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antibody from antibodies-online
Targeting: HIF1A
bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
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Immunocytochemistry Immunoprecipitation Immunohistochemistry
Gel shift Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [130]
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- Validations
- Western blot [4]
- Immunoprecipitation [1]
- Immunohistochemistry [4]
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- Product number
- ABIN151066 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (Internal Region) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Canine, Guinea Pig, Simian, Xenopus, Zebrafish
- Host
- Rabbit
- Epitope
- Internal Region
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma.
Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity.
Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.
Endothelial cells co-cultured with renal carcinoma cells significantly reduce RECK expression under chemical hypoxia.
Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.
A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea.
Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.
Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.
Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects.
Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis.
MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.
Yi Ai Fang, a traditional Chinese herbal formula, impacts the vasculogenic mimicry formation of human colorectal cancer through HIF-1α and epithelial mesenchymal transition.
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors.
Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis.
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.
Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia.
Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2.
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.
Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis.
Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model.
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation.
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model.
Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model.
Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress.
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.
Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma.
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.
Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells.
Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.
MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation.
Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
Intrauterine ischemic reperfusion switches the fetal transcriptional pattern from HIF-1α- to P53-dependent regulation in the murine brain.
Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function.
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.
Bcl-6 directly represses the gene program of the glycolysis pathway.
Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation.
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
Abcc9 is required for the transition to oxidative metabolism in the newborn heart.
Glucose transporter 1 expression accompanies hypoxia sensing in the cyclic canine corpus luteum.
Screening for possible miRNA-mRNA associations in a colon cancer cell line.
PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina.
Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.
STAT3 or USF2 contributes to HIF target gene specificity.
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.
Fundamental role for HIF-1α in constitutive expression of human β defensin-1.
Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells.
Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL.
The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury.
Multiple microvascular alterations in pancreatic islets and neuroendocrine tumors of a Men1 mouse model.
Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma.
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.
Hypoxia preconditioning enhances the viability of ADSCs to increase the survival rate of ischemic skin flaps in rats.
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.
Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis.
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target.
Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer.
Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells.
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice.
Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice.
2-Hydroxyestradiol slows progression of experimental polycystic kidney disease.
Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia.
Effects of dietary ratio of n-6 to n-3 polyunsaturated fatty acids on immunoglobulins, cytokines, fatty acid composition, and performance of lactating sows and suckling piglets.
Early genetic responses in rat vascular tissue after simulated diving.
Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.
Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia.
Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.
Anti-VEGF antibody treatment accelerates polycystic kidney disease.
Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways.
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors.
Adipose-derived stem cells accelerate neovascularization in ischaemic diabetic skin flap via expression of hypoxia-inducible factor-1α.
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Uremia aggravates left ventricular remodeling after myocardial infarction.
Relationship between urinary sodium excretion and pioglitazone-induced edema.
Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing.
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis.
Partial pulmonary embolization disrupts alveolarization in fetal sheep.
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia.
Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression.
Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance.
Adaptive response of the heart to long-term anemia induced by iron deficiency.
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells.
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.
Population origin, development and temperature of development affect the amounts of HSP70, HSP90 and the putative hypoxia-inducible factor in the tadpoles of the common frog Rana temporaria.
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Placental HIFs as markers of cerebral hypoxic distress in fetal mice.
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.
Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells.
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements.
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.
The neurohormone orexin stimulates hypoxia-inducible factor-1 activity.
Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine.
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.
VEGF receptor inhibition slows the progression of polycystic kidney disease.
Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha.
Differentiation arrest by hypoxia.
Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury.
Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells.
Dynamic HIF1A regulation during human placental development.
Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression.
Redox regulation of lung development and perinatal lung epithelial function.
Hypoxic preconditioning of cardiomyocytes and cardioprotection: phophorylation of HIF-1alpha induced by p42/p44 mitogen-activated protein kinases is involved.
LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen.
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain.
Eriksson JA, Wanka C, Burger MC, Urban H, Hartel I, von Renesse J, Harter PN, Mittelbronn M, Steinbach JP, Rieger J
Journal of neurochemistry 2018 Feb;144(4):421-430
Journal of neurochemistry 2018 Feb;144(4):421-430
Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity.
