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- Antigen structure
- References [126]
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- Product number
- 25840-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SMAD7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMAD7 antibody (Cat. #25840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The mechanism of the water layer extract of Cichorium pumilum Jacq water extract in the treatment of Hepatic fibrosis was investigated using HPLC-MS/MS and network pharmacology.
YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.
PZP deficiency impairs M2 macrophage polarization via TGF-β/Smad3 signaling, contributing to immune dysregulation at the maternal-fetal interface in preeclampsia.
Integrating WGCNA and network pharmacology to unravel the multi-target mechanisms of Ludangshen Oral liquid against nephrotic syndrome: Involvement of TGF-β1/Smad3 and gut microbiota.
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.
Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition.
Overexpression of Decorin Optimizes the Treatment Efficacy of Umbilical Cord Mesenchymal Stem Cells in Bleomycin-Induced Pulmonary Fibrosis in Rats.
Liuwei Dihuang pills ameliorate renal injury in experimental type 2 diabetes mellitus rat by regulating host-gut microbiota interaction.
GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
Rhein alleviates renal interstitial fibrosis by inhibiting Smad3 phosphorylation in TGF-β/Smad signalling pathway.
Fecal Microbiota Transplantation Attenuated Inflammation Through TGF-β1/Smad Signaling Pathway in Caco-2 and RAW264.7 Cells.
IGF2BP3 regulates EMP1 stability in an m(6)A-dependent manner and activates the TGF-β pathway to promote pancreatic cancer invasion.
Biosynthesis of the Natural Antioxidant Mycosporine-Glycine and Its Anti-Photodamage Properties.
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Zwitterion nanocomposite hydrogels with bioactivity and anti-adhesion properties for rapid prevention of postoperative and recurrent adhesion.
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.
Loss of peptidylarginine deiminase 4 mitigates maladaptive cardiac remodeling after myocardial infarction through inhibition of inflammatory and profibrotic pathways.
Elevated Sphingosine Levels Suppress Profibrotic TGF-β Signaling via the PKC/miR-21/SMAD7 Axis in Sphingosine Kinase 2-Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction-Induced Kidney Fibrosis.
Chemical compounds from Allii Tuberosi Semen exhibiting anti-fibrotic effects on hepatic stellate cells.
Sp3 ameliorated experimental autoimmune encephalomyelitis by triggering Socs3 in Th17 cells.
Combination of Lactiplantibacillus Plantarum ELF051 and Astragalus Polysaccharides Improves Intestinal Barrier Function and Gut Microbiota Profiles in Mice with Antibiotic-Associated Diarrhea.
HIC2 suppresses glioblastoma progression via transcriptional repression of SEMA3A and inhibition of TGF-β signaling.
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7.
MALAT1 Knockdown Inhibits the Proliferation, Migration, and Collagen Deposition of Human Hypertrophic Scar Fibroblasts via Targeting miR-29a-3p/Smurf2 Axis.
Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-β/Smad Signalling Pathway in Fibroblasts.
Transcriptomics of tissue exosomes to investigate miR-195-5p's amelioration of endometrial fibrosis via the YAP-Smad7 pathway: an animal study.
TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.
Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation.
HUC-MSCs combined with platelet lysate treat diabetic chronic cutaneous ulcers in Bama miniature pig.
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis.
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway.
Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial-mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.
INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation.
Effect and mechanism of pirfenidone combined with 2-methoxy-estradiol perfusion through portal vein on hepatic artery hypoxia-induced hepatic fibrosis.
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
K235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis.
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.
Dysfunction of Caveolae-Mediated Endocytic TβRI Degradation Results in Hypersensitivity of TGF-β/Smad Signaling in Osteogenesis Imperfecta.
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway.
Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis.
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.
JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis.
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.
Tocotrienol-Rich Fractions Offer Potential to Suppress Pulmonary Fibrosis Progression.
Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.
The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation.
Potential "Therapeutic" Effects of Tocotrienol-Rich Fraction (TRF) and Carotene "Against" Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways.
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.
Pharmacological activation of estrogenic receptor G protein-coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway.
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7.
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis.
High glucose inhibits the survival of HRMCs and its mechanism.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Jianpi Huayu decoction inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing exosomal miR-23a-3p/Smad signaling.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway.
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation.
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Epigenetic Control of circHNRNPH1 in Postischemic Myocardial Fibrosis through Targeting of TGF-β Receptor Type I.
MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.
Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.
Exosomal MicroRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by Inhibiting Smad7.
Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway.
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF-β1/SMAD7/RUNX2 pathway.
Exosomes derived from thymic stromal lymphopoietin-treated dendritic cells regulate T helper 17/regulatory T cell differentiation via miR-21/Smad7 axis.
Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway.
MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis.
TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition.
Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Exosomal miR-106a derived from gastric cancer promotes peritoneal metastasis via direct regulation of Smad7.
Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.
Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation.
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.
The RNA N(6)-methyladenosine modification landscape of human fetal tissues.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts.
Transcription factor KLF4 modulates microRNA-106a that targets Smad7 in gastric cancer.
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.
MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.
miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7.
AG490 suppresses interleukin-34-mediated osteoclastogenesis in mice bone marrow macrophages.
Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels.
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
Chen W, Dong N, Lu X, Qin D
Journal of natural medicines 2026 May;80(3):844-857
Journal of natural medicines 2026 May;80(3):844-857
YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.
Zhang Q, Man J, Cai J, Zhao T, Zhang Z
International journal of biological macromolecules 2026 Mar;348:150816
International journal of biological macromolecules 2026 Mar;348:150816
PZP deficiency impairs M2 macrophage polarization via TGF-β/Smad3 signaling, contributing to immune dysregulation at the maternal-fetal interface in preeclampsia.
Yan M, Yang H, He W, Lei H, Feng N, Guan W, Feng W, Han L
Molecular immunology 2026 Jun;194:1-12
Molecular immunology 2026 Jun;194:1-12
Integrating WGCNA and network pharmacology to unravel the multi-target mechanisms of Ludangshen Oral liquid against nephrotic syndrome: Involvement of TGF-β1/Smad3 and gut microbiota.
Cheng Z, Xiang W, Chen X, Xu X, Hou W, Gao J, Zhou J
Fitoterapia 2026 Jun;191:107239
Fitoterapia 2026 Jun;191:107239
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Xiang F, He Z, Yang C, Lin L, Peng Q, Zhang Z
Chinese medicine 2026 Jan 4;21(1):3
Chinese medicine 2026 Jan 4;21(1):3
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.
Jiang LJ, Zheng YY, Liang LM, Jia ZH, Du RH, Huang H, Dai X, Cheng PP, Zhao LQ, Li Q, Jiang YH, Cui XL, Ye SY, Hu SH, Zhang HD, Lian CY, Feng X, Song LJ, Yu F, He XL, Xiong L, Xiang F, Wang X, Liu AD, Wang M, Ye H, Ma WL
Respiratory research 2026 Feb 3;27(1)
Respiratory research 2026 Feb 3;27(1)
Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition.
Liu X, Sun S, He S, Xie L
Tobacco induced diseases 2025;23
Tobacco induced diseases 2025;23
Overexpression of Decorin Optimizes the Treatment Efficacy of Umbilical Cord Mesenchymal Stem Cells in Bleomycin-Induced Pulmonary Fibrosis in Rats.
Zhi Y, Shu M, Tang P, Li Y, Guo M, Deng J, Mo H, Wu M, Liu B, Mai Y, Ling J, Zhao X, Zhang X, Zuo W
Stem cells international 2025;2025:6324980
Stem cells international 2025;2025:6324980
Liuwei Dihuang pills ameliorate renal injury in experimental type 2 diabetes mellitus rat by regulating host-gut microbiota interaction.
Jiang H, Hu XW, Deng X, Huang XJ, Chen YL, Yang YF, Du Y, Ji S, Tang DQ
Frontiers in pharmacology 2025;16:1715600
Frontiers in pharmacology 2025;16:1715600
GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
Kuang X, Niu Z, Liu W, Huang Z, Li S, Zhang Y, Wang L, Cai X, Wang F, Zhang P
Frontiers in immunology 2025;16:1712741
Frontiers in immunology 2025;16:1712741
Rhein alleviates renal interstitial fibrosis by inhibiting Smad3 phosphorylation in TGF-β/Smad signalling pathway.
Zheng X, Wang L, Cheng Y, Lin H, Liu S, Chen X, Xiang Z
Chinese herbal medicines 2025 Oct;17(4):744-755
Chinese herbal medicines 2025 Oct;17(4):744-755
Fecal Microbiota Transplantation Attenuated Inflammation Through TGF-β1/Smad Signaling Pathway in Caco-2 and RAW264.7 Cells.
