Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10189-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10189-2-AP, RRID:AB_2123233
- Product name
- IGFBP3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IGFBP3 antibody (Cat. #10189-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p.
The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma.
3D reconstruction of a gastrulating human embryo.
Single-cell N(6)-methyladenosine-related genes function within the tumor microenvironment to affect the prognosis and treatment sensitivity in patients with gastric cancer.
Deciphering m6A signatures in hepatocellular carcinoma: Single-cell insights, immune landscape, and the protective role of IGFBP3.
Intramuscular injection of mesenchymal stem cells augments basal muscle protein synthesis after bouts of resistance exercise in male mice.
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.
Identification of the Kupffer cell-derived circulating IGFBP-3 as a universal radiation biomarker for heavy ion, proton, and X-ray exposure.
IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma.
Proteomic analysis identifies Stomatin as a biological marker for psychological stress.
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects.
Downregulation of LOX promotes castration-resistant prostate cancer progression via IGFBP3.
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.
Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1.
Interleukin-33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin-like growth factor-binding protein 3.
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases.
RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence.
Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration.
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer.
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats.
Kang SH, Oh SY, Lee KY, Lee HJ, Kim MS, Kwon TG, Kim JW, Lee ST, Choi SY, Hong SH
Theranostics 2024;14(2):460-479
Theranostics 2024;14(2):460-479
The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma.
Zang Q, Ju Y, Liu S, Wu S, Zhu C, Liu L, Xu W, He Y
Human cell 2024 May;37(3):752-767
Human cell 2024 May;37(3):752-767
3D reconstruction of a gastrulating human embryo.
Xiao Z, Cui L, Yuan Y, He N, Xie X, Lin S, Yang X, Zhang X, Shi P, Wei Z, Li Y, Wang H, Wang X, Wei Y, Guo J, Yu L
Cell 2024 May 23;187(11):2855-2874.e19
Cell 2024 May 23;187(11):2855-2874.e19
Single-cell N(6)-methyladenosine-related genes function within the tumor microenvironment to affect the prognosis and treatment sensitivity in patients with gastric cancer.
Wang Z, Chen C, Shu J, Ai J, Liu Y, Cao H, Jia Y, Qin Y
Cancer cell international 2024 Jan 25;24(1):44
Cancer cell international 2024 Jan 25;24(1):44
Deciphering m6A signatures in hepatocellular carcinoma: Single-cell insights, immune landscape, and the protective role of IGFBP3.
Chen S, Liu J, Zhang S, Zhao L, Zhang J, Han P, Zhang Q, Liu Y, Wang F, Li J
Environmental toxicology 2024 Feb 16;
Environmental toxicology 2024 Feb 16;
Intramuscular injection of mesenchymal stem cells augments basal muscle protein synthesis after bouts of resistance exercise in male mice.
Takegaki J, Sase K, Kono Y, Fujita T, Konishi S, Fujita S
Physiological reports 2024 Apr;12(7):e15991
Physiological reports 2024 Apr;12(7):e15991
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.
Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL, Turner AW, Kho M, Hasbani NR, de Vries PS, Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL, Becker LC, Bos D, Carr JJ, Cupples LA, de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs DR Jr, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O'Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL
Nature genetics 2023 Oct;55(10):1651-1664
Nature genetics 2023 Oct;55(10):1651-1664
Identification of the Kupffer cell-derived circulating IGFBP-3 as a universal radiation biomarker for heavy ion, proton, and X-ray exposure.
Bai H, Wang J, Wang Q, Chen Y, Miao G, Zhang T, Hua J, Zhang Y, He J, Ding N, Zhou H, Sui L, Wei W
Ecotoxicology and environmental safety 2023 Oct 15;265:115526
Ecotoxicology and environmental safety 2023 Oct 15;265:115526
IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma.
Zhang X, Wang G, Gong Y, Zhao L, Song P, Zhang H, Zhang Y, Ju H, Wang X, Wang B, Ren H, Zhu X, Dong Y
iScience 2023 May 19;26(5):106639
iScience 2023 May 19;26(5):106639
Proteomic analysis identifies Stomatin as a biological marker for psychological stress.
Cao Y, Ying SQ, Qiu XY, Guo J, Chen C, Li SJ, Dou G, Zheng CX, Chen D, Qiu JY, Jin Y, Sui BD, Jin F
Neurobiology of stress 2023 Jan;22:100513
Neurobiology of stress 2023 Jan;22:100513
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.
