PLAT

gene product
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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Novus Biologicals
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1 antibody
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Santa Cruz Biotechnology
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antibodies-online
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Abgent
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NovoPro Bioscience Inc.
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1 antibody
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ProSci
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Acris Antibodies GmbH
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Boster Biological Technology
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Green Mountain Antibodies
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2 antibodies
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Abbkine Scientific Co.Ltd.
1 antibody
R&D Systems
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Molecular Innovations
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GenWay
9 antibodies
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Abbexa
3 antibodies
EMD Millipore
1 antibody
Sigma-Aldrich
1 antibody