TPP2

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

Description

Tripeptidyl peptidase 2

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

13:q33.1 (102596986 - 102679958)

Ensembl ID

ENSG00000134900  (ver. 103.38)

Orthologs

Mouse Tpp2: ENSMUSG00000041763

UniProt

P29144

neXtProt

NX_P29144

Human splice variants
Mouse splice variants