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- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- HPA002318 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA002318, RRID:AB_1849700
- Product name
- Anti-GLDC
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human GLDC, Gene description: glycine dehydrogenase (decarboxylating), Alternative Gene Names: GCSP, NKH, Validated applications: IHC, WB, Uniprot ID: P23378, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness
Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice.
Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity
Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis.
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Jog R, Chen G, Wang J, Leff T
Physiological Reports 2021;9(15)
Physiological Reports 2021;9(15)
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness
Choi C, Maher E, Malloy C, Mickey B, Sherry A, DeBerardinis R, Patel T, Pan E, Madden C, Pinho M, Thomas B, Dimitrov I, Levy M, Baxter J, Askari P, Lewis C, Raisanen J, Ganji S, An Z, Zhang S, Gao A, Hatanpaa K, Daoud E, Tiwari V
Neuro-Oncology 2020;22(7):1018-1029
Neuro-Oncology 2020;22(7):1018-1029
Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice.
Santos C, Pai YJ, Mahmood MR, Leung KY, Savery D, Waddington SN, Copp AJ, Greene N
The Journal of clinical investigation 2020 Mar 2;130(3):1446-1452
The Journal of clinical investigation 2020 Mar 2;130(3):1446-1452
Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity
Alptekin A, Ye B, Yu Y, Poole C, van Riggelen J, Zha Y, Ding H
Oncogene 2019;38(50):7504-7520
Oncogene 2019;38(50):7504-7520
Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis.
Jäger K, Larribère L, Wu H, Weiss C, Gebhardt C, Utikal J
Cancers 2019 Jan 11;11(1)
Cancers 2019 Jan 11;11(1)
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, Boukhali M, Hayward M, Li Y, Chen T, Liesa M, Hammerman P, Wong K, Hayes D, Shirihai O, Dyson N, Haas W, Meissner A, Bardeesy N
Nature 2016;539(7629):390-395
Nature 2016;539(7629):390-395
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Kim D, Fiske B, Birsoy K, Freinkman E, Kami K, Possemato R, Chudnovsky Y, Pacold M, Chen W, Cantor J, Shelton L, Gui D, Kwon M, Ramkissoon S, Ligon K, Kang S, Snuderl M, Vander Heiden M, Sabatini D
Nature 2015;520(7547):363-367
Nature 2015;520(7547):363-367
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in Caco-2 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-GLDC antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human placenta and skeletal muscle tissues using HPA002318 antibody. Corresponding GLDC RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
