Xu B, Cao S, Li C, Zhao M, Wang Q, Xie X, Chen H, Xu R, Yi Q, Ke X, Zhu Y, Zhou L, Luo X
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120628
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120628
Yuanzi-Shichangpu herb pair ameliorates mitochondrial energetics and restores blood-brain barrier integrity in Alzheimer's disease through the HIF-1α/GSK3β-Nrf2/PGC-1α axis.
Yao Q, Wu Y, Luo Y
Journal of ethnopharmacology 2026 Aug 10;367:121696
Journal of ethnopharmacology 2026 Aug 10;367:121696
Roxadustat: A catalyst for diabetic wound healing through re-epithelialization and angiogenesis.
Tang D, Lin Q, Xu K, Lu QP
CytoJournal 2025;22:90
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Gua Sha Alleviates Radiculitis-Induced Pain Via HIF-1α-Mediated Metabolic Reprogramming Pathway in Rats.
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Pain research & management 2025;2025:9923147
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Cinobufagin Inhibits Invasion and Migration of Non-Small Cell Lung Cancer via Regulating Glucose Metabolism Reprogramming in Tumor-Associated Macrophages.
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IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.
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Frontiers in oncology 2025;15:1512177
Frontiers in oncology 2025;15:1512177
Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1-Mediated Epigenetic Modulation.
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Food science & nutrition 2025 Sep;13(9):e70892
Food science & nutrition 2025 Sep;13(9):e70892
Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms.
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European journal of medical research 2025 Sep 26;30(1):874
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Hypoxia-induced tumor cell-intrinsic PLAU activation drives immunotherapy resistance in collagenic lung adenocarcinoma.
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International immunopharmacology 2025 Sep 23;162:115161
International immunopharmacology 2025 Sep 23;162:115161
Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis.
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Lysophosphatidic acid (LPA) receptor signaling modulates cellular functions of colon cancer cells under cobalt chloride-induced hypoxic conditions.
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Advances in biological regulation 2025 May;96:101098
Advances in biological regulation 2025 May;96:101098
Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging.
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Genome medicine 2025 May 19;17(1):56
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Small-molecule RNA therapeutics to target prostate cancer.
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Microneedle-mediated hypoxic extracellular vesicle-encapsulated selenium nanoparticles delivery to treat androgenetic alopecia.
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Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113597
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113597
TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke.
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International immunopharmacology 2025 Mar 6;149:114148
International immunopharmacology 2025 Mar 6;149:114148
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
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Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Chondrocyte-targeted α-Solanine through HIF-1α regulating glycolysis to reduce the ferroptosis of chondrocyte in osteoarthritis.
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International immunopharmacology 2025 Jun 26;159:114841
International immunopharmacology 2025 Jun 26;159:114841
Retinal Pigment Epithelium and Monocytes' Mitochondrial Control of Ferroptosis and its Relevance to Age-Related Macular Degeneration.
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(124)I-labelled BMSC-Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP-Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis.
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Journal of extracellular vesicles 2025 Jul;14(7):e70130
Functionalized Biomimetic Nanoparticles Targeting the IL-10/IL-10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis.
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Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1α/VEGFA axis.
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156900
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156900
MiR-128-3p promotes hyperproliferation of keratinocytes and psoriasis-like inflammation by targeting SIRT1/HIF-1α.
You J, Wang Z, Jia X
Archives of dermatological research 2025 Jan 4;317(1):165
Archives of dermatological research 2025 Jan 4;317(1):165
Chinese herbal Jianpi Jiedu formula suppressed colorectal cancer growth in vitro and in vivo via modulating hypoxia-inducible factor 1 alpha-mediated fibroblasts activation.
He S, Hao L, Chen Y, Gong B, Xu X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118753
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118753
Transarterial Embolization Using an Inorganic Phosphate Binder Modulates Immunity- and Angiogenesis-Related Factors in a Rat Model of Liver Cancer.
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Journal of vascular and interventional radiology : JVIR 2025 Feb;36(2):320-331.e9
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway.
