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antibody from antibodies-online
Targeting: HIF1A
bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8
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- References [248]
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- Western blot [4]
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- Product number
- ABIN251641 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Goat, Hamster, Rabbit, Simian
- Host
- Rabbit
- Vial size
- 0.025 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signaling.
Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury.
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery.
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.
Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB.
Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
Pharmacological HIF-inhibition attenuates postoperative adhesion formation.
HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis.
Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice.
Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.
HIF-1α acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia.
Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension.
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation.
Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor.
Digoxin-induced retinal degeneration depends on rhodopsin.
The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression.
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis.
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.
Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.
CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α.
PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.
Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells.
VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.
Hypoxia-inducible factor 1 mediates intermittent hypoxia-induced migration of human breast cancer MDA-MB-231 cells.
Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health.
Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.
Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.
CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells.
Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1.
Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.
Oxygen-dependent regulation of aquaporin-3 expression.
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.
Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.
Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.
Selective Estrogen Receptor Modulators Suppress Hif1α Protein Accumulation in Mouse Osteoclasts.
Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion.
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Role for Runt-related Transcription Factor 2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension.
Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.
Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.
A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model.
Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity.
HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Notch-independent RBPJ controls angiogenesis in the adult heart.
Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice.
Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.
jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data.
PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma.
Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution.
Prognostic significance of hypoxic PET using (18)F-FAZA and (62)Cu-ATSM in non-small-cell lung cancer.
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia.
Hif1α is required for osteoclast activation and bone loss in male osteoporosis.
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.
Is the canine corpus luteum an insulin-sensitive tissue?
CD146(+) cells are essential for kidney vasculature development.
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma.
HIF-1α Is an Essential Mediator of IFN-γ-Dependent Immunity to Mycobacterium tuberculosis.
SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α.
Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.
AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia.
Effect of simvastatin on mitochondrial enzyme activities, ghrelin, hypoxia-inducible factor 1α in hepatic tissue during early phase of sepsis.
Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis.
Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice.
Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia.
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.
Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model.
HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.
Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma.
TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity.
Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation.
Tuning graft- and host-derived vascularization in modular tissue constructs: a potential role of HIF1 activation.
Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells.
Clinical significance of hypoxia-inducible factor 1 and VEGF-A in osteosarcoma.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Differential microscopic finding and glucose transporter 3 expression in terminal chorionic villi among birth weight-discordant twin placentas.
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.
A versatile modular vector system for rapid combinatorial mammalian genetics.
EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control.
Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes.
Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia.
Lights on for HIF-1α: genetically enhanced mouse cardiomyocytes for heart tissue imaging.
Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure.
Hypoxia induces an undifferentiated phenotype of oral keratinocytes in vitro.
In vivo imaging of hypoxia-inducible factor regulation in a subcutaneous and orthotopic GL261 glioma tumor model using a reporter gene assay.
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions.
Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.
Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction.
Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome.
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.
Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: potential roles of interleukin-6 and endothelin.
The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway.
Defining the role of oxygen tension in human neural progenitor fate.
HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition.
Tumor suppressor VHL functions in the control of mitotic fidelity.
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
Epidermal deletion of HIF-2α stimulates wound closure.
Development of photosynthetic biomaterials for in vitro tissue engineering.
Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1α in HepG2 cells.
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function.
Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.
Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation.
Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism.
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels.
The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.
Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors.
Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.
Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution.
TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway.
Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.
Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.
Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
HIF-1α in heart: protective mechanisms.
Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis.
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.
HIF1α and HIF2α independently activate SRC to promote melanoma metastases.
Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line.
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.
miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.
The critical role of mast cell-derived hypoxia-inducible factor-1α in human and mice melanoma growth.
Proteomic analysis reveals differentially expressed proteins in macrophages infected with Leishmania amazonensis or Leishmania major.
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells.
Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells.
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation.
Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.
Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.
TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells.
Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis.
cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.
Sprouty2 expression controls endothelial monolayer integrity and quiescence.
Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1-S cell cycle transition in radioresistance of perinecrotic tumor cells.
Epicardial HIF signaling regulates vascular precursor cell invasion into the myocardium.
Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.
HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes.
Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2α activation.
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle.
Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.
Aldosterone deficiency adversely affects pregnancy outcome in mice.
Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo.
Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.
Anthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host.
IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis.
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.
Adrenomedullin promotes human endothelial cell proliferation via HIF-1α.
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Testosterone replacement therapy promotes angiogenesis after acute myocardial infarction by enhancing expression of cytokines HIF-1a, SDF-1a and VEGF.
Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
Metastatic myeloma?
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer.
Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.
Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning.
Quantitative analysis of chromatin proteomes in disease.
Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.
Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors.
Two mutations impair the stability and function of ubiquitin-activating enzyme (E1).
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.
The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts.
Scaffold porosity and oxygenation of printed hydrogel constructs affect functionality of embedded osteogenic progenitors.
Cell-autonomous and non-cell-autonomous neuroprotective functions of RORα in neurons and astrocytes during hypoxia.
Antibody-mediated enhancement of HIV-1 and HIV-2 production from BST-2/tetherin-positive cells.
Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.
Cdk5 interacts with Hif-1α in neurons: a new hypoxic signalling mechanism?
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells.
Modulation of NF-κB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice.
Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium.
Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice.
MCM proteins are negative regulators of hypoxia-inducible factor 1.
Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.
Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision.
Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1α.
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.
Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo.
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.
Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.
HIF1A is essential for the development of the intermediate plexus of the retinal vasculature.
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning.
Rapid remodeling of airway vascular architecture at birth.
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.
Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.
Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.
Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions.
Mast cell survival and mediator secretion in response to hypoxia.
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
An anti-vascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu+ breast tumors in a mouse model.
Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma.
Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia-inducible factor-1 alpha expression in photoreceptors.
Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons.
Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity.
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization.
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs.
Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway.
High oxygen prevents fetal lethality due to lack of catecholamines.
HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.
Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts.
FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.
Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways.
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite.
Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats.
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter.
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.
Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine.
[Interrelationships between methylmercury exposure and selenium supplementation in cockerels using selected laboratory diagnostic parameters and toxicological parameters of residues].
The sail sign.
Bernard O, Jeny F, Uzunhan Y, Dondi E, Terfous R, Label R, Sutton A, Larghero J, Vanneaux V, Nunes H, Boncoeur E, Planès C, Dard N
American journal of physiology. Lung cellular and molecular physiology 2018 Mar 1;314(3):L360-L371
American journal of physiology. Lung cellular and molecular physiology 2018 Mar 1;314(3):L360-L371
Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury.
Tojo K, Tamada N, Nagamine Y, Yazawa T, Ota S, Goto T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan 5;:fj201700888R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan 5;:fj201700888R
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Sodi VL, Bacigalupa ZA, Ferrer CM, Lee JV, Gocal WA, Mukhopadhyay D, Wellen KE, Ivan M, Reginato MJ
Oncogene 2018 Feb 15;37(7):924-934
Oncogene 2018 Feb 15;37(7):924-934
Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery.
Carpinteri S, Sampurno S, Malaterre J, Millen R, Dean M, Kong J, Chittleborough T, Heriot A, Lynch AC, Ramsay RG
The British journal of surgery 2018 Apr;105(5):597-605
The British journal of surgery 2018 Apr;105(5):597-605
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
Ho JC, Abdullah LN, Pang QY, Jha S, Chow EK, Yang H, Kato H, Poellinger L, Ueda J, Lee KL
PloS one 2017;12(11):e0188051
PloS one 2017;12(11):e0188051
Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.
Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield SM, Ohta A, Sitkovsky MV
PloS one 2017;12(11):e0187314
PloS one 2017;12(11):e0187314
Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
Wang S, Zeng H, Chen ST, Zhou L, Xie XJ, He X, Tao YK, Tuo QH, Deng C, Liao DF, Chen JX
Journal of cellular and molecular medicine 2017 Sep;21(9):1967-1978
Journal of cellular and molecular medicine 2017 Sep;21(9):1967-1978
Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K
Developmental cell 2017 Sep 25;42(6):655-666.e3
Developmental cell 2017 Sep 25;42(6):655-666.e3
Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB.
Braverman J, Stanley SA
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 1;199(5):1805-1816
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 1;199(5):1805-1816
Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH
Kidney international 2017 Oct;92(4):900-908
Kidney international 2017 Oct;92(4):900-908
Pharmacological HIF-inhibition attenuates postoperative adhesion formation.
Strowitzki MJ, Ritter AS, Radhakrishnan P, Harnoss JM, Opitz VM, Biller M, Wehrmann J, Keppler U, Scheer J, Wallwiener M, Schmidt T, Ulrich A, Schneider M
Scientific reports 2017 Oct 13;7(1):13151
Scientific reports 2017 Oct 13;7(1):13151
HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis.
Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G
Haematologica 2017 Nov;102(11):1956-1968
Haematologica 2017 Nov;102(11):1956-1968
Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice.
Nunomiya A, Shin J, Kitajima Y, Dan T, Miyata T, Nagatomi R
Acta physiologica (Oxford, England) 2017 May;220(1):99-112
Acta physiologica (Oxford, England) 2017 May;220(1):99-112
Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
Jackson CS, Durandt C, Janse van Rensburg I, Praloran V, Brunet de la Grange P, Pepper MS
Stem cell research 2017 May;21:124-131
Stem cell research 2017 May;21:124-131
Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.
Duan C, Perez-Torres CJ, Yuan L, Engelbach JA, Beeman SC, Tsien CI, Rich KM, Schmidt RE, Ackerman JJH, Garbow JR
Journal of neuro-oncology 2017 May;133(1):9-16
Journal of neuro-oncology 2017 May;133(1):9-16
HIF-1α acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia.
Licarete E, Sesarman A, Rauca VF, Luput L, Patras L, Banciu M
Oncology letters 2017 May;13(5):3942-3950
Oncology letters 2017 May;13(5):3942-3950
Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension.
Schuoler C, Haider TJ, Leuenberger C, Vogel J, Ostergaard L, Kwapiszewska G, Kohler M, Gassmann M, Huber LC, Brock M
Basic research in cardiology 2017 May;112(3):30
Basic research in cardiology 2017 May;112(3):30
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K
The Journal of biological chemistry 2017 May 26;292(21):8716-8728
The Journal of biological chemistry 2017 May 26;292(21):8716-8728
Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation.
Brock M, Schuoler C, Leuenberger C, Bühlmann C, Haider TJ, Vogel J, Ulrich S, Gassmann M, Kohler M, Huber LC
Experimental biology and medicine (Maywood, N.J.) 2017 Mar;242(5):487-496
Experimental biology and medicine (Maywood, N.J.) 2017 Mar;242(5):487-496
Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor.
Maturu P, Jones D, Ruteshouser EC, Hu Q, Reynolds JM, Hicks J, Putluri N, Ekmekcioglu S, Grimm EA, Dong C, Overwijk WW
Neoplasia (New York, N.Y.) 2017 Mar;19(3):237-249
Neoplasia (New York, N.Y.) 2017 Mar;19(3):237-249
Digoxin-induced retinal degeneration depends on rhodopsin.
Landfried B, Samardzija M, Barben M, Schori C, Klee K, Storti F, Grimm C
Cell death & disease 2017 Mar 16;8(3):e2670
Cell death & disease 2017 Mar 16;8(3):e2670
The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression.
Hum JM, Clinkenbeard EL, Ip C, Cass TA, Allen M, White KE
Bone reports 2017 Jun;6:38-43
Bone reports 2017 Jun;6:38-43
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.
Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H
Scientific reports 2017 Jul 31;7(1):6879
Scientific reports 2017 Jul 31;7(1):6879
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis.
Casciello F, Al-Ejeh F, Kelly G, Brennan DJ, Ngiow SF, Young A, Stoll T, Windloch K, Hill MM, Smyth MJ, Gannon F, Lee JS
Proceedings of the National Academy of Sciences of the United States of America 2017 Jul 3;114(27):7077-7082
Proceedings of the National Academy of Sciences of the United States of America 2017 Jul 3;114(27):7077-7082
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.
Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA
Nature communications 2017 Jul 24;8(1):98
Nature communications 2017 Jul 24;8(1):98
Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.
Myllymäki MN, Määttä J, Dimova EY, Izzi V, Väisänen T, Myllyharju J, Koivunen P, Serpi R
Molecular and cellular biology 2017 Jan 15;37(2)
Molecular and cellular biology 2017 Jan 15;37(2)
CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α.
Tian X, Nguyen M, Foote HP, Caster JM, Roche KC, Peters CG, Wu P, Jayaraman L, Garmey EG, Tepper JE, Eliasof S, Wang AZ
Cancer research 2017 Jan 1;77(1):112-122
Cancer research 2017 Jan 1;77(1):112-122
PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.
Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, Raithatha K, Dudek J, Rehling P, Zieseniss A, Jatho A, Chong M, Santos CX, Shah AM, Katschinski DM
Molecular and cellular biology 2017 Jan 1;37(1)
Molecular and cellular biology 2017 Jan 1;37(1)
Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells.
Negrette-Guzmán M, Huerta-Yepez S, Vega MI, León-Contreras JC, Hernández-Pando R, Medina-Campos ON, Rodríguez E, Tapia E, Pedraza-Chaverri J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Feb;100:90-102
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Feb;100:90-102
VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.
Razafinjatovo CF, Stiehl D, Deininger E, Rechsteiner M, Moch H, Schraml P
Oncotarget 2017 Feb 7;8(6):10199-10212
Oncotarget 2017 Feb 7;8(6):10199-10212
Hypoxia-inducible factor 1 mediates intermittent hypoxia-induced migration of human breast cancer MDA-MB-231 cells.
Liu L, Liu W, Wang L, Zhu T, Zhong J, Xie N
Oncology letters 2017 Dec;14(6):7715-7722
Oncology letters 2017 Dec;14(6):7715-7722
Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health.
Heid J, Cencioni C, Ripa R, Baumgart M, Atlante S, Milano G, Scopece A, Kuenne C, Guenther S, Azzimato V, Farsetti A, Rossi G, Braun T, Pompilio G, Martelli F, Zeiher AM, Cellerino A, Gaetano C, Spallotta F
Scientific reports 2017 Dec 4;7(1):16839
Scientific reports 2017 Dec 4;7(1):16839
Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.
Buart S, Terry S, Noman MZ, Lanoy E, Boutros C, Fogel P, Dessen P, Meurice G, Gaston-Mathé Y, Vielh P, Roy S, Routier E, Marty V, Ferlicot S, Legrès L, Bouchtaoui ME, Kamsu-Kom N, Muret J, Deutsch E, Eggermont A, Soria JC, Robert C, Chouaib S
Oncotarget 2017 Dec 12;8(65):108786-108801
Oncotarget 2017 Dec 12;8(65):108786-108801
Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.
Sun W, Kato H, Kitajima S, Lee KL, Gradin K, Okamoto T, Poellinger L
Scientific reports 2017 Aug 3;7(1):7190
Scientific reports 2017 Aug 3;7(1):7190
CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells.
Johansson E, Grassi ES, Pantazopoulou V, Tong B, Lindgren D, Berg TJ, Pietras EJ, Axelson H, Pietras A
Cell reports 2017 Aug 15;20(7):1641-1653
Cell reports 2017 Aug 15;20(7):1641-1653
Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1.
Tokumoto Y, Tamaki S, Kabe Y, Takubo K, Suematsu M
Scientific reports 2017 Apr 21;7(1):1019
Scientific reports 2017 Apr 21;7(1):1019
Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.
Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R
Skeletal muscle 2016;6:5
Skeletal muscle 2016;6:5
Oxygen-dependent regulation of aquaporin-3 expression.
Hoogewijs D, Vogler M, Zwenger E, Krull S, Zieseniss A
Hypoxia (Auckland, N.Z.) 2016;4:91-97
Hypoxia (Auckland, N.Z.) 2016;4:91-97
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.
Koivunen P, Fell SM, Lu W, Rabinowitz JD, Kung AL, Schlisio S
Hypoxia (Auckland, N.Z.) 2016;4:15-27
Hypoxia (Auckland, N.Z.) 2016;4:15-27
Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.
Tan SC, Gomes RS, Yeoh KK, Perbellini F, Malandraki-Miller S, Ambrose L, Heather LC, Faggian G, Schofield CJ, Davies KE, Clarke K, Carr CA
Cell transplantation 2016;25(1):35-53
Cell transplantation 2016;25(1):35-53
Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle.
Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC
PloS one 2016;11(5):e0154309
PloS one 2016;11(5):e0154309
Selective Estrogen Receptor Modulators Suppress Hif1α Protein Accumulation in Mouse Osteoclasts.
Morita M, Sato Y, Iwasaki R, Kobayashi T, Watanabe R, Oike T, Miyamoto K, Toyama Y, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T
PloS one 2016;11(11):e0165922
PloS one 2016;11(11):e0165922
Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion.
Muinos-López E, Ripalda-Cemboráin P, López-Martínez T, González-Gil AB, Lamo-Espinosa JM, Valentí A, Mortlock DP, Valentí JR, Prósper F, Granero-Moltó F
Stem cells (Dayton, Ohio) 2016 Sep;34(9):2342-53
Stem cells (Dayton, Ohio) 2016 Sep;34(9):2342-53
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P
Human molecular genetics 2016 Sep 1;25(17):3810-3823
Human molecular genetics 2016 Sep 1;25(17):3810-3823
Role for Runt-related Transcription Factor 2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension.
