13092-1-AP

antibody from Proteintech Group

Targeting: MITF bHLHe32, MI, WS2, WS2A

Provider product page for 13092-1-AP

Western blot

ELISA

Immunoprecipitation

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [48]
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Validations
Western blot [1]

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Product number: 13092-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13092-1-AP, RRID:AB_10597698
Product name: MITF antibody
Antibody type: Polyclonal
Description: MITF antibody (Cat. #13092-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MITF protein structure - 13092-1-AP shown in red.

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Discovery of a first-in-class degrader for microphthalmia-associated transcription factor (MITF).

Shen W, Yang H, Chen Y, Bi S, Liu Z, Luo K, Wang Z, Wang J, Ding K
European journal of medicinal chemistry 2026 Jan 15;302(Pt 3):118367

Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.

Han M, Guan Q, Yan F, Wang M, Xi D, Ning Q
Cell communication and signaling : CCS 2026 Feb 2;24(1)

Clematis Tangutica (Maxim.) Korsh. extracts promote melanogenesis via PKA/CREB activation and multi-cytokine inhibition: A novel dual targeting strategy for vitiligo therapy.

Guo M, Peng J, Dong C, Lu J, Li S, Chen M, Zhu J, Chen A, Lu Y, Jing L, Xiao H, Fu D, Liang X, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157963

Eucommia ulmoides extract attenuates oxidative stress and promotes melanogenesis via Wnt/β-catenin signaling in B16 cells and mice.

Liu X, Qiu Y, Lv X, Chang L, Ji T, Gu Y, Chen S
Turkish journal of biology = Turk biyoloji dergisi 2025;49(7):790-799

Biocompatible exosomes derived from Pinctada martensii mucus for therapeutic melanin regulation via α-MSH/NF-κB/MITF pathway.

Mo D, Zheng W, Gao Z, Ma K, Yang K, Zeng T, Qin C, Luo Y, Zheng L, Xu S
Regenerative biomaterials 2025;12:rbaf072

SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.

Yaxian L, Xiaodong W, Futao M, Huizhen W, Chuansheng W, Mengdi M, Bo Y, Yida L, Xin X, Ziqing F, Mingdian L, Yuxian S, Yongxiang L
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188

CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.

Li BH, Liu L, Shi D, Wang XL, Meng TY, Xu XM, Zhai JL, He XJ, Wang GL, An TY, Jiang QL, Bi SX, Pan ZH, Zheng QS, Lu J, Li DF
Journal of translational medicine 2025 Oct 29;23(1):1186

3, 7-dihydroxy-2, 4-dimethoxyphenanthrene protects against UVB-induced skin hyperpigmentation via antioxidant and anti-melanogenic mechanisms.

Li M, Li D, Zhang Y, Wang J, Zhang Z, Wang W, Chen S, Lyu L, Liu W
Journal of photochemistry and photobiology. B, Biology 2025 Nov;272:113277

Exosomes enriched with miR-31-3p from keratinocytes under oxidative stress promote vitiligo progression by destructing melanocytes and activating CD8(+) T cells.

Ma J, Zhou Y, Chen J, Guo S, Zhang W, Yi X, Du P, Wang Y, Chen J, Li S, Gao T, Li C, Jian Z
International journal of biological macromolecules 2025 May;310(Pt 1):143070

ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma.

Xiong L, Chen S, Li S, He D, Wang Y, Zhang Q, He Z, Li M, He Q
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113622

Hydrolyzed conchiolin protein inhibits melanogenesis through PKA/CREB and MEK/ERK signalling pathways.

Zhang Y, Wang S, Yang A
International journal of cosmetic science 2025 Feb;47(1):31-44

Anti-melanogenic effects of Medicago sativa seed extracts on melanocytes.

Kim CR, Woo J, Kim KL, Choi M, Shin HJ, Kim J, Lim KM, Lee CS
International journal of cosmetic science 2025 Dec;47(6):1005-1016

Metformin inhibits melanin synthesis and melanosome transfer through the cAMP pathway.

