GPR78

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Description

G protein-coupled receptor 78

Tissue specificity

Tissue enhanced (esophagus, placenta)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

4 (8558725 - 8619761)

Ensembl ID

ENSG00000155269  (ver. 103.38)

Orthologs

-

UniProt

Q96P69

neXtProt

NX_Q96P69

Human splice variants

Protein structure