Zhou J, Lei Y, Zhang S, Liu Y, Yi D
CNS neuroscience & therapeutics 2025 Feb;31(2):e70233
CNS neuroscience & therapeutics 2025 Feb;31(2):e70233
mTOR/HIF-1α pathway-mediated glucose reprogramming and macrophage polarization by Sini decoction plus ginseng soup in ALF.
Zhang J, Hao L, Li S, He Y, Zhang Y, Li N, Hu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156374
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156374
STC2 Serves as a Critical Hypoxic Effector in Keloid Pathogenesis by Orchestrating Fibroblasts Activation and ECM Remodelling.
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Experimental dermatology 2025 Dec;34(12):e70193
Experimental dermatology 2025 Dec;34(12):e70193
Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway.
Pei X, Lu L, Huang Z, Wei Y, Li Y, Wang Q, Yang Y, Zhuang L, Jin G
Diabetology & metabolic syndrome 2025 Aug 29;17(1):362
Diabetology & metabolic syndrome 2025 Aug 29;17(1):362
Ferulic Acid Methyl Ester Attenuates Cerebral Ischemia-Reperfusion Injury in Rats by Modulating PI3K/HIF-1α/VEGF Signaling Pathway.
Zhou P, Yu S, Wang X, Zhang X, Guo D, Zhao C, Cheng J, Wang J, Sun J
Journal of inflammation research 2024;17:5741-5762
Journal of inflammation research 2024;17:5741-5762
HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis.
You M, Fu M, Shen Z, Feng Y, Zhang L, Zhu X, Zhuang Z, Mao Y, Hua W
Oncoimmunology 2024;13(1):2356942
Oncoimmunology 2024;13(1):2356942
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma.
Shan Q, Yin L, Zhan Q, Yu J, Pan S, Zhuo J, Zhou W, Bao J, Zhang L, Hong J, Xiang J, Que Q, Chen K, Xu S, Wang J, Zhu Y, He B, Wu J, Xie H, Zheng S, Feng T, Ling S, Xu X
Signal transduction and targeted therapy 2024 Sep 19;9(1):249
Signal transduction and targeted therapy 2024 Sep 19;9(1):249
PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms.
Cao T, Wang J
Translational cancer research 2024 Oct 31;13(10):5627-5648
Translational cancer research 2024 Oct 31;13(10):5627-5648
Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells.
Li L, Liu H, Chai Q, Wei J, Qin Y, Yang J, Liu H, Qi J, Guo C, Lu Z
Cellular and molecular life sciences : CMLS 2024 Nov 9;81(1):448
Cellular and molecular life sciences : CMLS 2024 Nov 9;81(1):448
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.
Zhao X, Su S, Wu C, Deng Y, Chen Y, Yu T, Li C, Zhang Y, Wang X, Zhou Y, Zhang X
Journal of nanobiotechnology 2024 Nov 21;22(1):725
Journal of nanobiotechnology 2024 Nov 21;22(1):725
Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy.
Yang Y, Wang Y, Zeng F, Chen Y, Chen Z, Yan F
Cell reports. Medicine 2024 May 21;5(5):101512
Cell reports. Medicine 2024 May 21;5(5):101512
Saturated fatty acids stimulate cytokine production in tanycytes via the PP2Ac-dependent signaling pathway.
Liu D, Wang T, Zhao X, Chen J, Yang T, Shen Y, Zhou YD
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Jun;44(6):985-999
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Jun;44(6):985-999
Hypoxia-inducible factor prolyl hydroxylase inhibitor alleviates heatstroke-induced acute kidney injury by activating BNIP3-mediated mitophagy.
Wang L, Song Y, Zhang P, Chen W, Xiao F, Zhou P, Yang X, Dai H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23723
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23723
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Genipin ameliorates diabetic retinopathy via the HIF-1α and AGEs-RAGE pathways.
Sun K, Chen Y, Zheng S, Wan W, Hu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155596
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155596
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.
Fan S, Tan Y, Yuan X, Liu C, Wu X, Dai T, Ni S, Wang J, Weng Y, Zhao H
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452
Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology.
