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antibody from antibodies-online
Targeting: ARNT
bHLHe2, HIF-1beta
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Gel shift Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [89]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN151055 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Bovine, Sheep, Simian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- H1beta234
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment.
Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility.
Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.
NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction.
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.
Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.
Hypoxia-inducible factors enhance glutamate signaling in cancer cells.
HIFs enhance the transcriptional activation and splicing of adrenomedullin.
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway.
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.
Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions.
BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart.
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage.
The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability.
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
An oxygen-regulated switch in the protein synthesis machinery.
Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.
Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning.
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.
The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition.
Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity.
Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation.
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line.
Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats.
Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells.
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy.
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells.
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.
Activation of hypoxia-inducible factor 1 during macrophage differentiation.
MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis.
Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion.
Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity.
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells.
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia.
Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19.
Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.
Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.
Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling.
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407.
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF.
Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance.
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells.
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
Protein expression profiles indicative for drug resistance of non-small cell lung cancer.
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.
Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells.
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression.
Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ
Oncogenesis 2017 Jan 16;6(1):e287
Oncogenesis 2017 Jan 16;6(1):e287
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment.
Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL
Cell reports 2017 Feb 21;18(8):1946-1957
Cell reports 2017 Feb 21;18(8):1946-1957
Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility.
Taylor SE, Bagnall J, Mason D, Levy R, Fernig DG, See V
Open biology 2016 Sep;6(9)
Open biology 2016 Sep;6(9)
Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D
Nature 2016 Sep 1;537(7618):63-68
Nature 2016 Sep 1;537(7618):63-68
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.
Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L
Immunity 2016 Jul 19;45(1):185-97
Immunity 2016 Jul 19;45(1):185-97
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL
Oncotarget 2016 Feb 9;7(6):6379-97
Oncotarget 2016 Feb 9;7(6):6379-97
NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction.
Kim KH, Kim D, Park JY, Jung HJ, Cho YH, Kim HK, Han J, Choi KY, Kwon HJ
Journal of molecular medicine (Berlin, Germany) 2015 May;93(5):499-509
Journal of molecular medicine (Berlin, Germany) 2015 May;93(5):499-509
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.
Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL
Oncotarget 2015 May 20;6(14):11768-78
Oncotarget 2015 May 20;6(14):11768-78
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.
Rossin F, D'Eletto M, Falasca L, Sepe S, Cocco S, Fimia GM, Campanella M, Mastroberardino PG, Farrace MG, Piacentini M
Cell death and differentiation 2015 Mar;22(3):408-18
Cell death and differentiation 2015 Mar;22(3):408-18
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM
The Journal of clinical endocrinology and metabolism 2015 Jan;100(1):E30-40
The Journal of clinical endocrinology and metabolism 2015 Jan;100(1):E30-40
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Altuntas S, Rossin F, Marsella C, D'Eletto M, Diaz-Hidalgo L, Farrace MG, Campanella M, Antonioli M, Fimia GM, Piacentini M
Oncotarget 2015 Dec 29;6(42):44941-54
Oncotarget 2015 Dec 29;6(42):44941-54
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.
Frey JL, Stonko DP, Faugere MC, Riddle RC
Bone research 2014;2:14005
Bone research 2014;2:14005
Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.
Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR
The Journal of physiology 2014 Sep 1;592(17):3841-58
The Journal of physiology 2014 Sep 1;592(17):3841-58
Hypoxia-inducible factors enhance glutamate signaling in cancer cells.
Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL
Oncotarget 2014 Oct 15;5(19):8853-68
Oncotarget 2014 Oct 15;5(19):8853-68
HIFs enhance the transcriptional activation and splicing of adrenomedullin.
Sena JA, Wang L, Pawlus MR, Hu CJ
Molecular cancer research : MCR 2014 May;12(5):728-41
Molecular cancer research : MCR 2014 May;12(5):728-41
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
Chaturvedi P, Gilkes DM, Takano N, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 May 20;111(20):E2120-9
Proceedings of the National Academy of Sciences of the United States of America 2014 May 20;111(20):E2120-9
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Pawlus MR, Wang L, Hu CJ
Oncogene 2014 Mar 27;33(13):1670-9
Oncogene 2014 Mar 27;33(13):1670-9
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL
The Biochemical journal 2014 Mar 1;458(2):203-11
The Biochemical journal 2014 Mar 1;458(2):203-11
Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway.
