PIAS2

This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]

Description

Protein inhibitor of activated STAT 2

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

18 (46803218 - 46920160)

Ensembl ID

ENSG00000078043  (ver. 103.38)

Orthologs

Mouse Pias2: ENSMUSG00000025423

UniProt

O75928

neXtProt

NX_O75928

Human splice variants
Mouse splice variants

Protein structure