GLDC

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). [provided by RefSeq, Jan 2010]

Description

Glycine decarboxylase

Tissue specificity

Tissue enriched (liver)

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (6532467 - 6645729)

Ensembl ID

ENSG00000178445  (ver. 103.38)

Orthologs

Mouse Gldc: ENSMUSG00000024827

UniProt

P23378

neXtProt

NX_P23378

Human splice variants
Mouse splice variants

Protein structure