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Protein structure

PRKAR2B

Protein kinase cAMP-dependent type II regulatory subunit beta
PRKAR2 
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
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426 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
12 antibodies
Novus Biologicals
4 antibodies
Boster Biological Technology
4 antibodies
Biorbyt
41 antibodies
Proteintech Group
2 antibodies
HUABIO Research
1 antibody
Abnova Corporation
5 antibodies
antibodies-online
146 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
NovoPro Bioscience Inc.
5 antibodies
GeneTex
3 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
4 antibodies
Aviva Systems Biology
5 antibodies
Affinity Biosciences
1 antibody
OriGene
7 antibodies
Acris Antibodies GmbH
6 antibodies
RabMAbs
8 antibodies
Bioworld Technology, Inc
1 antibody
Abgent
6 antibodies
Creative Biolabs
6 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Bioss
1 antibody
MyBioSource
8 antibodies
United States Biological
57 antibodies
Abbexa
9 antibodies
ProSci
3 antibodies
Enzo Life Sciences
2 antibodies
Creative Diagnostics
3 antibodies
RayBiotech, Inc.
1 antibody
Leading Biology
5 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
EMD Millipore
2 antibodies
GenWay
1 antibody