Zhang J, Ma WY
Genetics and molecular research : GMR 2014 Jan 24;13(4):9324-35
Genetics and molecular research : GMR 2014 Jan 24;13(4):9324-35
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 21;111(3):E384-93
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 21;111(3):E384-93
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.
Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL
Journal of molecular medicine (Berlin, Germany) 2014 Feb;92(2):151-64
Journal of molecular medicine (Berlin, Germany) 2014 Feb;92(2):151-64
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.
Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL
Oncotarget 2014 Dec 30;5(24):12509-27
Oncotarget 2014 Dec 30;5(24):12509-27
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 Aug 5;111(31):E3234-42
Proceedings of the National Academy of Sciences of the United States of America 2014 Aug 5;111(31):E3234-42
FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.
Balamurugan K, Sharan S, Klarmann KD, Zhang Y, Coppola V, Summers GH, Roger T, Morrison DK, Keller JR, Sterneck E
Nature communications 2013;4:1662
Nature communications 2013;4:1662
Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions.
Suzuki K, Nishi K, Takabuchi S, Kai S, Matsuyama T, Kurosawa S, Adachi T, Maruyama T, Fukuda K, Hirota K
PeerJ 2013;1:e220
PeerJ 2013;1:e220
BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.
Sena JA, Wang L, Hu CJ
Molecular and cellular biology 2013 Oct;33(19):3849-63
Molecular and cellular biology 2013 Oct;33(19):3849-63
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart.
Cai Z, Luo W, Zhan H, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 22;110(43):17462-7
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 22;110(43):17462-7
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis.
Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR
Proceedings of the National Academy of Sciences of the United States of America 2013 May 7;110(19):E1788-96
Proceedings of the National Academy of Sciences of the United States of America 2013 May 7;110(19):E1788-96
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E
Blood cells, molecules & diseases 2013 Jan;50(1):25-30
Blood cells, molecules & diseases 2013 Jan;50(1):25-30
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
Chaturvedi P, Gilkes DM, Wong CC, Kshitiz., Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL
The Journal of clinical investigation 2013 Jan;123(1):189-205
The Journal of clinical investigation 2013 Jan;123(1):189-205
Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.
Storti P, Bolzoni M, Donofrio G, Airoldi I, Guasco D, Toscani D, Martella E, Lazzaretti M, Mancini C, Agnelli L, Patrene K, Maïga S, Franceschi V, Colla S, Anderson J, Neri A, Amiot M, Aversa F, Roodman GD, Giuliani N
Leukemia 2013 Aug;27(8):1697-706
Leukemia 2013 Aug;27(8):1697-706
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM
PloS one 2012;7(8):e44078
PloS one 2012;7(8):e44078
Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage.
Singh AK, Mukhopadhyay C, Biswas S, Singh VK, Mukhopadhyay CK
PloS one 2012;7(6):e38489
PloS one 2012;7(6):e38489
The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability.
Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, Zhu L, Gao J, Huang C
The Journal of biological chemistry 2012 Oct 5;287(41):34361-71
The Journal of biological chemistry 2012 Oct 5;287(41):34361-71
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Pawlus MR, Wang L, Ware K, Hu CJ
Molecular and cellular biology 2012 Nov;32(22):4595-610
Molecular and cellular biology 2012 Nov;32(22):4595-610
An oxygen-regulated switch in the protein synthesis machinery.
Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S
Nature 2012 May 6;486(7401):126-9
Nature 2012 May 6;486(7401):126-9
Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.
Kaira K, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Endo M, Kondo H, Nakajima T, Yamamoto N
International journal of surgical pathology 2012 Jun;20(3):223-32
International journal of surgical pathology 2012 Jun;20(3):223-32
Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning.
Autheman D, Sheldon RA, Chaudhuri N, von Arx S, Siegenthaler C, Ferriero DM, Christen S
Pediatric research 2012 Dec;72(6):568-75
Pediatric research 2012 Dec;72(6):568-75
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.
Luo W, Chang R, Zhong J, Pandey A, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 4;109(49):E3367-76
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 4;109(49):E3367-76
The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.
Zhou L, Yang H
PloS one 2011;6(9):e23936
PloS one 2011;6(9):e23936
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2011 Sep 27;108(39):16369-74
Proceedings of the National Academy of Sciences of the United States of America 2011 Sep 27;108(39):16369-74
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL
Cell 2011 May 27;145(5):732-44
Cell 2011 May 27;145(5):732-44
Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition.
