Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10147-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10147-1-AP, RRID:AB_2299701
- Product name
- tPA antibody
- Antibody type
- Polyclonal
- Description
- tPA antibody (Cat. #10147-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
CD44s-activated tPA/LRP1-NFκB pathway drives lamellipodia outgrowth in luminal-type breast cancer cells.
An anti-inflammatory chondroitin sulfate-poly(lactic-co-glycolic acid) composite electrospinning membrane for postoperative abdominal adhesion prevention.
The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics.
Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy.
Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism.
Novel silk protein/hyaluronic acid hydrogel loaded with azithromycin as an immunomodulatory barrier to prevent postoperative adhesions.
Clostridium butyricum RH2 Alleviates Chronic Foot Shock Stress-Induced Behavioral Deficits in Rats via PAI-1.
A Prognostic Nomogram for Hepatocellular Carcinoma Based on Wound Healing and Immune Checkpoint Genes.
Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways.
Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer.
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
The Intestinal Microbiota Plays as a Protective Regulator Against Radiation Pneumonitis.
Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.
NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.
Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid.
tPA promotes the proliferation of lung fibroblasts and activates the Wnt/β-catenin signaling pathway in idiopathic pulmonary fibrosis.
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.
Tissue plasminogen activator contributes to alterations of neuronal migration and activity-dependent responses in fragile X mice.
Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice.
Okada A, Shimizu K, Kawashima A, Kayahara T, Itani M, Kurita H, Miyamoto S, Kataoka H, Aoki T
Scientific reports 2024 Feb 7;14(1):3105
Scientific reports 2024 Feb 7;14(1):3105
CD44s-activated tPA/LRP1-NFκB pathway drives lamellipodia outgrowth in luminal-type breast cancer cells.
Qiu Y, Wang H, Guo Q, Liu Y, He Y, Zhang G, Yang C, Du Y, Gao F
Frontiers in cell and developmental biology 2023;11:1224827
Frontiers in cell and developmental biology 2023;11:1224827
An anti-inflammatory chondroitin sulfate-poly(lactic-co-glycolic acid) composite electrospinning membrane for postoperative abdominal adhesion prevention.
Gao R, Li F, Zhang Y, Kong P, Gao Y, Wang J, Liu X, Li S, Jiang L, Zhang J, Zhang C, Feng Z, Huang P, Wang W
Biomaterials science 2023 Sep 26;11(19):6573-6586
Biomaterials science 2023 Sep 26;11(19):6573-6586
The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics.
Thapak P, Smith G, Ying Z, Paydar A, Harris N, Gomez-Pinilla F
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166781
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166781
Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy.
Klecker PH, Fritzen L, Mazura AD, Weggen S, Pietrzik CU
Journal of cellular biochemistry 2023 Jul;124(7):1040-1049
Journal of cellular biochemistry 2023 Jul;124(7):1040-1049
Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism.
Wu J, Jing X, Du Q, Sun X, Holgersson K, Gao J, He X, Hosaka K, Zhao C, Tao W, FitzGerald GA, Yang Y, Jensen LD, Cao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(24):e2301505
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(24):e2301505
Novel silk protein/hyaluronic acid hydrogel loaded with azithromycin as an immunomodulatory barrier to prevent postoperative adhesions.
Tian L, Sun T, Fan M, Lu H, Sun C
International journal of biological macromolecules 2023 Apr 30;235:123811
International journal of biological macromolecules 2023 Apr 30;235:123811
Clostridium butyricum RH2 Alleviates Chronic Foot Shock Stress-Induced Behavioral Deficits in Rats via PAI-1.
Zhang W, Ding T, Zhang H, Chen Y, Liu L, Jiang J, Song S, Cheng H, Wu C, Sun J, Wu Q
Frontiers in pharmacology 2022;13:845221
Frontiers in pharmacology 2022;13:845221
A Prognostic Nomogram for Hepatocellular Carcinoma Based on Wound Healing and Immune Checkpoint Genes.
Hu B, Shen X, Qin W, Zhang L, Zou T, Dong Q, Qin LX
Journal of clinical and translational hepatology 2022 Oct 28;10(5):891-900
Journal of clinical and translational hepatology 2022 Oct 28;10(5):891-900
Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.
Dong H, Qin YQ, Sun YC, Yao HJ, Cheng XK, Yu Y, Lu SS
Neuropsychiatric disease and treatment 2021;17:1057-1067
Neuropsychiatric disease and treatment 2021;17:1057-1067
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, Liu J, Fan W, Yi K, Kang C, Wu J
Redox biology 2021 Jan;38:101792
Redox biology 2021 Jan;38:101792
2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways.
Luo M, Shi X, Guo Q, Li S, Zhang Q, Sun X, Piao F
Bioscience reports 2021 Apr 30;41(4)
Bioscience reports 2021 Apr 30;41(4)
Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer.
Tang H, Zheng J, Bai X, Yue KL, Liang JH, Li DY, Wang LP, Wang JL, Guo Q
Frontiers in oncology 2020;10:564298
Frontiers in oncology 2020;10:564298
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
Dong Y, Hong W, Tang Z, Gao Y, Wu X, Liu H
Neurochemistry international 2020 Oct;139:104789
Neurochemistry international 2020 Oct;139:104789
The Intestinal Microbiota Plays as a Protective Regulator Against Radiation Pneumonitis.
Nie X, Li L, Yi M, Qin W, Zhao W, Li F, Wu B, Yuan X
Radiation research 2020 Jul 8;194(1):52-60
Radiation research 2020 Jul 8;194(1):52-60
Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.
Bres EE, Safina D, Müller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhäuser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, Faissner A
Glia 2020 Dec;68(12):2517-2549
Glia 2020 Dec;68(12):2517-2549
NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium.
Ma P, Li G, Jiang X, Shen X, Li H, Yang L, Liu W
Aging 2020 Dec 19;13(3):3661-3679
Aging 2020 Dec 19;13(3):3661-3679
Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid.
Halakos EG, Connell AJ, Glazewski L, Wei S, Mason RW
Journal of proteomics 2019 Oct 30;209:103491
Journal of proteomics 2019 Oct 30;209:103491
tPA promotes the proliferation of lung fibroblasts and activates the Wnt/β-catenin signaling pathway in idiopathic pulmonary fibrosis.
Chen L, Hou J, Fu X, Chen X, Wu J, Han X
Cell cycle (Georgetown, Tex.) 2019 Nov;18(22):3137-3146
Cell cycle (Georgetown, Tex.) 2019 Nov;18(22):3137-3146
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.
Liu Y, Wang S, Sun D, Liu Y, Liu Y, Wang Y, Liu C, Wu H, Lv Y, Ren Y, Guo X, Sun G, Ma X
Scientific reports 2016 Jul 19;6:29858
Scientific reports 2016 Jul 19;6:29858
Tissue plasminogen activator contributes to alterations of neuronal migration and activity-dependent responses in fragile X mice.
Achuta VS, Rezov V, Uutela M, Louhivuori V, Louhivuori L, Castrén ML
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Jan 29;34(5):1916-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Jan 29;34(5):1916-23
Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice.
Zhi X, Xu C, Zhang H, Tian D, Li X, Ning Y, Yin L
PloS one 2013;8(4):e60960
PloS one 2013;8(4):e60960
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The tPA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human tPA. This antibody recognizes human,mouse,rat antigen. The tPA antibody has been validated for the following applications: ELISA, WB analysis.