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- References [18]
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- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 18094-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CLOCK antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CLOCK antibody (Cat. #18094-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression.
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2.
A druggable copper-signalling pathway that drives inflammation.
Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.
Resveratrol reversed ambient particulate matter exposure-perturbed oscillations of hepatic glucose metabolism by regulating SIRT1 in mice.
The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.
The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway.
1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes.
Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.
Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.
Zhu G, Gao H, Li Y, Li X, Yang X, Wang C, Guo Z, Fan H, Fan L
Pathology, research and practice 2024 Jan;253:154969
Pathology, research and practice 2024 Jan;253:154969
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Fangninou FF, Yu Z, Li W, Xue L, Yin D
The Science of the total environment 2024 Feb 20;912:169305
The Science of the total environment 2024 Feb 20;912:169305
3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2.
Guan S, Wang Z, Zhang R, Chen S, Bu X, Lu J
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14351-14364
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14351-14364
A druggable copper-signalling pathway that drives inflammation.
Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R
Nature 2023 May;617(7960):386-394
Nature 2023 May;617(7960):386-394
Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.
Hammarlund JA, Li SY, Wu G, Lian JW, Howell SJ, Clarke R, Adamson A, Gonçalves CF, Hogenesch JB, Meng QJ, Anafi RC
bioRxiv : the preprint server for biology 2023 May 19;
bioRxiv : the preprint server for biology 2023 May 19;
Resveratrol reversed ambient particulate matter exposure-perturbed oscillations of hepatic glucose metabolism by regulating SIRT1 in mice.
Jiang J, Gu Y, Ding S, Zhang G, Ding J
Environmental science and pollution research international 2023 Mar;30(11):31821-31834
Environmental science and pollution research international 2023 Mar;30(11):31821-31834
The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.
Wu J, Bu D, Wang H, Shen D, Chong D, Zhang T, Tao W, Zhao M, Zhao Y, Fang L, Li P, Xue B, Li CJ
Nature communications 2023 Mar 24;14(1):1634
Nature communications 2023 Mar 24;14(1):1634
The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway.
Zhu X, Liu J, Cai M, Bao L, Pan Y, Wu P, Chu W, Zhang J
The British journal of nutrition 2023 Aug 28;130(4):604-615
The British journal of nutrition 2023 Aug 28;130(4):604-615
1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes.
Fan Y, Lu J, Fan J, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113670
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113670
Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations.
Padlom A, Ono D, Hamashima R, Furukawa Y, Yoshimura T, Nishiwaki-Ohkawa T
Scientific reports 2022 Nov 14;12(1):19519
Scientific reports 2022 Nov 14;12(1):19519
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.
Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, Liu W, Li G, Lu D, Meng G, Hu L, Yuan A, Lu X, Pu J
European heart journal 2022 Jun 21;43(24):2317-2334
European heart journal 2022 Jun 21;43(24):2317-2334
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.
Tan X, Cao F, Tang F, Lu C, Yu Q, Feng S, Yang Z, Chen S, He X, He J, Weng L, Sun L
Journal of immunology research 2021;2021:9995869
Journal of immunology research 2021;2021:9995869
Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.
Jia M, Su B, Mo L, Qiu W, Ying J, Lin P, Yang B, Li D, Wang D, Xu L, Li H, Zhou Z, Li X, Li J
Oncology reports 2021 Mar;45(3):1033-1043
Oncology reports 2021 Mar;45(3):1033-1043
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301
Cell death & disease 2021 Mar 19;12(4):301
Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Zhang L, Yang H, Zhang W, Liang Z, Huang Q, Xu G, Zhen X, Zheng LT
Journal of neurochemistry 2017 Aug;142(4):574-588
Journal of neurochemistry 2017 Aug;142(4):574-588
A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.
Cui M, Zheng M, Sun B, Wang Y, Ye L, Zhang X
Neoplasia (New York, N.Y.) 2015 Jan;17(1):79-88
Neoplasia (New York, N.Y.) 2015 Jan;17(1):79-88
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 18094-1-AP( CLOCK Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CLOCK antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CLOCK. This antibody recognizes human antigen. The CLOCK antibody has been validated for the following applications: ELISA, WB, IP analysis.