Tamama K, Kawasaki H, Kerpedjieva SS, Guan J, Ganju RK, Sen CK
Journal of cellular biochemistry 2011 Mar;112(3):804-17
Journal of cellular biochemistry 2011 Mar;112(3):804-17
Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.
Lunde IG, Anton SL, Bruusgaard JC, Rana ZA, Ellefsen S, Gundersen K
The Journal of physiology 2011 Mar 15;589(Pt 6):1443-54
The Journal of physiology 2011 Mar 15;589(Pt 6):1443-54
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Lin Q, Cong X, Yun Z
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 15;108(7):3065-70
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 15;108(7):3065-70
Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity.
Lysiak JJ, Kirby JL, Tremblay JJ, Woodson RI, Reardon MA, Palmer LA, Turner TT
Journal of andrology 2009 Mar-Apr;30(2):146-56
Journal of andrology 2009 Mar-Apr;30(2):146-56
Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Kransler KM, McGarrigle BP, Swartz DD, Olson JR
Toxicological sciences : an official journal of the Society of Toxicology 2009 Feb;107(2):498-511
Toxicological sciences : an official journal of the Society of Toxicology 2009 Feb;107(2):498-511
SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation.
Amir S, Wang R, Simons JW, Mabjeesh NJ
The Journal of biological chemistry 2009 Apr 24;284(17):11142-51
The Journal of biological chemistry 2009 Apr 24;284(17):11142-51
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE
Molecular pharmacology 2008 Jul;74(1):282-8
Molecular pharmacology 2008 Jul;74(1):282-8
Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, Bosco MC
Molecular cancer therapeutics 2008 Jul;7(7):1974-84
Molecular cancer therapeutics 2008 Jul;7(7):1974-84
Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line.
Aminova LR, Siddiq A, Ratan RR
Antioxidants & redox signaling 2008 Dec;10(12):1989-98
Antioxidants & redox signaling 2008 Dec;10(12):1989-98
Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats.
Engebretsen BJ, Irwin D, Valdez ME, O'Donovan MK, Tucker A, van Patot MT
High altitude medicine & biology 2007 Winter;8(4):312-21
High altitude medicine & biology 2007 Winter;8(4):312-21
Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells.
Cheng G, Shao Z, Chaudhari B, Agrawal DK
American journal of physiology. Lung cellular and molecular physiology 2007 Nov;293(5):L1339-47
American journal of physiology. Lung cellular and molecular physiology 2007 Nov;293(5):L1339-47
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.
Hu CJ, Sataur A, Wang L, Chen H, Simon MC
Molecular biology of the cell 2007 Nov;18(11):4528-42
Molecular biology of the cell 2007 Nov;18(11):4528-42
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL
The Journal of biological chemistry 2007 Nov 16;282(46):33358-66
The Journal of biological chemistry 2007 Nov 16;282(46):33358-66
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL
Cancer cell 2007 May;11(5):407-20
Cancer cell 2007 May;11(5):407-20
Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy.
Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, Aonuma K, Hattori Y, Miyauchi T
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H474-81
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H474-81
Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.
Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL
The Journal of biological chemistry 2007 Aug 10;282(32):23572-80
The Journal of biological chemistry 2007 Aug 10;282(32):23572-80
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC
Molecular and cellular biology 2006 May;26(9):3514-26
Molecular and cellular biology 2006 May;26(9):3514-26
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Mar;20(3):466-75
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Mar;20(3):466-75
Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells.
Schultz K, Fanburg BL, Beasley D
American journal of physiology. Heart and circulatory physiology 2006 Jun;290(6):H2528-34
American journal of physiology. Heart and circulatory physiology 2006 Jun;290(6):H2528-34
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.
Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL
The Journal of biological chemistry 2006 Jun 2;281(22):15554-63
The Journal of biological chemistry 2006 Jun 2;281(22):15554-63
Activation of hypoxia-inducible factor 1 during macrophage differentiation.
Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R
American journal of physiology. Cell physiology 2006 Jul;291(1):C104-13
American journal of physiology. Cell physiology 2006 Jul;291(1):C104-13
MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis.
Amir S, Wang R, Matzkin H, Simons JW, Mabjeesh NJ
Cancer research 2006 Jan 15;66(2):856-66
Cancer research 2006 Jan 15;66(2):856-66
Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion.
Slomiany MG, Rosenzweig SA
The Journal of pharmacology and experimental therapeutics 2006 Aug;318(2):666-75
The Journal of pharmacology and experimental therapeutics 2006 Aug;318(2):666-75
Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity.
Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Aug;20(10):1698-700
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Aug;20(10):1698-700
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells.