Qiu J, Wu C, Li S, Yang X
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Oct 10;37(2):161-169
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2025 Oct 10;37(2):161-169
IGF2BP3 regulates EMP1 stability in an m(6)A-dependent manner and activates the TGF-β pathway to promote pancreatic cancer invasion.
Liu L, Zhang Y, Huang Y, Zhao X, Fu H, Chen L, Wang Q, Liu X, Zheng X, Zhu H, Fang Z, Gao Z, Yan S
Cell death & disease 2025 Nov 24;16(1):858
Cell death & disease 2025 Nov 24;16(1):858
Biosynthesis of the Natural Antioxidant Mycosporine-Glycine and Its Anti-Photodamage Properties.
Wang K, Cao J, Yao M, Zhang Q, Lin H, Qin L, Zhang Z, Wei J, Zhang H, He Y, Qu C, Liu M, Miao J
Journal of agricultural and food chemistry 2025 May 7;73(18):11094-11109
Journal of agricultural and food chemistry 2025 May 7;73(18):11094-11109
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Yang F, Gao Y, Xie S, Yang W, Wang Q, Ye W, Sun L, Zhou J, Feng X
Food & function 2025 Mar 17;16(6):2316-2334
Food & function 2025 Mar 17;16(6):2316-2334
Zwitterion nanocomposite hydrogels with bioactivity and anti-adhesion properties for rapid prevention of postoperative and recurrent adhesion.
Zhu W, Fang J, Xu W, Yu D, Shi J, Xia Q, Wang J, Chen X, Zha H, Li S, Zhang W
Materials today. Bio 2025 Jun;32:101811
Materials today. Bio 2025 Jun;32:101811
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.
Wang ZQ, Mao P, Wang BA, Guo Q, Liu H, Yuan Y, Wang C, Liu JP, Zhu XM, Wei H
Chinese journal of integrative medicine 2025 Jun;31(6):518-528
Chinese journal of integrative medicine 2025 Jun;31(6):518-528
Loss of peptidylarginine deiminase 4 mitigates maladaptive cardiac remodeling after myocardial infarction through inhibition of inflammatory and profibrotic pathways.
Holthaus M, Xiong X, Eghbalzadeh K, Großmann C, Geißen S, Piontek F, Mollenhauer M, Abdallah AT, Kamphausen T, Rothschild M, Wahlers T, Paunel-Görgülü A
Translational research : the journal of laboratory and clinical medicine 2025 Jun;280:1-16
Translational research : the journal of laboratory and clinical medicine 2025 Jun;280:1-16
Elevated Sphingosine Levels Suppress Profibrotic TGF-β Signaling via the PKC/miR-21/SMAD7 Axis in Sphingosine Kinase 2-Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction-Induced Kidney Fibrosis.
Oftring A, Wagner V, Thomas D, Huber LS, Geisslinger G, Schaefer L, Vutukuri R, Pfeilschifter J, Schwalm S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70768
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70768
Chemical compounds from Allii Tuberosi Semen exhibiting anti-fibrotic effects on hepatic stellate cells.
Zhao R, Liu X, Liu J, Wang H, Cui Y, Yu R, Jin T, Wang S, Qin X, Wang M, Ji L, Wang T, Jalsrai A, Cong Y
Journal of ethnopharmacology 2025 Jun 12;349:119949
Journal of ethnopharmacology 2025 Jun 12;349:119949
Sp3 ameliorated experimental autoimmune encephalomyelitis by triggering Socs3 in Th17 cells.
Li Y, Zhu M, Yang P, Chen D, Zhou D, Ren Y, Zhang Z, Ruan C, Da Y, Zhang R
Journal of advanced research 2025 Dec;78:239-255
Journal of advanced research 2025 Dec;78:239-255
Combination of Lactiplantibacillus Plantarum ELF051 and Astragalus Polysaccharides Improves Intestinal Barrier Function and Gut Microbiota Profiles in Mice with Antibiotic-Associated Diarrhea.
Zhong B, Liang W, Zhao Y, Li F, Zhao Z, Gao Y, Yang G, Li S
Probiotics and antimicrobial proteins 2025 Dec;17(6):4267-4280
Probiotics and antimicrobial proteins 2025 Dec;17(6):4267-4280
HIC2 suppresses glioblastoma progression via transcriptional repression of SEMA3A and inhibition of TGF-β signaling.