Ruffenach G, Chabot S, Tanguay VF, Courboulin A, Boucherat O, Potus F, Meloche J, Pflieger A, Breuils-Bonnet S, Nadeau V, Paradis R, Tremblay E, Girerd B, Hautefort A, Montani D, Fadel E, Dorfmuller P, Humbert M, Perros F, Paulin R, Provencher S, Bonnet S
American journal of respiratory and critical care medicine 2016 Nov 15;194(10):1273-1285
American journal of respiratory and critical care medicine 2016 Nov 15;194(10):1273-1285
Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.
Valbuena GN, Rizzardini M, Cimini S, Siskos AP, Bendotti C, Cantoni L, Keun HC
Molecular neurobiology 2016 May;53(4):2222-40
Molecular neurobiology 2016 May;53(4):2222-40
Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.
Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL
Science signaling 2016 May 31;9(430):ra56
Science signaling 2016 May 31;9(430):ra56
A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model.
Msaki A, Pastò A, Curtarello M, Arigoni M, Barutello G, Calogero RA, Macagno M, Cavallo F, Amadori A, Indraccolo S
Oncotarget 2016 May 31;7(22):33081-95
Oncotarget 2016 May 31;7(22):33081-95
Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity.
Trinh NT, Yamashita T, Ohneda K, Kimura K, Salazar GT, Sato F, Ohneda O
Stem cells and development 2016 May 15;25(10):760-73
Stem cells and development 2016 May 15;25(10):760-73
HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.
Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P
Journal of molecular medicine (Berlin, Germany) 2016 Mar;94(3):301-10
Journal of molecular medicine (Berlin, Germany) 2016 Mar;94(3):301-10
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA
Cancer research 2016 Mar 15;76(6):1653-63
Cancer research 2016 Mar 15;76(6):1653-63
Notch-independent RBPJ controls angiogenesis in the adult heart.
Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M
Nature communications 2016 Jun 30;7:12088
Nature communications 2016 Jun 30;7:12088
Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice.
Xue H, Chen D, Zhong YK, Zhou ZD, Fang SX, Li MY, Guo C
Annals of the New York Academy of Sciences 2016 Jul;1375(1):52-65
Annals of the New York Academy of Sciences 2016 Jul;1375(1):52-65
Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.
Jung GS, Jeon JH, Choi YK, Jang SY, Park SY, Kim SW, Byun JK, Kim MK, Lee S, Shin EC, Lee IK, Kang YN, Park KG
Scientific reports 2016 Jul 29;6:30846
Scientific reports 2016 Jul 29;6:30846
jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data.
Christinat Y, Pawłowski R, Krek W
Bioinformatics (Oxford, England) 2016 Jul 15;32(14):2111-9
Bioinformatics (Oxford, England) 2016 Jul 15;32(14):2111-9
PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma.
Ruf M, Moch H, Schraml P
International journal of cancer 2016 Jul 15;139(2):396-403
International journal of cancer 2016 Jul 15;139(2):396-403
Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution.
Luo B, Wang J, Liu Z, Shen Z, Shi R, Liu YQ, Liu Y, Jiang M, Wu Y, Zhang Z
Nature communications 2016 Jul 11;7:12177
Nature communications 2016 Jul 11;7:12177
Prognostic significance of hypoxic PET using (18)F-FAZA and (62)Cu-ATSM in non-small-cell lung cancer.
Kinoshita T, Fujii H, Hayashi Y, Kamiyama I, Ohtsuka T, Asamura H
Lung cancer (Amsterdam, Netherlands) 2016 Jan;91:56-66
Lung cancer (Amsterdam, Netherlands) 2016 Jan;91:56-66
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia.
Aquino-Gálvez A, González-Ávila G, Delgado-Tello J, Castillejos-López M, Mendoza-Milla C, Zúñiga J, Checa M, Maldonado-Martínez HA, Trinidad-López A, Cisneros J, Torres-Espíndola LM, Hernández-Jiménez C, Sommer B, Cabello-Gutiérrez C, Gutiérrez-González LH
Oncology reports 2016 Jan;35(1):577-83
Oncology reports 2016 Jan;35(1):577-83
Hif1α is required for osteoclast activation and bone loss in male osteoporosis.
Tando T, Sato Y, Miyamoto K, Morita M, Kobayashi T, Funayama A, Kanaji A, Hao W, Watanabe R, Oike T, Nakamura M, Matsumoto M, Toyama Y, Miyamoto T
Biochemical and biophysical research communications 2016 Feb 5;470(2):391-396
Biochemical and biophysical research communications 2016 Feb 5;470(2):391-396
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG Jr, Godley LA, Koivunen P
The Journal of biological chemistry 2016 Feb 19;291(8):4256-65
The Journal of biological chemistry 2016 Feb 19;291(8):4256-65
Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.
Pandya PH, Fisher AJ, Mickler EA, Temm CJ, Lipking KP, Gracon A, Rothhaar K, Sandusky GE, Murray M, Pollok K, Renbarger J, Blum JS, Lahm T, Wilkes DS
American journal of respiratory cell and molecular biology 2016 Dec;55(6):889-898
American journal of respiratory cell and molecular biology 2016 Dec;55(6):889-898
Is the canine corpus luteum an insulin-sensitive tissue?
Sousa LM, Silva RD, Fonseca VU, Leandro RM, Di Vincenzo TS, Alves-Wagner AB, Machado UF, Papa PC
The Journal of endocrinology 2016 Dec;231(3):223-233
The Journal of endocrinology 2016 Dec;231(3):223-233
CD146(+) cells are essential for kidney vasculature development.
Halt KJ, Pärssinen HE, Junttila SM, Saarela U, Sims-Lucas S, Koivunen P, Myllyharju J, Quaggin S, Skovorodkin IN, Vainio SJ
Kidney international 2016 Aug;90(2):311-324
Kidney international 2016 Aug;90(2):311-324
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Clever D, Roychoudhuri R, Constantinides MG, Askenase MH, Sukumar M, Klebanoff CA, Eil RL, Hickman HD, Yu Z, Pan JH, Palmer DC, Phan AT, Goulding J, Gattinoni L, Goldrath AW, Belkaid Y, Restifo NP
Cell 2016 Aug 25;166(5):1117-1131.e14
Cell 2016 Aug 25;166(5):1117-1131.e14
Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma.
Guimarães TA, Farias LC, Santos ES, de Carvalho Fraga CA, Orsini LA, de Freitas Teles L, Feltenberger JD, de Jesus SF, de Souza MG, Santos SH, de Paula AM, Gomez RS, Guimarães AL
Oncotarget 2016 Aug 23;7(34):55057-55068
Oncotarget 2016 Aug 23;7(34):55057-55068
HIF-1α Is an Essential Mediator of IFN-γ-Dependent Immunity to Mycobacterium tuberculosis.
Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1287-97
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1287-97
SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α.
Zhou F, Dai A, Jiang Y, Tan X, Zhang X
Molecular medicine reports 2016 Apr;13(4):3482-90
Molecular medicine reports 2016 Apr;13(4):3482-90
Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.
Liu J, You P, Chen G, Fu X, Zeng X, Wang C, Huang Y, An L, Wan X, Navone N, Wu CL, McKeehan WL, Zhang Z, Zhong W, Wang F
Oncogene 2016 Apr 7;35(14):1750-9
Oncogene 2016 Apr 7;35(14):1750-9
AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia.
Lee SD, Kim W, Jeong JW, Park JW, Kim JE
Cancer letters 2016 Apr 1;373(1):138-145
Cancer letters 2016 Apr 1;373(1):138-145
Effect of simvastatin on mitochondrial enzyme activities, ghrelin, hypoxia-inducible factor 1α in hepatic tissue during early phase of sepsis.
Yorulmaz H, Ozkok E, Erguven M, Ates G, Aydın I, Tamer S
International journal of clinical and experimental medicine 2015;8(3):3640-50
International journal of clinical and experimental medicine 2015;8(3):3640-50
Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis.
Qian F, He M, Duan W, Mao L, Li Q, Yu Z, Zhou Z, Zhang Y
American journal of translational research 2015;7(11):2364-78
American journal of translational research 2015;7(11):2364-78
Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice.
Guo C, Zhang YX, Wang T, Zhong ML, Yang ZH, Hao LJ, Chai R, Zhang S
Frontiers in aging neuroscience 2015;7:104
Frontiers in aging neuroscience 2015;7:104
Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia.
Zieseniss A, Hesse AR, Jatho A, Krull S, Hölscher M, Vogel S, Katschinski DM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;36(3):843-51
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;36(3):843-51
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.
Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ
PloS one 2015;10(9):e0139270
PloS one 2015;10(9):e0139270
Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.
