NOTCH1

gene product
TAN1
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1290 antibodies from 50 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
111 antibodies
R&D Systems
30 antibodies
Invitrogen Antibodies
15 antibodies
GeneTex
17 antibodies
Proteintech Group
2 antibodies
antibodies-online
367 antibodies
Cell Signaling Technology, Inc
7 antibodies
OriGene
39 antibodies
Antibodies.com
3 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
LifeSpan BioSciences, Inc.
215 antibodies
St John's Laboratory
5 antibodies
NovoPro Bioscience Inc.
7 antibodies
Boster Biological Technology
6 antibodies
Arigo
7 antibodies
BioLegend
22 antibodies
Abnova Corporation
12 antibodies
Acris Antibodies GmbH
27 antibodies
Aviva Systems Biology
11 antibodies
Bethyl Laboratories
3 antibodies
Affinity Biosciences
1 antibody
Biorbyt
68 antibodies
Antibodies Incorporated / NeuroMab
2 antibodies
Enzo Life Sciences
1 antibody
Creative Biolabs
114 antibodies
Abgent
5 antibodies
RabMAbs
2 antibodies
Bioworld Technology, Inc
1 antibody
Abbexa
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
NSJ Bioreagents
4 antibodies
Creative Diagnostics
14 antibodies
ProSci
3 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
15 antibodies
United States Biological
52 antibodies
EMD Millipore
8 antibodies
Spring Bioscience
4 antibodies
MyBioSource
14 antibodies
GenWay
5 antibodies
Abiocode, Inc.
2 antibodies
RayBiotech, Inc.
5 antibodies
Leading Biology
7 antibodies
Sigma-Aldrich
5 antibodies
UC Davis/NIH NeuroMab Facility
2 antibodies
Abbiotec
1 antibody
eBioscience, An Affymetrix Company
8 antibodies
Active Motif
1 antibody
BioLegend (formerly Covance Antibody Products)
1 antibody