66730-1-Ig

antibody from Proteintech Group

Targeting: HIF1A bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8

Provider product page for 66730-1-Ig

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [51]
Comments [0]
Validations [0]

Submit

Product number: 66730-1-Ig - Provider product page
Provider: Proteintech Group
Product name: HIF1a antibody
Antibody type: Monoclonal
Description: HIF1a antibody (Cat. #66730-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1H3C12
Vial size: 20ul, 150ul

HIF1A protein structure - 66730-1-Ig shown in red.

Submitted references HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis.

You M, Fu M, Shen Z, Feng Y, Zhang L, Zhu X, Zhuang Z, Mao Y, Hua W
Oncoimmunology 2024;13(1):2356942

Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy.

Yang Y, Wang Y, Zeng F, Chen Y, Chen Z, Yan F
Cell reports. Medicine 2024 May 21;5(5):101512

Saturated fatty acids stimulate cytokine production in tanycytes via the PP2Ac-dependent signaling pathway.

Liu D, Wang T, Zhao X, Chen J, Yang T, Shen Y, Zhou YD
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Jun;44(6):985-999

Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.

Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529

Genipin ameliorates diabetic retinopathy via the HIF-1α and AGEs-RAGE pathways.

Sun K, Chen Y, Zheng S, Wan W, Hu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155596

Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.

Fan S, Tan Y, Yuan X, Liu C, Wu X, Dai T, Ni S, Wang J, Weng Y, Zhao H
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452

Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology.

Xu T, He P, namWangdu S, Xu C, Hou B, Ma P, Wang Z, Zhang L, Du G, Ring T, Ji T, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117254

Asiaticoside Down-Regulates HIF-1α to Inhibit Proliferation, Migration, and Angiogenesis in Thyroid Cancer Cells.

Zhang Y, Han Y, Dong J, Li F, Sun Y
Balkan medical journal 2024 Jan 3;41(1):23-29

Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma.

Shi M, Huang K, Wei J, Wang S, Yang W, Wang H, Li Y
International journal of molecular sciences 2024 Jan 14;25(2)

Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia.

Cui Y, Wu S, Liu K, Zhao H, Ma B, Gong L, Zhou Q, Li X
Journal of reproductive immunology 2024 Feb;161:104186

Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation.

Li H, Song C, Zhang Y, Liu G, Mi H, Li Y, Chen Z, Ma X, Zhang P, Cheng L, Peng P, Zhu H, Chen Z, Dong M, Chen S, Meng H, Xiao Q, Li H, Wu Q, Wang B, Zhang S, Shu K, Wan F, Guo D, Zhou W, Zhou L, Mao F, Rich JN, Yu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305620

miR-622 Increases miR-30a Expression through Inhibition of Hypoxia-Inducible Factor 1α to Improve Metastasis and Chemoresistance in Human Invasive Breast Cancer Cells.

Cheng CW, Liu YF, Liao WL, Chen PM, Hung YT, Lee HJ, Cheng YC, Wu PE, Lu YS, Shen CY
Cancers 2024 Feb 3;16(3)

Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury.

Zhang W, Guo C, Li Y, Wang H, Wang H, Wang Y, Wu T, Wang H, Cheng G, Man J, Chen S, Fu S, Yang L
Renal failure 2024 Dec;46(1):2332492

GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.

Liang Y, Zhang H, Li J, Wang X, Xie J, Li Y, Li J, Qian Y, Zhang H, Wang T, Tang H, Chen X
Cell biology international 2024 Apr;48(4):510-520

4D label-free proteomics analysis of oxygen-induced retinopathy with or without anti-VEGF treatment.

Xu Z, Wu Y, Mao J, Chen Y, Chen H, Zhang S, Yu J, Deng X, Shen L
BMC genomics 2024 Apr 26;25(1):415

Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.

Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789

Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer.

