Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AF1029 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Cathepsin D Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse Cathepsin D in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant human Cathepsin D is observed and less than 1% cross-reactivity with recombinant mouse Cathepsin E is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype.
Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy.
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.
Renal type a intercalated cells contain albumin in organelles with aldosterone-regulated abundance.
Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells.
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.
Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice.
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.
Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.
Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages.
Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, Luo J, Lee JK, Liang C, Chen JF
Autophagy 2020 Sep;16(9):1635-1650
Autophagy 2020 Sep;16(9):1635-1650
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Li JG, Chiu J, Ramanjulu M, Blass BE, Praticò D
Molecular neurodegeneration 2020 Jan 22;15(1):1
Molecular neurodegeneration 2020 Jan 22;15(1):1
Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype.
Atiskova Y, Bartsch S, Danyukova T, Becker E, Hagel C, Storch S, Bartsch U
Scientific reports 2019 Oct 2;9(1):14185
Scientific reports 2019 Oct 2;9(1):14185
Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy.
Kishimoto A, Kimura S, Nio-Kobayashi J, Takahashi-Iwanaga H, Park AM, Iwanaga T
Experimental eye research 2018 Jul;172:1-9
Experimental eye research 2018 Jul;172:1-9
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.
Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF
Science advances 2016 Sep;2(9):e1601167
Science advances 2016 Sep;2(9):e1601167
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R
Scientific reports 2016 Dec 6;6:38278
Scientific reports 2016 Dec 6;6:38278
RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.
Kretzer NM, Theisen DJ, Tussiwand R, Briseño CG, Grajales-Reyes GE, Wu X, Durai V, Albring J, Bagadia P, Murphy TL, Murphy KM
The Journal of experimental medicine 2016 Dec 12;213(13):2871-2883
The Journal of experimental medicine 2016 Dec 12;213(13):2871-2883
Renal type a intercalated cells contain albumin in organelles with aldosterone-regulated abundance.
Jensen TB, Cheema MU, Szymiczek A, Damkier HH, Praetorius J
PloS one 2015;10(4):e0124902
PloS one 2015;10(4):e0124902
Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells.
Kern U, Wischnewski V, Biniossek ML, Schilling O, Reinheckel T
Molecular cancer 2015 Feb 15;14:39
Molecular cancer 2015 Feb 15;14:39
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.
Lee JK, Jin HK, Park MH, Kim BR, Lee PH, Nakauchi H, Carter JE, He X, Schuchman EH, Bae JS
The Journal of experimental medicine 2014 Jul 28;211(8):1551-70
The Journal of experimental medicine 2014 Jul 28;211(8):1551-70
Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice.
Lai NC, Gao MH, Tang E, Tang R, Guo T, Dalton ND, Deng A, Tang T
Laboratory investigation; a journal of technical methods and pathology 2012 Nov;92(11):1518-26
Laboratory investigation; a journal of technical methods and pathology 2012 Nov;92(11):1518-26
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.
Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, Schalkwijk J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Oct;24(10):3744-55
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Oct;24(10):3744-55
Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.
Schähs P, Weidinger P, Probst OC, Svoboda B, Stadlmann J, Beug H, Waerner T, Mach L
Experimental cell research 2008 Oct 1;314(16):3036-47
Experimental cell research 2008 Oct 1;314(16):3036-47
Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages.
Uppington H, Menager N, Boross P, Wood J, Sheppard M, Verbeek S, Mastroeni P
Immunology 2006 Oct;119(2):147-58
Immunology 2006 Oct;119(2):147-58
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Mouse Cathepsin D by Western Blot. Detection of Mouse Cathepsin D by Western Blot.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cathepsin D in Mouse Intestine. Cathepsin D in Mouse Intestine.