FHL2

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]

Description

Four and a half LIM domains 2

Tissue specificity

Group enriched (heart muscle, ovary)

Subcell location

Actin filaments, Focal adhesion sites

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (105357712 - 105438513)

Ensembl ID

ENSG00000115641  (ver. 103.38)

Orthologs

Mouse Fhl2: ENSMUSG00000008136

UniProt

Q14192

neXtProt

NX_Q14192

Human splice variants
Mouse splice variants

Protein structure