Liu X, Sun X, Liu Y, Wang W, Yang H, Ge Y, Yang Y, Chen X, Lin T
Scientific reports 2025 Apr 3;15(1):11442

Momordica charantia Extract Ameliorates Melanoma Cell Proliferation and Invasion into Mouse Lungs by Suppressing PAX3 Expression.

Hiramoto K, Oikawa H
International journal of molecular sciences 2024 Nov 28;25(23)

MITF regulates the subcellular location of HIF1α through SUMOylation to promote the invasion and metastasis of daughter cells derived from polyploid giant cancer cells.

Zheng M, Tian S, Zhou X, Yan M, Zhou M, Yu Y, Zhang Y, Wang X, Li N, Ren L, Zhang S
Oncology reports 2024 May;51(5)

EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.

Li Y, Zhu T, Yang J, Zhang Q, Xu S, Ge S, Jia R, Zhang J, Fan X
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203

Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.

Alves PKN, Schauer A, Augstein A, Prieto Jarabo ME, Männel A, Barthel P, Vahle B, Moriscot AS, Linke A, Adams V
Cells 2024 Mar 13;13(6)

Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling.

Xu L, Zhang L, Zhang S, Yang J, Zhu A, Sun J, Kalvakolanu DV, Cong X, Zhang J, Tang J, Guo B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155199

Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways.

Xia ZY, Liu L, Kuok CF, Wang XL, Shi D, Ma Q, Cheng XY, Wang GL, Li MJ, Zheng QS, Liu XN, Li DF, Li BH
Biological & pharmaceutical bulletin 2024 Feb 22;47(2):486-498

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia.

Tian X, Wang H, Liu S, Liu W, Zhang K, Gao X, Li Q, Zhao H, Zhang L, Liu P, Liu M, Wang Y, Zhu X, Cui R, Zhou J
PLoS biology 2024 Dec;22(12):e3002940

miR-25-5p in exosomes derived from UVB-induced fibroblasts regulates melanogenesis via TSC2-dominated cellular organelle dysfunction.

Yang H, Zhang X, Wang W, Ge Y, Yang Y, Lin T
Journal of dermatological science 2024 Aug;115(2):75-84

Anti-Melanogenic Effects of Takifugu flavidus Muscle Hydrolysate in B16F10 Melanoma Cells and Zebrafish.

Hu J, Chen B, Qu S, Liu S, Yang X, Qiao K, Su Y, Liu Z, Chen X, Liu Z, Wang Q
Marine drugs 2024 Apr 29;22(5)

α-Mangostin Suppresses Melanoma Growth, Migration, and Invasion and Potentiates the Anti-tumor Effect of Chemotherapy.

Xie Y, Gong C, Xia Y, Zhou Y, Ye T, Mei T, Chen H, Chen J
International journal of medical sciences 2023;20(9):1220-1234

HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.

He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002

Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.

Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150

Silver Carp (Hypophthalmichthys molitrix) Scale Collagen Peptides-1 (SCPs1) Inhibit Melanogenesis through Downregulation of the cAMP-CREB Signaling Pathway.

Li HL, Li MJ, Xiong GQ, Cai J, Liao T, Zu XY
Nutrients 2023 May 24;15(11)

Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment.

Chong S, Wei C, Feng L, Guo R
ACS biomaterials science & engineering 2023 Jun 12;9(6):3368-3378

MiR-182 Is Upregulated in Prostate Cancer and Contributes to Tumor Progression by Targeting MITF.

Stafford MYC, McKenna DJ
International journal of molecular sciences 2023 Jan 17;24(3)

Effects of MITF on marker protein expression of multivesicular bodies and miRNA omics of extracellular vesicles of mice melanocyte cell line.

Zhao L, Han H, Li Y, Pang Q
Acta histochemica 2023 Feb;125(2):152011

1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.

