CAPN1

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Description

calpain 1

Protein family

Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

11:q13.1 (65180566 - 65212006)

Ensembl ID

ENSG00000014216  (ver. 99.38)

Orthologs

Mouse Capn1: ENSMUSG00000024942

UniProt

P07384

neXtProt

NX_P07384

Human splice variants
Mouse splice variants