Zeng Z, Huang WD, Gao Q, Su ML, Yang YF, Liu ZC, Zhu BH
International journal of molecular medicine 2015 Sep;36(3):685-97
International journal of molecular medicine 2015 Sep;36(3):685-97
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model.
Chen X, Liu J, He B, Li Y, Liu S, Wu B, Wang S, Zhang S, Xu X, Wang J
Human reproduction (Oxford, England) 2015 Sep;30(9):2160-70
Human reproduction (Oxford, England) 2015 Sep;30(9):2160-70
HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W
Nature 2015 Jun 25;522(7557):444-449
Nature 2015 Jun 25;522(7557):444-449
Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
Hwang HJ, Lynn SG, Vengellur A, Saini Y, Grier EA, Ferguson-Miller SM, LaPres JJ
Biochemistry 2015 Jun 23;54(24):3739-48
Biochemistry 2015 Jun 23;54(24):3739-48
PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.
Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C
The Journal of clinical investigation 2015 Jul 1;125(7):2759-71
The Journal of clinical investigation 2015 Jul 1;125(7):2759-71
Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma.
Takahashi H, Inoue A, Kawabe Y, Hosokawa Y, Iwata S, Sugimoto K, Yano H, Yamashita D, Harada H, Kohno S, Ohue S, Ohnishi T, Tanaka J
Brain tumor pathology 2015 Jan;32(1):31-40
Brain tumor pathology 2015 Jan;32(1):31-40
TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity.
Stantic M, Sakil HA, Zirath H, Fang T, Sanz G, Fernandez-Woodbridge A, Marin A, Susanto E, Mak TW, Arsenian Henriksson M, Wilhelm MT
Proceedings of the National Academy of Sciences of the United States of America 2015 Jan 6;112(1):220-5
Proceedings of the National Academy of Sciences of the United States of America 2015 Jan 6;112(1):220-5
Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation.
Fine JM, Renner DB, Forsberg AC, Cameron RA, Galick BT, Le C, Conway PM, Stroebel BM, Frey WH 2nd, Hanson LR
Neuroscience letters 2015 Jan 1;584:362-7
Neuroscience letters 2015 Jan 1;584:362-7
Tuning graft- and host-derived vascularization in modular tissue constructs: a potential role of HIF1 activation.
Lam GC, Sefton MV
Tissue engineering. Part A 2015 Feb;21(3-4):803-16
Tissue engineering. Part A 2015 Feb;21(3-4):803-16
Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells.
Qiao N, Xu C, Zhu YX, Cao Y, Liu DC, Han X
Cell death & disease 2015 Feb 19;6:e1650
Cell death & disease 2015 Feb 19;6:e1650
Clinical significance of hypoxia-inducible factor 1 and VEGF-A in osteosarcoma.
Zhao H, Wu Y, Chen Y, Liu H
International journal of clinical oncology 2015 Dec;20(6):1233-43
International journal of clinical oncology 2015 Dec;20(6):1233-43
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
Differential microscopic finding and glucose transporter 3 expression in terminal chorionic villi among birth weight-discordant twin placentas.
Lee M, Choi SY, Kang BH, Yoo HJ, Song SY, Seong IO, Suh KS, Kim KH
Histology and histopathology 2015 Aug;30(8):955-62
Histology and histopathology 2015 Aug;30(8):955-62
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.
Conley SJ, Baker TL, Burnett JP, Theisen RL, Lazarus D, Peters CG, Clouthier SG, Eliasof S, Wicha MS
Breast cancer research and treatment 2015 Apr;150(3):559-67
Breast cancer research and treatment 2015 Apr;150(3):559-67
A versatile modular vector system for rapid combinatorial mammalian genetics.
Albers J, Danzer C, Rechsteiner M, Lehmann H, Brandt LP, Hejhal T, Catalano A, Busenhart P, Gonçalves AF, Brandt S, Bode PK, Bode-Lesniewska B, Wild PJ, Frew IJ
The Journal of clinical investigation 2015 Apr;125(4):1603-19
The Journal of clinical investigation 2015 Apr;125(4):1603-19
EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control.
Yang EJ, Lee J, Lee SY, Kim EK, Moon YM, Jung YO, Park SH, Cho ML
PloS one 2014;9(2):e86062
PloS one 2014;9(2):e86062
Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes.
Sato Y, Inoue M, Yoshizawa T, Yamagata K
PloS one 2014;9(12):e114868
PloS one 2014;9(12):e114868
Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia.
Clarke RH, Moosa S, Anzivino M, Wang Y, Floyd DH, Purow BW, Lee KS
PloS one 2014;9(10):e111199
PloS one 2014;9(10):e111199
Lights on for HIF-1α: genetically enhanced mouse cardiomyocytes for heart tissue imaging.
Hesse AR, Levent E, Zieseniss A, Tiburcy M, Zimmermann WH, Katschinski DM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;34(2):455-62
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;34(2):455-62
Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure.
Ostergaard L, Rudiger A, Wellmann S, Gammella E, Beck-Schimmer B, Struck J, Maggiorini M, Gassmann M
Hypoxia (Auckland, N.Z.) 2014;2:143-151
Hypoxia (Auckland, N.Z.) 2014;2:143-151
Hypoxia induces an undifferentiated phenotype of oral keratinocytes in vitro.
Kato H, Izumi K, Uenoyama A, Shiomi A, Kuo S, Feinberg SE
Cells, tissues, organs 2014;199(5-6):393-404
Cells, tissues, organs 2014;199(5-6):393-404
In vivo imaging of hypoxia-inducible factor regulation in a subcutaneous and orthotopic GL261 glioma tumor model using a reporter gene assay.
Bürgi S, Seuwen A, Keist R, Vom Berg J, Grandjean J, Rudin M
Molecular imaging 2014;13
Molecular imaging 2014;13
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions.
Swain L, Wottawa M, Hillemann A, Beneke A, Odagiri H, Terada K, Endo M, Oike Y, Farhat K, Katschinski DM
Journal of leukocyte biology 2014 Sep;96(3):365-75
Journal of leukocyte biology 2014 Sep;96(3):365-75
Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.
Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR
The Journal of physiology 2014 Sep 1;592(17):3841-58
The Journal of physiology 2014 Sep 1;592(17):3841-58
Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E
Developmental biology 2014 Sep 1;393(1):124-36
Developmental biology 2014 Sep 1;393(1):124-36
HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction.
Rahtu-Korpela L, Karsikas S, Hörkkö S, Blanco Sequeiros R, Lammentausta E, Mäkelä KA, Herzig KH, Walkinshaw G, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P
Diabetes 2014 Oct;63(10):3324-33
Diabetes 2014 Oct;63(10):3324-33
Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome.
Kaasinen E, Rahikkala E, Koivunen P, Miettinen S, Wamelink MM, Aavikko M, Palin K, Myllyharju J, Moilanen JS, Pajunen L, Karhu A, Aaltonen LA
European journal of medical genetics 2014 Oct;57(10):543-51
European journal of medical genetics 2014 Oct;57(10):543-51
HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
Chen RL, Ogunshola OO, Yeoh KK, Jani A, Papadakis M, Nagel S, Schofield CJ, Buchan AM
Journal of neurochemistry 2014 Oct;131(2):177-89
Journal of neurochemistry 2014 Oct;131(2):177-89
Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.
Okon IS, Coughlan KA, Zhang C, Moriasi C, Ding Y, Song P, Zhang W, Li G, Zou MH
The Journal of clinical investigation 2014 Oct;124(10):4590-602
The Journal of clinical investigation 2014 Oct;124(10):4590-602
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
Kono K, Tamashiro DA, Alarcon VB
Developmental biology 2014 Oct 1;394(1):142-55
Developmental biology 2014 Oct 1;394(1):142-55
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H, Poellinger L
Molecular and cellular biology 2014 Oct 1;34(19):3702-20
Molecular and cellular biology 2014 Oct 1;34(19):3702-20
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation.
Abu-Remaileh M, Aqeilan RI
Cell death and differentiation 2014 Nov;21(11):1805-14
Cell death and differentiation 2014 Nov;21(11):1805-14
Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: potential roles of interleukin-6 and endothelin.
Van Hung T, Emoto N, Vignon-Zellweger N, Nakayama K, Yagi K, Suzuki Y, Hirata K
Life sciences 2014 Nov 24;118(2):313-28
Life sciences 2014 Nov 24;118(2):313-28
The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway.
Takamiya R, Takahashi M, Uehara Y, Ariki S, Hashimoto J, Hasegawa Y, Kuroki Y
Biochemical and biophysical research communications 2014 Nov 21;454(3):364-8
Biochemical and biophysical research communications 2014 Nov 21;454(3):364-8
Defining the role of oxygen tension in human neural progenitor fate.