Slater K, Bosch R, Smith KF, Jahangir CA, Garcia-Mulero S, Rahman A, O'Connell F, Piulats JM, O'Neill V, Horgan N, Coupland SE, O'Sullivan J, Gallagher WM, Villanueva A, Kennedy BN
Frontiers in medicine 2022;9:1036322

Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.

Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L, Xu GT
iScience 2022 Oct 21;25(10):105050

The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma.

Ferro I, Gavini J, Gallo S, Bracher L, Landolfo M, Candinas D, Stroka DM, Polacek N
Autophagy 2022 Jan;18(1):191-203

The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes.

Qin H, Chen Y, Wang S, Ge S, Pang Q
Acta histochemica 2022 Jan;124(1):151839

Generation and Differentiation of Induced Pluripotent Stem Cells from Mononuclear Cells in An Age-Related Macular Degeneration Patient.

Wang T, Liu J, Chen J, Qin B
Cell journal 2022 Dec 1;24(12):764-773

Extracellular Vesicles from Korean Codium fragile and Sargassum fusiforme Negatively Regulate Melanin Synthesis.

Jang B, Chung H, Jung H, Song HK, Park E, Choi HS, Jung K, Choe H, Yang S, Oh ES
Molecules and cells 2021 Oct 31;44(10):736-745

Ultraviolet B irradiation enhances the secretion of exosomes by human primary melanocytes and changes their exosomal miRNA profile.

Shen Z, Sun J, Shao J, Xu J
PloS one 2020;15(8):e0237023

TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.

Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302

Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent.

Lee SH, Bae IH, Lee ES, Kim HJ, Lee J, Lee CS
International journal of molecular sciences 2020 Mar 3;21(5)

D-tyrosine adds an anti-melanogenic effect to cosmetic peptides.

Park J, Jung H, Jang B, Song HK, Han IO, Oh ES
Scientific reports 2020 Jan 14;10(1):262

mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.

Asrani K, Murali S, Lam B, Na CH, Phatak P, Sood A, Kaur H, Khan Z, Noë M, Anchoori RK, Talbot CC Jr, Smith B, Skaro M, Lotan TL
The Journal of clinical investigation 2019 Dec 2;129(12):5584-5599

D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity.

Park J, Jung H, Kim K, Lim KM, Kim JY, Jho EH, Oh ES
Pigment cell & melanoma research 2018 May;31(3):374-383

Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.

Hwang JA, Park NH, Na YJ, Lee HK, Lee JH, Kim YJ, Lee CS
Biological & pharmaceutical bulletin 2017;40(4):535-539

Phenylacylphenol derivatives with anti-melanogenic activity from Stewartia pseudocamellia.

Seong ZK, Kim HS, Won YM, Kim JL, Song HH, Kim DY, Oh SR, Cho HW, Cho JH, Lee HK
Archives of pharmacal research 2016 May;39(5):636-45

(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.

Park J, Chung H, Bang SH, Han AR, Seo EK, Chang SE, Kang DH, Oh ES
PloS one 2015;10(11):e0141988

Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis.

Won YM, Seong ZK, Kim JL, Kim HS, Song HH, Kim DY, Kim JH, Oh SR, Cho HW, Cho JH, Lee HK
Archives of pharmacal research 2015 Aug;38(8):1541-51

Identification of sake extract as a new anti-melanogenic ingredient by in vitro and clinical trials.

Hwang JA, Goh MJ, Kim EJ, Lee MR, Park NH, Na YJ, Cho JC, Lee HK
Natural product communications 2013 Nov;8(11):1605-8

Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation.

Lee CS, Park M, Han J, Lee JH, Bae IH, Choi H, Son ED, Park YH, Lim KM
The Journal of investigative dermatology 2013 Apr;133(4):1063-71

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 13092-1-AP(MITF antibody) at dilution of 1:400
Sample type: cell line