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- Product number
- 25840-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SMAD7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMAD7 antibody (Cat. #25840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.
Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation.
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis.
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway.
Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial-mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.
Effect and mechanism of pirfenidone combined with 2-methoxy-estradiol perfusion through portal vein on hepatic artery hypoxia-induced hepatic fibrosis.
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
K235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis.
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.
Dysfunction of Caveolae-Mediated Endocytic TβRI Degradation Results in Hypersensitivity of TGF-β/Smad Signaling in Osteogenesis Imperfecta.
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway.
Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis.
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.
JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis.
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.
Tocotrienol-Rich Fractions Offer Potential to Suppress Pulmonary Fibrosis Progression.
Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.
The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation.
Potential "Therapeutic" Effects of Tocotrienol-Rich Fraction (TRF) and Carotene "Against" Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways.
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.
Pharmacological activation of estrogenic receptor G protein-coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway.
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7.
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis.
High glucose inhibits the survival of HRMCs and its mechanism.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Jianpi Huayu decoction inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing exosomal miR-23a-3p/Smad signaling.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation.
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Epigenetic Control of circHNRNPH1 in Postischemic Myocardial Fibrosis through Targeting of TGF-β Receptor Type I.
MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.
Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.
Exosomal MicroRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by Inhibiting Smad7.
Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway.
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF-β1/SMAD7/RUNX2 pathway.
Exosomes derived from thymic stromal lymphopoietin-treated dendritic cells regulate T helper 17/regulatory T cell differentiation via miR-21/Smad7 axis.
Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway.
MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis.
TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition.
Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.
Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation.
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.
The RNA N(6)-methyladenosine modification landscape of human fetal tissues.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts.
Transcription factor KLF4 modulates microRNA-106a that targets Smad7 in gastric cancer.
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.
MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.
miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7.
AG490 suppresses interleukin-34-mediated osteoclastogenesis in mice bone marrow macrophages.
Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels.
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Wu JZ, Zhou C, Liu S, Zhang JX, Yang W, Shi HB, Zhou WZ
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.
Liang S, Zheng R, Zuo B, Li J, Wang Y, Han Y, Dong H, Zhao X, Zhang Y, Wang P, Meng R, Jia L, Yang A, Yan B
Cellular & molecular immunology 2024 Mar;21(3):213-226
Cellular & molecular immunology 2024 Mar;21(3):213-226
Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation.
Lin QY, Yu WJ, Bai J, Jiang WX, Li HH
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167048
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167048
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis.
Xie C, Zhong L, Feng H, Wang R, Shi Y, Lv Y, Hu Y, Li J, Xiao D, Liu S, Chen Q, Tao Y
International journal of oral science 2024 Jun 20;16(1):48
International journal of oral science 2024 Jun 20;16(1):48
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Zhang Y, Lu YB, Zhu WJ, Gong XX, Qian R, Lu YJ, Li Y, Yao WF, Bao BH, Zhang Y, Zhang L, Cheng FF
Journal of ethnopharmacology 2024 Apr 24;324:117737
Journal of ethnopharmacology 2024 Apr 24;324:117737
SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway.
Gao Y, Li H, Wang P, Wang J, Yao X
Journal of Cancer 2023;14(13):2455-2467
Journal of Cancer 2023;14(13):2455-2467
Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial-mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway.
Liu L, Liu L, Liu R, Liu J, Cheng Q
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):711-718
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):711-718
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.
Zhao Z, Zhang H, Zhang F, Ji Y, Peng Y, Wang F, Zhao L
Acta biochimica Polonica 2023 Oct 18;70(4):855-863
Acta biochimica Polonica 2023 Oct 18;70(4):855-863
Effect and mechanism of pirfenidone combined with 2-methoxy-estradiol perfusion through portal vein on hepatic artery hypoxia-induced hepatic fibrosis.
Zheng H, Huang N, Lin JQ, Yan LY, Jiang QG, Yang WZ
Advances in medical sciences 2023 Mar;68(1):46-53
Advances in medical sciences 2023 Mar;68(1):46-53
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.
