25840-1-AP

antibody from Proteintech Group

Targeting: SMAD7 MADH7, MADH8

Provider product page for 25840-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [48]
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Validations
Western blot [1]

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Product number: 25840-1-AP - Provider product page
Provider: Proteintech Group
Product name: SMAD7 antibody
Antibody type: Polyclonal
Description: KD/KO validated SMAD7 antibody (Cat. #25840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SMAD7 protein structure - 25840-1-AP shown in red.

Submitted references The epigenetic regulator RINF (CXXC5) maintains <i>SMAD7</i> expression in human immature erythroid cells and sustains red blood cells expansion.

Astori A, Matherat G, Munoz I, Gautier EF, Surdez D, Zermati Y, Verdier F, Zaidi S, Feuillet V, Kadi A, Lauret E, Delattre O, Lefèvre C, Fontenay M, Ségal-Bendirdjian E, Dusanter-Fourt I, Bouscary D, Hermine O, Mayeux P, Pendino F
Haematologica 2022 Jan 1;107(1):268-283

Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.

Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643

Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.

Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530

Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.

Wang Q, Liu J, Hu Y, Pan T, Xu Y, Yu J, Xiong W, Zhou Q, Wang Y
Theranostics 2021;11(14):7110-7125

The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.

Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472

MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation.

Hong Y, Ye M, Wang F, Fang J, Wang C, Luo J, Liu J, Liu J, Liu L, Zhao Q, Chang Y
Frontiers in oncology 2021;11:642030

Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.

Lv W, Ren Y, Wu M, Luo X, Yu J, Zhang Q, Wu Y
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372

Epigenetic Control of circHNRNPH1 in Postischemic Myocardial Fibrosis through Targeting of TGF-β Receptor Type I.

Li W, Wang Y, Deng Y, Ni H, Shen G, Liu X, Li J, Wang F
Molecular therapy. Nucleic acids 2021 Sep 3;25:93-104

MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.

Mao Y, Jiang L
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30

Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.

Liu S, Hu Y, Wang Y, Sun Y, Qin SL, Xu D
Ecotoxicology and environmental safety 2021 Nov 30;228:113040

Exosomal MicroRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by Inhibiting Smad7.

Li Q, Fang L, Chen J, Zhou S, Zhou K, Cheng F, Cen Y, Qing Y, Wu J
Journal of burn care & research : official publication of the American Burn Association 2021 Nov 24;42(6):1266-1274

Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway.

Guo Y, Gao X, An S, Li X, Pan L, Liu H, Liu J, Gao J, Zhao Z, Li G, Han Y, Li Y, Ji Z
Aging 2021 Nov 11;13(21):24339-24348

Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.

Yang Y, Sun M, Li W, Liu C, Jiang Z, Gu P, Li J, Wang W, You R, Ba Q, Li X, Wang H
Clinical and translational medicine 2021 Jul;11(7):e410

The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation.

Sun Y, Li ZJ
Acta pharmacologica Sinica 2021 Jul 30;

Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF-β1/SMAD7/RUNX2 pathway.

Li ZZ, Wang HT, Lee GY, Yang Y, Zou YP, Wang B, Gong CJ, Cai Y, Ren JG, Zhao JH
British journal of pharmacology 2021 Jan;178(2):312-327

Exosomes derived from thymic stromal lymphopoietin-treated dendritic cells regulate T helper 17/regulatory T cell differentiation via miR-21/Smad7 axis.

Ji Q, Liu J, Dong Y, Wang L, Dong K, Setiz B, Szentmáry N, Qu B, Shi L
Experimental cell research 2021 Jan 1;398(1):112393

Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway.

Xu M, Li S, Wang J, Huang S, Zhang A, Zhang Y, Gu W, Yu X, Jia Z
Frontiers in medicine 2020;7:626140

MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis.

Yang S, Chen Y, Mi X, Zhang S, Yang Y, Hui R, Zhang W
Disease markers 2020;2020:8864322

TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition.

Xiao Y, Qing J, Li B, Chen L, Nong S, Yang W, Tang X, Chen Z
OncoTargets and therapy 2020;13:1993-2006

Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.