Xie Y, Zhang J, Lin Y, Gaeta X, Meng X, Wisidagama DR, Cinkornpumin J, Koehler CM, Malone CS, Teitell MA, Lowry WE
Stem cell reports 2014 Nov 11;3(5):743-57
Stem cell reports 2014 Nov 11;3(5):743-57
HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition.
Ekman M, Uvelius B, Albinsson S, Swärd K
Laboratory investigation; a journal of technical methods and pathology 2014 May;94(5):557-68
Laboratory investigation; a journal of technical methods and pathology 2014 May;94(5):557-68
Tumor suppressor VHL functions in the control of mitotic fidelity.
Hell MP, Duda M, Weber TC, Moch H, Krek W
Cancer research 2014 May 1;74(9):2422-31
Cancer research 2014 May 1;74(9):2422-31
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
Zhu J, Jiang X, Chehab FF
Journal of lipid research 2014 Mar;55(3):431-42
Journal of lipid research 2014 Mar;55(3):431-42
Epidermal deletion of HIF-2α stimulates wound closure.
Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS
The Journal of investigative dermatology 2014 Mar;134(3):801-808
The Journal of investigative dermatology 2014 Mar;134(3):801-808
Development of photosynthetic biomaterials for in vitro tissue engineering.
Hopfner U, Schenck TL, Chávez MN, Machens HG, Bohne AV, Nickelsen J, Giunta RE, Egaña JT
Acta biomaterialia 2014 Jun;10(6):2712-7
Acta biomaterialia 2014 Jun;10(6):2712-7
Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1α in HepG2 cells.
Yu Z, Ge Y, Xie L, Zhang T, Huang L, Zhao X, Liu J, Huang G
Cellular signalling 2014 Jul;26(7):1560-6
Cellular signalling 2014 Jul;26(7):1560-6
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q
Genes & development 2014 Jul 1;28(13):1429-44
Genes & development 2014 Jul 1;28(13):1429-44
HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function.
Weissmüller T, Glover LE, Fennimore B, Curtis VF, MacManus CF, Ehrentraut SF, Campbell EL, Scully M, Grove BD, Colgan SP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):256-64
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jan;28(1):256-64
Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.
Lijkwan MA, Hellingman AA, Bos EJ, van der Bogt KE, Huang M, Kooreman NG, de Vries MR, Peters HA, Robbins RC, Hamming JF, Quax PH, Wu JC
Human gene therapy 2014 Jan;25(1):41-9
Human gene therapy 2014 Jan;25(1):41-9
Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation.
Yang B, Janardhanan R, Vohra P, Greene EL, Bhattacharya S, Withers S, Roy B, Nieves Torres EC, Mandrekar J, Leof EB, Mukhopadhyay D, Misra S
Kidney international 2014 Feb;85(2):289-306
Kidney international 2014 Feb;85(2):289-306
Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism.
Xuan Y, Hur H, Ham IH, Yun J, Lee JY, Shim W, Kim YB, Lee G, Han SU, Cho YK
Experimental cell research 2014 Feb 15;321(2):219-30
Experimental cell research 2014 Feb 15;321(2):219-30
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels.
Huang BW, Miyazawa M, Tsuji Y
Cellular signalling 2014 Dec;26(12):2702-9
Cellular signalling 2014 Dec;26(12):2702-9
The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.
Slominski A, Kim TK, Brożyna AA, Janjetovic Z, Brooks DL, Schwab LP, Skobowiat C, Jóźwicki W, Seagroves TN
Archives of biochemistry and biophysics 2014 Dec 1;563:79-93
Archives of biochemistry and biophysics 2014 Dec 1;563:79-93
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH
Nature 2014 Apr 3;508(7494):103-107
Nature 2014 Apr 3;508(7494):103-107
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.
Mochizuki A, Pace A, Rockwell CE, Roth KJ, Chow A, O'Brien KM, Albee R, Kelly K, Towery K, Luyendyk JP, Copple BL
Journal of immunology (Baltimore, Md. : 1950) 2014 Apr 15;192(8):3847-3857
Journal of immunology (Baltimore, Md. : 1950) 2014 Apr 15;192(8):3847-3857
Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors.
De A, De A, Papasian C, Hentges S, Banerjee S, Haque I, Banerjee SK
PloS one 2013;8(8):e72748
PloS one 2013;8(8):e72748
Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.
Puri S, García-Núñez A, Hebrok M, Cano DA
PloS one 2013;8(8):e72213
PloS one 2013;8(8):e72213
Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution.
Vogler M, Vogel S, Krull S, Farhat K, Leisering P, Lutz S, Wuertz CM, Katschinski DM, Zieseniss A
PloS one 2013;8(7):e69128
PloS one 2013;8(7):e69128
TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway.
Kopriva SE, Chiasson VL, Mitchell BM, Chatterjee P
PloS one 2013;8(7):e67760
PloS one 2013;8(7):e67760
Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.
Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU
PloS one 2013;8(4):e61438
PloS one 2013;8(4):e61438
Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.
Wiesner D, Merdian I, Lewerenz J, Ludolph AC, Dupuis L, Witting A
PloS one 2013;8(10):e76670
PloS one 2013;8(10):e76670
Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.
Jones LW, Fels DR, West M, Allen JD, Broadwater G, Barry WT, Wilke LG, Masko E, Douglas PS, Dash RC, Povsic TJ, Peppercorn J, Marcom PK, Blackwell KL, Kimmick G, Turkington TG, Dewhirst MW
Cancer prevention research (Philadelphia, Pa.) 2013 Sep;6(9):925-37
Cancer prevention research (Philadelphia, Pa.) 2013 Sep;6(9):925-37
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA
Cancer research 2013 Sep 15;73(18):5810-20
Cancer research 2013 Sep 15;73(18):5810-20
HIF-1α in heart: protective mechanisms.
Wu J, Chen P, Li Y, Ardell C, Der T, Shohet R, Chen M, Wright GL
American journal of physiology. Heart and circulatory physiology 2013 Sep 15;305(6):H821-8
American journal of physiology. Heart and circulatory physiology 2013 Sep 15;305(6):H821-8
Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis.
Nabatov AA, Hatzis P, Rouschop KM, van Diest P, Vooijs M
Biochimica et biophysica acta 2013 Nov;1830(11):5277-86
Biochimica et biophysica acta 2013 Nov;1830(11):5277-86
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.
Klug F, Prakash H, Huber PE, Seibel T, Bender N, Halama N, Pfirschke C, Voss RH, Timke C, Umansky L, Klapproth K, Schäkel K, Garbi N, Jäger D, Weitz J, Schmitz-Winnenthal H, Hämmerling GJ, Beckhove P
Cancer cell 2013 Nov 11;24(5):589-602
Cancer cell 2013 Nov 11;24(5):589-602
HIF1α and HIF2α independently activate SRC to promote melanoma metastases.
Hanna SC, Krishnan B, Bailey ST, Moschos SJ, Kuan PF, Shimamura T, Osborne LD, Siegel MB, Duncan LM, O'Brien ET 3rd, Superfine R, Miller CR, Simon MC, Wong KK, Kim WY
The Journal of clinical investigation 2013 May;123(5):2078-93
The Journal of clinical investigation 2013 May;123(5):2078-93
Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line.
Nagai J, Yamamoto A, Yumoto R, Takano M
Biochemical and biophysical research communications 2013 May 10;434(3):670-5
Biochemical and biophysical research communications 2013 May 10;434(3):670-5
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.
Takeuchi-Yorimoto A, Noto T, Yamada A, Miyamae Y, Oishi Y, Matsumoto M
Toxicology and applied pharmacology 2013 May 1;268(3):264-77
Toxicology and applied pharmacology 2013 May 1;268(3):264-77
miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling.
Momose K, Minami A, Shimono Y, Mizutani K, Nobutani K, Azuma T, Takai Y
Genes to cells : devoted to molecular & cellular mechanisms 2013 Mar;18(3):195-202
Genes to cells : devoted to molecular & cellular mechanisms 2013 Mar;18(3):195-202
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Gualtieri F, Marinelli C, Longo D, Pugnaghi M, Nichelli PF, Meletti S, Biagini G
Neuromolecular medicine 2013 Mar;15(1):133-46
Neuromolecular medicine 2013 Mar;15(1):133-46
Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.
Ikeda J, Ichiki T, Matsuura H, Inoue E, Kishimoto J, Watanabe A, Sankoda C, Kitamoto S, Tokunou T, Takeda K, Fong GH, Sunagawa K
Journal of the American Heart Association 2013 Jun 18;2(3):e000178
Journal of the American Heart Association 2013 Jun 18;2(3):e000178
The critical role of mast cell-derived hypoxia-inducible factor-1α in human and mice melanoma growth.
