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- References [19]
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- Immunohistochemistry [2]
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- Product number
- 21619-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21619-1-AP, RRID:AB_10860263
- Product name
- FHL2 antibody
- Antibody type
- Polyclonal
- Description
- FHL2 antibody (Cat. #21619-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deubiquitinating Enzyme UCHL1 Modulates FHL2 to Block Ferroptosis and Counteract CD8 (+) T Cell Anti-Tumour Immunity in Lung Adenocarcinoma.
ATF6 ameliorates renal warm ischemia-reperfusion injury through FHL2-mediated NF-κB signaling pathway.
FHL2 facilitates LUSC growth and therapy resistance through PI3K/AKT/mTOR activation.
Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.
FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways.
Identification of CFH and FHL2 as biomarkers for idiopathic pulmonary fibrosis.
Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice.
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells.
The mechanical regulation of RNA binding protein hnRNPC in the failing heart.
Oxymatrine Synergistically Enhances Doxorubicin Anticancer Effects in Colorectal Cancer.
Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2-M checkpoint modulation.
Expression, location and biological effects of four and a half LIM domain protein 2 (FHL2) on granulosa cells in ovine.
Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome.
Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.
A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.
Chen X, Li J, Tang B, Wang X, Huang Y
Immunology 2026 Feb;177(2):384-397
Immunology 2026 Feb;177(2):384-397
ATF6 ameliorates renal warm ischemia-reperfusion injury through FHL2-mediated NF-κB signaling pathway.
Wu X, Shi JH, Bai Y, Yang DJ, Jia MY, Guo DF, Zhang JK, Shi XY, Zhang HP, Guo WZ, Zhang SJ
iScience 2026 Apr 17;29(4):115173
iScience 2026 Apr 17;29(4):115173
FHL2 facilitates LUSC growth and therapy resistance through PI3K/AKT/mTOR activation.
Zhang L, Wang D, Zeng L, Chen S, Li K, Yuan T, Wang J, Ma X, Zhu S, Wu Y
The Journal of biological chemistry 2025 Jul;301(7):110332
The Journal of biological chemistry 2025 Jul;301(7):110332
Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.
Yan S, Fu P, Zhu Y, Li H, Shan R, Gong B
Microbial pathogenesis 2025 Feb;199:107248
Microbial pathogenesis 2025 Feb;199:107248
FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways.
Li Y, Wang F, Ji B, Amati A, Cao L
BMC musculoskeletal disorders 2025 Apr 4;26(1):331
BMC musculoskeletal disorders 2025 Apr 4;26(1):331
Identification of CFH and FHL2 as biomarkers for idiopathic pulmonary fibrosis.
Liu X, Yang M, Li J, Liu H, Dong Y, Zheng J, Huang Y
Frontiers in medicine 2024;11:1363643
Frontiers in medicine 2024;11:1363643
Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
Dasgupta N, Lei X, Shi CH, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Liu T, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Yip KY, Berger SL, Adams PD
Molecular cell 2024 Sep 5;84(17):3271-3287.e8
Molecular cell 2024 Sep 5;84(17):3271-3287.e8
Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
Dasgupta N, Lei X, Shi CH, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Liu T, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Yip KY, Berger SL, Adams PD
bioRxiv : the preprint server for biology 2024 Jun 25;
bioRxiv : the preprint server for biology 2024 Jun 25;
Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice.
Ren L, Du W, Song D, Lu H, Hamblin MH, Wang C, Du C, Fan GC, Becker RC, Fan Y
iScience 2023 Jan 20;26(1):105769
iScience 2023 Jan 20;26(1):105769
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Xu Z, Tian M, Tan Q, Hao P, Gao Z, Li C, Jin N
International journal of molecular sciences 2023 Dec 26;25(1)
International journal of molecular sciences 2023 Dec 26;25(1)
FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells.
Wang C, Sun H, Davis JS, Wang X, Huo L, Sun N, Huang Q, Lv X, Wang C, He C, He C, Zhou Y, Wu J, Yang L, Hua G
Cell death & disease 2023 Apr 5;14(4):239
Cell death & disease 2023 Apr 5;14(4):239
The mechanical regulation of RNA binding protein hnRNPC in the failing heart.
Martino F, Varadarajan NM, Perestrelo AR, Hejret V, Durikova H, Vukic D, Horvath V, Cavalieri F, Caruso F, Albihlal WS, Gerber AP, O'Connell MA, Vanacova S, Pagliari S, Forte G
Science translational medicine 2022 Nov 23;14(672):eabo5715
Science translational medicine 2022 Nov 23;14(672):eabo5715
Oxymatrine Synergistically Enhances Doxorubicin Anticancer Effects in Colorectal Cancer.
Pan D, Zhang W, Zhang N, Xu Y, Chen Y, Peng J, Chen Y, Zhang Y, Shen X
Frontiers in pharmacology 2021;12:673432
Frontiers in pharmacology 2021;12:673432
Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2-M checkpoint modulation.
Cao Y, Gao A, Li X, Min H, He C, Sun X, Ding WQ, Zhou J
Cancer medicine 2021 May;10(9):3101-3112
Cancer medicine 2021 May;10(9):3101-3112
Expression, location and biological effects of four and a half LIM domain protein 2 (FHL2) on granulosa cells in ovine.
Zhang L, Li R, Chen L, Xing Z, Song Y, Nie X, Wang L, Han H, Liu A, Ma X, Ma RZ, Tian S
Reproduction in domestic animals = Zuchthygiene 2020 Jun;55(6):737-746
Reproduction in domestic animals = Zuchthygiene 2020 Jun;55(6):737-746
Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome.
Zhou R, Li S, Liu J, Wu H, Yao G, Sun Y, Chen ZJ, Li W, Du Y
EBioMedicine 2020 Feb;52:102635
EBioMedicine 2020 Feb;52:102635
Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
Lukash T, Agback T, Dominguez F, Shiliaev N, Meshram C, Frolova EI, Agback P, Frolov I
Journal of virology 2020 Dec 9;95(1)
Journal of virology 2020 Dec 9;95(1)
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.
Johnson RM, Yu H, Strank NO, Karunakaran K, Zhu Y, Brunham RC
Infection and immunity 2018 Feb;86(2)
Infection and immunity 2018 Feb;86(2)
A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.
Xu X, Fan Z, Liang C, Li L, Wang L, Liang Y, Wu J, Chang S, Yan Z, Lv Z, Fu J, Liu Y, Jin S, Wang T, Hong T, Dong Y, Ding L, Cheng L, Liu R, Fu S, Jiao S, Ye Q
Nature communications 2017 Jan 17;8:14059
Nature communications 2017 Jan 17;8:14059
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse ovary tissue were subjected to SDS PAGE followed by western blot with 21619-1-AP(FHL2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 21619-1-AP(FHL2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FHL2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FHL2. This antibody recognizes human, mouse, rat antigen. The FHL2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
