ADARB1

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Description

adenosine deaminase, RNA-specific, B1

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

21:q22.3 (45073853 - 45226560)

Ensembl ID

ENSG00000197381  (ver. 84.38)

Orthologs

Mouse Adarb1: ENSMUSG00000020262

UniProt

P78563

neXtProt

NX_P78563

Human splice variants
Mouse splice variants