Jeong HJ, Oh HA, Nam SY, Han NR, Kim YS, Kim JH, Lee SJ, Kim MH, Moon PD, Kim HM, Oh HA
International journal of cancer 2013 Jun 1;132(11):2492-501
International journal of cancer 2013 Jun 1;132(11):2492-501
Proteomic analysis reveals differentially expressed proteins in macrophages infected with Leishmania amazonensis or Leishmania major.
Menezes JP, Almeida TF, Petersen AL, Guedes CE, Mota MS, Lima JG, Palma LC, Buck GA, Krieger MA, Probst CM, Veras PS
Microbes and infection 2013 Jul-Aug;15(8-9):579-91
Microbes and infection 2013 Jul-Aug;15(8-9):579-91
Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Kaufmann MR, Barth S, Konietzko U, Wu B, Egger S, Kunze R, Marti HH, Hick M, Müller U, Camenisch G, Wenger RH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 30;33(5):1915-26
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 30;33(5):1915-26
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells.
Shimojo Y, Akimoto M, Hisanaga T, Tanaka T, Tajima Y, Honma Y, Takenaga K
Clinical & experimental metastasis 2013 Feb;30(2):143-54
Clinical & experimental metastasis 2013 Feb;30(2):143-54
Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells.
Gammella E, Leuenberger C, Gassmann M, Ostergaard L
American journal of physiology. Lung cellular and molecular physiology 2013 Feb 15;304(4):L230-9
American journal of physiology. Lung cellular and molecular physiology 2013 Feb 15;304(4):L230-9
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.
Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R
American journal of physiology. Cell physiology 2013 Feb 15;304(4):C342-53
American journal of physiology. Cell physiology 2013 Feb 15;304(4):C342-53
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation.
Karuppagounder SS, Basso M, Sleiman SF, Ma TC, Speer RE, Smirnova NA, Gazaryan IG, Ratan RR
Journal of neuroscience research 2013 Aug;91(8):1066-75
Journal of neuroscience research 2013 Aug;91(8):1066-75
Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.
Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P
Molecular and cellular biology 2013 Aug;33(16):3321-9
Molecular and cellular biology 2013 Aug;33(16):3321-9
Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.
Storti P, Bolzoni M, Donofrio G, Airoldi I, Guasco D, Toscani D, Martella E, Lazzaretti M, Mancini C, Agnelli L, Patrene K, Maïga S, Franceschi V, Colla S, Anderson J, Neri A, Amiot M, Aversa F, Roodman GD, Giuliani N
Leukemia 2013 Aug;27(8):1697-706
Leukemia 2013 Aug;27(8):1697-706
TNFα induces expression of HIF-1α mRNA and protein but inhibits hypoxic stimulation of HIF-1 transcriptional activity in airway smooth muscle cells.
Tsapournioti S, Mylonis I, Hatziefthimiou A, Ioannou MG, Stamatiou R, Koukoulis GK, Simos G, Molyvdas PA, Paraskeva E
Journal of cellular physiology 2013 Aug;228(8):1745-53
Journal of cellular physiology 2013 Aug;228(8):1745-53
Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis.
Luo B, Jiang M, Yang X, Zhang Z, Xiong J, Schluesener HJ, Zhang Z, Wu Y
Biochimica et biophysica acta 2013 Aug;1832(8):1260-70
Biochimica et biophysica acta 2013 Aug;1832(8):1260-70
cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.
Nakayama K
The Journal of biological chemistry 2013 Aug 2;288(31):22584-95
The Journal of biological chemistry 2013 Aug 2;288(31):22584-95
Sprouty2 expression controls endothelial monolayer integrity and quiescence.
Peier M, Walpen T, Christofori G, Battegay E, Humar R
Angiogenesis 2013 Apr;16(2):455-68
Angiogenesis 2013 Apr;16(2):455-68
Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1-S cell cycle transition in radioresistance of perinecrotic tumor cells.
Zhu Y, Zhao T, Itasaka S, Zeng L, Yeom CJ, Hirota K, Suzuki K, Morinibu A, Shinomiya K, Ou G, Yoshimura M, Hiraoka M, Harada H
Oncogene 2013 Apr 18;32(16):2058-68
Oncogene 2013 Apr 18;32(16):2058-68
Epicardial HIF signaling regulates vascular precursor cell invasion into the myocardium.
Tao J, Doughman Y, Yang K, Ramirez-Bergeron D, Watanabe M
Developmental biology 2013 Apr 15;376(2):136-49
Developmental biology 2013 Apr 15;376(2):136-49
Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.
Muratsu-Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R
PloS one 2012;7(7):e41462
PloS one 2012;7(7):e41462
HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes.
Valle-Casuso JC, González-Sánchez A, Medina JM, Tabernero A
PloS one 2012;7(2):e32448
PloS one 2012;7(2):e32448
Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2α activation.
Zhang S, Han CH, Chen XS, Zhang M, Xu LM, Zhang JJ, Xia Q
PloS one 2012;7(1):e29876
PloS one 2012;7(1):e29876
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V
Journal of molecular medicine (Berlin, Germany) 2012 Sep;90(9):1079-89
Journal of molecular medicine (Berlin, Germany) 2012 Sep;90(9):1079-89
Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle.
Basic VT, Tadele E, Elmabsout AA, Yao H, Rahman I, Sirsjö A, Abdel-Halim SM
American journal of physiology. Lung cellular and molecular physiology 2012 Sep 15;303(6):L519-27
American journal of physiology. Lung cellular and molecular physiology 2012 Sep 15;303(6):L519-27
Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization.
Lin M, Hu Y, Chen Y, Zhou KK, Jin J, Zhu M, Le YZ, Ge J, Ma JX
Investigative ophthalmology & visual science 2012 Sep 14;53(10):6197-206
Investigative ophthalmology & visual science 2012 Sep 14;53(10):6197-206
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.
Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K
The Journal of biological chemistry 2012 Sep 14;287(38):31962-72
The Journal of biological chemistry 2012 Sep 14;287(38):31962-72
Aldosterone deficiency adversely affects pregnancy outcome in mice.
Todkar A, Di Chiara M, Loffing-Cueni D, Bettoni C, Mohaupt M, Loffing J, Wagner CA
Pflugers Archiv : European journal of physiology 2012 Oct;464(4):331-43
Pflugers Archiv : European journal of physiology 2012 Oct;464(4):331-43
Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo.
Becquart P, Cambon-Binder A, Monfoulet LE, Bourguignon M, Vandamme K, Bensidhoum M, Petite H, Logeart-Avramoglou D
Tissue engineering. Part A 2012 Oct;18(19-20):2084-94
Tissue engineering. Part A 2012 Oct;18(19-20):2084-94
Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.
Aro E, Khatri R, Gerard-O'Riley R, Mangiavini L, Myllyharju J, Schipani E
The Journal of biological chemistry 2012 Oct 26;287(44):37134-44
The Journal of biological chemistry 2012 Oct 26;287(44):37134-44
Anthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host.
Tanaka T, Yamaguchi J, Shoji K, Nangaku M
The Journal of biological chemistry 2012 Oct 12;287(42):34866-82
The Journal of biological chemistry 2012 Oct 12;287(42):34866-82
IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis.
Zhang C, Lu L, Li Y, Wang X, Zhou J, Liu Y, Fu P, Gallicchio MA, Bach LA, Duan C
International journal of cancer 2012 May 1;130(9):2003-12
International journal of cancer 2012 May 1;130(9):2003-12
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?
Xekouki P, Pacak K, Almeida M, Wassif CA, Rustin P, Nesterova M, de la Luz Sierra M, Matro J, Ball E, Azevedo M, Horvath A, Lyssikatos C, Quezado M, Patronas N, Ferrando B, Pasini B, Lytras A, Tolis G, Stratakis CA
The Journal of clinical endocrinology and metabolism 2012 Mar;97(3):E357-66
The Journal of clinical endocrinology and metabolism 2012 Mar;97(3):E357-66
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
Cell 2012 Mar 30;149(1):49-62
Cell 2012 Mar 30;149(1):49-62
Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.
Xu Y, Li Y, Pang Y, Ling M, Shen L, Jiang R, Zhao Y, Zhou J, Wang X, Liu Q
Archives of toxicology 2012 Jun;86(6):947-59
Archives of toxicology 2012 Jun;86(6):947-59
Adrenomedullin promotes human endothelial cell proliferation via HIF-1α.
Chen L, Qiu JH, Zhang LL, Luo XD
Molecular and cellular biochemistry 2012 Jun;365(1-2):263-73
Molecular and cellular biochemistry 2012 Jun;365(1-2):263-73
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Fine JM, Baillargeon AM, Renner DB, Hoerster NS, Tokarev J, Colton S, Pelleg A, Andrews A, Sparley KA, Krogh KM, Frey WH, Hanson LR
Experimental brain research 2012 Jun;219(3):381-90
Experimental brain research 2012 Jun;219(3):381-90
Testosterone replacement therapy promotes angiogenesis after acute myocardial infarction by enhancing expression of cytokines HIF-1a, SDF-1a and VEGF.
