600-401-252S

antibody from Rockland Immunochemicals, Inc.

Targeting: TERT EST2, hEST2, TCS1, TP2, TRT

Provider product page for 600-401-252S

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [42]
Comments [0]
Validations
Immunocytochemistry [1]

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Product number: 600-401-252S - Provider product page
Provider: Rockland Immunochemicals, Inc.
Proper citation: Rockland Cat#600-401-252S, RRID:AB_10707282
Product name: Anti-Telomerase catalytic subunit (RABBIT) Antibody - 600-401-252S
Antibody type: Polyclonal
Vial size: 25 µl

TERT protein structure - 600-401-252S shown in red.

Submitted references Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus.

Muranyi W, Schwerk C, Herold R, Stump-Guthier C, Lampe M, Fallier-Becker P, Weiß C, Sticht C, Ishikawa H, Schroten H
iScience 2022 Jun 17;25(6):104383

The clinical and functional effects of TERT variants in myelodysplastic syndrome.

Reilly CR, Myllymäki M, Redd R, Padmanaban S, Karunakaran D, Tesmer V, Tsai FD, Gibson CJ, Rana HQ, Zhong L, Saber W, Spellman SR, Hu ZH, Orr EH, Chen MM, De Vivo I, DeAngelo DJ, Cutler C, Antin JH, Neuberg D, Garber JE, Nandakumar J, Agarwal S, Lindsley RC
Blood 2021 Sep 9;138(10):898-911

Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.

Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF
The EMBO journal 2021 May 3;40(9):e106048

HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles.

Gómez-Ferrer M, Villanueva-Badenas E, Sánchez-Sánchez R, Sánchez-López CM, Baquero MC, Sepúlveda P, Dorronsoro A
International journal of molecular sciences 2021 Mar 26;22(7)

Telomerase therapy attenuates cardiotoxic effects of doxorubicin.

Chatterjee S, Hofer T, Costa A, Lu D, Batkai S, Gupta SK, Bolesani E, Zweigerdt R, Megias D, Streckfuss-Bömeke K, Brandenberger C, Thum T, Bär C
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Apr 7;29(4):1395-1410

Telomerase Reverse Transcriptase (TERT) Expression, Telomerase Activity, and Expression of Matrix Metalloproteinases (MMP)-1/-2/-9 in Feline Oral Squamous Cell Carcinoma Cell Lines Associated With Felis catus Papillomavirus Type-2 Infection.

Altamura G, Martano M, Licenziato L, Maiolino P, Borzacchiello G
Frontiers in veterinary science 2020;7:148

Extracellular vesicles from rat-bone-marrow mesenchymal stromal/stem cells improve tendon repair in rat Achilles tendon injury model in dose-dependent manner: A pilot study.

Gissi C, Radeghieri A, Antonetti Lamorgese Passeri C, Gallorini M, Calciano L, Oliva F, Veronesi F, Zendrini A, Cataldi A, Bergese P, Maffulli N, Berardi AC
PloS one 2020;15(3):e0229914

DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during H. pylori-Induced Chronic Inflammation.

Bussière FI, Michel V, Fernandes J, Costa L, Camilo V, Nigro G, De Reuse H, Fiette L, Touati E
Journal of oncology 2019;2019:5415761

Telomerase promotes formation of a telomere protective complex in cancer cells.

Perera ON, Sobinoff AP, Teber ET, Harman A, Maritz MF, Yang SF, Pickett HA, Cesare AJ, Arthur JW, MacKenzie KL, Bryan TM
Science advances 2019 Oct;5(10):eaav4409

Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.

Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA
The Journal of biological chemistry 2019 Jul 5;294(27):10564-10578

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.

Kabacik S, Horvath S, Cohen H, Raj K
Aging 2018 Oct 17;10(10):2800-2815

Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs.

Bernal A, Zafon E, Domínguez D, Bertran E, Tusell L
International journal of molecular sciences 2018 Jul 17;19(7)

Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma.

Hugdahl E, Kalvenes MB, Mannelqvist M, Ladstein RG, Akslen LA
British journal of cancer 2018 Jan;118(1):98-105

Dynamics of human telomerase recruitment depend on template-telomere base pairing.

Schmidt JC, Zaug AJ, Kufer R, Cech TR
Molecular biology of the cell 2018 Apr 1;29(7):869-880

RNA-seq reveals distinctive RNA profiles of small extracellular vesicles from different human liver cancer cell lines.

Berardocco M, Radeghieri A, Busatto S, Gallorini M, Raggi C, Gissi C, D'Agnano I, Bergese P, Felsani A, Berardi AC
Oncotarget 2017 Oct 10;8(47):82920-82939

The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.

Li B, Reddy S, Comai L
Molecular and cellular biology 2017 Feb 1;37(3)

In Vitro Assessment of the Expression and T Cell Immunogenicity of the Tumor-Associated Antigens BORIS, MUC1, hTERT, MAGE-A3 and Sp17 in Uterine Cancer.

Vanderstraeten A, Tuyaerts S, Everaert T, Van Bree R, Verbist G, Luyten C, Amant F
International journal of molecular sciences 2016 Sep 9;17(9)

Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition.

Qing H, Aono J, Findeisen HM, Jones KL, Heywood EB, Bruemmer D
Journal of cellular physiology 2016 Jun;231(6):1276-82

Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons.

Eitan E, Braverman C, Tichon A, Gitler D, Hutchison ER, Mattson MP, Priel E
Cerebellum (London, England) 2016 Aug;15(4):509-17

Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1.

Hong J, Lee JH, Chung IK
Journal of cell science 2016 Apr 15;129(8):1566-79

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.