Xu T, He P, namWangdu S, Xu C, Hou B, Ma P, Wang Z, Zhang L, Du G, Ring T, Ji T, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117254
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117254
Asiaticoside Down-Regulates HIF-1α to Inhibit Proliferation, Migration, and Angiogenesis in Thyroid Cancer Cells.
Zhang Y, Han Y, Dong J, Li F, Sun Y
Balkan medical journal 2024 Jan 3;41(1):23-29
Balkan medical journal 2024 Jan 3;41(1):23-29
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma.
Shi M, Huang K, Wei J, Wang S, Yang W, Wang H, Li Y
International journal of molecular sciences 2024 Jan 14;25(2)
International journal of molecular sciences 2024 Jan 14;25(2)
Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia.
Cui Y, Wu S, Liu K, Zhao H, Ma B, Gong L, Zhou Q, Li X
Journal of reproductive immunology 2024 Feb;161:104186
Journal of reproductive immunology 2024 Feb;161:104186
Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using (13)C metabolic flux analysis.
Shan B, Zhou H, Guo C, Liu X, Wu M, Zhai R, Chen J
Journal of pharmaceutical analysis 2024 Feb;14(2):244-258
Journal of pharmaceutical analysis 2024 Feb;14(2):244-258
Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation.
Li H, Song C, Zhang Y, Liu G, Mi H, Li Y, Chen Z, Ma X, Zhang P, Cheng L, Peng P, Zhu H, Chen Z, Dong M, Chen S, Meng H, Xiao Q, Li H, Wu Q, Wang B, Zhang S, Shu K, Wan F, Guo D, Zhou W, Zhou L, Mao F, Rich JN, Yu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305620
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305620
miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells.
Cheng CW, Liu YF, Liao WL, Chen PM, Hung YT, Lee HJ, Cheng YC, Wu PE, Lu YS, Shen CY
Cancers 2024 Feb 3;16(3)
Cancers 2024 Feb 3;16(3)
Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury.
Zhang W, Guo C, Li Y, Wang H, Wang H, Wang Y, Wu T, Wang H, Cheng G, Man J, Chen S, Fu S, Yang L
Renal failure 2024 Dec;46(1):2332492
Renal failure 2024 Dec;46(1):2332492
Mussel-Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration.
Zhou W, Liu Y, Dong J, Hu X, Su Z, Zhang X, Zhu C, Xiong L, Huang W, Bai J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2401833
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2401833
GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
Liang Y, Zhang H, Li J, Wang X, Xie J, Li Y, Li J, Qian Y, Zhang H, Wang T, Tang H, Chen X
Cell biology international 2024 Apr;48(4):510-520
Cell biology international 2024 Apr;48(4):510-520
4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment.
Xu Z, Wu Y, Mao J, Chen Y, Chen H, Zhang S, Yu J, Deng X, Shen L
BMC genomics 2024 Apr 26;25(1):415
BMC genomics 2024 Apr 26;25(1):415
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer.
Bai X, Xiong J, Li L, Yu C, Sun C
European journal of pharmacology 2024 Apr 15;969:176431
European journal of pharmacology 2024 Apr 15;969:176431
Overexpression of KLF4 Suppresses Pulmonary Fibrosis through the HIF-1α/Endoplasmic Reticulum Stress Signaling Pathway.
Wei S, Qi F, Wu Y, Liu X
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407
Cell death and differentiation 2023 Nov;30(11):2393-2407
FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway.
Xu X, Ye X, Zhu M, Zhang Q, Li X, Yan J
BMC pregnancy and childbirth 2023 Mar 1;23(1):131
BMC pregnancy and childbirth 2023 Mar 1;23(1):131
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.
Guo Y, Shen R, Yang K, Wang Y, Song H, Liu X, Cheng X, Wu R, Song Y, Wang D
Cell death discovery 2023 Jun 30;9(1):205
Cell death discovery 2023 Jun 30;9(1):205
Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes.