Zhang L, Yang J, Ke X, Huang N, Zhou D, Cai H
Free radical biology & medicine 2025 Dec 1;240:674-684
Free radical biology & medicine 2025 Dec 1;240:674-684
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7.
Chang X, Zhang Y, Deng M, Yang R, Zhang J, Hao M, Miao J
Molecular human reproduction 2025 Apr 3;31(2)
Molecular human reproduction 2025 Apr 3;31(2)
MALAT1 Knockdown Inhibits the Proliferation, Migration, and Collagen Deposition of Human Hypertrophic Scar Fibroblasts via Targeting miR-29a-3p/Smurf2 Axis.
Guo C, Liu X, Qiu K, Tu L, Liu D
Clinical, cosmetic and investigational dermatology 2024;17:1387-1404
Clinical, cosmetic and investigational dermatology 2024;17:1387-1404
Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-β/Smad Signalling Pathway in Fibroblasts.
Pan H, Song J, An Q, Chen J, Zheng W, Zhang L, Gu J, Deng C, Yang B
Experimental dermatology 2024 Oct;33(10):e15186
Experimental dermatology 2024 Oct;33(10):e15186
Transcriptomics of tissue exosomes to investigate miR-195-5p's amelioration of endometrial fibrosis via the YAP-Smad7 pathway: an animal study.
Chen JM, Huang QY, Chen WH, Wu JX, Zheng LT, You HJ, Shi YC, Lin S, Shi QR
Journal of translational medicine 2024 Nov 21;22(1):1050
Journal of translational medicine 2024 Nov 21;22(1):1050
TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
Wu JZ, Zhou C, Liu S, Zhang JX, Yang W, Shi HB, Zhou WZ
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.
Liang S, Zheng R, Zuo B, Li J, Wang Y, Han Y, Dong H, Zhao X, Zhang Y, Wang P, Meng R, Jia L, Yang A, Yan B
Cellular & molecular immunology 2024 Mar;21(3):213-226
Cellular & molecular immunology 2024 Mar;21(3):213-226
Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation.
Lin QY, Yu WJ, Bai J, Jiang WX, Li HH
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167048
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167048
HUC-MSCs combined with platelet lysate treat diabetic chronic cutaneous ulcers in Bama miniature pig.
Gao Y, Chen L, Li Y, Sun S, Ran X
Regenerative therapy 2024 Jun;26:1138-1149
Regenerative therapy 2024 Jun;26:1138-1149
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis.
Xie C, Zhong L, Feng H, Wang R, Shi Y, Lv Y, Hu Y, Li J, Xiao D, Liu S, Chen Q, Tao Y
International journal of oral science 2024 Jun 20;16(1):48
International journal of oral science 2024 Jun 20;16(1):48
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Guo L, Li K, Ma Y, Niu H, Li J, Shao X, Li N, Sun Y, Wang H
Human cell 2024 Jul;37(4):972-985
Human cell 2024 Jul;37(4):972-985
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Zhang Y, Lu YB, Zhu WJ, Gong XX, Qian R, Lu YJ, Li Y, Yao WF, Bao BH, Zhang Y, Zhang L, Cheng FF
Journal of ethnopharmacology 2024 Apr 24;324:117737
Journal of ethnopharmacology 2024 Apr 24;324:117737
SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway.
Gao Y, Li H, Wang P, Wang J, Yao X
Journal of Cancer 2023;14(13):2455-2467
Journal of Cancer 2023;14(13):2455-2467
Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial-mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway.
Liu L, Liu L, Liu R, Liu J, Cheng Q
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):711-718
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):711-718
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.
Zhao Z, Zhang H, Zhang F, Ji Y, Peng Y, Wang F, Zhao L
Acta biochimica Polonica 2023 Oct 18;70(4):855-863
Acta biochimica Polonica 2023 Oct 18;70(4):855-863
INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation.
Zhang H, Huang Y, Wen Q, Li Y, Guo L, Ge N
Journal of orthopaedic surgery and research 2023 Nov 8;18(1):848
Journal of orthopaedic surgery and research 2023 Nov 8;18(1):848
Effect and mechanism of pirfenidone combined with 2-methoxy-estradiol perfusion through portal vein on hepatic artery hypoxia-induced hepatic fibrosis.
Zheng H, Huang N, Lin JQ, Yan LY, Jiang QG, Yang WZ
Advances in medical sciences 2023 Mar;68(1):46-53
Advances in medical sciences 2023 Mar;68(1):46-53
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.