Li D, Du Y, Yuan X, Han X, Dong Z, Chen X, Wu H, Zhang J, Xu L, Han C, Zhang M, Xia Q
Free radical biology & medicine 2017 Sep;110:102-116
Free radical biology & medicine 2017 Sep;110:102-116
Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.
Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ
Oncogenesis 2017 Jan 16;6(1):e287
Oncogenesis 2017 Jan 16;6(1):e287
Endothelial cells co-cultured with renal carcinoma cells significantly reduce RECK expression under chemical hypoxia.
Zhang X, Liu L, Liu J, Cheng Z, Wang Z, Shi C, Ding F, Chen S, Chen P
Cell biology international 2017 Aug;41(8):922-927
Cell biology international 2017 Aug;41(8):922-927
Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia.
Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M
Physiological reports 2017 Apr;5(8)
Physiological reports 2017 Apr;5(8)
A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea.
Campillo N, Jorba I, Schaedel L, Casals B, Gozal D, Farré R, Almendros I, Navajas D
Frontiers in physiology 2016;7:319
Frontiers in physiology 2016;7:319
Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.
Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, Aburatani H
American journal of nephrology 2016;44(4):276-285
American journal of nephrology 2016;44(4):276-285
Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.
Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC
PloS one 2016;11(5):e0154309
PloS one 2016;11(5):e0154309
Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects.
Kowitzke B, Cohrs G, Leuschner I, Koch A, Synowitz M, Mehdorn HM, Held-Feindt J, Knerlich-Lukoschus F
Journal of neuropathology and experimental neurology 2016 Sep;75(9):827-42
Journal of neuropathology and experimental neurology 2016 Sep;75(9):827-42
Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis.
Jang JE, Ko MS, Yun JY, Kim MO, Kim JH, Park HS, Kim AR, Kim HJ, Kim BJ, Ahn YE, Oh JS, Lee WJ, Harris RA, Koh EH, Lee KU
Diabetes 2016 Sep;65(9):2516-28
Diabetes 2016 Sep;65(9):2516-28
MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.
Sullivan AE, Peet DJ, Whitelaw ML
The FEBS journal 2016 Sep;283(18):3488-502
The FEBS journal 2016 Sep;283(18):3488-502
Yi Ai Fang, a traditional Chinese herbal formula, impacts the vasculogenic mimicry formation of human colorectal cancer through HIF-1α and epithelial mesenchymal transition.
Hou F, Li W, Shi Q, Li H, Liu S, Zong S, Ren J, Chai J, Xu J
BMC complementary and alternative medicine 2016 Nov 2;16(1):428
BMC complementary and alternative medicine 2016 Nov 2;16(1):428
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Nature communications 2016 May 18;7:11635
Nature communications 2016 May 18;7:11635
Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Hung YH, Chang SH, Huang CT, Yin JH, Hwang CS, Yang LY, Yang DI
Molecular neurobiology 2016 Mar;53(2):793-809
Molecular neurobiology 2016 Mar;53(2):793-809
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA
Cancer research 2016 Mar 15;76(6):1653-63
Cancer research 2016 Mar 15;76(6):1653-63
Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors.
Salvi V, Vermi W, Gianello V, Lonardi S, Gagliostro V, Naldini A, Sozzani S, Bosisio D
Oncotarget 2016 Jun 28;7(26):39256-39269
Oncotarget 2016 Jun 28;7(26):39256-39269
Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis.
Spitzbarth I, Lempp C, Kegler K, Ulrich R, Kalkuhl A, Deschl U, Baumgärtner W, Seehusen F
Brain and behavior 2016 Jul;6(7):e00472
Brain and behavior 2016 Jul;6(7):e00472
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Zhang J, Han C, Dai H, Hou J, Dong Y, Cui X, Xu L, Zhang M, Xia Q
Journal of the American Society of Nephrology : JASN 2016 Jan;27(1):92-106
Journal of the American Society of Nephrology : JASN 2016 Jan;27(1):92-106
Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.
Cheng S, Xing W, Pourteymoor S, Schulte J, Mohan S
Endocrinology 2016 Jan;157(1):127-40
Endocrinology 2016 Jan;157(1):127-40
Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia.
Song M, Liu T, Shi C, Zhang X, Chen X
ACS nano 2016 Jan 26;10(1):633-647
ACS nano 2016 Jan 26;10(1):633-647
Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2.
de Jong OG, van Balkom BW, Gremmels H, Verhaar MC
Journal of cellular and molecular medicine 2016 Feb;20(2):342-50
Journal of cellular and molecular medicine 2016 Feb;20(2):342-50
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L
Nature cell biology 2016 Feb;18(2):213-24
Nature cell biology 2016 Feb;18(2):213-24
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.
Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA
Scientific reports 2016 Feb 10;6:21520
Scientific reports 2016 Feb 10;6:21520
Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis.
Mammadzada P, Gudmundsson J, Kvanta A, André H
Acta ophthalmologica 2016 Dec;94(8):805-814
Acta ophthalmologica 2016 Dec;94(8):805-814
Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model.
Hoang NT, Kadonosono T, Kuchimaru T, Kizaka-Kondoh S
Cancer science 2016 Aug;107(8):1151-8
Cancer science 2016 Aug;107(8):1151-8
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE
Nature medicine 2016 Apr;22(4):439-45
Nature medicine 2016 Apr;22(4):439-45
Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation.
Park IS, Chung PS, Ahn JC
PloS one 2015;10(6):e0122776
PloS one 2015;10(6):e0122776
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model.
Chen X, Liu J, He B, Li Y, Liu S, Wu B, Wang S, Zhang S, Xu X, Wang J
Human reproduction (Oxford, England) 2015 Sep;30(9):2160-70
Human reproduction (Oxford, England) 2015 Sep;30(9):2160-70
Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model.
André H, Tunik S, Aronsson M, Kvanta A
Investigative ophthalmology & visual science 2015 Oct;56(11):6591-604
Investigative ophthalmology & visual science 2015 Oct;56(11):6591-604
Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, Powell RJ, Engler GA, Diakiw SM, Zannettino AC, Martin S, Pattabiraman D, D'Andrea RJ, Lewis ID, Levesque JP
Leukemia 2015 Oct;29(10):2075-85
Leukemia 2015 Oct;29(10):2075-85
NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress.
Chen PJ, Weng JY, Hsu PH, Shew JY, Huang YS, Lee WH
Nucleic acids research 2015 Oct 30;43(19):9393-404
Nucleic acids research 2015 Oct 30;43(19):9393-404
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Koh HS, Chang CY, Jeon SB, Yoon HJ, Ahn YH, Kim HS, Kim IH, Jeon SH, Johnson RS, Park EJ
Nature communications 2015 Mar 20;6:6340
Nature communications 2015 Mar 20;6:6340
HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.
Saeedi BJ, Kao DJ, Kitzenberg DA, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE
Molecular biology of the cell 2015 Jun 15;26(12):2252-62
Molecular biology of the cell 2015 Jun 15;26(12):2252-62
Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma.
García LN, Leimgruber C, Uribe Echevarría EM, Acosta PL, Brahamian JM, Polack FP, Miró MS, Quintar AA, Sotomayor CE, Maldonado CA
Experimental biology and medicine (Maywood, N.J.) 2015 Jul;240(7):904-16
Experimental biology and medicine (Maywood, N.J.) 2015 Jul;240(7):904-16
Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
Obama T, Takayanagi T, Kobayashi T, Bourne AM, Elliott KJ, Charbonneau M, Dubois CM, Eguchi S
American journal of hypertension 2015 Jan;28(1):10-4
American journal of hypertension 2015 Jan;28(1):10-4
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.
Highet AR, Khoda SM, Buckberry S, Leemaqz S, Bianco-Miotto T, Harrington E, Ricciardelli C, Roberts CT
European journal of cell biology 2015 Dec;94(12):589-602
European journal of cell biology 2015 Dec;94(12):589-602
Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells.
Wang J, Ding N, Li Y, Cheng H, Wang D, Yang Q, Deng Y, Yang Y, Li Y, Ruan X, Xie F, Zhao H, Fang X
Oncotarget 2015 Aug 21;6(24):20636-49
Oncotarget 2015 Aug 21;6(24):20636-49
Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.
Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN
Kidney international 2015 Apr;87(4):761-70
Kidney international 2015 Apr;87(4):761-70
MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation.
