ABIN181988

antibody from antibodies-online

Targeting: NOTCH1 TAN1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

ABIN181988

Provider

antibodies-online

Product name

anti-Notch 1 (NOTCH1) antibody

Antibody type

Monoclonal

Antigen

Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.

Description

Affinity chromatography on Protein G

Reactivity

Human, Mouse

Host

Mouse

Isotype

IgG

Antibody clone number

mN1A

Vial size

0.25 mg

Concentration

1.0 mg/mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Zoledronic acid inhibits osteosarcoma growth in an orthotopic model.

Dass CR, Choong PF
Molecular cancer therapeutics 2007 Dec;6(12 Pt 1):3263-70

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Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.

Kang-Decker N, Tong C, Boussouar F, Baker DJ, Xu W, Leontovich AA, Taylor WR, Brindle PK, van Deursen JM
Cancer cell 2004 Feb;5(2):177-89

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p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR.

Espinosa L, Santos S, Inglés-Esteve J, Muñoz-Canoves P, Bigas A
Journal of cell science 2002 Mar 15;115(Pt 6):1295-303

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R
Nature 2000 Jun 22;405(6789):966-70

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Evidence for a physical interaction between presenilin and Notch.

Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 16;96(6):3263-8