Cheng Q, Wang D, Lai X, Liu Y, Zuo Y, Zhang W, Lei L, Chen J, Liu H, Wang Y, Liu H, Zheng H, Wu D, Xu Y
Blood 2023 Mar 23;141(12):1474-1488
Blood 2023 Mar 23;141(12):1474-1488
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Zhang YB, Bao YR, Wang S, Li TJ, Tai H, Leng JP, Yang XX, Wang BC, Meng XS
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Ren HL, Zhang JH, Xiao JH
Heliyon 2023 Jun;9(6):e16849
Heliyon 2023 Jun;9(6):e16849
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Yu J, Zhao X, Yan X, Li W, Liu Y, Wang J, Wang J, Yang Y, Hao Y, Liang Z, Tao Y, Yuan Y, Du Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
K235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis.
Zhang XL, Chen XH, Xu B, Chen M, Zhu S, Meng N, Wang JZ, Zhu H, Chen D, Liu JB, Yan GR
Nature communications 2023 Jun 27;14(1):3815
Nature communications 2023 Jun 27;14(1):3815
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.
Liu C, Wu J, Li M, Gao R, Zhang X, Ye-Lehmann S, Song J, Zhu T, Chen C
Journal of neuroinflammation 2023 Jul 28;20(1):175
Journal of neuroinflammation 2023 Jul 28;20(1):175
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.
Feng S, Jia J, Lv G, Wang Y
Archives of biochemistry and biophysics 2023 Jul 1;742:109620
Archives of biochemistry and biophysics 2023 Jul 1;742:109620
Dysfunction of Caveolae-Mediated Endocytic TβRI Degradation Results in Hypersensitivity of TGF-β/Smad Signaling in Osteogenesis Imperfecta.
Shi C, Sun B, Wu H, Zhang R, Wu L, Guo L, Li C, Xi Y, Yuan W, Zhang Y, Xu G
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Jan;38(1):103-118
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Jan;38(1):103-118
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Zhang B, Liu S, Sun Y, Xu D
Toxicology 2023 Jan 15;484:153392
Toxicology 2023 Jan 15;484:153392
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
Chen C, Chen J, Wang Y, Fang L, Guo C, Sang T, Peng H, Zhao Q, Chen S, Lin X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway.
Wan G, Chen Z, Lei L, Geng X, Zhang Y, Yang C, Cao W, Pan Z
Chinese medicine 2023 Feb 24;18(1):20
Chinese medicine 2023 Feb 24;18(1):20
Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis.
Li Z, Zhang B, Shang J, Wang Y, Jia L, She X, Xu X, Zhang D, Guo J, Zhang F
International immunopharmacology 2023 Dec;125(Pt B):111190
International immunopharmacology 2023 Dec;125(Pt B):111190
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
Feng P, Che Y, Gao C, Chu X, Li Z, Li L, Li J, Gao J, Dong Y
iScience 2023 Dec 15;26(12):108484
iScience 2023 Dec 15;26(12):108484
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Zhao Y, Chen X, Lin Y, Li Z, Su X, Fan S, Chen Y, Wang X, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.
Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359
Clinical and translational medicine 2023 Aug;13(8):e1359
JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.
Liu LH, Fang CK, Ge FC, Wang JN, Zhang XB, Luo R, Zhang Y, Feng KL, Qiu ZW, Zhong C
Journal of oncology 2022;2022:7823433
Journal of oncology 2022;2022:7823433
Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.
Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY
Cardiology research and practice 2022;2022:3972829
Cardiology research and practice 2022;2022:3972829
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y
Drug design, development and therapy 2022;16:647-664
Drug design, development and therapy 2022;16:647-664
CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis.
Feng KL, Diao N, Zhou ZW, Fang CK, Wang JN, Zhang Y, Luo R, Zhong C
Frontiers in cell and developmental biology 2022;10:850708
Frontiers in cell and developmental biology 2022;10:850708
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.
Yao H, Song W, Cao R, Ye C, Zhang L, Chen H, Wang J, Shi Y, Li R, Li Y, Liu X, Zhou X, Shao R, Li L
Nature communications 2022 Sep 20;13(1):5506
Nature communications 2022 Sep 20;13(1):5506
Tocotrienol-Rich Fractions Offer Potential to Suppress Pulmonary Fibrosis Progression.