Sun KT, Chen MY, Tu MG, Wang IK, Chang SS, Li CY
Bone 2015 Apr;73:145-53
Bone 2015 Apr;73:145-53
Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.
Wang C, Cai Y, Zhang Y, Xiong Z, Li G, Cui L
PloS one 2014;9(6):e100818
PloS one 2014;9(6):e100818
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
Robertson ED, Wasylyk C, Ye T, Jung AC, Wasylyk B
PloS one 2014;9(11):e113050
PloS one 2014;9(11):e113050
Intrauterine ischemic reperfusion switches the fetal transcriptional pattern from HIF-1α- to P53-dependent regulation in the murine brain.
Dong Y, Ito T, Velayo C, Sato T, Iida K, Endo M, Funamoto K, Sato N, Yaegashi N, Kimura Y
PloS one 2014;9(10):e110577
PloS one 2014;9(10):e110577
Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function.
Neary MT, Ng KE, Ludtmann MH, Hall AR, Piotrowska I, Ong SB, Hausenloy DJ, Mohun TJ, Abramov AY, Breckenridge RA
Journal of molecular and cellular cardiology 2014 Sep;74:340-52
Journal of molecular and cellular cardiology 2014 Sep;74:340-52
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I, Simon MC
Nature 2014 Sep 11;513(7517):251-5
Nature 2014 Sep 11;513(7517):251-5
KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.
Li X, Liu X, Xu Y, Liu J, Xie M, Ni W, Chen S
International journal of oncology 2014 Oct;45(4):1507-14
International journal of oncology 2014 Oct;45(4):1507-14
Bcl-6 directly represses the gene program of the glycolysis pathway.
Oestreich KJ, Read KA, Gilbertson SE, Hough KP, McDonald PW, Krishnamoorthy V, Weinmann AS
Nature immunology 2014 Oct;15(10):957-64
Nature immunology 2014 Oct;15(10):957-64
Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.
Takeda K, Duan LJ, Takeda H, Fong GH
The American journal of pathology 2014 Mar;184(3):686-96
The American journal of pathology 2014 Mar;184(3):686-96
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Pawlus MR, Wang L, Hu CJ
Oncogene 2014 Mar 27;33(13):1670-9
Oncogene 2014 Mar 27;33(13):1670-9
Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation.
Ganapathy S, Xiao S, Seo SJ, Lall R, Yang M, Xu T, Su H, Shadfan M, Ha CS, Yuan ZM
Oncogene 2014 Mar 13;33(11):1359-66
Oncogene 2014 Mar 13;33(11):1359-66
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
Zecchini V, Madhu B, Russell R, Pértega-Gomes N, Warren A, Gaude E, Borlido J, Stark R, Ireland-Zecchini H, Rao R, Scott H, Boren J, Massie C, Asim M, Brindle K, Griffiths J, Frezza C, Neal DE, Mills IG
The EMBO journal 2014 Jun 17;33(12):1365-82
The EMBO journal 2014 Jun 17;33(12):1365-82
Abcc9 is required for the transition to oxidative metabolism in the newborn heart.
Fahrenbach JP, Stoller D, Kim G, Aggarwal N, Yerokun B, Earley JU, Hadhazy M, Shi NQ, Makielski JC, McNally EM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jul;28(7):2804-15
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jul;28(7):2804-15
Glucose transporter 1 expression accompanies hypoxia sensing in the cyclic canine corpus luteum.
Papa Pde C, Sousa LM, Silva Rdos S, de Fátima LA, da Fonseca VU, do Amaral VC, Hoffmann B, Alves-Wagner AB, Machado UF, Kowalewski MP
Reproduction (Cambridge, England) 2014 Jan;147(1):81-9
Reproduction (Cambridge, England) 2014 Jan;147(1):81-9
Screening for possible miRNA-mRNA associations in a colon cancer cell line.
Kanematsu S, Tanimoto K, Suzuki Y, Sugano S
Gene 2014 Jan 10;533(2):520-31
Gene 2014 Jan 10;533(2):520-31
PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina.
Guo X, Dason ES, Zanon-Moreno V, Jiang Q, Nahirnyj A, Chan D, Flanagan JG, Sivak JM
The American journal of pathology 2014 Apr;184(4):1017-1029
The American journal of pathology 2014 Apr;184(4):1017-1029
Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.