Bai X, Xiong J, Li L, Yu C, Sun C
European journal of pharmacology 2024 Apr 15;969:176431

Overexpression of KLF4 Suppresses Pulmonary Fibrosis through the HIF-1α/Endoplasmic Reticulum Stress Signaling Pathway.

Wei S, Qi F, Wu Y, Liu X
International journal of molecular sciences 2023 Sep 12;24(18)

USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.

Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407

FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway.

Xu X, Ye X, Zhu M, Zhang Q, Li X, Yan J
BMC pregnancy and childbirth 2023 Mar 1;23(1):131

RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.

Guo Y, Shen R, Yang K, Wang Y, Song H, Liu X, Cheng X, Wu R, Song Y, Wang D
Cell death discovery 2023 Jun 30;9(1):205

Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes.

Jia Y, Yin C, Ke W, Liu J, Guo B, Wang X, Zhao P, Hu S, Zhang C, Li X, Liu R, Zheng X, Wang Y, Wang G, Pan H, Hu W, Song Z
The Science of the total environment 2023 Jun 20;878:163069

Auto- and paracrine rewiring of NIX-mediated mitophagy by insulin-like growth factor-binding protein 7 in septic AKI escalates inflammation-coupling tubular damage.

Hu BC, Zhu JW, Wu GH, Cai JJ, Yang X, Shao ZQ, Zheng Y, Lai JM, Shen Y, Yang XH, Liu JQ, Sun RH, Zhu HP, Ye XM, Mo SJ
Life sciences 2023 Jun 1;322:121653

Bifidobacterium infantis-Mediated Herpes Simplex Virus-TK/Ganciclovir Treatment Inhibits Cancer Metastasis in Mouse Model.

Wang C, Shen Y, Ma Y
International journal of molecular sciences 2023 Jul 21;24(14)

Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis.

Li Y, Yang W, Zheng Y, Dai W, Ji J, Wu L, Cheng Z, Zhang J, Li J, Xu X, Wu J, Yang M, Feng J, Guo C
Journal of experimental & clinical cancer research : CR 2023 Jan 6;42(1):6

Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma.

Chen L, Kong Q, Tian M, Zhang Q, Xia C, Deng C
Nanoscale advances 2023 Jan 31;5(3):851-860

Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer.

Ma B, Wen S, Luo Y, Zhang T, Yang Y, Shen C, Zhang Y, Ji Q, Qu N, Wang Y
The Journal of clinical endocrinology and metabolism 2023 Jan 17;108(2):368-384

ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma.

Shi Y, Shang J, Li Y, Zhong D, Zhang Z, Yang Q, Lai C, Feng T, Yao Y, Huang X
Cancer medicine 2023 Feb;12(3):3786-3796

Gelatin methacryloyl (GelMA) loaded with concentrated hypoxic pretreated adipose-derived mesenchymal stem cells(ADSCs) conditioned medium promotes wound healing and vascular regeneration in aged skin.

Li S, Sun J, Yang J, Yang Y, Ding H, Yu B, Ma K, Chen M
Biomaterials research 2023 Feb 13;27(1):11

The mechanisms of Huangqi Guizhi Wuwu decoction in treating ischaemic stroke based on network pharmacology and experiment verification.

Liao W, Wang M, Wu Y, Du J, Li Y, Su A, Zhong L, Xie Z, Gong M, Liang J, Wang P, Liu Z, Wang L
Pharmaceutical biology 2023 Dec;61(1):1014-1029

RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.

Yang Q, Meng X, Chen J, Li X, Huang Y, Xiao X, Li R, Wu X
Cell death discovery 2023 Dec 5;9(1):440

Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased inflammatory cellular reaction.

Höfner M, Eubler K, Herrmann C, Berg U, Berg D, Welter H, Imhof A, Forné I, Mayerhofer A
Molecular human reproduction 2023 Dec 24;30(1)

Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression.