Jia Y, Yin C, Ke W, Liu J, Guo B, Wang X, Zhao P, Hu S, Zhang C, Li X, Liu R, Zheng X, Wang Y, Wang G, Pan H, Hu W, Song Z
The Science of the total environment 2023 Jun 20;878:163069
The Science of the total environment 2023 Jun 20;878:163069
Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.
Hu BC, Zhu JW, Wu GH, Cai JJ, Yang X, Shao ZQ, Zheng Y, Lai JM, Shen Y, Yang XH, Liu JQ, Sun RH, Zhu HP, Ye XM, Mo SJ
Life sciences 2023 Jun 1;322:121653
Life sciences 2023 Jun 1;322:121653
Bifidobacterium infantis-Mediated Herpes Simplex Virus-TK/Ganciclovir Treatment Inhibits Cancer Metastasis in Mouse Model.
Wang C, Shen Y, Ma Y
International journal of molecular sciences 2023 Jul 21;24(14)
International journal of molecular sciences 2023 Jul 21;24(14)
Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis.
Li Y, Yang W, Zheng Y, Dai W, Ji J, Wu L, Cheng Z, Zhang J, Li J, Xu X, Wu J, Yang M, Feng J, Guo C
Journal of experimental & clinical cancer research : CR 2023 Jan 6;42(1):6
Journal of experimental & clinical cancer research : CR 2023 Jan 6;42(1):6
Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma.
Chen L, Kong Q, Tian M, Zhang Q, Xia C, Deng C
Nanoscale advances 2023 Jan 31;5(3):851-860
Nanoscale advances 2023 Jan 31;5(3):851-860
Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer.
Ma B, Wen S, Luo Y, Zhang T, Yang Y, Shen C, Zhang Y, Ji Q, Qu N, Wang Y
The Journal of clinical endocrinology and metabolism 2023 Jan 17;108(2):368-384
The Journal of clinical endocrinology and metabolism 2023 Jan 17;108(2):368-384
ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma.
Shi Y, Shang J, Li Y, Zhong D, Zhang Z, Yang Q, Lai C, Feng T, Yao Y, Huang X
Cancer medicine 2023 Feb;12(3):3786-3796
Cancer medicine 2023 Feb;12(3):3786-3796
Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.
Li S, Sun J, Yang J, Yang Y, Ding H, Yu B, Ma K, Chen M
Biomaterials research 2023 Feb 13;27(1):11
Biomaterials research 2023 Feb 13;27(1):11
The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification.
Liao W, Wang M, Wu Y, Du J, Li Y, Su A, Zhong L, Xie Z, Gong M, Liang J, Wang P, Liu Z, Wang L
Pharmaceutical biology 2023 Dec;61(1):1014-1029
Pharmaceutical biology 2023 Dec;61(1):1014-1029
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Yang Q, Meng X, Chen J, Li X, Huang Y, Xiao X, Li R, Wu X
Cell death discovery 2023 Dec 5;9(1):440
Cell death discovery 2023 Dec 5;9(1):440
Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased inflammatory cellular reaction.
Höfner M, Eubler K, Herrmann C, Berg U, Berg D, Welter H, Imhof A, Forné I, Mayerhofer A
Molecular human reproduction 2023 Dec 24;30(1)
Molecular human reproduction 2023 Dec 24;30(1)
Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression.
Zhou L, Luo Y, Liu Y, Zeng Y, Tong J, Li M, Hou Y, Du K, Qi Y, Pan W, Liu Y, Wang R, Tian F, Gu C, Chen K
Cancer research 2023 Dec 1;83(23):3920-3939
Cancer research 2023 Dec 1;83(23):3920-3939
IGFL2-AS1-induced suppression of HIF-1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9.
Qin M, Liu Q, Yang W, Wang Q, Xiang Z
Cancer medicine 2023 Apr;12(7):8415-8432
Cancer medicine 2023 Apr;12(7):8415-8432
Chitosan Oligosaccharides Alleviate H(2)O(2)-stimulated Granulosa Cell Damage via HIF-1α Signaling Pathway.