Prasad P, Gordijo CR, Abbasi AZ, Maeda A, Ip A, Rauth AM, DaCosta RS, Wu XY
ACS nano 2014 Apr 22;8(4):3202-12
ACS nano 2014 Apr 22;8(4):3202-12
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP
Cancer cell 2014 Apr 14;25(4):455-68
Cancer cell 2014 Apr 14;25(4):455-68
Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.
Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro J, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y
Genome biology 2014 Apr 10;15(4):R63
Genome biology 2014 Apr 10;15(4):R63
STAT3 or USF2 contributes to HIF target gene specificity.
Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ
PloS one 2013;8(8):e72358
PloS one 2013;8(8):e72358
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA
Cancer research 2013 Sep 15;73(18):5810-20
Cancer research 2013 Sep 15;73(18):5810-20
BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.
Sena JA, Wang L, Hu CJ
Molecular and cellular biology 2013 Oct;33(19):3849-63
Molecular and cellular biology 2013 Oct;33(19):3849-63
Fundamental role for HIF-1α in constitutive expression of human β defensin-1.
Kelly CJ, Glover LE, Campbell EL, Kominsky DJ, Ehrentraut SF, Bowers BE, Bayless AJ, Saeedi BJ, Colgan SP
Mucosal immunology 2013 Nov;6(6):1110-8
Mucosal immunology 2013 Nov;6(6):1110-8
Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells.
Tadokoro H, Umezu T, Ohyashiki K, Hirano T, Ohyashiki JH
The Journal of biological chemistry 2013 Nov 29;288(48):34343-51
The Journal of biological chemistry 2013 Nov 29;288(48):34343-51
Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL.
Hernandez-Luna MA, Rocha-Zavaleta L, Vega MI, Huerta-Yepez S
Leukemia & lymphoma 2013 May;54(5):1048-55
Leukemia & lymphoma 2013 May;54(5):1048-55
The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury.
Enzmann G, Mysiorek C, Gorina R, Cheng YJ, Ghavampour S, Hannocks MJ, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L
Acta neuropathologica 2013 Mar;125(3):395-412
Acta neuropathologica 2013 Mar;125(3):395-412
Multiple microvascular alterations in pancreatic islets and neuroendocrine tumors of a Men1 mouse model.
Chu X, Gao X, Jansson L, Quach M, Skogseid B, Barbu A
The American journal of pathology 2013 Jun;182(6):2355-67
The American journal of pathology 2013 Jun;182(6):2355-67
Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma.
Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M
The American journal of pathology 2013 Jun;182(6):2191-203
The American journal of pathology 2013 Jun;182(6):2191-203
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Carbajo-Pescador S, Ordoñez R, Benet M, Jover R, García-Palomo A, Mauriz JL, González-Gallego J
British journal of cancer 2013 Jul 9;109(1):83-91
British journal of cancer 2013 Jul 9;109(1):83-91
Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.
Forristal CE, Winkler IG, Nowlan B, Barbier V, Walkinshaw G, Levesque JP
Blood 2013 Jan 31;121(5):759-69
Blood 2013 Jan 31;121(5):759-69
Hypoxia preconditioning enhances the viability of ADSCs to increase the survival rate of ischemic skin flaps in rats.
Yue Y, Zhang P, Liu D, Yang JF, Nie C, Yang D
Aesthetic plastic surgery 2013 Feb;37(1):159-70
Aesthetic plastic surgery 2013 Feb;37(1):159-70
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.
Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R
American journal of physiology. Cell physiology 2013 Feb 15;304(4):C342-53
American journal of physiology. Cell physiology 2013 Feb 15;304(4):C342-53
Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis.
Glover LE, Bowers BE, Saeedi B, Ehrentraut SF, Campbell EL, Bayless AJ, Dobrinskikh E, Kendrick AA, Kelly CJ, Burgess A, Miller L, Kominsky DJ, Jedlicka P, Colgan SP
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):19820-5
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):19820-5
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.
Bett JS, Ibrahim AF, Garg AK, Kelly V, Pedrioli P, Rocha S, Hay RT
The Biochemical journal 2013 Apr 15;451(2):185-94
The Biochemical journal 2013 Apr 15;451(2):185-94
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target.
