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- Antibody Data
- Antigen structure
- References [23]
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- Validations
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- Product number
- 19700-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19700-1-AP, RRID:AB_10640428
- Product name
- LRP2-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LRP2-Specific antibody (Cat. #19700-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney.
Cystinosin regulates Na(+)/H(+) exchanger 3 trafficking and function in kidney proximal tubular cells.
Differential early tubular injury in minimal Change disease and Focal segmental Glomerulosclerosis: A Multifaceted analysis.
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction.
Renal-Targeted Drug Delivery by Chitosan Oligosaccharide Micelles with HSA-Enriched Protein Corona for the Treatment of Ischemia/Reperfusion-Induced Acute Kidney Injury.
Inhibiting miRNA-146a suppresses mouse gallstone formation by regulating LXR/megalin/cubilin-media cholesterol absorption.
Megalin-targeted acetylcysteine polymeric prodrug ameliorates ischemia-reperfusion-induced acute kidney injury.
Megalin-targeting and ROS-responsive elamipretide-conjugated polymeric prodrug for treatment of acute kidney injury.
Dent disease 1-linked novel CLCN5 mutations result in aberrant location and reduced ion currents.
Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway.
TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
Effects of elevation of ANP and its deficiency on cardiorenal function.
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.
Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells.
Generation of a homozygous LRP2 knockout human embryonic stem cell line (FDCHDPe010-A-56) by CRISPR/Cas9 system.
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Evidence for a regulated Ca(2+) entry in proximal tubular cells and its implication in calcium stone formation.
Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.
Gelofusine Attenuates Tubulointerstitial Injury Induced by cRGD-Conjugated siRNA by Regulating the TLR3 Signaling Pathway.
TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin.
Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition.
Lian CY, Xia WH, Sun MC, Wan XM, Zhou XL, Wang L
Journal of advanced research 2026 Mar;81:1079-1093
Journal of advanced research 2026 Mar;81:1079-1093
Cystinosin regulates Na(+)/H(+) exchanger 3 trafficking and function in kidney proximal tubular cells.
Khare V, Farré JC, Ait Kbaich M, Rocca CJ, Tang C, Ma X, Biederman K, Mathur I, Badell-Grau RA, Sivakumar A, Chen R, Catz SD, Cherqui S
EMBO reports 2026 Apr;27(8):2088-2117
EMBO reports 2026 Apr;27(8):2088-2117
Differential early tubular injury in minimal Change disease and Focal segmental Glomerulosclerosis: A Multifaceted analysis.
Zhao Y, Qing J, Wang X, Li Y, Wu J
Gene 2026 Apr 20;988:150043
Gene 2026 Apr 20;988:150043
Epigenetic reprogramming of HDAC2 in CA1 excitatory neurons determines Pb-induced non-spatial memory deficits.
Wang M, Huang C, Ai S, Xia Y, Li C, Zhi Y, Wang K, Nie M, Gu X, Xu Y, Zhang H, Wang HL
Journal of hazardous materials 2025 Sep 5;495:138818
Journal of hazardous materials 2025 Sep 5;495:138818
Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction.
Heng Z, Hong M, Zhang Z, Ye X, Zhou J, Wu W, Rong J, Xu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e07554
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e07554
Renal-Targeted Drug Delivery by Chitosan Oligosaccharide Micelles with HSA-Enriched Protein Corona for the Treatment of Ischemia/Reperfusion-Induced Acute Kidney Injury.
Nan S, Che Y, Gong T, Zhang Z, Fu Y
ACS applied materials & interfaces 2024 Sep 18;16(37):49913-49925
ACS applied materials & interfaces 2024 Sep 18;16(37):49913-49925
Inhibiting miRNA-146a suppresses mouse gallstone formation by regulating LXR/megalin/cubilin-media cholesterol absorption.
Yang B, Cao P, Bao G, Wu M, Chen W, Wu S, Luo D, Bi P
Heliyon 2024 Sep 15;10(17):e36679
Heliyon 2024 Sep 15;10(17):e36679
Megalin-targeted acetylcysteine polymeric prodrug ameliorates ischemia-reperfusion-induced acute kidney injury.
Huang HL, Cheng N, Zhou CX, Liang J
Heliyon 2024 May 30;10(10):e30947
Heliyon 2024 May 30;10(10):e30947
Megalin-targeting and ROS-responsive elamipretide-conjugated polymeric prodrug for treatment of acute kidney injury.
