TPMT

gene product
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
414 antibodies from 30 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
48 antibodies
Abnova Corporation
6 antibodies
antibodies-online
145 antibodies
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
55 antibodies
OriGene
15 antibodies
GeneTex
8 antibodies
Invitrogen Antibodies
7 antibodies
Biorbyt
17 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abgent
3 antibodies
Affinity Biosciences
1 antibody
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
1 antibody
St John's Laboratory
2 antibodies
Boster Biological Technology
2 antibodies
Creative Biolabs
19 antibodies
Acris Antibodies GmbH
4 antibodies
Creative Diagnostics
5 antibodies
RabMAbs
2 antibodies
NSJ Bioreagents
1 antibody
Aviva Systems Biology
2 antibodies
United States Biological
49 antibodies
MyBioSource
5 antibodies
Leading Biology
3 antibodies
Sigma-Aldrich
2 antibodies
Abbexa
3 antibodies
EMD Millipore
1 antibody
RayBiotech, Inc.
1 antibody
Everest Biotech
1 antibody