Jeong SA, Kim K, Lee JH, Cha JS, Khadka P, Cho HS, Chung IK
Journal of cell science 2015 Jun 15;128(12):2287-301

Microenvironmental regulation of telomerase isoforms in human embryonic stem cells.

Radan L, Hughes CS, Teichroeb JH, Vieira Zamora FM, Jewer M, Postovit LM, Betts DH
Stem cells and development 2014 Sep 1;23(17):2046-66

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Theurillat JP, Udeshi ND, Errington WJ, Svinkina T, Baca SC, Pop M, Wild PJ, Blattner M, Groner AC, Rubin MA, Moch H, Prive GG, Carr SA, Garraway LA
Science (New York, N.Y.) 2014 Oct 3;346(6205):85-89

Modulation of telomerase activity, bTERT and c-Myc induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin during Bovine Herpesvirus 1 infection in MDBK cells.

Fiorito F, Cantiello A, Granato GE, Marfè G, Ciarcia R, Florio S, Pagnini U, De Martino L, Iovane G
Toxicology in vitro : an international journal published in association with BIBRA 2014 Feb;28(1):24-30

Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions.

Gonzalez OG, Assfalg R, Koch S, Schelling A, Meena JK, Kraus J, Lechel A, Katz SF, Benes V, Scharffetter-Kochanek K, Kestler HA, Günes C, Iben S
Nature communications 2014 Aug 13;5:4599

Upregulation of Nrf2 expression by human cytomegalovirus infection protects host cells from oxidative stress.

Lee J, Koh K, Kim YE, Ahn JH, Kim S
The Journal of general virology 2013 Jul;94(Pt 7):1658-1668

Telomere length and regulatory proteins in human skeletal muscle with and without ongoing regenerative cycles.

Ponsot E, Echaniz-Laguna A, Delis AM, Kadi F
Experimental physiology 2012 Jun;97(6):774-84

Role for telomerase in Listeria monocytogenes infection.

Samba-Louaka A, Stavru F, Cossart P
Infection and immunity 2012 Dec;80(12):4257-63

Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis.

Eitan E, Tichon A, Gazit A, Gitler D, Slavin S, Priel E
EMBO molecular medicine 2012 Apr;4(4):313-29

Telomerase expression in adult and old mouse Purkinje neurons.

Eitan E, Tichon A, Daniel G, Priel E
Rejuvenation research 2012 Apr;15(2):206-9

Immortalisation of normal human urothelial cells compromises differentiation capacity.

Georgopoulos NT, Kirkwood LA, Varley CL, MacLaine NJ, Aziz N, Southgate J
European urology 2011 Jul;60(1):141-9

Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages.

Gizard F, Heywood EB, Findeisen HM, Zhao Y, Jones KL, Cudejko C, Post GR, Staels B, Bruemmer D
Arteriosclerosis, thrombosis, and vascular biology 2011 Feb;31(2):245-52

2,3,7,8-tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line.

Fiorito F, Ciarcia R, Granato GE, Marfe G, Iovane V, Florio S, De Martino L, Pagnini U
Toxicology 2011 Dec 18;290(2-3):258-70

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.

Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP
Molecular and cellular biology 2010 Jun;30(12):2971-82

Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.

Liu S, Qi Y, Ge Y, Duplessis T, Rowan BG, Ip C, Cheng H, Rennie PS, Horikawa I, Lustig AJ, Yu Q, Zhang H, Dong Y
Molecular cancer therapeutics 2010 Jul;9(7):2016-25

Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells.

Tuntiwechapikul W, Taka T, Songsomboon C, Kaewtunjai N, Imsumran A, Makonkawkeyoon L, Pompimon W, Lee TR
Journal of medicinal food 2010 Dec;13(6):1347-54

Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals.

Tichon A, Gowda BK, Slavin S, Gazit A, Priel E
Cytotherapy 2009;11(7):837-48

Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining.

Jakupciak JP, Gallant ND, Smith AH, Becker ML, Tona A, Atha DH
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2009 Oct;84(5):195-206

Immunohistochemical determination of the appropriate anti-hTERT antibodies for in situ detection of telomerase activity in frozen sections of head and neck squamous cell carcinomas and tumor margin tissues.

Fabricius EM, Kruse-Boitschenko U, Khoury R, Wildner GP, Raguse JD, Klein M
International journal of oncology 2009 May;34(5):1257-79

Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues.

Fabricius EM, Kruse-Boitschenko U, Khoury R, Wildner GP, Raguse JD, Klein M, Hoffmeister B
International journal of oncology 2009 Dec;35(6):1377-94

PML-IV functions as a negative regulator of telomerase by interacting with TERT.

Oh W, Ghim J, Lee EW, Yang MR, Kim ET, Ahn JH, Song J
Journal of cell science 2009 Aug 1;122(Pt 15):2613-22

Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3.

Chau MN, El Touny LH, Jagadeesh S, Banerjee PP
Carcinogenesis 2007 Nov;28(11):2282-90

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Supportive validation

Submitted by: Rockland Immunochemicals, Inc. (provider)
Main image
Experimental details: Rockland anti hTERT antibody-Immunofluorescence#Rockland anti hTERT antibody was used to stain hTERT on hTERT-over-expressing fibroblasts. Cells were untreated (Left) or treated (Right) with 500 uM H202, fixed in 4% PFA (in PBS) for 10 min and frozen in -80 after 3 min air-drying before staining with Rockland anti hTERT 1:2000 overnight. Confocal images provided by G. Saretzki, Institute for Ageing and Health, Newcastle University, UK. See Ahmed et. Al. for more information.
Sample type: IF Microscopy