Chen Y, Fu L, Han Y, Teng Y, Sun J, Xie R, Cao J
European journal of pharmacology 2012 Jun 5;684(1-3):116-24
European journal of pharmacology 2012 Jun 5;684(1-3):116-24
Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.
Zheng X, Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Björklund A, Inoue M, Catrina SB, Brismar K, Poellinger L, Pereira TS
Cell death & disease 2012 Jun 14;3:e322
Cell death & disease 2012 Jun 14;3:e322
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
Azab AK, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, Thompson B, Maiso P, Sun JD, Hart CP, Roccaro AM, Sacco A, Ngo HT, Lin CP, Kung AL, Carrasco RD, Vanderkerken K, Ghobrial IM
Blood 2012 Jun 14;119(24):5782-94
Blood 2012 Jun 14;119(24):5782-94
Metastatic myeloma?
Shain K
Blood 2012 Jun 14;119(24):5612-3
Blood 2012 Jun 14;119(24):5612-3
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.
Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW
Development (Cambridge, England) 2012 Jul;139(13):2340-50
Development (Cambridge, England) 2012 Jul;139(13):2340-50
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S
The Journal of cell biology 2012 Jul 9;198(1):103-14
The Journal of cell biology 2012 Jul 9;198(1):103-14
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer.
Schwab LP, Peacock DL, Majumdar D, Ingels JF, Jensen LC, Smith KD, Cushing RC, Seagroves TN
Breast cancer research : BCR 2012 Jan 7;14(1):R6
Breast cancer research : BCR 2012 Jan 7;14(1):R6
Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.
Ogle ME, Gu X, Espinera AR, Wei L
Neurobiology of disease 2012 Feb;45(2):733-42
Neurobiology of disease 2012 Feb;45(2):733-42
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.
Flügel D, Görlach A, Kietzmann T
Blood 2012 Feb 2;119(5):1292-301
Blood 2012 Feb 2;119(5):1292-301
Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning.
Autheman D, Sheldon RA, Chaudhuri N, von Arx S, Siegenthaler C, Ferriero DM, Christen S
Pediatric research 2012 Dec;72(6):568-75
Pediatric research 2012 Dec;72(6):568-75
Quantitative analysis of chromatin proteomes in disease.
Monte E, Chen H, Kolmakova M, Parvatiyar M, Vondriska TM, Franklin S
Journal of visualized experiments : JoVE 2012 Dec 28;(70)
Journal of visualized experiments : JoVE 2012 Dec 28;(70)
Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.
Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF
Molecular and cellular biology 2012 Aug;32(15):3081-94
Molecular and cellular biology 2012 Aug;32(15):3081-94
Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.
Omarova S, Charvet CD, Reem RE, Mast N, Zheng W, Huang S, Peachey NS, Pikuleva IA
The Journal of clinical investigation 2012 Aug;122(8):3012-23
The Journal of clinical investigation 2012 Aug;122(8):3012-23
A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
Branitzki-Heinemann K, Okumura CY, Völlger L, Kawakami Y, Kawakami T, Naim HY, Nizet V, Von Köckritz-Blickwede M
The Biochemical journal 2012 Aug 15;446(1):159-63
The Biochemical journal 2012 Aug 15;446(1):159-63
Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors.
Tan SC, Carr CA, Yeoh KK, Schofield CJ, Davies KE, Clarke K
Molecular biology reports 2012 Apr;39(4):4857-67
Molecular biology reports 2012 Apr;39(4):4857-67
Two mutations impair the stability and function of ubiquitin-activating enzyme (E1).
Lao T, Chen S, Sang N
Journal of cellular physiology 2012 Apr;227(4):1561-8
Journal of cellular physiology 2012 Apr;227(4):1561-8
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.
Bandau S, Knebel A, Gage ZO, Wood NT, Alexandru G
BMC biology 2012 Apr 26;10:36
BMC biology 2012 Apr 26;10:36
The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts.
Vengellur A, Grier E, Lapres JJ
Journal of toxicology 2011;2011:391074
Journal of toxicology 2011;2011:391074
Scaffold porosity and oxygenation of printed hydrogel constructs affect functionality of embedded osteogenic progenitors.
Fedorovich NE, Kuipers E, Gawlitta D, Dhert WJ, Alblas J
Tissue engineering. Part A 2011 Oct;17(19-20):2473-86
Tissue engineering. Part A 2011 Oct;17(19-20):2473-86
Cell-autonomous and non-cell-autonomous neuroprotective functions of RORα in neurons and astrocytes during hypoxia.
Jolly S, Journiac N, Naudet F, Gautheron V, Mariani J, Vernet-der Garabedian B
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct 5;31(40):14314-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct 5;31(40):14314-23
Antibody-mediated enhancement of HIV-1 and HIV-2 production from BST-2/tetherin-positive cells.
Miyagi E, Andrew A, Kao S, Yoshida T, Strebel K
Journal of virology 2011 Nov;85(22):11981-94
Journal of virology 2011 Nov;85(22):11981-94
Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.
Tandon R, SenGupta D, Ndhlovu LC, Vieira RG, Jones RB, York VA, Vieira VA, Sharp ER, Wiznia AA, Ostrowski MA, Rosenberg MG, Nixon DF
Journal of virology 2011 Nov;85(21):11526-31
Journal of virology 2011 Nov;85(21):11526-31
Cdk5 interacts with Hif-1α in neurons: a new hypoxic signalling mechanism?
Antoniou X, Gassmann M, Ogunshola OO
Brain research 2011 Mar 24;1381:1-10
Brain research 2011 Mar 24;1381:1-10
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Lin Q, Cong X, Yun Z
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells.
Lin M, Chen Y, Jin J, Hu Y, Zhou KK, Zhu M, Le YZ, Ge J, Johnson RS, Ma JX
Diabetologia 2011 Jun;54(6):1554-66
Diabetologia 2011 Jun;54(6):1554-66
Modulation of NF-κB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice.
Olson N, Kasahara DI, Hristova M, Bernstein R, Janssen-Heininger Y, van der Vliet A
American journal of respiratory cell and molecular biology 2011 Jun;44(6):813-23
American journal of respiratory cell and molecular biology 2011 Jun;44(6):813-23
Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium.
Polosukhin VV, Cates JM, Lawson WE, Milstone AP, Matafonov AG, Massion PP, Lee JW, Randell SH, Blackwell TS
The Journal of pathology 2011 Jun;224(2):203-11
The Journal of pathology 2011 Jun;224(2):203-11
Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice.
Zhang L, Huang H, Cheng J, Liu J, Zhao H, Vizcaychipi MP, Ma D
Life sciences 2011 Jun 20;88(25-26):1102-7
Life sciences 2011 Jun 20;88(25-26):1102-7
MCM proteins are negative regulators of hypoxia-inducible factor 1.
Hubbi ME, Luo W, Baek JH, Semenza GL
Molecular cell 2011 Jun 10;42(5):700-12
Molecular cell 2011 Jun 10;42(5):700-12
Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.
Lange C, Heynen SR, Tanimoto N, Thiersch M, Le YZ, Meneau I, Seeliger MW, Samardzija M, Caprara C, Grimm C
Investigative ophthalmology & visual science 2011 Jul 29;52(8):5872-80
Investigative ophthalmology & visual science 2011 Jul 29;52(8):5872-80
Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision.
Lange C, Caprara C, Tanimoto N, Beck S, Huber G, Samardzija M, Seeliger M, Grimm C
Neurobiology of disease 2011 Jan;41(1):119-30
Neurobiology of disease 2011 Jan;41(1):119-30
Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1α.
Schelter F, Halbgewachs B, Bäumler P, Neu C, Görlach A, Schrötzlmair F, Krüger A
Clinical & experimental metastasis 2011 Feb;28(2):91-9
Clinical & experimental metastasis 2011 Feb;28(2):91-9
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
Olson N, Hristova M, Heintz NH, Lounsbury KM, van der Vliet A
American journal of physiology. Lung cellular and molecular physiology 2011 Dec;301(6):L993-L1002
American journal of physiology. Lung cellular and molecular physiology 2011 Dec;301(6):L993-L1002
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.
Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA
The Journal of pharmacology and experimental therapeutics 2011 Aug;338(2):492-502
The Journal of pharmacology and experimental therapeutics 2011 Aug;338(2):492-502
Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo.
