Tissue expression
Cell line expression

CLOCK

gene product
bHLHe8, KAT13D, KIAA0334 
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
More gene data

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539 antibodies from 40 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
Invitrogen Antibodies
34 antibodies
antibodies-online
150 antibodies
Abnova Corporation
7 antibodies
LifeSpan BioSciences, Inc.
82 antibodies
Novus Biologicals
29 antibodies
Affinity Biosciences
3 antibodies
NSJ Bioreagents
3 antibodies
HUABIO Research
2 antibodies
GeneTex
6 antibodies
Cusabio Biotech Co., Ltd
6 antibodies
Atlas Antibodies
2 antibodies
NovoPro Bioscience Inc.
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
Biorbyt
31 antibodies
OriGene
35 antibodies
Acris Antibodies GmbH
12 antibodies
Aviva Systems Biology
3 antibodies
Boster Biological Technology
2 antibodies
Abgent
4 antibodies
RabMAbs
2 antibodies
Bioworld Technology, Inc
1 antibody
Bethyl Laboratories
2 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Diagnostics
5 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
ProSci
2 antibodies
Arigo
1 antibody
R&D Systems
1 antibody
Abbexa
10 antibodies
Creative Biolabs
41 antibodies
MyBioSource
6 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
United States Biological
29 antibodies
Abbiotec
2 antibodies
Leading Biology
3 antibodies
EMD Millipore
1 antibody
Everest Biotech
1 antibody
GenWay
1 antibody