Lu Y, Zhang Y, Xu D, Wang Y, Pan D, Wang P, Xia J, Yin S, Liao W, Wang S, Sun G
International journal of molecular sciences 2022 Nov 18;23(22)
International journal of molecular sciences 2022 Nov 18;23(22)
Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.
Zhu M, Zhang N, Ma J, He S
Cellular signalling 2022 Mar;91:110230
Cellular signalling 2022 Mar;91:110230
The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation.
Sun Y, Li ZJ
Acta pharmacologica Sinica 2022 Mar;43(3):634-644
Acta pharmacologica Sinica 2022 Mar;43(3):634-644
Potential "Therapeutic" Effects of Tocotrienol-Rich Fraction (TRF) and Carotene "Against" Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways.
Lu Y, Zhang Y, Pan Z, Yang C, Chen L, Wang Y, Xu D, Xia H, Wang S, Chen S, Hao YJ, Sun G
Nutrients 2022 Mar 5;14(5)
Nutrients 2022 Mar 5;14(5)
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313
European journal of medicinal chemistry 2022 Jun 5;236:114313
CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.
Feng X, Xiang Q, Jia J, Guo T, Liao Z, Yang S, Cai X, Liu X
Molecular therapy. Nucleic acids 2022 Jun 14;28:99-113
Molecular therapy. Nucleic acids 2022 Jun 14;28:99-113
Pharmacological activation of estrogenic receptor G protein-coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway.
Liu D, Zhan Y, Ono K, Yin Y, Wang L, Wei M, Ji L, Liu M, Liu G, Zhou X, Zheng M
Molecular biology reports 2022 Jul;49(7):6341-6355
Molecular biology reports 2022 Jul;49(7):6341-6355
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
Guo T, You K, Chen X, Sun Y, Wu Y, Wu P, Jiang Y
Cell death discovery 2022 Jul 14;8(1):320
Cell death discovery 2022 Jul 14;8(1):320
MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7.
Jia G, Liang C, Li W, Dai H
Bioengineered 2022 Jan;13(1):119-127
Bioengineered 2022 Jan;13(1):119-127
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
Astori A, Matherat G, Munoz I, Gautier EF, Surdez D, Zermati Y, Verdier F, Zaidi S, Feuillet V, Kadi A, Lauret E, Delattre O, Lefèvre C, Fontenay M, Ségal-Bendirdjian E, Dusanter-Fourt I, Bouscary D, Hermine O, Mayeux P, Pendino F
Haematologica 2022 Jan 1;107(1):268-283
Haematologica 2022 Jan 1;107(1):268-283
Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis.
Lu Y, Zhang Y, Xu D, Wang Y, Pan D, Xia H, Sun G
International immunopharmacology 2022 Dec;113(Pt B):109465
International immunopharmacology 2022 Dec;113(Pt B):109465
High glucose inhibits the survival of HRMCs and its mechanism.
Zhu Y, Ruan CX, Wang J, Jiang FF, Xiong LS, Sheng X, Le J, Yu AQ, Wang Q, Liu YT, Qin SL
European review for medical and pharmacological sciences 2022 Aug;26(16):5683-5688
European review for medical and pharmacological sciences 2022 Aug;26(16):5683-5688
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Jianpi Huayu decoction inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing exosomal miR-23a-3p/Smad signaling.
Xie CF, Feng KL, Wang JN, Luo R, Fang CK, Zhang Y, Shen CP, Zhong C
Journal of ethnopharmacology 2022 Aug 10;294:115360
Journal of ethnopharmacology 2022 Aug 10;294:115360
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643
Frontiers in cardiovascular medicine 2021;8:659643
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway.
Xue Q, Jiang H, Wang J, Wei D
Canadian respiratory journal 2021;2021:5277409
Canadian respiratory journal 2021;2021:5277409
Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway.
Pan J, Cao Z, Fang C, Lei Y, Sun J, Huang X, Han D
Frontiers in pharmacology 2021;12:722530
Frontiers in pharmacology 2021;12:722530
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
Wang Q, Liu J, Hu Y, Pan T, Xu Y, Yu J, Xiong W, Zhou Q, Wang Y
Theranostics 2021;11(14):7110-7125
Theranostics 2021;11(14):7110-7125
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
MiR-21-3p Promotes Hepatocellular Carcinoma Progression via SMAD7/YAP1 Regulation.
