PROS1

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Description

Protein S

Tissue specificity

Group enriched (choroid plexus, heart muscle, liver)

Predicted location

Intracellular, Secreted to blood

Protein family

Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (93873051 - 93980003)

Ensembl ID

ENSG00000184500  (ver. 103.38)

Orthologs

Mouse Pros1: ENSMUSG00000022912

UniProt

P07225

neXtProt

NX_P07225

Human splice variants
Mouse splice variants

Protein structure