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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Product number
- ABIN362225 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Breakpoint Cluster Region (BCR) (pTyr177) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr177 (P-F-Y (p) -V-N) derived from Human Bcr. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- pTyr177
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase.
Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.
BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis.
Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA
Molecular and cellular biology 2004 Jun;24(11):4685-95
Molecular and cellular biology 2004 Jun;24(11):4685-95
Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.
Li S, Couvillon AD, Brasher BB, Van Etten RA
The EMBO journal 2001 Dec 3;20(23):6793-804
The EMBO journal 2001 Dec 3;20(23):6793-804
BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis.
Sattler M, Verma S, Byrne CH, Shrikhande G, Winkler T, Algate PA, Rohrschneider LR, Griffin JD
Molecular and cellular biology 1999 Nov;19(11):7473-80
Molecular and cellular biology 1999 Nov;19(11):7473-80
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