Yang Z, Hong W, Zheng K, Feng J, Hu C, Tan J, Zhong Z, Zheng Y
Oxidative medicine and cellular longevity 2022;2022:4247042
Oxidative medicine and cellular longevity 2022;2022:4247042
Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy.
Gao L, Xu QH, Ma LN, Luo J, Muyayalo KP, Wang LL, Huang DH, Xiao XJ, Cheng SB, Mor G, Liao AH
International journal of biological sciences 2022;18(2):599-616
International journal of biological sciences 2022;18(2):599-616
Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.
Luo S, Li Y, Li S, Jiang R, Deng F, Liu G, Zhang J
Frontiers in physiology 2022;13:856427
Frontiers in physiology 2022;13:856427
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.
Ye C, Li H, Li Y, Zhang Y, Liu G, Mi H, Li H, Xiao Q, Niu L, Yu X
iScience 2022 Sep 16;25(9):104872
iScience 2022 Sep 16;25(9):104872
Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.
Cao W, Lei S, Zeng Z, Xiao C, Sun B, Xie P, Li Y, Luo D, Yu W
Bioengineered 2022 May;13(5):13238-13251
Bioengineered 2022 May;13(5):13238-13251
TSH-TSHR axis promotes tumor immune evasion.
Wu Z, Xi Z, Xiao Y, Zhao X, Li J, Feng N, Hu L, Zheng R, Zhang N, Wang S, Huang T
Journal for immunotherapy of cancer 2022 Jan;10(1)
Journal for immunotherapy of cancer 2022 Jan;10(1)
Accumulated ROS Activates HIF-1α-Induced Glycolysis and Exerts a Protective Effect on Sensory Hair Cells Against Noise-Induced Damage.
Liang S, Dong S, Liu W, Wang M, Tian S, Ai Y, Wang H
Frontiers in molecular biosciences 2021;8:806650
Frontiers in molecular biosciences 2021;8:806650
Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2.
Qin X, Chen H, Tu L, Ma Y, Liu N, Zhang H, Li D, Riedl B, Bierer D, Yin F, Li Z
Journal of medicinal chemistry 2021 Sep 23;64(18):13693-13703
Journal of medicinal chemistry 2021 Sep 23;64(18):13693-13703
FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma.
Ruan W, Yang Y, Yu Q, Huang T, Wang Y, Hua L, Zeng Z, Pan R
Cell biology international 2021 Nov;45(11):2275-2286
Cell biology international 2021 Nov;45(11):2275-2286
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T, Gao L
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway.
Liu W, Yuan Y, Liu D
Tissue engineering and regenerative medicine 2021 Dec;18(6):1035-1044
Tissue engineering and regenerative medicine 2021 Dec;18(6):1035-1044
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059
Theranostics 2020;10(26):12044-12059
The CDK4/6 inhibitor PD0332991 stabilizes FBP1 by repressing MAGED1 expression in pancreatic ductal adenocarcinoma.
Zhang B, Li D, Jin X, Zhang K
The international journal of biochemistry & cell biology 2020 Nov;128:105859
The international journal of biochemistry & cell biology 2020 Nov;128:105859
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Li L, Yang L, Fan Z, Xue W, Shen Z, Yuan Y, Sun X, Wang D, Lian J, Wang L, Zhao J, Zhang Y
Signal transduction and targeted therapy 2020 May 22;5(1):54
Signal transduction and targeted therapy 2020 May 22;5(1):54
Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo.
Deng Q, Wei J, Zou P, Xiao Y, Zeng Z, Shi Y, Zhan Y, Zhang H, Tang B, Zeng Q, Xiao R
Oxidative medicine and cellular longevity 2019;2019:2503924
Oxidative medicine and cellular longevity 2019;2019:2503924
Stanniocalcin‑1 promotes cell proliferation, chemoresistance and metastasis in hypoxic gastric cancer cells via Bcl‑2.
Wang Y, Qi Z, Zhou M, Yang W, Hu R, Li G, Ma X, Zhang Z
Oncology reports 2019 Mar;41(3):1998-2008
Oncology reports 2019 Mar;41(3):1998-2008
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