Cheng Q, Wang D, Lai X, Liu Y, Zuo Y, Zhang W, Lei L, Chen J, Liu H, Wang Y, Liu H, Zheng H, Wu D, Xu Y
Blood 2023 Mar 23;141(12):1474-1488
Blood 2023 Mar 23;141(12):1474-1488
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Zhang YB, Bao YR, Wang S, Li TJ, Tai H, Leng JP, Yang XX, Wang BC, Meng XS
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Ren HL, Zhang JH, Xiao JH
Heliyon 2023 Jun;9(6):e16849
Heliyon 2023 Jun;9(6):e16849
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Yu J, Zhao X, Yan X, Li W, Liu Y, Wang J, Wang J, Yang Y, Hao Y, Liang Z, Tao Y, Yuan Y, Du Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
K235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis.
Zhang XL, Chen XH, Xu B, Chen M, Zhu S, Meng N, Wang JZ, Zhu H, Chen D, Liu JB, Yan GR
Nature communications 2023 Jun 27;14(1):3815
Nature communications 2023 Jun 27;14(1):3815
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.
Liu C, Wu J, Li M, Gao R, Zhang X, Ye-Lehmann S, Song J, Zhu T, Chen C
Journal of neuroinflammation 2023 Jul 28;20(1):175
Journal of neuroinflammation 2023 Jul 28;20(1):175
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.
Feng S, Jia J, Lv G, Wang Y
Archives of biochemistry and biophysics 2023 Jul 1;742:109620
Archives of biochemistry and biophysics 2023 Jul 1;742:109620
Dysfunction of Caveolae-Mediated Endocytic TβRI Degradation Results in Hypersensitivity of TGF-β/Smad Signaling in Osteogenesis Imperfecta.
Shi C, Sun B, Wu H, Zhang R, Wu L, Guo L, Li C, Xi Y, Yuan W, Zhang Y, Xu G
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Jan;38(1):103-118
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Jan;38(1):103-118
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Zhang B, Liu S, Sun Y, Xu D
Toxicology 2023 Jan 15;484:153392
Toxicology 2023 Jan 15;484:153392
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
Chen C, Chen J, Wang Y, Fang L, Guo C, Sang T, Peng H, Zhao Q, Chen S, Lin X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway.
Wan G, Chen Z, Lei L, Geng X, Zhang Y, Yang C, Cao W, Pan Z
Chinese medicine 2023 Feb 24;18(1):20
Chinese medicine 2023 Feb 24;18(1):20
Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis.
Li Z, Zhang B, Shang J, Wang Y, Jia L, She X, Xu X, Zhang D, Guo J, Zhang F
International immunopharmacology 2023 Dec;125(Pt B):111190
International immunopharmacology 2023 Dec;125(Pt B):111190
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
Feng P, Che Y, Gao C, Chu X, Li Z, Li L, Li J, Gao J, Dong Y
iScience 2023 Dec 15;26(12):108484
iScience 2023 Dec 15;26(12):108484
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Zhao Y, Chen X, Lin Y, Li Z, Su X, Fan S, Chen Y, Wang X, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.
Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359
Clinical and translational medicine 2023 Aug;13(8):e1359
JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.
Liu LH, Fang CK, Ge FC, Wang JN, Zhang XB, Luo R, Zhang Y, Feng KL, Qiu ZW, Zhong C
Journal of oncology 2022;2022:7823433
Journal of oncology 2022;2022:7823433
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY
Cardiology research and practice 2022;2022:3972829
Cardiology research and practice 2022;2022:3972829
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y
Drug design, development and therapy 2022;16:647-664
Drug design, development and therapy 2022;16:647-664
CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis.
Feng KL, Diao N, Zhou ZW, Fang CK, Wang JN, Zhang Y, Luo R, Zhong C
Frontiers in cell and developmental biology 2022;10:850708
Frontiers in cell and developmental biology 2022;10:850708
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.
