14105-1-AP

antibody from Proteintech Group

Targeting: ARNT bHLHe2, HIF-1beta

Provider product page for 14105-1-AP

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References [29]
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Product number: 14105-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14105-1-AP, RRID:AB_10639523
Product name: ARNT,HIF1B antibody
Antibody type: Polyclonal
Description: KD/KO validated ARNT,HIF1B antibody (Cat. #14105-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ARNT protein structure - 14105-1-AP shown in red.

Submitted references Lactylation of HIF-1α at K172 drives HIF-1 complex assembly to promote hypoxia-induced immune evasion in esophageal squamous cell carcinoma.

Cong J, Zheng S, Zhang H, Li Y, Liu Z
Cancer letters 2026 Jul 28;651:218548

Unveiling the active component of HuoXueTongFu formula: Emodin attenuates postoperative intra-abdominal adhesion by inhibiting HIF-1α-mediated glycolytic reprogramming.

Chen Y, Miao J, Yang L, Fang Y, Lian Y, Li G, Kong Z, Zhang L, Zeng L, Bian Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157719

Mantis shrimp saddle-mimetic amorphous calcium (zinc) phosphate/chitin scaffolds with superior mechanical properties and bioactivity for bone regeneration.

Zhao Z, Gao J, Vecchio KS, Cao L, Liu X, Wang H, Yang R, Tang P, Li M, Zhang X
Bioactive materials 2026 Apr;58:738-754

Chronic exposure to B[a]P induces malignant transformation of breast epithelial cells through the mechanism via TGF-β signaling pathway.

Tang Y, Feng Z, Ma C, Jang N, Chen X, He Y, Martin FL, Liu H, Pang W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115574

Quercetin protected the gut barrier in ulcerative colitis by activating aryl hydrocarbon receptor.

Wei Q, Jiang H, Zeng J, Xu J, Zhang H, Xiao E, Lu Q, Huang G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156633

Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.

Duah M, Zheng F, Shen J, Xu Y, Cao S, Yan Z, Lan Q, Wang Y, Xu K, Pan B
Acta pharmaceutica Sinica. B 2025 Jan;15(1):224-238

Butylphthalide mitigates traumatic brain injury by activating anti-ferroptotic AHR-CYP1B1 pathway.

Yan L, Gu L, Lv X, Ni Z, Qian W, Chen Z, Yang S, Zhuge Q, Yuan L, Ni H
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118758

3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.

Liu C, Wang Y, Sheng L, Zhang Y, Luo G, Ruan XZ, Chen Y, Huang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445

dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening.

Allen TP, Roennfeldt AE, Reckdharajkumar M, Sullivan AE, Liu M, Quinn RJ, Russell DL, Peet DJ, Whitelaw ML, Bersten DC
Nature communications 2025 Apr 7;16(1):3298

Benvitimod Inhibits IL-4- and IL-13-Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes.

Wang X, Mao D, Jia J, Zhang J
The Journal of investigative dermatology 2024 Mar;144(3):509-519.e7

Sustained AhR activity programs memory fate of early effector CD8(+) T cells.

Zhang H, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 12;121(11):e2317658121

Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.

Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529

The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy.

Wang J, Yang C, Xu H, Fan X, Jia L, Du Y, Liu S, Wang W, Zhang J, Zhang Y, Wang X, Liu Z, Bao J, Li S, Yang J, Wu C, Tang J, Chen G, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2303904

AHR activation relieves deoxynivalenol-induced disruption of porcine intestinal epithelial barrier functions.

Hu ZY, Yang SJ, Chang YH, Wang XQ, Liu RQ, Jiang FW, Chen MS, Wang JX, Liu S, Zhu HM, Shi YS, Zhao Y, Li JL
Journal of hazardous materials 2024 Dec 5;480:136095

L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes.

Schlichtner S, Yasinska IM, Klenova E, Abooali M, Lall GS, Berger SM, Ruggiero S, Cholewa D, Milošević M, Gibbs BF, Fasler-Kan E, Sumbayev VV
Oncoimmunology 2023;12(1):2244330

EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1, TRF2, and RAD50.

Li KQ, Liu GJ, Liu XY, Chen QF, Huang XY, Tu Q, Zhang J, Chang Q, Xie YH, Hua R, Xu DM, Liu Z, Zhao B
Zoological research 2023 May 18;44(3):636-649

Fine particulate matter (PM2.5) induces inhibitory memory alveolar macrophages through the AhR/IL-33 pathway.

Liu Y, Yuan Q, Zhang X, Chen Z, Jia X, Wang M, Xu T, Wang Z, Jiang J, Ma Q, Zhang M, Huang M, Ji N
Cellular immunology 2023 Apr;386:104694

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.

Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365

Induction of estrogen receptor β-mediated autophagy sensitizes breast cancer cells to TAD1822-7, a novel biphenyl urea taspine derivative.

Su Q, Wu Q, Chen K, Wang J, Sarwar A, Zhang Y
Molecular biology reports 2022 Feb;49(2):1223-1232

High-fat diet and alcohol induced-mice could cause colonic injury through molecular mechanisms of endogenous toxins.

Zhu S, Huang H, Xu S, Liu Y, Wu Y, Xu S, Huang S, Gao J, He L
Toxicology research 2022 Aug;11(4):696-706

Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome.

Kunitomi C, Harada M, Kusamoto A, Azhary JM, Nose E, Koike H, Xu Z, Urata Y, Takahashi N, Wada-Hiraike O, Hirota Y, Koga K, Fujii T, Osuga Y
Molecular human reproduction 2021 Feb 27;27(3)

Fine Particulate Matter (PM(2).(5)) Promotes CD146 Expression in Alveolar Epithelial Cells and Cryptococcus neoformans Pulmonary Infection.

Sun Z, Ji N, Jiang J, Tao Y, Zhang E, Yang X, Wang Z, Chen Z, Huang M, Zhang M
Frontiers in microbiology 2020;11:525976

Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis.

Jia Y, Tao Y, Lv C, Xia Y, Wei Z, Dai Y
Cell death & disease 2019 Jan 15;10(2):38

Fine Particulate Matter (PM(2.5)) Promoted the Invasion of Lung Cancer Cells via an ARNT2/PP2A/STAT3/MMP2 Pathway.

Chen Z, Ji N, Wang Z, Wu C, Sun Z, Li Y, Hu F, Wang Z, Huang M, Zhang M
Journal of biomedical nanotechnology 2018 Dec 1;14(12):2172-2184

Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.

Liu Q, Wu J, Song J, Liang P, Zheng K, Xiao G, Liu L, Zouboulis CC, Lei T
International journal of molecular medicine 2017 Oct;40(4):1029-1036

Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation.

Seo S, Seo K, Ki SH, Shin SM
Biological & pharmaceutical bulletin 2016;39(11):1830-1838

Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.

Seo K, Seo S, Ki SH, Shin SM
Free radical biology & medicine 2016 Dec;101:511-523

Interferon-γ-induced intestinal epithelial barrier dysfunction by NF-κB/HIF-1α pathway.

Yang S, Yu M, Sun L, Xiao W, Yang X, Sun L, Zhang C, Ma Y, Yang H, Liu Y, Lu D, Teitelbaum DH, Yang H
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Mar;34(3):195-203

PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.

Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ARNT,HIF1B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ARNT,HIF1B. This antibody recognizes human, mouse antigen. The ARNT,HIF1B antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14105-1-AP.pdf

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