Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 13092-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13092-1-AP, RRID:AB_10597698
- Product name
- MITF antibody
- Antibody type
- Polyclonal
- Description
- MITF antibody (Cat. #13092-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MITF regulates the subcellular location of HIF1α through SUMOylation to promote the invasion and metastasis of daughter cells derived from polyploid giant cancer cells.
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.
Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.
Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling.
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
α-Mangostin Suppresses Melanoma Growth, Migration, and Invasion and Potentiates the Anti-tumor Effect of Chemotherapy.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Silver Carp (Hypophthalmichthys molitrix) Scale Collagen Peptides-1 (SCPs1) Inhibit Melanogenesis through Downregulation of the cAMP-CREB Signaling Pathway.
Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment.
MiR-182 Is Upregulated in Prostate Cancer and Contributes to Tumor Progression by Targeting MITF.
Effects of MITF on marker protein expression of multivesicular bodies and miRNA omics of extracellular vesicles of mice melanocyte cell line.
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.
Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.
The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma.
The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes.
Generation and Differentiation of Induced Pluripotent Stem Cells from Mononuclear Cells in An Age-Related Macular Degeneration Patient.
Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis.
Ultraviolet B irradiation enhances the secretion of exosomes by human primary melanocytes and changes their exosomal miRNA profile.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent.
D-tyrosine adds an anti-melanogenic effect to cosmetic peptides.
mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity.
Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia.
(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.
Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis.
Identification of sake extract as a new anti-melanogenic ingredient by in vitro and clinical trials.
Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation.
Zheng M, Tian S, Zhou X, Yan M, Zhou M, Yu Y, Zhang Y, Wang X, Li N, Ren L, Zhang S
Oncology reports 2024 May;51(5)
Oncology reports 2024 May;51(5)
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.
Li Y, Zhu T, Yang J, Zhang Q, Xu S, Ge S, Jia R, Zhang J, Fan X
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203
Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.
Alves PKN, Schauer A, Augstein A, Prieto Jarabo ME, Männel A, Barthel P, Vahle B, Moriscot AS, Linke A, Adams V
Cells 2024 Mar 13;13(6)
Cells 2024 Mar 13;13(6)
Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling.
Xu L, Zhang L, Zhang S, Yang J, Zhu A, Sun J, Kalvakolanu DV, Cong X, Zhang J, Tang J, Guo B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155199
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155199
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.
Xia ZY, Liu L, Kuok CF, Wang XL, Shi D, Ma Q, Cheng XY, Wang GL, Li MJ, Zheng QS, Liu XN, Li DF, Li BH
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498
α-Mangostin Suppresses Melanoma Growth, Migration, and Invasion and Potentiates the Anti-tumor Effect of Chemotherapy.
Xie Y, Gong C, Xia Y, Zhou Y, Ye T, Mei T, Chen H, Chen J
International journal of medical sciences 2023;20(9):1220-1234
International journal of medical sciences 2023;20(9):1220-1234
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150
Cell death and differentiation 2023 Sep;30(9):2135-2150
Silver Carp (Hypophthalmichthys molitrix) Scale Collagen Peptides-1 (SCPs1) Inhibit Melanogenesis through Downregulation of the cAMP-CREB Signaling Pathway.
Li HL, Li MJ, Xiong GQ, Cai J, Liao T, Zu XY
Nutrients 2023 May 24;15(11)
Nutrients 2023 May 24;15(11)
Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment.
Chong S, Wei C, Feng L, Guo R
ACS biomaterials science & engineering 2023 Jun 12;9(6):3368-3378
ACS biomaterials science & engineering 2023 Jun 12;9(6):3368-3378
MiR-182 Is Upregulated in Prostate Cancer and Contributes to Tumor Progression by Targeting MITF.
Stafford MYC, McKenna DJ
International journal of molecular sciences 2023 Jan 17;24(3)
International journal of molecular sciences 2023 Jan 17;24(3)
Effects of MITF on marker protein expression of multivesicular bodies and miRNA omics of extracellular vesicles of mice melanocyte cell line.
Zhao L, Han H, Li Y, Pang Q
Acta histochemica 2023 Feb;125(2):152011
Acta histochemica 2023 Feb;125(2):152011
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.
Slater K, Bosch R, Smith KF, Jahangir CA, Garcia-Mulero S, Rahman A, O'Connell F, Piulats JM, O'Neill V, Horgan N, Coupland SE, O'Sullivan J, Gallagher WM, Villanueva A, Kennedy BN
Frontiers in medicine 2022;9:1036322
Frontiers in medicine 2022;9:1036322
Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.
Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L, Xu GT
iScience 2022 Oct 21;25(10):105050
iScience 2022 Oct 21;25(10):105050
The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma.
Ferro I, Gavini J, Gallo S, Bracher L, Landolfo M, Candinas D, Stroka DM, Polacek N
Autophagy 2022 Jan;18(1):191-203
Autophagy 2022 Jan;18(1):191-203
The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes.
Qin H, Chen Y, Wang S, Ge S, Pang Q
Acta histochemica 2022 Jan;124(1):151839
Acta histochemica 2022 Jan;124(1):151839
Generation and Differentiation of Induced Pluripotent Stem Cells from Mononuclear Cells in An Age-Related Macular Degeneration Patient.
Wang T, Liu J, Chen J, Qin B
Cell journal 2022 Dec 1;24(12):764-773
Cell journal 2022 Dec 1;24(12):764-773
Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis.
Jang B, Chung H, Jung H, Song HK, Park E, Choi HS, Jung K, Choe H, Yang S, Oh ES
Molecules and cells 2021 Oct 31;44(10):736-745
Molecules and cells 2021 Oct 31;44(10):736-745
Ultraviolet B irradiation enhances the secretion of exosomes by human primary melanocytes and changes their exosomal miRNA profile.
Shen Z, Sun J, Shao J, Xu J
PloS one 2020;15(8):e0237023
PloS one 2020;15(8):e0237023
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent.
Lee SH, Bae IH, Lee ES, Kim HJ, Lee J, Lee CS
International journal of molecular sciences 2020 Mar 3;21(5)
International journal of molecular sciences 2020 Mar 3;21(5)
D-tyrosine adds an anti-melanogenic effect to cosmetic peptides.
Park J, Jung H, Jang B, Song HK, Han IO, Oh ES
Scientific reports 2020 Jan 14;10(1):262
Scientific reports 2020 Jan 14;10(1):262
mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
Asrani K, Murali S, Lam B, Na CH, Phatak P, Sood A, Kaur H, Khan Z, Noë M, Anchoori RK, Talbot CC Jr, Smith B, Skaro M, Lotan TL
The Journal of clinical investigation 2019 Dec 2;129(12):5584-5599
The Journal of clinical investigation 2019 Dec 2;129(12):5584-5599
D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity.
Park J, Jung H, Kim K, Lim KM, Kim JY, Jho EH, Oh ES
Pigment cell & melanoma research 2018 May;31(3):374-383
Pigment cell & melanoma research 2018 May;31(3):374-383
Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
Hwang JA, Park NH, Na YJ, Lee HK, Lee JH, Kim YJ, Lee CS
Biological & pharmaceutical bulletin 2017;40(4):535-539
Biological & pharmaceutical bulletin 2017;40(4):535-539
Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia.
Seong ZK, Kim HS, Won YM, Kim JL, Song HH, Kim DY, Oh SR, Cho HW, Cho JH, Lee HK
Archives of pharmacal research 2016 May;39(5):636-45
Archives of pharmacal research 2016 May;39(5):636-45
(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.
Park J, Chung H, Bang SH, Han AR, Seo EK, Chang SE, Kang DH, Oh ES
PloS one 2015;10(11):e0141988
PloS one 2015;10(11):e0141988
Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis.
Won YM, Seong ZK, Kim JL, Kim HS, Song HH, Kim DY, Kim JH, Oh SR, Cho HW, Cho JH, Lee HK
Archives of pharmacal research 2015 Aug;38(8):1541-51
Archives of pharmacal research 2015 Aug;38(8):1541-51
Identification of sake extract as a new anti-melanogenic ingredient by in vitro and clinical trials.
Hwang JA, Goh MJ, Kim EJ, Lee MR, Park NH, Na YJ, Cho JC, Lee HK
Natural product communications 2013 Nov;8(11):1605-8
Natural product communications 2013 Nov;8(11):1605-8
Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation.
Lee CS, Park M, Han J, Lee JH, Bae IH, Choi H, Son ED, Park YH, Lim KM
The Journal of investigative dermatology 2013 Apr;133(4):1063-71
The Journal of investigative dermatology 2013 Apr;133(4):1063-71
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 13092-1-AP(MITF antibody) at dilution of 1:400
- Sample type
- cell line