Yao H, Song W, Cao R, Ye C, Zhang L, Chen H, Wang J, Shi Y, Li R, Li Y, Liu X, Zhou X, Shao R, Li L
Nature communications 2022 Sep 20;13(1):5506
Nature communications 2022 Sep 20;13(1):5506
Tocotrienol-Rich Fractions Offer Potential to Suppress Pulmonary Fibrosis Progression.
Lu Y, Zhang Y, Xu D, Wang Y, Pan D, Wang P, Xia J, Yin S, Liao W, Wang S, Sun G
International journal of molecular sciences 2022 Nov 18;23(22)
International journal of molecular sciences 2022 Nov 18;23(22)
Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.
Zhu M, Zhang N, Ma J, He S
Cellular signalling 2022 Mar;91:110230
Cellular signalling 2022 Mar;91:110230
The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation.
Sun Y, Li ZJ
Acta pharmacologica Sinica 2022 Mar;43(3):634-644
Acta pharmacologica Sinica 2022 Mar;43(3):634-644
Potential "Therapeutic" Effects of Tocotrienol-Rich Fraction (TRF) and Carotene "Against" Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways.
Lu Y, Zhang Y, Pan Z, Yang C, Chen L, Wang Y, Xu D, Xia H, Wang S, Chen S, Hao YJ, Sun G
Nutrients 2022 Mar 5;14(5)
Nutrients 2022 Mar 5;14(5)
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313
European journal of medicinal chemistry 2022 Jun 5;236:114313
CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.
Feng X, Xiang Q, Jia J, Guo T, Liao Z, Yang S, Cai X, Liu X
Molecular therapy. Nucleic acids 2022 Jun 14;28:99-113
Molecular therapy. Nucleic acids 2022 Jun 14;28:99-113
Pharmacological activation of estrogenic receptor G protein-coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway.
Liu D, Zhan Y, Ono K, Yin Y, Wang L, Wei M, Ji L, Liu M, Liu G, Zhou X, Zheng M
Molecular biology reports 2022 Jul;49(7):6341-6355
Molecular biology reports 2022 Jul;49(7):6341-6355
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
Guo T, You K, Chen X, Sun Y, Wu Y, Wu P, Jiang Y
Cell death discovery 2022 Jul 14;8(1):320
Cell death discovery 2022 Jul 14;8(1):320
MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7.
Jia G, Liang C, Li W, Dai H
Bioengineered 2022 Jan;13(1):119-127
Bioengineered 2022 Jan;13(1):119-127
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
Astori A, Matherat G, Munoz I, Gautier EF, Surdez D, Zermati Y, Verdier F, Zaidi S, Feuillet V, Kadi A, Lauret E, Delattre O, Lefèvre C, Fontenay M, Ségal-Bendirdjian E, Dusanter-Fourt I, Bouscary D, Hermine O, Mayeux P, Pendino F
Haematologica 2022 Jan 1;107(1):268-283
Haematologica 2022 Jan 1;107(1):268-283
Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis.
Lu Y, Zhang Y, Xu D, Wang Y, Pan D, Xia H, Sun G
International immunopharmacology 2022 Dec;113(Pt B):109465
International immunopharmacology 2022 Dec;113(Pt B):109465
High glucose inhibits the survival of HRMCs and its mechanism.
Zhu Y, Ruan CX, Wang J, Jiang FF, Xiong LS, Sheng X, Le J, Yu AQ, Wang Q, Liu YT, Qin SL
European review for medical and pharmacological sciences 2022 Aug;26(16):5683-5688
European review for medical and pharmacological sciences 2022 Aug;26(16):5683-5688
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Jianpi Huayu decoction inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing exosomal miR-23a-3p/Smad signaling.
Xie CF, Feng KL, Wang JN, Luo R, Fang CK, Zhang Y, Shen CP, Zhong C
Journal of ethnopharmacology 2022 Aug 10;294:115360
Journal of ethnopharmacology 2022 Aug 10;294:115360
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643
Frontiers in cardiovascular medicine 2021;8:659643
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway.
