Tissue expression
Cell line expression
Protein structure
SMAD7
SMAD family member 7MADH7, MADH8
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Top validated antibodies |
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Invitrogen Antibodies | 42-0400 | 10 references | Polyclonal |
WB
ICC
IHC
FC
OA
|
|
Novus Biologicals | NBP2-24710 | 11 references | Polyclonal |
WB
EL
IP
IHC |
|
Proteintech Group | 25840-1-AP | 48 references | Polyclonal |
WB
EL
IHC
|
|
R&D Systems | MAB2029 | 23 references | Monoclonal |
WB
IHC |
|
antibodies-online | ABIN670206 | 3 references | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider