18094-1-AP

antibody from Proteintech Group

Targeting: CLOCK bHLHe8, KAT13D, KIAA0334

Provider product page for 18094-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [28]
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Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 18094-1-AP - Provider product page
Provider: Proteintech Group
Product name: CLOCK antibody
Antibody type: Polyclonal
Description: KD/KO validated CLOCK antibody (Cat. #18094-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CLOCK protein structure - 18094-1-AP shown in red.

Submitted references Circadian Clock Dysfunction Exacerbate Autistic-Like Behaviour and Wnt/β-Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin.

Zhang Y, Chen Y, Li W, Tang L, Wang G, Li J, Feng X
Journal of cellular and molecular medicine 2026 Jan;30(1):e70991

BMAL1-mediated circadian-ferroptosis crosstalk drives neuronal vulnerability after TBI.

Huang R, Pang Q, Shen D, Zheng L, Wang L, Jia B, Xu Y, Du J, Li Y, Dai F, Sun W, Shen Y, Gao C, Gu Z, Wang Z, Tao L, Wang T
Free radical biology & medicine 2026 Feb 1;243:548-563

Circadian Rhythm Disorder-Related Dysfunctions are Exacerbated by Aging and Ameliorated by Time-Restricted Feeding.

Huo F, Liu Q, Zhang S, Liu X, Lv S, Zhao M, Liu Y, Zhu X, Huang C, Feng S, Wang H, Xu S, Shen J, Gao J, Su T, Wu Y, Jiang R, Zhu JK, Liu H
Neuroscience bulletin 2026 Apr;42(4):872-896

Long-term low-dose exposure to 9-chlorophenanthrene induces liver lipid accumulation via disrupting circadian rhythm.

Liu M, Lu Y, Zhou H, Chen Y, Li Y, Zhang T
Journal of hazardous materials 2025 Sep 5;495:139145

Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.

Chen W, Zhang H, Guo B, Tao Y, Zhang J, Wang J, Chen G, Cheng M, Hong Q, Cao Y, Xie F
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104

RORα fine-tunes the circadian control of hepatic triglyceride synthesis and gluconeogenesis.

Monnier C, Ganbold M, Auclair M, Roblot N, Boutin AB, Boutin PK, Fève B, Antoine B
Scientific reports 2025 Mar 26;15(1):10464

Spatiotemporal Circadian Oscillator Manipulation for Enhanced Ovarian Cancer Therapy Using a Versatile Nanoplatform.

Lin J, Zhang Q, Xin Y, Lin K, Zhou Z, Yang X, Zhou Y, Wang Y, Li J, Yang H, Xie Z, Lu W, Bi Z, Guo Y, Zheng J, Shen J, Yang X, Shen J, Qi R
ACS applied materials & interfaces 2025 Jun 18;17(24):35023-35039

Loss of ARNTL Enhances ER Stress and Apoptosis in CKD Through Disruption of NRF2 Signaling.

He L, Zhang Q, Sheng X, Yin J, Yan Y, Wu M, Bao H, Hu S, Wang N, Cao A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70715

Dynamic and functional analyses of exosomal miRNAs regulating cellular microenvironment of ovarian cancer cells.

Wang Z, Huang Y, He S, Zhou Y, Zhao L, Wang F
Journal of ovarian research 2025 Feb 10;18(1):25

Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice.

Chen YN, Zhao ST, Hu MA, Li W, Yu J, Ma MJ, Tang LY, Feng X, Li JS, Zhang YX
Journal of neuroinflammation 2025 Dec 11;23(1):23

Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression.

Zhu G, Gao H, Li Y, Li X, Yang X, Wang C, Guo Z, Fan H, Fan L
Pathology, research and practice 2024 Jan;253:154969

Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.

Fangninou FF, Yu Z, Li W, Xue L, Yin D
The Science of the total environment 2024 Feb 20;912:169305

3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2.

Guan S, Wang Z, Zhang R, Chen S, Bu X, Lu J
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14351-14364

A druggable copper-signalling pathway that drives inflammation.

Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R
Nature 2023 May;617(7960):386-394

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.

Hammarlund JA, Li SY, Wu G, Lian JW, Howell SJ, Clarke R, Adamson A, Gonçalves CF, Hogenesch JB, Meng QJ, Anafi RC
bioRxiv : the preprint server for biology 2023 May 19;

Resveratrol reversed ambient particulate matter exposure-perturbed oscillations of hepatic glucose metabolism by regulating SIRT1 in mice.

Jiang J, Gu Y, Ding S, Zhang G, Ding J
Environmental science and pollution research international 2023 Mar;30(11):31821-31834

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.

Wu J, Bu D, Wang H, Shen D, Chong D, Zhang T, Tao W, Zhao M, Zhao Y, Fang L, Li P, Xue B, Li CJ
Nature communications 2023 Mar 24;14(1):1634

The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway.

Zhu X, Liu J, Cai M, Bao L, Pan Y, Wu P, Chu W, Zhang J
The British journal of nutrition 2023 Aug 28;130(4):604-615

1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes.

Fan Y, Lu J, Fan J, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113670

Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations.

Padlom A, Ono D, Hamashima R, Furukawa Y, Yoshimura T, Nishiwaki-Ohkawa T
Scientific reports 2022 Nov 14;12(1):19519

Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.

Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)

Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.

Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, Liu W, Li G, Lu D, Meng G, Hu L, Yuan A, Lu X, Pu J
European heart journal 2022 Jun 21;43(24):2317-2334

Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.

Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803

Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration.

Tan X, Cao F, Tang F, Lu C, Yu Q, Feng S, Yang Z, Chen S, He X, He J, Weng L, Sun L
Journal of immunology research 2021;2021:9995869

Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.

Jia M, Su B, Mo L, Qiu W, Ying J, Lin P, Yang B, Li D, Wang D, Xu L, Li H, Zhou Z, Li X, Li J
Oncology reports 2021 Mar;45(3):1033-1043

hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.

Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301

Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.

Zhang L, Yang H, Zhang W, Liang Z, Huang Q, Xu G, Zhen X, Zheng LT
Journal of neurochemistry 2017 Aug;142(4):574-588

A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis.

Cui M, Zheng M, Sun B, Wang Y, Ye L, Zhang X
Neoplasia (New York, N.Y.) 2015 Jan;17(1):79-88

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 18094-1-AP( CLOCK Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CLOCK antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CLOCK. This antibody recognizes human antigen. The CLOCK antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 18094-1-AP.pdf

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