Shafighi M, Olariu R, Fathi AR, Djafarzadeh S, Jakob SM, Banic A, Constantinescu MA
Plastic and reconstructive surgery 2011 Aug;128(2):415-22
Plastic and reconstructive surgery 2011 Aug;128(2):415-22
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.
Shen C, Beroukhim R, Schumacher SE, Zhou J, Chang M, Signoretti S, Kaelin WG Jr
Cancer discovery 2011 Aug;1(3):222-35
Cancer discovery 2011 Aug;1(3):222-35
Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.
Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M
The Journal of biological chemistry 2011 Apr 8;286(14):12524-32
The Journal of biological chemistry 2011 Apr 8;286(14):12524-32
HIF1A is essential for the development of the intermediate plexus of the retinal vasculature.
Caprara C, Thiersch M, Lange C, Joly S, Samardzija M, Grimm C
Investigative ophthalmology & visual science 2011 Apr 4;52(5):2109-17
Investigative ophthalmology & visual science 2011 Apr 4;52(5):2109-17
IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer.
Anglesio MS, George J, Kulbe H, Friedlander M, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG, Australian Ovarian Cancer Study Group., Okamoto A, Birrer MJ, Huntsman DG, de Fazio A, Kalloger SE, Balkwill F, Gilks CB, Bowtell DD
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Apr 15;17(8):2538-48
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Apr 15;17(8):2538-48
Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.
Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A
The Journal of biological chemistry 2011 Apr 1;286(13):11185-94
The Journal of biological chemistry 2011 Apr 1;286(13):11185-94
Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning.
Francis KR, Wei L
Cell death & disease 2010;1:e22
Cell death & disease 2010;1:e22
Rapid remodeling of airway vascular architecture at birth.
Ni A, Lashnits E, Yao LC, Baluk P, McDonald DM
Developmental dynamics : an official publication of the American Association of Anatomists 2010 Sep;239(9):2354-66
Developmental dynamics : an official publication of the American Association of Anatomists 2010 Sep;239(9):2354-66
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr
Circulation 2010 Sep 7;122(10):1004-16
Circulation 2010 Sep 7;122(10):1004-16
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.
Raitila A, Lehtonen HJ, Arola J, Heliövaara E, Ahlsten M, Georgitsi M, Jalanko A, Paetau A, Aaltonen LA, Karhu A
The American journal of pathology 2010 Oct;177(4):1969-76
The American journal of pathology 2010 Oct;177(4):1969-76
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.
Luo T, Zhang X, Nicholson WL, Zhu B, McBride JW
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97
Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.
Brökers N, Le-Huu S, Vogel S, Hagos Y, Katschinski DM, Kleinschmidt M
Cancer science 2010 Jan;101(1):129-36
Cancer science 2010 Jan;101(1):129-36
Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.
Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, Lapres JJ
American journal of physiology. Lung cellular and molecular physiology 2010 Feb;298(2):L139-47
American journal of physiology. Lung cellular and molecular physiology 2010 Feb;298(2):L139-47
Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions.
Lee SB, Wong AP, Kanasaki K, Xu Y, Shenoy VK, McElrath TF, Whitesides GM, Kalluri R
The American journal of pathology 2010 Feb;176(2):710-20
The American journal of pathology 2010 Feb;176(2):710-20
Mast cell survival and mediator secretion in response to hypoxia.
Gulliksson M, Carvalho RF, Ullerås E, Nilsson G
PloS one 2010 Aug 23;5(8):e12360
PloS one 2010 Aug 23;5(8):e12360
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J
The Journal of biological chemistry 2010 Apr 30;285(18):13646-57
The Journal of biological chemistry 2010 Apr 30;285(18):13646-57
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG Jr
Molecular and cellular biology 2009 Nov;29(21):5729-41
Molecular and cellular biology 2009 Nov;29(21):5729-41
An anti-vascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu+ breast tumors in a mouse model.
Seavey MM, Maciag PC, Al-Rawi N, Sewell D, Paterson Y
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5537-46
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5537-46
Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma.
Ishikawa T, Nakashiro K, Klosek SK, Goda H, Hara S, Uchida D, Hamakawa H
Oncology reports 2009 Mar;21(3):707-12
Oncology reports 2009 Mar;21(3):707-12
Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia-inducible factor-1 alpha expression in photoreceptors.
Thiersch M, Lange C, Joly S, Heynen S, Le YZ, Samardzija M, Grimm C
The European journal of neuroscience 2009 Jun;29(12):2291-302
The European journal of neuroscience 2009 Jun;29(12):2291-302
Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons.
Deli L, Wittmann G, Kalló I, Lechan RM, Watanabe M, Liposits Z, Fekete C
Endocrinology 2009 Jan;150(1):98-103
Endocrinology 2009 Jan;150(1):98-103
Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity.
Kim Y, Lin Q, Zelterman D, Yun Z
Cancer research 2009 Dec 15;69(24):9271-80
Cancer research 2009 Dec 15;69(24):9271-80
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization.
Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, Påhlman S
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Dec 1;15(23):7130-6
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Dec 1;15(23):7130-6
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J
Genes to cells : devoted to molecular & cellular mechanisms 2009 Aug;14(8):991-1001
Genes to cells : devoted to molecular & cellular mechanisms 2009 Aug;14(8):991-1001
Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs.
Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW
The Journal of nutrition 2009 Aug;139(8):1474-9
The Journal of nutrition 2009 Aug;139(8):1474-9
Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway.
Zhang J, Liu A, Hou R, Zhang J, Jia X, Jiang W, Chen J
European journal of pharmacology 2009 Apr 1;607(1-3):6-14
European journal of pharmacology 2009 Apr 1;607(1-3):6-14
High oxygen prevents fetal lethality due to lack of catecholamines.
Ream MA, Chandra R, Peavey M, Ray AM, Roffler-Tarlov S, Kim HG, Wetsel WC, Rockman HA, Chikaraishi DM
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Sep;295(3):R942-53
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Sep;295(3):R942-53
HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.
Saini Y, Harkema JR, LaPres JJ
The Journal of biological chemistry 2008 Nov 28;283(48):33650-7
The Journal of biological chemistry 2008 Nov 28;283(48):33650-7
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG Jr
Blood 2008 Mar 15;111(6):3236-44
Blood 2008 Mar 15;111(6):3236-44
Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.
Thiersch M, Raffelsberger W, Frigg R, Samardzija M, Wenzel A, Poch O, Grimm C
BMC genomics 2008 Feb 8;9:73
BMC genomics 2008 Feb 8;9:73
Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts.
Wirthner R, Wrann S, Balamurugan K, Wenger RH, Stiehl DP
Carcinogenesis 2008 Dec;29(12):2306-16
Carcinogenesis 2008 Dec;29(12):2306-16
FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.
LeBoeuf AC, Levy SF, Gaylord M, Bhattacharya A, Singh AK, Jordan MA, Wilson L, Feinstein SC
The Journal of biological chemistry 2008 Dec 26;283(52):36406-15
The Journal of biological chemistry 2008 Dec 26;283(52):36406-15
Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways.
Kundu CN, Balusu R, Jaiswal AS, Narayan S
Carcinogenesis 2007 Oct;28(10):2089-95
Carcinogenesis 2007 Oct;28(10):2089-95
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite.
Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK
Blood 2007 Oct 15;110(8):3039-48
Blood 2007 Oct 15;110(8):3039-48
Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats.
McLaren AT, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui AK, Li X, Yucel Y, Robb M, Boyd SR, Liu E, Yu J, Hare GM
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Jan;292(1):R403-14
American journal of physiology. Regulatory, integrative and comparative physiology 2007 Jan;292(1):R403-14
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter.
Ramanathan M, Pinhal-Enfield G, Hao I, Leibovich SJ
Molecular biology of the cell 2007 Jan;18(1):14-23
Molecular biology of the cell 2007 Jan;18(1):14-23
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.
Liao D, Corle C, Seagroves TN, Johnson RS
Cancer research 2007 Jan 15;67(2):563-72
Cancer research 2007 Jan 15;67(2):563-72
Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine.
Kariuki TM, Van Dam GJ, Deelder AM, Farah IO, Yole DS, Wilson RA, Coulson PS
Infection and immunity 2006 Jul;74(7):3979-86
Infection and immunity 2006 Jul;74(7):3979-86
[Interrelationships between methylmercury exposure and selenium supplementation in cockerels using selected laboratory diagnostic parameters and toxicological parameters of residues].
Wilsdorf G, Schulz O, Walzel R
DTW. Deutsche tierarztliche Wochenschrift 1991 Oct;98(10):373-6
DTW. Deutsche tierarztliche Wochenschrift 1991 Oct;98(10):373-6
The sail sign.
Chapman S
British journal of hospital medicine 1991 Dec;46(6):399-400
British journal of hospital medicine 1991 Dec;46(6):399-400
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- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