Hong Y, Ye M, Wang F, Fang J, Wang C, Luo J, Liu J, Liu J, Liu L, Zhao Q, Chang Y
Frontiers in oncology 2021;11:642030
Frontiers in oncology 2021;11:642030
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Lv W, Ren Y, Wu M, Luo X, Yu J, Zhang Q, Wu Y
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Epigenetic Control of circHNRNPH1 in Postischemic Myocardial Fibrosis through Targeting of TGF-β Receptor Type I.
Li W, Wang Y, Deng Y, Ni H, Shen G, Liu X, Li J, Wang F
Molecular therapy. Nucleic acids 2021 Sep 3;25:93-104
Molecular therapy. Nucleic acids 2021 Sep 3;25:93-104
MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.
Mao Y, Jiang L
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30
Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.
Liu S, Hu Y, Wang Y, Sun Y, Qin SL, Xu D
Ecotoxicology and environmental safety 2021 Nov 30;228:113040
Ecotoxicology and environmental safety 2021 Nov 30;228:113040
Exosomal MicroRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by Inhibiting Smad7.
Li Q, Fang L, Chen J, Zhou S, Zhou K, Cheng F, Cen Y, Qing Y, Wu J
Journal of burn care & research : official publication of the American Burn Association 2021 Nov 24;42(6):1266-1274
Journal of burn care & research : official publication of the American Burn Association 2021 Nov 24;42(6):1266-1274
Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway.
Guo Y, Gao X, An S, Li X, Pan L, Liu H, Liu J, Gao J, Zhao Z, Li G, Han Y, Li Y, Ji Z
Aging 2021 Nov 11;13(21):24339-24348
Aging 2021 Nov 11;13(21):24339-24348
Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Yang Y, Sun M, Li W, Liu C, Jiang Z, Gu P, Li J, Wang W, You R, Ba Q, Li X, Wang H
Clinical and translational medicine 2021 Jul;11(7):e410
Clinical and translational medicine 2021 Jul;11(7):e410
Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF-β1/SMAD7/RUNX2 pathway.
Li ZZ, Wang HT, Lee GY, Yang Y, Zou YP, Wang B, Gong CJ, Cai Y, Ren JG, Zhao JH
British journal of pharmacology 2021 Jan;178(2):312-327
British journal of pharmacology 2021 Jan;178(2):312-327
Exosomes derived from thymic stromal lymphopoietin-treated dendritic cells regulate T helper 17/regulatory T cell differentiation via miR-21/Smad7 axis.
Ji Q, Liu J, Dong Y, Wang L, Dong K, Setiz B, Szentmáry N, Qu B, Shi L
Experimental cell research 2021 Jan 1;398(1):112393
Experimental cell research 2021 Jan 1;398(1):112393
Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway.
Xu M, Li S, Wang J, Huang S, Zhang A, Zhang Y, Gu W, Yu X, Jia Z
Frontiers in medicine 2020;7:626140
Frontiers in medicine 2020;7:626140
MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis.
Yang S, Chen Y, Mi X, Zhang S, Yang Y, Hui R, Zhang W
Disease markers 2020;2020:8864322
Disease markers 2020;2020:8864322
TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition.
Xiao Y, Qing J, Li B, Chen L, Nong S, Yang W, Tang X, Chen Z
OncoTargets and therapy 2020;13:1993-2006
OncoTargets and therapy 2020;13:1993-2006
Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.
Yuan H, Xu J, Zhu Y, Li L, Wang Q, Yu Y, Zhou B, Liu Y, Xu X, Wang Z
Molecular medicine reports 2020 Sep;22(3):2021-2031
Molecular medicine reports 2020 Sep;22(3):2021-2031
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Che H, Wang Y, Li Y, Lv J, Li H, Liu Y, Dong R, Sun Y, Xu X, Zhao J, Wang L
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Exosomal miR-106a derived from gastric cancer promotes peritoneal metastasis via direct regulation of Smad7.
Zhu M, Zhang N, He S, Lu X
Cell cycle (Georgetown, Tex.) 2020 May;19(10):1200-1221
Cell cycle (Georgetown, Tex.) 2020 May;19(10):1200-1221
Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.
Sasaki N, Itakura Y, Toyoda M
Cell communication and signaling : CCS 2020 Mar 12;18(1):43
Cell communication and signaling : CCS 2020 Mar 12;18(1):43
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.
Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X
Cell death and differentiation 2020 Feb;27(2):497-508
Cell death and differentiation 2020 Feb;27(2):497-508
Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation.
Zhang YC, Chen BX, Xie XY, Zhou Y, Qian Q, Jiang CQ
World journal of gastroenterology 2020 Feb 21;26(7):717-724
World journal of gastroenterology 2020 Feb 21;26(7):717-724
A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.
Li X, Liu Y, Yue W, Tan Y, Wang H, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
Evidence-based complementary and alternative medicine : eCAM 2019;2019:9121347
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Sun L, Xu T, Chen Y, Qu W, Sun D, Song X, Yuan Q, Yao L
Life sciences 2019 Sep 1;232:116609
Life sciences 2019 Sep 1;232:116609
Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.
Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
Qiu Y, Zhou J, Zhang H, Zhou H, Tang H, Lei C, Ye C, You C, Chen Y, Wang Y, Xiong J, Su H, Yao G, Zhang C
Journal of ethnopharmacology 2019 Oct 28;243:112078
Journal of ethnopharmacology 2019 Oct 28;243:112078
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.
Fan J, Wang Q, Zhang Z, Sun L
Drug development research 2019 Nov;80(7):992-999
Drug development research 2019 Nov;80(7):992-999
The RNA N(6)-methyladenosine modification landscape of human fetal tissues.
Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M, He C, Xia L
Nature cell biology 2019 May;21(5):651-661
Nature cell biology 2019 May;21(5):651-661
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C
Nature cell biology 2019 Jul;21(7):856-866
Nature cell biology 2019 Jul;21(7):856-866
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31
Brain research bulletin 2019 Jul;149:21-31
Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts.
Zhang Q, Tu W, Tian K, Han L, Wang Q, Chen P, Zhou X
Journal of cellular biochemistry 2019 Jan;120(1):93-104
Journal of cellular biochemistry 2019 Jan;120(1):93-104
Transcription factor KLF4 modulates microRNA-106a that targets Smad7 in gastric cancer.
Zhu M, Zhang N, He S
Pathology, research and practice 2019 Aug;215(8):152467
Pathology, research and practice 2019 Aug;215(8):152467
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Lin L, Li R, Cai M, Huang J, Huang W, Guo Y, Yang L, Yang G, Lan T, Zhu K
Oxidative medicine and cellular longevity 2018;2018:7808656
Oxidative medicine and cellular longevity 2018;2018:7808656
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Gao F, He X, Liang S, Liu S, Liu H, He Q, Chen L, Jiang H, Zhang Y
RSC advances 2018 Oct 15;8(62):35413-35421
RSC advances 2018 Oct 15;8(62):35413-35421
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in Mice.
Li J, Wang S, Bai J, Yang XL, Zhang YL, Che YL, Li HH, Yang YZ
Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):866-876
Hypertension (Dallas, Tex. : 1979) 2018 May;71(5):866-876
MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis.
Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, Yang H, Zhang L, Da Y, Yao Z, Zhang R
Brain, behavior, and immunity 2018 May;70:305-314
Brain, behavior, and immunity 2018 May;70:305-314
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway.
Chen S, Huang Y, Wan S, Huang Y, Liang H, Chen S
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2018 Jun;38(3):419-426
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2018 Jun;38(3):419-426
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.
Ma Y, Zhang H, Xiong C, Liu Z, Xu Q, Feng J, Zhang J, Wang Z, Yan X
Cancer letters 2018 Aug 28;430:201-214
Cancer letters 2018 Aug 28;430:201-214
miR-590 promotes the proliferation of HUMSCs and induces ECM synthesis by targeting Smad7.
Liu T, Wu Y, Huang T, Zhang X, Cai Y
Oncology letters 2017 Oct;14(4):3941-3946
Oncology letters 2017 Oct;14(4):3941-3946
AG490 suppresses interleukin-34-mediated osteoclastogenesis in mice bone marrow macrophages.
Cheng X, Wan QL, Li ZB
Cell biology international 2017 Jun;41(6):659-668
Cell biology international 2017 Jun;41(6):659-668
Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels.
Ni C, Ma P, Qu L, Wu F, Hao J, Wang R, Lu Y, Yang W, Erben U, Qin Z
The Journal of pathology 2017 Jul;242(3):334-346
The Journal of pathology 2017 Jul;242(3):334-346
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 25840-1-AP( SMAD7 Antibody) at dilution of 1:1000
- Validation comment
- WB