Xue Q, Jiang H, Wang J, Wei D
Canadian respiratory journal 2021;2021:5277409
Canadian respiratory journal 2021;2021:5277409
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
Wang Q, Liu J, Hu Y, Pan T, Xu Y, Yu J, Xiong W, Zhou Q, Wang Y
Theranostics 2021;11(14):7110-7125
Theranostics 2021;11(14):7110-7125
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation.
Hong Y, Ye M, Wang F, Fang J, Wang C, Luo J, Liu J, Liu J, Liu L, Zhao Q, Chang Y
Frontiers in oncology 2021;11:642030
Frontiers in oncology 2021;11:642030
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Lv W, Ren Y, Wu M, Luo X, Yu J, Zhang Q, Wu Y
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Epigenetic Control of circHNRNPH1 in Postischemic Myocardial Fibrosis through Targeting of TGF-β Receptor Type I.
Li W, Wang Y, Deng Y, Ni H, Shen G, Liu X, Li J, Wang F
Molecular therapy. Nucleic acids 2021 Sep 3;25:93-104
Molecular therapy. Nucleic acids 2021 Sep 3;25:93-104
MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.
Mao Y, Jiang L
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30
Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.
Liu S, Hu Y, Wang Y, Sun Y, Qin SL, Xu D
Ecotoxicology and environmental safety 2021 Nov 30;228:113040
Ecotoxicology and environmental safety 2021 Nov 30;228:113040
Exosomal MicroRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by Inhibiting Smad7.
Li Q, Fang L, Chen J, Zhou S, Zhou K, Cheng F, Cen Y, Qing Y, Wu J
Journal of burn care & research : official publication of the American Burn Association 2021 Nov 24;42(6):1266-1274
Journal of burn care & research : official publication of the American Burn Association 2021 Nov 24;42(6):1266-1274
Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway.
Guo Y, Gao X, An S, Li X, Pan L, Liu H, Liu J, Gao J, Zhao Z, Li G, Han Y, Li Y, Ji Z
Aging 2021 Nov 11;13(21):24339-24348
Aging 2021 Nov 11;13(21):24339-24348
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Yang Y, Sun M, Li W, Liu C, Jiang Z, Gu P, Li J, Wang W, You R, Ba Q, Li X, Wang H
Clinical and translational medicine 2021 Jul;11(7):e410
Clinical and translational medicine 2021 Jul;11(7):e410
Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF-β1/SMAD7/RUNX2 pathway.
Li ZZ, Wang HT, Lee GY, Yang Y, Zou YP, Wang B, Gong CJ, Cai Y, Ren JG, Zhao JH
British journal of pharmacology 2021 Jan;178(2):312-327
British journal of pharmacology 2021 Jan;178(2):312-327
Exosomes derived from thymic stromal lymphopoietin-treated dendritic cells regulate T helper 17/regulatory T cell differentiation via miR-21/Smad7 axis.
Ji Q, Liu J, Dong Y, Wang L, Dong K, Setiz B, Szentmáry N, Qu B, Shi L
Experimental cell research 2021 Jan 1;398(1):112393
Experimental cell research 2021 Jan 1;398(1):112393
Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway.
Xu M, Li S, Wang J, Huang S, Zhang A, Zhang Y, Gu W, Yu X, Jia Z
Frontiers in medicine 2020;7:626140
Frontiers in medicine 2020;7:626140
MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis.
Yang S, Chen Y, Mi X, Zhang S, Yang Y, Hui R, Zhang W
Disease markers 2020;2020:8864322
Disease markers 2020;2020:8864322
TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition.
Xiao Y, Qing J, Li B, Chen L, Nong S, Yang W, Tang X, Chen Z
OncoTargets and therapy 2020;13:1993-2006
OncoTargets and therapy 2020;13:1993-2006
Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.
Yuan H, Xu J, Zhu Y, Li L, Wang Q, Yu Y, Zhou B, Liu Y, Xu X, Wang Z
Molecular medicine reports 2020 Sep;22(3):2021-2031
Molecular medicine reports 2020 Sep;22(3):2021-2031
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Che H, Wang Y, Li Y, Lv J, Li H, Liu Y, Dong R, Sun Y, Xu X, Zhao J, Wang L
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.