Zhou L, Luo Y, Liu Y, Zeng Y, Tong J, Li M, Hou Y, Du K, Qi Y, Pan W, Liu Y, Wang R, Tian F, Gu C, Chen K
Cancer research 2023 Dec 1;83(23):3920-3939

IGFL2-AS1-induced suppression of HIF-1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9.

Qin M, Liu Q, Yang W, Wang Q, Xiang Z
Cancer medicine 2023 Apr;12(7):8415-8432

Chitosan Oligosaccharides Alleviate H(2)O(2)-stimulated Granulosa Cell Damage via HIF-1α Signaling Pathway.

Yang Z, Hong W, Zheng K, Feng J, Hu C, Tan J, Zhong Z, Zheng Y
Oxidative medicine and cellular longevity 2022;2022:4247042

Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy.

Gao L, Xu QH, Ma LN, Luo J, Muyayalo KP, Wang LL, Huang DH, Xiao XJ, Cheng SB, Mor G, Liao AH
International journal of biological sciences 2022;18(2):599-616

Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.

Luo S, Li Y, Li S, Jiang R, Deng F, Liu G, Zhang J
Frontiers in physiology 2022;13:856427

Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.

Ye C, Li H, Li Y, Zhang Y, Liu G, Mi H, Li H, Xiao Q, Niu L, Yu X
iScience 2022 Sep 16;25(9):104872

Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.

Cao W, Lei S, Zeng Z, Xiao C, Sun B, Xie P, Li Y, Luo D, Yu W
Bioengineered 2022 May;13(5):13238-13251

TSH-TSHR axis promotes tumor immune evasion.

Wu Z, Xi Z, Xiao Y, Zhao X, Li J, Feng N, Hu L, Zheng R, Zhang N, Wang S, Huang T
Journal for immunotherapy of cancer 2022 Jan;10(1)

Accumulated ROS Activates HIF-1α-Induced Glycolysis and Exerts a Protective Effect on Sensory Hair Cells Against Noise-Induced Damage.

Liang S, Dong S, Liu W, Wang M, Tian S, Ai Y, Wang H
Frontiers in molecular biosciences 2021;8:806650

Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2.

Qin X, Chen H, Tu L, Ma Y, Liu N, Zhang H, Li D, Riedl B, Bierer D, Yin F, Li Z
Journal of medicinal chemistry 2021 Sep 23;64(18):13693-13703

FUT11 is a target gene of HIF1α that promotes the progression of hepatocellular carcinoma.

Ruan W, Yang Y, Yu Q, Huang T, Wang Y, Hua L, Zeng Z, Pan R
Cell biology international 2021 Nov;45(11):2275-2286

Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.

Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)

CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.

Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T, Gao L
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway.

Liu W, Yuan Y, Liu D
Tissue engineering and regenerative medicine 2021 Dec;18(6):1035-1044

ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.

Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059

The CDK4/6 inhibitor PD0332991 stabilizes FBP1 by repressing MAGED1 expression in pancreatic ductal adenocarcinoma.

Zhang B, Li D, Jin X, Zhang K
The international journal of biochemistry & cell biology 2020 Nov;128:105859

Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.

Li L, Yang L, Fan Z, Xue W, Shen Z, Yuan Y, Sun X, Wang D, Lian J, Wang L, Zhao J, Zhang Y
Signal transduction and targeted therapy 2020 May 22;5(1):54

Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo.

Deng Q, Wei J, Zou P, Xiao Y, Zeng Z, Shi Y, Zhan Y, Zhang H, Tang B, Zeng Q, Xiao R
Oxidative medicine and cellular longevity 2019;2019:2503924

Stanniocalcin‑1 promotes cell proliferation, chemoresistance and metastasis in hypoxic gastric cancer cells via Bcl‑2.

Wang Y, Qi Z, Zhou M, Yang W, Hu R, Li G, Ma X, Zhang Z
Oncology reports 2019 Mar;41(3):1998-2008

No comments: Submit comment

No validations: Submit validation data