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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB5317P-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Notch-1 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Notch-1.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P46531- Isotype
- IgG
- Antibody clone number
- 527425
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Notch Signaling Mediates Secondary Senescence.
Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA2-IIA.
Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia.
Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis.
Teo YV, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, Kiourtis C, Müller M, Green AR, Adams PD, Acosta JC, Bird TG, Kirschner K, Neretti N, Chandra T
Cell reports 2019 Apr 23;27(4):997-1007.e5
Cell reports 2019 Apr 23;27(4):997-1007.e5
Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA2-IIA.
Al-Attar A, Alimova Y, Kirakodu S, Kozal A, Novak MJ, Stromberg AJ, Orraca L, Gonzalez-Martinez J, Martinez M, Ebersole JL, Gonzalez OA
Mucosal immunology 2018 Jul;11(4):1047-1059
Mucosal immunology 2018 Jul;11(4):1047-1059
Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia.
Baldoni S, Del Papa B, Dorillo E, Aureli P, De Falco F, Rompietti C, Sorcini D, Varasano E, Cecchini D, Zei T, Di Tommaso A, Rosati E, Alexe G, Roti G, Stegmaier K, Di Ianni M, Falzetti F, Sportoletti P
International journal of cancer 2018 Aug 15;143(4):958-970
International journal of cancer 2018 Aug 15;143(4):958-970
Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis.
Piggott K, Deng J, Warrington K, Younge B, Kubo JT, Desai M, Goronzy JJ, Weyand CM
Circulation 2011 Jan 25;123(3):309-18
Circulation 2011 Jan 25;123(3):309-18
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Notch-1 in U2OS Human Cell Line by Flow Cytometry. U2OS human osteosarcoma cell line was stained with Mouse Anti-Human Notch-1 PE-conjugated Monoclonal Antibody (Catalog # FAB5317P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
