MYOM2

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]

Description

Myomesin 2

Tissue specificity

Group enriched (heart muscle, skeletal muscle)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

8 (2045046 - 2165552)

Ensembl ID

ENSG00000036448  (ver. 103.38)

Orthologs

Mouse Myom2: ENSMUSG00000031461

UniProt

P54296

neXtProt

NX_P54296

Human splice variants
Mouse splice variants

Protein structure