Sasaki N, Itakura Y, Toyoda M
Cell communication and signaling : CCS 2020 Mar 12;18(1):43
Cell communication and signaling : CCS 2020 Mar 12;18(1):43
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.
Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X
Cell death and differentiation 2020 Feb;27(2):497-508
Cell death and differentiation 2020 Feb;27(2):497-508
Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation.
Zhang YC, Chen BX, Xie XY, Zhou Y, Qian Q, Jiang CQ
World journal of gastroenterology 2020 Feb 21;26(7):717-724
World journal of gastroenterology 2020 Feb 21;26(7):717-724
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
Li X, Liu Y, Yue W, Tan Y, Wang H, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Sun L, Xu T, Chen Y, Qu W, Sun D, Song X, Yuan Q, Yao L
Life sciences 2019 Sep 1;232:116609
Life sciences 2019 Sep 1;232:116609
Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.
Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
Qiu Y, Zhou J, Zhang H, Zhou H, Tang H, Lei C, Ye C, You C, Chen Y, Wang Y, Xiong J, Su H, Yao G, Zhang C
Journal of ethnopharmacology 2019 Oct 28;243:112078
Journal of ethnopharmacology 2019 Oct 28;243:112078
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.
Fan J, Wang Q, Zhang Z, Sun L
Drug development research 2019 Nov;80(7):992-999
Drug development research 2019 Nov;80(7):992-999
The RNA N(6)-methyladenosine modification landscape of human fetal tissues.
Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M, He C, Xia L
Nature cell biology 2019 May;21(5):651-661
Nature cell biology 2019 May;21(5):651-661
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C
Nature cell biology 2019 Jul;21(7):856-866
Nature cell biology 2019 Jul;21(7):856-866
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31
Brain research bulletin 2019 Jul;149:21-31
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts.
Zhang Q, Tu W, Tian K, Han L, Wang Q, Chen P, Zhou X
Journal of cellular biochemistry 2019 Jan;120(1):93-104
Journal of cellular biochemistry 2019 Jan;120(1):93-104
Transcription factor KLF4 modulates microRNA-106a that targets Smad7 in gastric cancer.
Zhu M, Zhang N, He S
Pathology, research and practice 2019 Aug;215(8):152467
Pathology, research and practice 2019 Aug;215(8):152467
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Lin L, Li R, Cai M, Huang J, Huang W, Guo Y, Yang L, Yang G, Lan T, Zhu K
Oxidative medicine and cellular longevity 2018;2018:7808656
Oxidative medicine and cellular longevity 2018;2018:7808656
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Gao F, He X, Liang S, Liu S, Liu H, He Q, Chen L, Jiang H, Zhang Y
RSC advances 2018 Oct 15;8(62):35413-35421
RSC advances 2018 Oct 15;8(62):35413-35421
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.
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Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):866-876
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MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis.
Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, Yang H, Zhang L, Da Y, Yao Z, Zhang R
Brain, behavior, and immunity 2018 May;70:305-314
Brain, behavior, and immunity 2018 May;70:305-314
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
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Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway.
Chen S, Huang Y, Wan S, Huang Y, Liang H, Chen S
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2018 Jun;38(3):419-426
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2018 Jun;38(3):419-426
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
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Cancer letters 2018 Aug 28;430:201-214
Cancer letters 2018 Aug 28;430:201-214
miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7.
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Oncology letters 2017 Oct;14(4):3941-3946
Oncology letters 2017 Oct;14(4):3941-3946
AG490 suppresses interleukin-34-mediated osteoclastogenesis in mice bone marrow macrophages.
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Cell biology international 2017 Jun;41(6):659-668
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The Journal of pathology 2017 Jul;242(3):334-346
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Oncogene 2016 Oct 20;35(42):5468-5479
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The American journal of Chinese medicine 2015;43(2):231-40
The American journal of Chinese medicine 2015;43(2):231-40
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 25840-1-AP( SMAD7 Antibody) at dilution of 1:1000
- Validation comment
- WB
