LRP2

gene product
DBS, gp330
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR). [provided by RefSeq, Aug 2009]
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194 antibodies from 31 providers.

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AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
13 antibodies
Atlas Antibodies
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
Proteintech Group
1 antibody
antibodies-online
57 antibodies
LifeSpan BioSciences, Inc.
33 antibodies
Biorbyt
7 antibodies
Acris Antibodies GmbH
4 antibodies
Invitrogen Antibodies
5 antibodies
OriGene
6 antibodies
R&D Systems
8 antibodies
ReliaTech GmbH
1 antibody
GeneTex
1 antibody
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
Creative Biolabs
4 antibodies
Abgent
2 antibodies
Abnova Corporation
2 antibodies
Aviva Systems Biology
1 antibody
NSJ Bioreagents
1 antibody
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Boster Biological Technology
1 antibody
MyBioSource
5 antibodies
Creative Diagnostics
3 antibodies
RayBiotech, Inc.
1 antibody
Sigma-Aldrich
1 antibody
United States Biological
13 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
RabMAbs
1 antibody