Tissue expression
Cell line expression

LRP2

gene product
DBS, gp330 
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR). [provided by RefSeq, Aug 2009]
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371 antibodies from 34 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
Novus Biologicals
57 antibodies
antibodies-online
116 antibodies
OriGene
5 antibodies
Atlas Antibodies
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
ReliaTech GmbH
1 antibody
Invitrogen Antibodies
9 antibodies
Cusabio Biotech Co., Ltd
11 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
LifeSpan BioSciences, Inc.
48 antibodies
Biorbyt
21 antibodies
Acris Antibodies GmbH
4 antibodies
R&D Systems
8 antibodies
Boster Biological Technology
2 antibodies
GeneTex
1 antibody
Affinity Biosciences
1 antibody
Abgent
2 antibodies
Abnova Corporation
2 antibodies
Aviva Systems Biology
1 antibody
NSJ Bioreagents
1 antibody
Abbexa
16 antibodies
Creative Biolabs
12 antibodies
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
MyBioSource
5 antibodies
Creative Diagnostics
3 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
RayBiotech, Inc.
1 antibody
United States Biological
13 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
Leading Biology
1 antibody
RabMAbs
1 antibody