PPARA

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Description

Peroxisome proliferator activated receptor alpha

Tissue specificity

Tissue enhanced (tongue)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Chromosome

22 (46150521 - 46243756)

Ensembl ID

ENSG00000186951  (ver. 103.38)

Orthologs

Mouse Ppara: ENSMUSG00000022383

UniProt

Q07869

neXtProt

NX_Q07869

Human splice variants
Mouse splice variants

Protein structure