Nakamura K, Martin KC, Jackson JK, Beppu K, Woo CW, Thiele CJ
Cancer research 2006 Apr 15;66(8):4249-55
Cancer research 2006 Apr 15;66(8):4249-55
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia.
Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L
American journal of physiology. Lung cellular and molecular physiology 2004 Sep;287(3):L525-32
American journal of physiology. Lung cellular and molecular physiology 2004 Sep;287(3):L525-32
Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19.
Slomiany MG, Rosenzweig SA
American journal of physiology. Cell physiology 2004 Sep;287(3):C746-53
American journal of physiology. Cell physiology 2004 Sep;287(3):C746-53
Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.
Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL
The Journal of biological chemistry 2004 Oct 1;279(40):41521-8
The Journal of biological chemistry 2004 Oct 1;279(40):41521-8
Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation.
Alam H, Maizels ET, Park Y, Ghaey S, Feiger ZJ, Chandel NS, Hunzicker-Dunn M
The Journal of biological chemistry 2004 May 7;279(19):19431-40
The Journal of biological chemistry 2004 May 7;279(19):19431-40
Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis.
Arsham AM, Plas DR, Thompson CB, Simon MC
Cancer research 2004 May 15;64(10):3500-7
Cancer research 2004 May 15;64(10):3500-7
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling.
Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K
The Journal of biological chemistry 2004 Jan 23;279(4):2550-8
The Journal of biological chemistry 2004 Jan 23;279(4):2550-8
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G
Cancer research 2004 Feb 15;64(4):1475-82
Cancer research 2004 Feb 15;64(4):1475-82
IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407.
Slomiany MG, Rosenzweig SA
Investigative ophthalmology & visual science 2004 Aug;45(8):2838-47
Investigative ophthalmology & visual science 2004 Aug;45(8):2838-47
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
Fukuda R, Kelly B, Semenza GL
Cancer research 2003 May 1;63(9):2330-4
Cancer research 2003 May 1;63(9):2330-4
Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF.
Mabjeesh NJ, Willard MT, Harris WB, Sun HY, Wang R, Zhong H, Umbreit JN, Simons JW
Biochemical and biophysical research communications 2003 Mar 28;303(1):279-86
Biochemical and biophysical research communications 2003 Mar 28;303(1):279-86
Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).
Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I
The Journal of biological chemistry 2003 Feb 28;278(9):7520-30
The Journal of biological chemistry 2003 Feb 28;278(9):7520-30
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC
Molecular and cellular biology 2003 Dec;23(24):9361-74
Molecular and cellular biology 2003 Dec;23(24):9361-74
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P
Cancer cell 2003 Apr;3(4):363-75
Cancer cell 2003 Apr;3(4):363-75
Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance.
Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR
The Journal of biological chemistry 2002 Oct 18;277(42):39728-38
The Journal of biological chemistry 2002 Oct 18;277(42):39728-38
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells.
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL
The Journal of biological chemistry 2002 Oct 11;277(41):38205-11
The Journal of biological chemistry 2002 Oct 11;277(41):38205-11
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
Mabjeesh NJ, Post DE, Willard MT, Kaur B, Van Meir EG, Simons JW, Zhong H
Cancer research 2002 May 1;62(9):2478-82
Cancer research 2002 May 1;62(9):2478-82
Protein expression profiles indicative for drug resistance of non-small cell lung cancer.
Volm M, Koomägi R, Mattern J, Efferth T
British journal of cancer 2002 Jul 29;87(3):251-7
British journal of cancer 2002 Jul 29;87(3):251-7
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
Rapisarda A, Uranchimeg B, Scudiero DA, Selby M, Sausville EA, Shoemaker RH, Melillo G
Cancer research 2002 Aug 1;62(15):4316-24
Cancer research 2002 Aug 1;62(15):4316-24
Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.
Tendler DS, Bao C, Wang T, Huang EL, Ratovitski EA, Pardoll DA, Lowenstein CJ
Cancer research 2001 May 1;61(9):3682-8
Cancer research 2001 May 1;61(9):3682-8
Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells.
Zhong H, Hanrahan C, van der Poel H, Simons JW
Biochemical and biophysical research communications 2001 Jun 8;284(2):352-6
Biochemical and biophysical research communications 2001 Jun 8;284(2):352-6
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression.
Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL
Cancer 2000 Jun 1;88(11):2606-18
Cancer 2000 Jun 1;88(11):2606-18
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Supportive validation
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- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