Li Y, Liu B, Yin X, Jiang Z, Fang C, Chen N, Zhang B, Dai L, Yin Y
Clinical epigenetics 2022 Jul 20;14(1):92
Clinical epigenetics 2022 Jul 20;14(1):92
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Yin Y, Jiang Z, Fu J, Li Y, Fang C, Yin X, Chen Y, Chen N, Li J, Ji Y, Su X, Qiu M, Huang W, Zhang B, Deng H, Dai L
Cancer letters 2022 Jan 28;525:55-66
Cancer letters 2022 Jan 28;525:55-66
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Liu Y, Lv H, Li X, Liu J, Chen S, Chen Y, Jin Y, An R, Yu S, Wang Z
International journal of biological sciences 2021;17(13):3522-3537
International journal of biological sciences 2021;17(13):3522-3537
Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects.
Escuin-Ordinas H, Liu Y, Sun L, Hugo W, Dimatteo R, Huang RR, Krystofinski P, Azhdam A, Lee J, Comin-Anduix B, Cochran AJ, Lo RS, Segura T, Scumpia PO, Ribas A
PloS one 2021;16(6):e0252597
PloS one 2021;16(6):e0252597
Downregulation of LOX promotes castration-resistant prostate cancer progression via IGFBP3.
Chen X, Shao Y, Wei W, Shen H, Li Y, Chen Y, Ma Q, Li H, Yang Z, Niu Y, Shang Z
Journal of Cancer 2021;12(24):7349-7357
Journal of Cancer 2021;12(24):7349-7357
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
Wu D, Yu HQ, Xiong HJ, Zhang YJ, Lin XT, Zhang J, Wu W, Wang T, Liu XY, Xie CM
Frontiers in oncology 2021;11:743824
Frontiers in oncology 2021;11:743824
The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.
Carroll PA, Freie BW, Cheng PF, Kasinathan S, Gu H, Hedrich T, Dowdle JA, Venkataramani V, Ramani V, Wu X, Raftery D, Shendure J, Ayer DE, Muller CH, Eisenman RN
PLoS biology 2021 Oct;19(10):e3001085
PLoS biology 2021 Oct;19(10):e3001085
Podocyte apoptosis in diabetic nephropathy by BASP1 activation of the p53 pathway via WT1.
Zhang Y, Xu C, Ye Q, Tong L, Jiang H, Zhu X, Huang L, Lin W, Fu H, Wang J, Persson PB, Lai EY, Mao J
Acta physiologica (Oxford, England) 2021 May;232(1):e13634
Acta physiologica (Oxford, England) 2021 May;232(1):e13634
Interleukin-33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin-like growth factor-binding protein 3.
Wu MX, Wang SH, Xie Y, Chen ZT, Guo Q, Yuan WL, Guan C, Xu CZ, Huang YN, Wang JF, Zhang HF, Chen YX
Journal of cellular physiology 2021 Jun;236(6):4403-4419
Journal of cellular physiology 2021 Jun;236(6):4403-4419
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Zhang J, Yang S, Guan H, Zhou J, Gao Y
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases.
Rada M, Kapelanski-Lamoureux A, Petrillo S, Tabariès S, Siegel P, Reynolds AR, Lazaris A, Metrakos P
Communications biology 2021 Aug 10;4(1):950
Communications biology 2021 Aug 10;4(1):950
RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis.
Tatomir A, Beltrand A, Nguyen V, Boodhoo D, Mekala A, Cudrici C, Badea TC, Muresanu DF, Rus V, Rus H
Frontiers in immunology 2020;11:608294
Frontiers in immunology 2020;11:608294
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence.
Jiang YH, Jiang LY, Wang YC, Ma DF, Li X
Frontiers in pharmacology 2020;11:512
Frontiers in pharmacology 2020;11:512
Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration.
Chen S, Tang Y, Liu Y, Zhang P, Lv L, Zhang X, Jia L, Zhou Y
Cell proliferation 2019 Sep;52(5):e12669
Cell proliferation 2019 Sep;52(5):e12669
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, Huang G, Chen Z
Stem cell research 2019 Jul;38:101464
Stem cell research 2019 Jul;38:101464
Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer.
Liu X, Sun Z, Deng J, Liu J, Ma K, Si Y, Zhang T, Feng T, Liu Y, Tan Y
International journal of oncology 2018 Sep;53(3):1279-1288
International journal of oncology 2018 Sep;53(3):1279-1288
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, Herman JG, Fuks F, Dong G, Guo M
Clinical epigenetics 2017;9:116
Clinical epigenetics 2017;9:116
Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Yang J, Hamid S, Cai J, Liu Q, Xu S, Zhang Z
Cellular signalling 2017 Oct;38:192-200
Cellular signalling 2017 Oct;38:192-200
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats.
Chen J, Song H
Environmental toxicology and pharmacology 2016 Jul;45:315-20
Environmental toxicology and pharmacology 2016 Jul;45:315-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A2780 cells were subjected to SDS PAGE followed by western blot with 10189-2-AP(IGFBP3 antibody) at dilution of 1:100
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IGFBP3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IGFBP3. This antibody recognizes human,mouse,rat antigen. The IGFBP3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.