Yuan H, Xu J, Zhu Y, Li L, Wang Q, Yu Y, Zhou B, Liu Y, Xu X, Wang Z
Molecular medicine reports 2020 Sep;22(3):2021-2031

Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.

Che H, Wang Y, Li Y, Lv J, Li H, Liu Y, Dong R, Sun Y, Xu X, Zhao J, Wang L
Journal of cellular physiology 2020 Nov;235(11):7769-7779

Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.

Sasaki N, Itakura Y, Toyoda M
Cell communication and signaling : CCS 2020 Mar 12;18(1):43

Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.

Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132

REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.

Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X
Cell death and differentiation 2020 Feb;27(2):497-508

Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation.

Zhang YC, Chen BX, Xie XY, Zhou Y, Qian Q, Jiang CQ
World journal of gastroenterology 2020 Feb 21;26(7):717-724

A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.

Li X, Liu Y, Yue W, Tan Y, Wang H, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347

Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.

Sun L, Xu T, Chen Y, Qu W, Sun D, Song X, Yuan Q, Yao L
Life sciences 2019 Sep 1;232:116609

Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.

Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748

Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.

Qiu Y, Zhou J, Zhang H, Zhou H, Tang H, Lei C, Ye C, You C, Chen Y, Wang Y, Xiong J, Su H, Yao G, Zhang C
Journal of ethnopharmacology 2019 Oct 28;243:112078

Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.

Fan J, Wang Q, Zhang Z, Sun L
Drug development research 2019 Nov;80(7):992-999

The RNA N⁶-methyladenosine modification landscape of human fetal tissues.

Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M, He C, Xia L
Nature cell biology 2019 May;21(5):651-661

The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.

Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243

An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.

Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C
Nature cell biology 2019 Jul;21(7):856-866

miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.

Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31

Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts.

Zhang Q, Tu W, Tian K, Han L, Wang Q, Chen P, Zhou X
Journal of cellular biochemistry 2019 Jan;120(1):93-104

Transcription factor KLF4 modulates microRNA-106a that targets Smad7 in gastric cancer.

Zhu M, Zhang N, He S
Pathology, research and practice 2019 Aug;215(8):152467

Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.

Lin L, Li R, Cai M, Huang J, Huang W, Guo Y, Yang L, Yang G, Lan T, Zhu K
Oxidative medicine and cellular longevity 2018;2018:7808656

Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.

Li J, Wang S, Bai J, Yang XL, Zhang YL, Che YL, Li HH, Yang YZ
Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):866-876

MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis.

Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, Yang H, Zhang L, Da Y, Yao Z, Zhang R
Brain, behavior, and immunity 2018 May;70:305-314

Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.

Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45

Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway.

Chen S, Huang Y, Wan S, Huang Y, Liang H, Chen S
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2018 Jun;38(3):419-426

Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.

Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854

CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.

Ma Y, Zhang H, Xiong C, Liu Z, Xu Q, Feng J, Zhang J, Wang Z, Yan X
Cancer letters 2018 Aug 28;430:201-214

miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7.

Liu T, Wu Y, Huang T, Zhang X, Cai Y
Oncology letters 2017 Oct;14(4):3941-3946

AG490 suppresses interleukin-34-mediated osteoclastogenesis in mice bone marrow macrophages.

Cheng X, Wan QL, Li ZB
Cell biology international 2017 Jun;41(6):659-668

Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels.

Ni C, Ma P, Qu L, Wu F, Hao J, Wang R, Lu Y, Yang W, Erben U, Qin Z
The Journal of pathology 2017 Jul;242(3):334-346

Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.

Wu J, Lu M, Li Y, Shang YK, Wang SJ, Meng Y, Wang Z, Li ZS, Chen H, Chen ZN, Bian H
Oncogene 2016 Oct 20;35(42):5468-5479

Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.

Chen MS, Zhang JH, Wang JL, Gao L, Chen XX, Xiao JH
The American journal of Chinese medicine 2015;43(2):231-40

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 25840-1-AP( SMAD7 Antibody) at dilution of 1:1000
Validation comment: WB
Appendix: 25840-1-AP.pdf

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