10-8004-25

antibody from ABEOMICS Inc.
Targeting: MITF bHLHe32, MI, WS2, WS2A
Provider product page for 10-8004-25

Antibody data

Product number
10-8004-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-MITF Antibody
Antibody type
Monoclonal
Description
MITF (Microphthalmia-associated transcription factor) is a basic helix-loop-helix leucine zipper (bHLH-Zip) family factor, involved in lineage-specific pathway regulation of many types of cells including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. It plays a critical role in melanogenesis as a transcriptional activator of tyrosinase, TRP-1, and TRP-2. Moreover, it regulates specification, survival, and proliferation of normal melanocytes, and controls proliferation, migration and invasion of melanoma cells. MITF is the most characterized member of the MIT family, mutations of which can lead to diseases such as Melanoma, Waardenburg syndrome, and Tietz syndrome.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant MITF p
rotein (amino acids 150-427) was us
ed as the immunogen for this antibo
dy.
Isotype
IgG
Antibody clone number
ABM1H91
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
MITF protein structure - 10-8004-25 shown in red.