Huang HL, Cheng N, Zhou CX
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116804
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116804
Dent disease 1-linked novel CLCN5 mutations result in aberrant location and reduced ion currents.
Wang Y, Xu L, Zhang Y, Fu H, Gao L, Guan Y, Gu W, Sun J, Chen X, Yang F, Lai E, Wang J, Jin Y, Kou Z, Qiu X, Mao J, Hu L
International journal of biological macromolecules 2024 Feb;257(Pt 2):128564
International journal of biological macromolecules 2024 Feb;257(Pt 2):128564
Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway.
Butkovič R, Walker AP, Healy MD, McNally KE, Liu M, Veenendaal T, Kato K, Liv N, Klumperman J, Collins BM, Cullen PJ
Nature communications 2024 Aug 21;15(1):7180
Nature communications 2024 Aug 21;15(1):7180
TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
Xie H, Shi Y, Zhou Y, Liu H
Molecular biology reports 2022 Oct;49(10):9181-9194
Molecular biology reports 2022 Oct;49(10):9181-9194
Effects of elevation of ANP and its deficiency on cardiorenal function.
Ilatovskaya DV, Levchenko V, Winsor K, Blass GR, Spires DR, Sarsenova E, Polina I, Zietara A, Paterson M, Kriegel AJ, Staruschenko A
JCI insight 2022 May 9;7(9)
JCI insight 2022 May 9;7(9)
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.
Chen Y, Wu X, Zhang J, Pan G, Wang X, Guo X, Wang J, Cui X, Gao H, Cheng M, Yang J, Zhang C, Jiang F
EMBO reports 2022 Feb 3;23(3):e53373
EMBO reports 2022 Feb 3;23(3):e53373
Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells.
Uchida Y, Torisu K, Ueki K, Tsuruya K, Nakano T, Kitazono T
American journal of physiology. Renal physiology 2021 Nov 1;321(5):F572-F586
American journal of physiology. Renal physiology 2021 Nov 1;321(5):F572-F586
Generation of a homozygous LRP2 knockout human embryonic stem cell line (FDCHDPe010-A-56) by CRISPR/Cas9 system.
You J, Cheng Y, Yang XJ, Chen L
Stem cell research 2021 May;53:102342
Stem cell research 2021 May;53:102342
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
He J, Chen H, Zhou W, Chen M, Yao Y, Zhang Z, Tan N
International journal of pharmaceutics 2020 Jun 30;584:119455
International journal of pharmaceutics 2020 Jun 30;584:119455
Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Otomo H, Nara M, Kato S, Shimizu T, Suganuma Y, Sato T, Morii T, Yamada Y, Fujita H
Metabolism: clinical and experimental 2020 Dec;113:154405
Metabolism: clinical and experimental 2020 Dec;113:154405
Evidence for a regulated Ca(2+) entry in proximal tubular cells and its implication in calcium stone formation.
Ibeh CL, Yiu AJ, Kanaras YL, Paal E, Birnbaumer L, Jose PA, Bandyopadhyay BC
Journal of cell science 2019 Apr 30;132(9)
Journal of cell science 2019 Apr 30;132(9)
Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.
Fatah H, Benfaed N, Chana RS, Chunara MH, Barratt J, Baines RJ, Brunskill NJ
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018 Jun 1;33(6):934-943
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018 Jun 1;33(6):934-943
Gelofusine Attenuates Tubulointerstitial Injury Induced by cRGD-Conjugated siRNA by Regulating the TLR3 Signaling Pathway.
Cen B, Liao W, Wang Z, Gao L, Wei Y, Huang W, He S, Wang W, Liu X, Pan X, Ji A
Molecular therapy. Nucleic acids 2018 Jun 1;11:300-311
Molecular therapy. Nucleic acids 2018 Jun 1;11:300-311
TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin.
Mazzocchi LC, Vohwinkel CU, Mayer K, Herold S, Morty RE, Seeger W, Vadász I
American journal of physiology. Lung cellular and molecular physiology 2017 Nov 1;313(5):L807-L824
American journal of physiology. Lung cellular and molecular physiology 2017 Nov 1;313(5):L807-L824
Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition.
Sun C, Velazquez MA, Marfy-Smith S, Sheth B, Cox A, Johnston DA, Smyth N, Fleming TP
Development (Cambridge, England) 2014 Mar;141(5):1140-50
Development (Cambridge, England) 2014 Mar;141(5):1140-50
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LRP2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human LRP2-Specific. This antibody recognizes human antigen. The LRP2-Specific antibody has been validated for the following applications: ELISA, WB analysis.