Aguado-Fraile E, Ramos E, Sáenz-Morales D, Conde E, Blanco-Sánchez I, Stamatakis K, del Peso L, Cuppen E, Brüne B, Bermejo ML
PloS one 2012;7(9):e44305
PloS one 2012;7(9):e44305
Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer.
Tuomela J, Sandholm J, Karihtala P, Ilvesaro J, Vuopala KS, Kauppila JH, Kauppila S, Chen D, Pressey C, Härkönen P, Harris KW, Graves D, Auvinen PK, Soini Y, Jukkola-Vuorinen A, Selander KS
Breast cancer research and treatment 2012 Sep;135(2):481-93
Breast cancer research and treatment 2012 Sep;135(2):481-93
Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells.
Vakili H, Jin Y, Cattini PA
The Journal of biological chemistry 2012 Sep 28;287(40):33282-92
The Journal of biological chemistry 2012 Sep 28;287(40):33282-92
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 9;109(41):E2784-93
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 9;109(41):E2784-93
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Pawlus MR, Wang L, Ware K, Hu CJ
Molecular and cellular biology 2012 Nov;32(22):4595-610
Molecular and cellular biology 2012 Nov;32(22):4595-610
Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice.
Copple BL, Kaska S, Wentling C
The Journal of pharmacology and experimental therapeutics 2012 May;341(2):307-16
The Journal of pharmacology and experimental therapeutics 2012 May;341(2):307-16
Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice.
Rennie MY, Detmar J, Whiteley KJ, Jurisicova A, Adamson SL, Sled JG
American journal of physiology. Heart and circulatory physiology 2012 Mar 15;302(6):H1261-73
American journal of physiology. Heart and circulatory physiology 2012 Mar 15;302(6):H1261-73
2-Hydroxyestradiol slows progression of experimental polycystic kidney disease.
Anderson S, Oyama TT, Lindsley JN, Schutzer WE, Beard DR, Gattone VH 2nd, Komers R
American journal of physiology. Renal physiology 2012 Mar 1;302(5):F636-45
American journal of physiology. Renal physiology 2012 Mar 1;302(5):F636-45
Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia.
Bansal A, Harris RA, DeGrado TR
Journal of lipid research 2012 Jan;53(1):149-57
Journal of lipid research 2012 Jan;53(1):149-57
Effects of dietary ratio of n-6 to n-3 polyunsaturated fatty acids on immunoglobulins, cytokines, fatty acid composition, and performance of lactating sows and suckling piglets.
Yao W, Li J, Wang JJ, Zhou W, Wang Q, Zhu R, Wang F, Thacker P
Journal of animal science and biotechnology 2012 Dec 27;3(1):43
Journal of animal science and biotechnology 2012 Dec 27;3(1):43
Early genetic responses in rat vascular tissue after simulated diving.
Eftedal I, Jørgensen A, Røsbjørgen R, Flatberg A, Brubakk AO
Physiological genomics 2012 Dec 18;44(24):1201-7
Physiological genomics 2012 Dec 18;44(24):1201-7
Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.
Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y
Molecular and cellular biology 2012 Aug;32(15):3018-32
Molecular and cellular biology 2012 Aug;32(15):3018-32
Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia.
Morote-Garcia JC, Napiwotzky D, Köhler D, Rosenberger P
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14146-51
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14146-51
Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.
Edrey YH, Casper D, Huchon D, Mele J, Gelfond JA, Kristan DM, Nevo E, Buffenstein R
Aging cell 2012 Apr;11(2):213-22
Aging cell 2012 Apr;11(2):213-22
Anti-VEGF antibody treatment accelerates polycystic kidney disease.
Raina S, Honer M, Krämer SD, Liu Y, Wang X, Segerer S, Wüthrich RP, Serra AL
American journal of physiology. Renal physiology 2011 Oct;301(4):F773-83
American journal of physiology. Renal physiology 2011 Oct;301(4):F773-83
Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways.
Ravichandran K, Tyagi A, Deep G, Agarwal C, Agarwal R
Indian journal of experimental biology 2011 Nov;49(11):840-7
Indian journal of experimental biology 2011 Nov;49(11):840-7
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Farrow EG, Yu X, Summers LJ, Davis SI, Fleet JC, Allen MR, Robling AG, Stayrook KR, Jideonwo V, Magers MJ, Garringer HJ, Vidal R, Chan RJ, Goodwin CB, Hui SL, Peacock M, White KE
Proceedings of the National Academy of Sciences of the United States of America 2011 Nov 15;108(46):E1146-55
Proceedings of the National Academy of Sciences of the United States of America 2011 Nov 15;108(46):E1146-55
Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Belibi F, Zafar I, Ravichandran K, Segvic AB, Jani A, Ljubanovic DG, Edelstein CL
American journal of physiology. Renal physiology 2011 May;300(5):F1235-43
American journal of physiology. Renal physiology 2011 May;300(5):F1235-43
Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors.
Erman A, Wabitsch M, Goodyer CG
International journal of obesity (2005) 2011 Dec;35(12):1520-9
International journal of obesity (2005) 2011 Dec;35(12):1520-9
Adipose-derived stem cells accelerate neovascularization in ischaemic diabetic skin flap via expression of hypoxia-inducible factor-1α.
Gao W, Qiao X, Ma S, Cui L
Journal of cellular and molecular medicine 2011 Dec;15(12):2575-85
Journal of cellular and molecular medicine 2011 Dec;15(12):2575-85
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T
Molecular cancer research : MCR 2011 Aug;9(8):1100-11
Molecular cancer research : MCR 2011 Aug;9(8):1100-11
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW
Autophagy 2011 Aug;7(8):829-39
Autophagy 2011 Aug;7(8):829-39
Uremia aggravates left ventricular remodeling after myocardial infarction.
Dikow R, Schmidt U, Kihm LP, Schaier M, Schwenger V, Gross ML, Katus HA, Zeier M, Hardt SE
American journal of nephrology 2010;32(1):13-22
American journal of nephrology 2010;32(1):13-22
Relationship between urinary sodium excretion and pioglitazone-induced edema.
Nakamura A, Osonoi T, Terauchi Y
Journal of diabetes investigation 2010 Oct 19;1(5):208-11
Journal of diabetes investigation 2010 Oct 19;1(5):208-11
Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing.
Tanimoto K, Tsuchihara K, Kanai A, Arauchi T, Esumi H, Suzuki Y, Sugano S
The HUGO journal 2010 Dec;4(1-4):35-48
The HUGO journal 2010 Dec;4(1-4):35-48
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis.
Gubin MM, Calaluce R, Davis JW, Magee JD, Strouse CS, Shaw DP, Ma L, Brown A, Hoffman T, Rold TL, Atasoy U
Cell cycle (Georgetown, Tex.) 2010 Aug 15;9(16):3337-46
Cell cycle (Georgetown, Tex.) 2010 Aug 15;9(16):3337-46
Partial pulmonary embolization disrupts alveolarization in fetal sheep.
Filby CE, Hooper SB, Wallace MJ
Respiratory research 2010 Apr 23;11:42
Respiratory research 2010 Apr 23;11:42
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia.
Xia X, Kung AL
Genome biology 2009;10(10):R113
Genome biology 2009;10(10):R113
Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression.
Legendre C, Hori T, Loyer P, Aninat C, Ishida S, Glaise D, Lucas-Clerc C, Boudjema K, Guguen-Guillouzo C, Corlu A, Morel F
European journal of cancer (Oxford, England : 1990) 2009 Nov;45(16):2882-92
European journal of cancer (Oxford, England : 1990) 2009 Nov;45(16):2882-92
Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance.
Frede S, Stockmann C, Winning S, Freitag P, Fandrey J
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6470-6
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6470-6
Adaptive response of the heart to long-term anemia induced by iron deficiency.
Naito Y, Tsujino T, Matsumoto M, Sakoda T, Ohyanagi M, Masuyama T
American journal of physiology. Heart and circulatory physiology 2009 Mar;296(3):H585-93
American journal of physiology. Heart and circulatory physiology 2009 Mar;296(3):H585-93
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.
Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M
Circulation research 2009 Apr 10;104(7):879-86
Circulation research 2009 Apr 10;104(7):879-86
A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells.
Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, Lago TG, Honigman A
Molecular cancer research : MCR 2008 Sep;6(9):1397-409
Molecular cancer research : MCR 2008 Sep;6(9):1397-409
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.
