PRSS3

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

Description

Serine protease 3

Tissue specificity

Tissue enriched (pancreas)

Subcell location

Endoplasmic reticulum, Vesicles

Predicted location

Intracellular, Secreted to digestive system

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9:p13.3 (33750679 - 33799231)

Ensembl ID

ENSG00000010438  (ver. 103.38)

Orthologs

-

UniProt

P35030

neXtProt

NX_P35030

Human splice variants