Westfall SD, Sachdev S, Das P, Hearne LB, Hannink M, Roberts RM, Ezashi T
Stem cells and development 2008 Oct;17(5):869-81
Stem cells and development 2008 Oct;17(5):869-81
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.
Singh RP, Gu M, Agarwal R
Cancer research 2008 Mar 15;68(6):2043-50
Cancer research 2008 Mar 15;68(6):2043-50
Population origin, development and temperature of development affect the amounts of HSP70, HSP90 and the putative hypoxia-inducible factor in the tadpoles of the common frog Rana temporaria.
Nikinmaa M, Leveelahti L, Dahl E, Rissanen E, Rytkönen KT, Laurila A
The Journal of experimental biology 2008 Jun;211(Pt 12):1999-2004
The Journal of experimental biology 2008 Jun;211(Pt 12):1999-2004
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE
Molecular pharmacology 2008 Jul;74(1):282-8
Molecular pharmacology 2008 Jul;74(1):282-8
Placental HIFs as markers of cerebral hypoxic distress in fetal mice.
Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dötsch J, Rascher W, Gassmann M
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Dec;295(6):R1973-81
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Dec;295(6):R1973-81
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.
Botusan IR, Sunkari VG, Savu O, Catrina AI, Grünler J, Lindberg S, Pereira T, Ylä-Herttuala S, Poellinger L, Brismar K, Catrina SB
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 9;105(49):19426-31
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 9;105(49):19426-31
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.
Ohtomo S, Nangaku M, Izuhara Y, Takizawa S, Strihou Cv, Miyata T
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Apr;23(4):1166-72
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Apr;23(4):1166-72
Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells.
Piantadosi CA, Suliman HB
The Journal of biological chemistry 2008 Apr 18;283(16):10967-77
The Journal of biological chemistry 2008 Apr 18;283(16):10967-77
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL
The Journal of biological chemistry 2008 Apr 18;283(16):10892-903
The Journal of biological chemistry 2008 Apr 18;283(16):10892-903
Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements.
Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM
American journal of respiratory cell and molecular biology 2007 Sep;37(3):273-90
American journal of respiratory cell and molecular biology 2007 Sep;37(3):273-90
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV
Molecular and cellular biology 2007 Nov;27(21):7381-93
Molecular and cellular biology 2007 Nov;27(21):7381-93
The neurohormone orexin stimulates hypoxia-inducible factor-1 activity.
Sikder D, Kodadek T
Genes & development 2007 Nov 15;21(22):2995-3005
Genes & development 2007 Nov 15;21(22):2995-3005
Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine.
Harvey AJ, Kind KL, Thompson JG
Biology of reproduction 2007 Jul;77(1):93-101
Biology of reproduction 2007 Jul;77(1):93-101
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.
Liao D, Corle C, Seagroves TN, Johnson RS
Cancer research 2007 Jan 15;67(2):563-72
Cancer research 2007 Jan 15;67(2):563-72
VEGF receptor inhibition slows the progression of polycystic kidney disease.
Tao Y, Kim J, Yin Y, Zafar I, Falk S, He Z, Faubel S, Schrier RW, Edelstein CL
Kidney international 2007 Dec;72(11):1358-66
Kidney international 2007 Dec;72(11):1358-66
Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha.
Pfäfflin A, Brodbeck K, Heilig CW, Häring HU, Schleicher ED, Weigert C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;18(4-5):199-210
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;18(4-5):199-210
Differentiation arrest by hypoxia.
Lin Q, Lee YJ, Yun Z
The Journal of biological chemistry 2006 Oct 13;281(41):30678-83
The Journal of biological chemistry 2006 Oct 13;281(41):30678-83
Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury.
Harris JR, Brown GA, Jorgensen M, Kaushal S, Ellis EA, Grant MB, Scott EW
Investigative ophthalmology & visual science 2006 May;47(5):2108-13
Investigative ophthalmology & visual science 2006 May;47(5):2108-13
Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells.
Litz J, Krystal GW
Molecular cancer therapeutics 2006 Jun;5(6):1415-22
Molecular cancer therapeutics 2006 Jun;5(6):1415-22
Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I
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Annals of neurology 2000 Sep;48(3):285-96
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